Tıp Fakültesi / Faculty of Medicine

Permanent URI for this collectionhttps://hdl.handle.net/11727/1403

Browse

Filters

2015 - 20172

Settings

Subject: search.filters.subject.Sarcoidosis

Search Results

Now showing 1 - 2 of 2
  • No Thumbnail Available
    Item
    Conventional Markers in Determination of Activity of Sarcoidosis
    (2015) Gungor, Sinem; Ozseker, Ferhan; Yalcinsoy, Murat; Akkaya, Esen; Can, Gunay; Eroglu, Hacer; Genc, Nilgun Sema; 25623898; GPG-3152-2022
    Aim and background: Currently, there are no objective criteria to determine sarcoidosis activity. The present study aimed to discover a sensitive serum marker that would determine the activity of sarcoidosis and can be used during disease follow-up. Methods: Forty-eight patients with sarcoidosis and twenty healthy volunteers as a control group were included in the study. On their control visits, the patients were divided into active and inactive groups based on their clinical, physiological, and radiological status. Angiotensin converting enzyme (ACE), adenosine deaminase (ADA), total IgE (T-IgE), C-reactive protein (CRP), serum amyloid-A (SAA), and soluble interleukin-2 receptor (sIL2R) serum levels and classical findings of activity were compared, and the utilization of these parameters as markers of activity was investigated. Results: Thirty-nine cases were female (female/male: 39/9) and the mean age was 44.29 +/- 10.9 years. Thirty-seven cases were active and 11 cases were inactive. Serum ACE, ADA, sIL2R, and SAA levels were significantly higher while T-IgE levels were lower in the sarcoidosis cases. A comparison of the markers between active and inactive cases showed that only SAA was significantly higher (p < 0.001). sIL2R was elevated in cases with extra-pulmonary involvement (p < 0.014). The area under the curve value was rather high for ADA (0.98 CI: 0.96-1.0); it also had high sensitivity (93.8%) and specificity (100%), and therefore had the highest diagnostic value (96.6%). Conclusion: The current study showed that SAA wil be helpfull for detecting the activity of srcoidosis, IL2R measurement in exploring the extra-pulmonary organ involvement (C) 2015 Elsevier B.V. All rights reserved.
  • No Thumbnail Available
    Item
    Acute Pancreatitis Caused by Primary Pancreatic Lymphoma in A Geriatric Patient with Sarcoidosis: Report of A Complex Case
    (2017) Ozer Etik, Digdem; Suna, Nuretdin; Tepeoglu, Merih; Coskun, Mehmet; Selcuk, Haldun; 0000-0002-4724-0728; 0000-0001-6234-7788; 0000-0002-9894-8005; 0000-0001-5630-022X; 0000-0002-8445-6413; AAJ-4707-2021; AAI-8822-2021; AAK-5222-2021; AAM-4120-2021; AAJ-6976-2021
    The purpose of reporting this case is to raise the awareness of the rapid worsening clinical presentation of acute pancreatitis in an older patient, unexpected encounter with pancreatic lymphoma, and sarcoidosis-lymphoma syndrome. An 80-year-old woman was diagnosed with sarcoidosis 16 years ago. Following recent hospitalization because of acute pancreatitis, non-obstructive and non-invasive pancreatic mass was found on radiological images. Histopathology confirmed the mass to be diffuse large B-cell lymphoma. We report this case because of its complicated the etiology of acute pancreatitis in an older patient, presentation of pancreatic lymphoma, and immune pathogenesis of sarcoidosis-lymphoma syndrome.