Tıp Fakültesi / Faculty of Medicine
Permanent URI for this collectionhttps://hdl.handle.net/11727/1403
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Item Serum YKL-40 (Chitinase 3-Like Protein 1) Levels in Migraine Patients During An Attack(2023) Horasanli, Bahriye; Sak, Zeynep Caliskan; Ozsahin, Aysun; Karabulut, Keziban UcarObjectives: The aim of this study was to investigate YKL-40 in migraine patients during migraine attacks. Methods: In this prospective study, 30 migraine patients with aura (MWA) and 30 migraine patients without aura (MWOA) who presented to the Neurological Outpatient Department of Konya City Hospital during a migraine episode as well as 28 healthy controls were included. According to the manufacturer's recommendations, serum YKL-40 levels were determined using an ELISA kit (FineTest). Statistical analysis of the data was performed with the IBM SPSS version 20.0 program. Results: The mean gender and age were similar between groups (p > 0.05). The serum YKL-40 level was 3575 +/- 604.975 pg/ml in the MWA group, 3339 +/- 492.689 pg/ml in the MWOA group and 3190 +/- 544.018 pg/ml in the control group. YKL-40 levels were significantly higher in MWA than in the control group (p=0.028). YKL-40 levels were similar in the MWA and MWOA groups (p=0.302). No significant difference was found between the group with MWOA and the control group (p=0.915). Conclusion: Although YKL-40 levels are increased in patients with migraine with aura during an attack, comprehensive studies with a larger sample are needed to clarify the relationship between YKL-40 and migraine.Item Serum YKL-40/chitinase 3-Like Protein 1 Level Is an Independent Predictor of Atherosclerosis Development in Patients with Obstructive Sleep Apnea Syndrome(2015) Bakirci, Eftal Murat; Unver, Edhem; Degirmenci, Husnu; Kivanc, Tulay; Gunay, Murat; Hamur, Hikmet; Buyuklu, Mutlu; Ceyhun, Gokhan; Topal, Ergun; Coban, Taha Abdulkadir; 26142786Objective: The inflammatory process plays an important role in the development of cardiovascular complications in patients with obstructive sleep apnea syndrome (OSAS). YKL-40/chitinase 3-like protein 1 is a novel biomarker of systemic inflammation. This study aimed to investigate whether carotid intima-media thickness (CIMT), a useful marker for early atherosclerosis, is associated with serum YKL-40/chitinase 3-like protein 1 levels in patients with normotensive and nondiabetic OSAS. Methods: The study included 40 OSAS patients and 40 agesex- and body mass index-matched healthy controls. Serum YKL-40 levels were detected by enzyme-linked immunosorbent assay. CIMT was measured by B-mode ultrasound. Results: The patients with OSAS had significantly increased CIMT and higher YKL-40 and high sensitivity C-reactive protein (hsCRP) levels than those of the controls. CIMT was strongly correlated with serum YKL-40 levels (r=0.694, p<0.001), hsCRP (r=0.622, p<0.001), age (r=0.525, p=0.001), and weakly correlated with apnea-hypopnea index (AHI) (r=0.365, p=0.021) and the percentage of recording time spent (PRTS) of oxygen saturation <90% (r=0.488, p=0.001). Moreover, it was detected that serum YKL-40 levels were strongly correlated with AHI (r=0.617, p<0.001), and weakly correlated with SaO 2 <90% of PRTS (r=0.394, p=0.012) and hsCRP (r=0.486, p=0.001). In multiple regression analyses, age and serum levels of YKL-40 and hsCRP were found to be independent predictors of CIMT. Conclusion: In patients with OSAS, CIMT was increased. This increase was associated with serum YKL-40 level. Increased serum level of YKL-40 may be an early predictor of atherosclerosis development in patients with OSAS.Item Relationship between plasma YKL-40 levels and endothelial dysfunction in chronic kidney disease(2019) Keskin, Gul Sema; Helvaci, Ozant; Yayla, Cagri; Pasaoglu, Ozge T.; Keskin, Caglar; Arinsoy, Turgay; Deric, Ulver B.; 30763987Background/aim: We aimed to evaluate the relationship between YKL-40 and endothelial dysfunction in chronic kidney disease. Materials and methods: Twenty-nine hemodialysis patients, 101 patients with nondialytic (stage 2, 3, 4, and 5 ND) chronic kidney disease (CKD), and 38 healthy individuals as a control group were included. YKL-40 levels were measured by ELISA. Endothelial dysfunction was indirectly measured by flow-mediated dilatation percentage (FMD) in the brachial artery. Results: YKL-40 levels were higher in CKD patients than controls and highest in HD patients (P = 0.001). FMD values were lower in nondialytic CKD patients and lowest in HD patients (P = 0.001). YKL-40 negatively correlated with eGFR and FMD values (r = -0.674 and r = -0.471, respectively). Conclusion: This study shows that YKL-40 increases with CKD stage and is negatively correlated with FMD measurements.Item Tekrarlayan bronşiyolit tanılı hastalarda serum ykl-40, periostin, neopterin düzeylerinin değerlendirilmesi(Başkent Üniversitesi Tıp Fakültesi, 2017) Aykurt, Oğuzhan; Yılmaz Özbek, ÖzlemHışıltı küçük havayollarında daralmanın neden olduğu, genellikle ekspiryumda uzamanın eşlik ettiği ince ıslığa benzer bir sestir. Hışıltılı bebek; iki yaş altı en az bir ay devam eden hışıltı ya da iki aylık sürede üç veya daha fazla hışıltı atağı geçiren ve altta yatan hastalık bulunmayan çocuklar için kullanılmaktadır. Hışıltılı çocuk, astım ve alerjik hastalıkların görülme insidansı gün geçtikçe artmaktadır. Gelişmiş ülkelerde beş yaşından küçük çocuklarda hışıltının prevalansı %15-32 olarak bulunmuştur. Tekrarlayan hışıltı atakları geçiren çocuklarda hışıltının süresi ve zamanına göre tanı ve takip kolaylığı açısından epizodik hışıltı ve çoklu tetikleyici hışıltı olmak üzere 2 fenotip belirlenmiştir. Bu çalışmanın amacı tekrarlayan hışıltısı olan çocuklarda neopterin, YKL-40, periostin düzeylerini değerlendirmek, epizodik hışıltısı ve çoklu tetikleyici hışıltısı olan hastalar arasında fark olup olmadığı değerlendirmeyi amaçlamıştır. Çalışmaya Temmuz 2016 – Haziran 2017 tarihleri arasında bir yıl boyunca Başkent Üniversitesi Tıp Fakültesi Hastanesi, Çocuk Sağlığı ve Hastalıkları, Çocuk Acil ve Çocuk Alerji Polikliniğine en az 4 defa hışıltı geçirme öyküsü ile başvuran 0-3 yaş arası cinsiyet farkı gözetmeksizin atak döneminde olmayan 61 epizodik hışıltılı çocuk, 51 çoklu tetikleyici hışıltılı çocuk ve benzer yaş ve cinsiyette 56 sağlam çocuk alındı. Hasta ve kontrol grubundan YKL-40, periostin, neopterin bakılabilmesi için rutin biyokimya testlerinde kullanılan tüplere 2 ml kan örneği alındı. YKL-40, periostin, neopterin değerleri gruplar arasında değerlendirildi. Çalışmaya katılan 168 hastanın tamamı 3 yaş altı çocuklardan alınmıştır. neopterin, YKL-40, periostin değerleri tekrarlayan hışıltı tanılı grupta kontrol grubuna göre daha düşük görülmüş ancak istatistiksel olarak anlamlı bir farklılık saptanmamıştır. Astım Prediktif İndeks‟e göre; neopterin, periostin, YKL-40 değerlerinin karşılaştırılmasında istatistiksel olarak anlamlı bir farklılık saptanmadı. Montelukast tedavisi altında olan hışıltılı çocukların YKL-40 ve periostin değerleri istatistiksel olarak anlamlı düşük bulunmuştur (p<0,05). Yaş ile neopterin, periostin ve YKL-40 düzeyi arasında negatif bir korelasyon bulunmuştur (p<0,05).Sonuç olarak çalışmamızda tekrarlayan hışıltı atağı geçiren çocuklarda; hışıltının fenotipine ve Astım Prediktif İndeks‟e göre periostin, YKL-40, neopterin değerleri arasında bir farklılık saptanmadı. Bu çalışma literatürde 3 yaş altı tekrarlayan hışıltılı çocuklarda serum periostin ve neopterin düzeylerinin incelendiği ilk çalışmadır. Bu konuda hasta sayısını daha fazla olduğu ve atak dönemi ile karşılaştırmaların yapılacağı kapsamlı çalışmalara ihtiyaç vardır. The wheezing is caused by the narrowing of the small airways, a scale similar to that of a thin one, often accompanied by extension in the expiration. Sweet baby; it is used for wheezing that lasts for at least one month under two years, or for children who have had three or more wheeze shots for two months and no underlying disease. The incidence of wheezing, asthma and allergic diseases is increasing day by day. The prevalence of wheezing in children under five years in developed countries was found to be 15-32%. In children with recurrent wheeze episodes were identified in terms of the duration and timing of wheezing and the ease of diagnosis and follow-up episodic wheeze and multiple trigger wheeze to be two phenotypes. The aim of this study in children with recurrent wheezing was to evaluate neopterin, YKL-40, periostin levels and to assess whether there is any difference between patients with episodic wheezing and multiple triggering wheeze. This study, between July 2016 and June 2017 Başkent University Medical Faculty Hospital, Child Health and Disease, Pediatric Emergency and Child Allergy Polyclinic were admitted to aged between 0-3 years who with at least 4 occasions whispering for a year wheezing non-attack period a total of 61 epizodic children, 51 multiple-triggering wheeze, and 56 healthy children of similar age and gender. Patients and control group received 2 ml blood samples from tubes used in routine biochemistry tests for YKL-40, Periostin, Neopterin. YKL-40, periostin and neopterin values were evaluated among the groups. All 168 patients participating in the study were from children under 3 years of age. Neopterin, YKL-40, periostin values were lower in the recurrent wheezing group than in the control group, but no statistically significant difference was found. According to Asthma Predictive Index; neopterin, periostin and YKL-40 values were not statistically different.YKL-40 and periostin values were found to be statistically lower in the wheezy children under montelukast treatment (p <0,05). There was a negative correlation between age and neopterin, periostin and YKL-40 levels (p <0.05).As a result, in our study, children who had recurring wheeze; There was no difference in periostin, YKL-40, neopterin levels according to the wheeze phenotype and Asthma Predictive Index. This is the first study of serum periostin and neopterin levels in children with recurrent wheezing in the literatüre. In this regard, there is a need for more patient numbers and extensive studies to compare with the episode.