Güzel Sanatlar Tasarım ve Mimarlık Fakültesi / Faculty of Fine Arts, Design and Architecture

Permanent URI for this collectionhttps://hdl.handle.net/11727/1397

Browse

Filters

20242

Settings

search.filters.applied.f.language: search.filters.language.en_US

Search Results

Now showing 1 - 2 of 2
  • No Thumbnail Available
    Item
    Investigation of the Genotoxic Effect of Fluoxetine Hydrochloride in Drosophila melanogaster
    (KSU TARIM VE DOGA DERGISI-KSU JOURNAL OF AGRICULTURE AND NATURE, 2024-04-17) Oz, Selda; Sarikaya, Zeynep Nur; Larcin, Ozum; Sarikaya, Rabia
    This study aimed to determine the potential genotoxic effect of fluoxetine hydrochloride (FLX-HCl), an antidepressant commonly used for treating depression, using Somatic Mutation and Recombination Test (SMART). Third-instar Drosophila melanogaster larvae transheterozygous for the mutations multiple wing hair (mwh) and flare (flr3) were chronically fed in a medium containing different concentrations of FLX-HCl (0.1, 0.5, 1, and 2 mg/mL) in the experimental group. Distilled water, 0.1 mM ethyl methane sulfonate (EMS), and 2% dimethyl sulfoxide (DMSO) were used in negative, positive, and solvent control groups, respectively. The survival percentages were calculated by determining the number of individuals surviving when the larvae completed their development in the experimental and control groups. In all application groups, the wings of 40 individuals with both normal and serrate wing phenotypes were examined under a microscope, and genetic changes were evaluated by counting the mutant clones in the wings. The data obtained show that 1 and 2 mg/mL concentrations of FLX-HCl caused toxic effects in D. melanogaster individuals. Additionally, FLX-HCl showed a negative genotoxic effect at 0.1 mg/mL concentration, insignificant at 0.5 mg/mL concentration, and positive at 1 and 2 mg/mL concentrations in terms of total mutation evaluation and clone induction frequency in D. melanogaster individuals.
  • No Thumbnail Available
    Item
    Metataxonomic Sequencing to Assess Microbial Safety of Buffalo Yogurts in Amasra Region
    (FOODBORNE PATHOGENS AND DISEASE, 2024) Delikanli-Kiyak, Berrak; Yilmaz, Ilkay
    Interest in the "microbiota" of dairy products and studies on this subject is increasing day by day. In this study, homemade buffalo yogurt was collected from five different local producers in Amasra province, and their microbiota was evaluated by next-generation sequencing. Salmonella enterica was found in all yogurts (1.2-3.17%). Klebsiella pneumoniae was found to be 1.12% and 5.15% in two of the samples. Staphylococcus aureus was found to be 3.17% in only a single sample. The presence of these potentially pathogenic bacteria suggests that more attention should be paid to hygiene rules during homemade production, processing, and distribution of these products being offered for sale in public markets. These yogurt products can potentially carry risks of contamination and should be periodically checked by the relevant authorities.