Tıp Fakültesi / Faculty of Medicine

Permanent URI for this collectionhttps://hdl.handle.net/11727/1403

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    Evaluation of the Relationship between Inflammatory, Metabolic, and Liver-Related Indexes and Blood Pressure Dipping Ratios: A Retrospective Study
    (2023) Guven, A. T.; 0000-0002-6310-4240; 38158357; GNW-3516-2022
    Background:Nighttime blood pressure dipping is a normal physiologic phenomenon. Lack of dipping is associated with increased cardiovascular disease; thus, non-dipping patients are candidates for more strict risk reduction strategies. Dipping presence can be identified using ambulatory blood pressure measurement (ABPM). Recent findings indicate that inflammatory, metabolic, and liver-related indices may have a role in predicting dipping presence dichotomously.Aim:To investigate whether dipping ratios correlate with that inflammatory, metabolic, and liver-related indices.Materials and Methods:Hypertensive patients with ABPM recordings were retrospectively collected. Patient characteristics, co-morbidities, medications, laboratory results, and ABPM results were analyzed. The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), triglyceride-glucose index (TyG), triglyceride-to-HDL ratio (TG/HDL), total cholesterol-to-HDL ratio (TC/HDL), AST-to-ALT ratio (AST/ALT), fibrosis-4 (FIB-4), and AST-to-platelet ratio index (APRI) were calculated. Differences and correlations were analyzed between indices, dipping patterns, and ratios.Results:Ninety-three patients were included in the study. Forty-five had either a systolic or diastolic dipping pattern. NLR, PLR, TG/HDL, and TC/HDL indices correlated negatively with dipping ratios. AST/ALT was higher in systolic dippers (1.04 vs 0.88, P = 0.03). However, no difference was observed between NLR, PLR, TyG, TG/HDL, TC/HDL, FIB-4, and APRI among different dipping presences.Conclusion:This study showed for the first time that there was a negative correlation between inflammatory and metabolic indices and dipping ratios.
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    Assessment of Subclinical Atherosclerosis by Carotid Intima-Media Thickness and Epicardial Adipose Tissue Thickness in Prediabetes
    (2016) Altin, Cihan; Sade, Leyla Elif; Gezmis, Esin; Ozen, Necmi; Duzceker, Ozkan; Bozbas, Huseyin; Eroglu, Serpil; Muderrisoglu, Haldun; 0000-0002-1001-6028; 0000-0003-3737-8595; 0000-0002-9635-6313; 0000-0003-3055-7953; 27069111; AAE-8301-2021; AAQ-7583-2021; ABG-1582-2021; AAG-8233-2020
    Impaired fasting glucose (IFG) and impaired glucose intolerance (IGT) are predictors of cardiovascular disease (CVD). We tested the hypothesis that epicardial fat thickness (EFT) and carotid intima-media thickness (cIMT), as markers of early atherosclerosis, are increased in patients with prediabetes. We prospectively enrolled 246 patients (162 with prediabetes and 84 controls). Prediabetes was defined according to American Diabetes Association criteria, and patients were divided into 3 groups: group 1IFG, group 2IGT, and group 3IFG + IGT. Both cIMT and EFT were significantly greater in patients with prediabetes compared with controls (0.81 +/- 0.20 mm vs 0.68 +/- 0.16 mm, P < .001 and 7.0 +/- 2.0 mm vs 5.6 +/- 1.6 mm, P < .001, respectively). This difference was mainly attributed to patients with IGT. Age, waist circumference, and 2-hour glucose independently predicted cIMT, while 2-hour glucose was the only independent predictor of EFT in multivariate analysis among other relevant parameters for cIMT and EFT. The cIMT and EFT (measured noninvasively) could be useful indicators of CVD risk in these patients. In order to prove this hypothesis, long-term prospective studies with greater patient numbers are required.
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    Morning Blood Pressure Surge Is Associated with Carotid Intima-Media Thickness in Prehypertensive Patients
    (2017) Alpaydin, Sertac; Turan, Yasar; Caliskan, Mustafa; Caliskan, Zuhal; Aksu, Feyza; Ozyildirim, Serhan; Buyukterzi, Zafer; Kostek, Osman; Muderrisoglu, Haldun; https://orcid.org/0000-0002-9635-6313; 28272109; AAG-8233-2020
    Objective Morning blood pressure (BP) surge (MBPS) is defined as an excessive increase in the morning BP from the lowest systolic BP during sleep and is reported as a risk factor for cardiovascular events in current clinical studies. In this study, we aimed to investigate the relationship between MBPS and carotid intima-media thickness (C-IMT) in prehypertensive patients. Patients and methods We evaluated the association between the rate of BP variation derived from ambulatory BP monitoring and C-IMT in patients with prehypertension. Results One hundred and seventy patients with prehypertension were included in the study. All office BP measurements and ambulatory 24-h, day-time, and night-time measurements were similar between each group. C-IMT [0.60 (range: 0.57-0.65) vs. 0.55 (range: 0.50-0.60) cm; P < 0.001] and the mean platelet volume [8.7 (range: 7.9-9.1) vs. 7.9 (range: 7.3-8.8) fl; P = 0.002] were significantly higher in the greater MBPS group than the lower group. In multivariate analysis, male sex [odds ratio (OR): 2.271, confidence interval (CI): 1.011-5.100, P = 0.047], greater MBPS (OR: 8.474, CI: 3.623-19.608, P < 0.001), and elevated mean platelet volume levels (OR: 3.359, CI: 1.978-5.705, P < 0.001) were found to be independent predictors of greater C-IMT in prehypertensive patients. Conclusion Our study suggests that greater MBPS is associated independently with C-IMT in prehypertensive patients. Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved.
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    Comparison of Epicardial Fat, Carotid and Femoral Intima-Media Thicknesses Between Hypertensive, Pre-Hypertensive and Control Groups
    (2020) Gunesli, Aylin; Yilmaz, Mustafa; 0000-0002-2557-9579; S-6973-2016
    Objective: The aim of this study was to evaluate whether pre-hypertension is a risk factor for cardiovascular events. For this reason epicardial fat thickness (EFT), carotid intima-media thickness (CIMT) and femoral intima-media thickness (FIMT), known as markers for subclinical atherosclerosis and cardiovascular risks were measured and compared among the pre-hypertensive, hypertensive and control groups. Material and methods: This cross-sectional study included 57 healthy controls (group 1), 58 pre-hypertensive patients (group 2) and 56 hypertensive patients (group 3). Pre-hypertension is defined as systolic blood pressure (SBP) 120-140 mm Hg and diastolic blood pressure (DBP) 80-90 mm Hg. Hypertension is defined as SBP>140 mm Hg and/or DBP>90 mm Hg. EFT, CIMT and FIMT were measured and compared among these groups. Results: There was a statistically significant difference among the groups in terms of EFT and CIMT (p<0.001, for both comparison). In addition there was a statistically significant difference between groups 2 and 1, and between groups 3 and 2 in terms of EFT and CIMT (p<0.001, for all comparisons). When we compared the all groups in terms of FIMT, we found a statistically significant difference (p<0.001). There was a statistically significant difference between groups 3 and 2 (p=0.001). However, there was not a statistically significant difference between groups 2 and 1 (p=0.773). Conclusion: These results may indirectly suggest that subclinical atherosclerosis and cardiovascular risks may be increased in pre-hypertensive patients. However, atherosclerosis in the carotid arteries may be affected by lower blood pressure than the femoral arteries.
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    Assesment of Spatial QRS-T Angle in Patients with Cardiac Syndrome X
    (2019) Muderrisoglu, Mustafa; Muderrisoglu, Haldun; 0000-0002-9635-6313; AAG-8233-2020
    Objective: Cardiac syndrome x (CSX) is defined as typical exertional angina, one or more abnormal cardiac stress test(s), and normal coronary arteries after exclusion of spontaneous or inducible epicardial coronary spasm. The aim of this study was to investigate cardiovascular adverse events risks in patients with CSX. For this purpose, spatial QRS-T angle that is predictor of these risks was evaluated in patients with CSX and control subjects. Methods: In a retrospective study, a total of 179 subjects (95 patients with CSX, 84 control) were examined. Control subjects had a normal coronary computed tomography. Spatial QRS-T angle value was calculated and compared in patients with CSX and control group, p values <0.05 were considered as statistically significant. Results: There was a statistically significant difference between the groups in terms of spatial QRS-T angle values [control group spatial QRS-T angle value median 35 (12.5 - 60), CSX group spatial QRS-T angle value median 51 (27 - 115), p<0.001]. Conclusion: According to our results, spatial QRS-T angle value was elevated in patients with CSX than in normal population. Furthermore, these results may indirectly suggest that the risk of adverse cardiac events may be increased in patients with CSX.