Relationship between plasma YKL-40 levels and endothelial dysfunction in chronic kidney disease
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Date
2019
Authors
Keskin, Gul Sema
Helvaci, Ozant
Yayla, Cagri
Pasaoglu, Ozge T.
Keskin, Caglar
Arinsoy, Turgay
Deric, Ulver B.
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Abstract
Background/aim: We aimed to evaluate the relationship between YKL-40 and endothelial dysfunction in chronic kidney disease.
Materials and methods: Twenty-nine hemodialysis patients, 101 patients with nondialytic (stage 2, 3, 4, and 5 ND) chronic kidney disease (CKD), and 38 healthy individuals as a control group were included. YKL-40 levels were measured by ELISA. Endothelial dysfunction was indirectly measured by flow-mediated dilatation percentage (FMD) in the brachial artery.
Results: YKL-40 levels were higher in CKD patients than controls and highest in HD patients (P = 0.001). FMD values were lower in nondialytic CKD patients and lowest in HD patients (P = 0.001). YKL-40 negatively correlated with eGFR and FMD values (r = -0.674 and r = -0.471, respectively).
Conclusion: This study shows that YKL-40 increases with CKD stage and is negatively correlated with FMD measurements.
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Keywords
YKL-40, CKD, hemodialysis, atherosclerosis, endothelial dysfunction