Tıp Fakültesi / Faculty of Medicine
Permanent URI for this collectionhttps://hdl.handle.net/11727/1403
Browse
25 results
Search Results
Item Evaluating the Aspects of Quality of Life in Individuals with Substance Use Disorder: A Systematic Review Based on the WHOQOL Questionnaire(2023) Bratu, Melania Lavinia; Sandesc, Dorel; Anghel, Teodora; Tudor, Raluca; Shaaban, Luai; Ali, Ayesha; Toma, Ana-Olivia; Bratosin, Felix; Turcu, Izabela; Gantsa, Andrei; Fericean, Roxana Manuela; Bondrescu, Mariana; Barata, Paula Irina; 38164463Substance Use Disorder (SUD) has become a significant public health concern and it profoundly impacts an individual's quality of life (QOL). This systematic review aimed to assess the QOL among patients with SUD, and to understand the differential impact of SUD on physical, mental, social, and environmental QOL domains, considering a variety of substances and identifying key factors that influence these outcomes. A comprehensive search was conducted in PubMed, Web of Science, Cochrane, and Scopus in January 2023, covering literature published until December 2022. The QOL was assessed using the World Health Organization Quality of Life (WHOQOL) instrument and the brief version of the WHOQOL, identifying the same four domains of QOL (physical, mental, social, and environmental). A total of 19 studies were selected for inclusion in the systematic review, based on individuals' polysubstance use, and excluding those using only nicotine or alcohol. The analysis included 6079 patients, with only 40.3% women, and a mean age of 36.6 years. The substances most commonly involved in SUD were cocaine (47.1%), alcohol (46.3%), and amphetamine (43.6%), considering most individuals being polysubstance users. The highest variability in QOL scores was observed in the physical domain. Mental disorders were reported in 68.3% of the patients, while long-term use of drugs, criminal history, unemployment, and low levels of education were identified as significant predictors for lower QOL by some of the studies. Similarly, sleep problems and teeth decay were also identified as significant worsening factors for QOL. This systematic review highlights that the WHOQOL survey is widely accepted and applicable for individuals with SUD worldwide. The results suggest a substantial negative impact of SUD on the QOL of affected individuals. The findings underscore the need for comprehensive interventions to address the physical, psychological, social, and environmental dimensions of QOL among individuals with SUD.Item Quality of Life And Anxiety in Turkish Patients with Anorectal Malformation(2014) Sari, Burcu Akin; Demirogullari, Billur; Ozen, Onur; Iseri, Elvan; Kale, Nuri; Basaklar, Can; https://orcid.org/0000-0002-9730-7206; 2-s2.0-84894287822; S-3910-2019AimThe aim of this study was to investigate quality of life (QoL) and anxiety level in Turkish children with anorectal malformation as well as the anxiety level of their mothers and the support group effects on anxiety. MethodsA total of 87 children and their parents were included. They were grouped according to children's age: <8 years (group 1), 8-12 years (group 2) and >12 years (group 3). The anxiety of all mothers and of children in group 3 was assessed by Spielberger's State-Trait Anxiety Index-2. The QoL of children in groups 2 and 3 was evaluated with the Ped-QL 4.0 test by self-report and proxy report. The QoL results in groups 2 and 3 were compared with age-matched controls. ResultsMothers in groups 1 and 3 were more anxious than were those in group 2. Adolescents in group 3 had poorer QoL compared with controls by self- and proxy reports. A significant difference was observed in QoL between the children who did and those who did not soil. The anxiety level was significantly lower in parents who attended more than one meeting. ConclusionsHigh anxiety and poor QoL levels in adolescence may have been related to the growing importance of body image. The higher anxiety levels of mothers in group 1 could be explained by an encounter with a baby who was different from the imagined baby and the newness of illness. QoL may have been perceived as being worse than what it was for psychological reasons.Item Impact of Rheumatoid Arthritis in Turkey: A Questionnaire Study(2014) Yucel, E.; https://orcid.org/0000-0002-4860-9072; 24960289; F-8858-2011Objective Unmet needs of rheumatoid arthritis (RA) patients regarding physician/patient communication, treatment preferences and quality of life issues were investigated in a Turkish survey study. Methods The study was conducted with the contribution of 33 rheumatologists, and included 519 RA patients. The study population included patients who had been on biologic therapy for >6 months and were still receiving biologic therapy (BT group), and those who were biologic naive, but found eligible for biologic treatment (NBT group). Of the RA patients, 35.5% initially had a visit to an internal disease specialist, 25.5% to a physical therapy and rehabilitation specialist, and 12.2% to a rheumatology specialist for their RA complaints. The diagnosis of RA was made by a rheumatologist in 48.2% of patients. Results The majority of RA patients (86.3%) visit their doctor within 15-week intervals. Most of the physician-patient communication focused on disease symptoms (99.0%) and impact of the disease on quality of life (61.8%). The proportion of RA patients who perceived their health status as good/very good/excellent was higher in the BT group than in the NBT group (74.3% vs. 51.5%, p<0.001). However, of those RA patients in the NBT group, only 24.8% have been recommended to start a biologic treatment by their doctors. With respect to dose frequency options, once-monthly injections were preferred (80%) to a bi-weekly injection schedule (8%). Conclusion In conclusion, RA patients receiving biologic therapy reported higher rates of improved symptoms and better quality of life and seemed to be more satisfied with their treatment in our study.Item Evaluation of Restless Legs Syndrome in Fibromyalgia Syndrome: An Analysis of Quality of Sleep and Life(2014) Civelek, Gul Mete; Ciftkaya, Pinar Oztop; Karatas, Metin; 24867908; AAD-3858-2021BACKGROUND AND OBJECTIVE: The aim of this study is to find prevalence and severity of restless legs syndrome (RLS) in patients with fibromyalgia syndrome (FMS) and detect effect of FMS and RLS coexistance on quality of sleep and life. METHODS: In this study, presence and severity of RLS were detected in patients with FMS and Pitsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS) and Fibromyalgia Impact Questionnaire (FIQ) scores of all patients were measured. RESULTS: One hundred and fifteen female patients with median age 49 (39.0-57.0) [median (25-75% interquartile range)] were included in the study. In 42.6% of patients RLS coexisting with FMS was found. RLS was classified as moderate in 42.9% of patients and as severe in 49.0% of patients. In patients with FMS ans RLS sleep quality, daytime sleepiness and quality of life were more severely impaired (PSQI scores were 9.0 +/- 4.4 vs 7.8 +/- 4.3, p = 0.003; ESS scores were 5.0(3.0-7.5) vs 3.0(1.0-4.3), p = 0.036 and FIQ scores were 68.1 +/- 9.8 vs 59.4 +/- 16.9, p = 0.027) compared to patients with only FMS. Prevalence of RLS was found higher in FMS than normal population and quality of sleep and quality of life were worse in patients with RLS. CONCLUSIONS: Presence of RLS should be investigated in every patient with FMS and treatment plans should also cover RLS in case of coexistance with FMS. Prospective cohort studies are needed for better explanation of FMS and RLS coexistance.Item The Impact of Psychiatric Disorders with Cardiac Syndrome X on Quality of Life: 3 Months Prospective Study(2014) Altintas, Ebru; Yigit, Fatma; Taskintuna, Nilgun; https://orcid.org/0000-0003-2735-4805; https://orcid.org/0000-0003-1541-6167; 25419392; G-8832-2015; ABC-8170-2021The aim of the study is to investigate the impact of psychiatric disorders with cardiac syndrome X (CSX) on the patients' quality of life, as well as the efficacy of psychiatric support. Fifty-six CSX and fifty-three Coronary Heart Disease patients were included in the study after coronary angiography. Patients were evaluated right after the angiography and 3 months thereafter. The socio-demographic characteristics, comorbid disorders, Beck Anxiety (BAI), Depression (BDI) Inventory, and Health Related Quality of Life (SF-36) were compared between groups. The most common mental disorders was depression which account for 41%, the next were anxiety disorders (64%, n = 36) and somatoform (24%, n = 14). Initially, BAI, BDI in the CSX group were significantly higher when compared to the control group. There was significant difference in all subgroups of SF-36 at the end of the second evaluation versus the first evaluation in the CSX patients. The present study revealed that patients with CSX have higher prevalence of psychiatric comorbidities and lower quality of life. Psychiatric approaches are benefit for CSX patients to improvement their quality of life.Item Parental Perceptions Concerning the Effect of Center-Based Childcare on Quality of Life for Healthy 2-To 4-Year-Old Children(2015) Atay, Gulsum; Uneri, Ozden Sukran; Vatandas, Nilgun Salk; Taskintuna, Nilgun; 0000-0001-8710-1426; 26613218; B-9987-2009In this study, we investigated the effects of center-based childcare on the quality of life in healthy 2- to 4-year-old children. The study was conducted in the Baskent University School of Medicine Department of Pediatrics, and comprised 168 healthy 2- to 4-year-old children followed in the well-child outpatient clinic. After giving informed consent, the accompanying parent was asked to complete the parent proxy report of the Pediatric Quality of Life Inventory (TM) 4.0 and a sociodemographic information form. Among the children in the study group, 42.26% (n=71) were girls and 31.36 % (n=51) were attending childcare; 69% of the respondent parents were mothers (n=116). The mean total scale score of the study sample was 82.71 +/- 11.77. Total scale scores as well as psychosocial health, physical health, social functioning and emotional functioning subscale scores were significantly higher in children attending childcare. In particular, mothers whose children were attending center-based childcare perceived their children's quality of life as higher, regardless of their educational and employment status. Improving access to center-based childcare may help to improve the quality of life for young children in Turkey.Item Patient-Reported Outcomes with Cemiplimab Monotherapy for First-Line Treatment of Advanced Non-Small Cell Lung Cancer with PD-L1 Of >= 50%: The EMPOWER-Lung 1 Study(2023) Gumus, Mahmut; Chen, Chieh-, I; Ivanescu, Cristina; Kilickap, Saadettin; Bondarenko, Igor; Ozguroglu, Mustafa; Gogishvili, Miranda; Turk, Haci M.; Cicin, Irfan; Harnett, James; Mastey, Vera; Naumann, Ulrike; Reaney, Matthew; Konidaris, Gerasimos; Sasane, Medha; Brady, Keri J. S.; Li, Siyu; Gullo, Giuseppe; Rietschel, Petra; Sezer, Ahmet; 36308296Background In the EMPOWER-Lung 1 trial (, NCT03088540), cemiplimab conferred longer survival than platinum-doublet chemotherapy for advanced non-small cell lung cancer (NSCLC) with programmed cell death-ligand 1 (PD-L1) >= 50%. Patient-reported outcomes were evaluated among trial participants. Methods Adults with NSCLC and Eastern Cooperative Oncology Group performance status 0 to 1 were randomly assigned cemiplimab 350 mg every 3 weeks or platinum-doublet chemotherapy. At baseline and day 1 of each treatment cycle, patients were administered the European Organization for Research and Treatment of Cancer Quality of Life-Core 30 (QLQ-C30) and Lung Cancer Module (QLQ-LC13) questionnaires. Mixed-model repeated measures analysis estimated overall change from baseline for PD-L1 >= 50% and intention-to-treat populations. Kaplan-Meier analysis estimated time to definitive deterioration. Results In PD-L1 >= 50% patients (cemiplimab, n = 283; chemotherapy, n = 280), baseline QLQ-C30 and QLQ-LC13 scores showed moderate-to-high functioning and low symptom burden. Change from baseline favored cemiplimab on global health status/quality of life (GHS/QOL), functioning, and most symptom scales. Risk of definitive deterioration across functioning scales was reduced versus chemotherapy; hazard ratios were 0.48 (95% CI, 0.32-0.71) to 0.63 (95% CI, 0.41-0.96). Cemiplimab showed lower risk of definitive deterioration for disease-related (dyspnea, cough, pain in chest, pain in other body parts, fatigue) and treatment-related symptoms (peripheral neuropathy, alopecia, nausea/vomiting, appetite loss, constipation, diarrhea) (nominal p < .05). Results were similar in the intention-to-treat population. Conclusions Results support cemiplimab for first-line therapy of advanced NSCLC from the patient's perspective. Improved survival is accompanied by improvements versus platinum-doublet chemotherapy in GHS/QOL and functioning and reduction in symptom burden.Item The Validity and Reliability of A Turkish Version of The Poverty-Related Quality of Life (Pqol) Questionnaire(2016) Yilmaz, Fikriye; 0000-0002-4884-3803; AAF-7789-2020Measuring poverty in health care settings may help to identify patients living in poverty and also support development of appropriate policies to reduce health inequalities. The objective of this study was to translate the Poverty-Related Quality of Life Questionnaire into Turkish and then test its validity and reliability for a Turkish patient population. The psychometric properties of the scale were examined by collecting data from 300 patients in emergency departments in three randomly selected hospitals in Ankara, Turkey. The results of the study suggest that the Turkish version of the Poverty-Related Quality of Life Questionnaire has satisfactory validity and reliability.Item Restless Legs Syndrome and Quality of Life in Chronic Hemodialysis Patients(2018) Kutlu, R.; Selcuk, N. Y.; Sayin, S.; Kal, O.; https://orcid.org/0000-0002-7751-4961; 29735856; AAJ-7586-2021Context: Restless legs syndrome (RLS) is a sensorimotor disorder that often has a profound impact on sleep and one of the most troublesome conditions experienced in hemodialysis patients. Aims: The aim of study was to search frequency of RLS and effects of RLS on quality of life (QoL) in chronic hemodialysis patients. Settings and Design: Chronic hemodialysis patients of classical hemodialysis units were chosen. Length of the study was approximately 1 year. Subjects and Methods: Two hundred and thirty-seven patients were investigated. RLS was diagnosed using to international the RLS questionnaire. The International RLS (IRLS) rating scale was used to calculate RLS severity. QoL was assessed using the World Health Organization QoL brief version (WHOQOL-BREF) instrument. Statistical Analysis Used: Student's t-test, Chi-square test or Fisher's exact test, Bonferroni correction for multiple comparisons, and Pearson or Spearman correlation analysis were used. Significance level was P < 0.05. Results: The overall prevalence of RLS according to the four essential criteria was 18.6% (n = 44). According to IRLS, 22.7% of the patients with RLS were mild (n = 10), 63.6% were moderate (n = 28), and 13.7% were severe (n = 6). The parameters of QoL were compared in RLS-positive and negative patients. There was no significant difference in psychological health (P = 0.971), social relationships (P = 0.462), and environment (P = 0.483) between two groups. Only the physical health scores were higher in without RLS than patients with RLS (P = 0.027). Conclusions: This study revealed that the frequency of RLS among chronic hemodialysis patients is 18.6% and RLS leads to physical life quality disturbances.Item Anxiety, depression, and sexual dysfunction in patients with psoriasis(2022) Dogan, Yusuf; Kilic, Fatma; Ozcelik, SinanBackground: There are few studies investigating the association between psoriasis and depression, anxiety, sexual dysfunction in the literature. Aims: We aimed to investigate depression, anxiety, and sexual dysfunction in patients with psoriasis and the association between the psychiatric comorbidity and the severity and involvement sites of psoriasis. Materials and Methods: A total of 200 participants, including 100 psoriasis patients and 100 healthy volunteers as a control group, were included in the study. All participants were questioned about sociodemographic characteristics, smoking, alcohol use, and comorbidities. All participants completed the Dermatology Life Quality Index, Beck Depression Scale, Beck Anxiety Scale, Arizona Sexual Experiences Scale, Female Sexual Function Scale/International Erectile Function Index. Results: In the psoriasis group, an increased risk for depression and anxiety was observed, regardless of the clinical features and severity of psoriasis, and a positive correlation was detected between the severity of the disease and impaired quality of life. An increased risk for sexual dysfunction regardless of clinical features and severity in male patients with psoriasis was detected compared with the control group. It was found that the risk for erectile dysfunction in patients with psoriasis increased regardless of the risk factors such as smoking, alcohol, diabetes, hypertension, and cardiovascular disease. Conclusion: Our study shows that psoriasis increases the risk for impaired quality of life, depression, anxiety, and sexual dysfunction in individuals. This increase is not always associated with the clinical characteristics of psoriasis such as severity, duration, and sites of involvement. Therefore, dermatologists should consider not only the skin findings of psoriasis but also the psychosocial status of the patient and refer the patient to psychiatry if necessary.
- «
- 1 (current)
- 2
- 3
- »