Tıp Fakültesi / Faculty of Medicine
Permanent URI for this collectionhttps://hdl.handle.net/11727/1403
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Item Osteoporosis Knowledge Level of the Women Living in the City of Kirikkale(2015) Arslan, Saniye A.; Daskapan, Arzu; Atalay, Didem K.; Tuzun, Emine H.; Korkem, DuyguPurpose: Osteoporosis is an important common public health problem among postmenopausal women. Purpose of this study is to research osteoporosis awareness level of the women living in the city of Kirikkale and releationship between awareness level and age and level of education. Methods: 263 women participated to the study. Osteoporosis related risk factors of the participants, such as; socio-demographic data, marital status, occupational status, education level, physical exercise and smoking level were recorded. In accordance with the literature, participants were divided into two groups as young adults (under 45 years) and middle aged (45-64 years). They were also divided according to education levels as; primary education (8 years of education or less) and secondary and higher education (more than 8 years of education). Osteoporosis knowledge level was evaluated by Osteoporosis Self-efficacy Scale Turkish Version and Osteoporosis General Knowledge Score Scale (KOS). Results: Mean age of the participants is 38.98 +/- 13.81 year, body mass index (BMI) 27.26 +/- 0.39 kg/m(2), education level is 8.65 +/- 5.16 years. There was positive correlation between Osteoporosis Exercise Self Sufficiency (a subscale of Osteoporosis Self-efficacy Scale), education level (p = 0.001; r = 0.326), Osteoporosis Exercise Self Sufficiency score and regular exercise (p = 0.001). Similarly, There was positive correlation between Osteoporosis Self Sufficiency Scale total score and education level (p = 0.001; r = 0.293), Osteoporosis Self Sufficiency Scale total score and regular exercise (p = 0.001). There was positive correlation between Osteoporosis Calcium Self Sufficiency Subscale (a subscale of Osteoporosis Self-efficacy Scale) score and education level (p = 0.006; r = 0.170). There was no significant correlation between Osteoporosis Calcium Self Sufficiency Subscale score and regular exercise (p = 0.816). Discussion: Our study shows that osteoporosis knowledge level of the women living in Kirikkale increases in parallel to their education level and osteoporosis knowledge levels of younger women are higher.Item Balloon Kyphoplasty Is a Safe and Effective Option for the Treatment of Vertebral Compression Fractures in Solid-Organ Transplant Recipients(2020) Sonmez, Erkin; Comert, Serhat; Akdur, Aydincan; Karakaya, Emre; Gulsen, Salih; Yilmaz, Cem; Altinors, Nur; Haberal, Mehmet; 0000-0002-7535-1804; 0000-0002-8726-3369; 0000-0002-3462-7632; 0000-0002-5693-3542; 0000-0002-4879-7974; 0000-0002-2353-8044; 27063841; AAJ-5746-2021; AAA-3068-2021; AAJ-8097-2021; AAI-8820-2021; AAD-5466-2021; AAK-2948-2021Objectives: Solid-organ transplant recipients are at great risk for osteoporotic vertebral compression fractures because of both underlying pretransplant bone diseases and posttransplant immunosuppressive treatments. Balloon kyphoplasty is a minimally invasive procedure that is used to treat painful osteoporotic vertebral compression fractures. It involves injection of polymethylmethacrylate into the vertebral body to stabilize the fracture and to alleviate the pain immediately. In this study, we report the results of balloon kyphoplasty for treatment of vertebral compression fractures in solid-organ transplant recipients. Materials and Methods: We retrospectively reviewed 512 liver transplant and 2248 kidney transplant procedures that were performed in our center between 1985 and 2015. Seven transplant recipients with a total of 10 acute, symptomatic vertebral compression fractures who were unresponsive to conservative treatment for 3 weeks underwent balloon kyphoplasty. Clinical outcome was graded using the visual analog scale. Radiographic evaluation included measurement of the segmental kyphosis by the Cobb method. Results: There were 4 female and 3 male patients in our study group. Ages of patients ranged from 56 to 63 years with an average age of 58.8 years. The affected vertebral levels varied from T12 to L4. Mean follow-up after balloon kyphoplasty was 3.4 years, and mean time interval from transplant to balloon kyphoplasty was 8.6 years. Statistically significant difference is evident 3 years after transplant surgery (P < .05). Sagittal alignment improved (> 5 degrees) in 2 of 7 patients (28%). Conclusions: Transplant recipients are at great risk in terms of vertebral compression fracture development, especially within 1 year after transplant. Although conservative treatment has been the first treatment choice for vertebral compression fracture, long treatment time and high costs may be needed to achieve cure. Experience with our small patient population showed that balloon kyphoplasty was effective and safe for obtaining rapid pain relief and earlier mobilization with fewer complications.Item Bilateral Femoral Head Insufficiency Fractures and Multiple Vertebral Fractures: A Case Report on Rare Presentations of Pregnancy and Lactation-associated Osteoporosis and Their Outcomes(2020) Ozen, Selin; Yemisci, Oya Umit; Sozay, Seyhan; 0000-0002-7290-8558; 0000-0002-0501-5127; ABC-1305-2020Pregnancy and lactation-associated osteoporosis (PLO) is a rare condition seen in the last trimester of pregnancy and early puerperal period which can result in vertebral and femoral fractures. In this case report, two cases of fractures secondary to PLO, their management and clinical outcomes are presented. Case one describes a patient with vertebral fractures secondary to PLO who was treated with bisphosphonates. Case two describes a rare case of bilateral femoral head stress fractures secondary to PLO, treated with bed rest, a home exercise programme and calcium and vitamin D supplementations. Pharmacological treatment of PLO includes teriparatide and strontium ranelate and crossover treatments-all of which require the cessation of breastfeeding. The optimal PLO treatment remains to be determined. Further studies comparing the clinical and biological outcomes of these drugs are necessary so that clinicians can accurately advise women on the risks and benefits of each, for both themselves and their child and guide patients in making a suitably informed decision regarding treatment.Item Evaluation of bone mineral density and its associated factors in postpartum women(2019) Eroglu, Semra; Karatas, Gulsah; Aziz, Vusale; Gursoy, Aybala Fatma; Ozel, Sule; Gulerman, Hacer Cavidan; 31759531; AAD-8353-2020Objective: Although osteoporosis commonly appears among postmenopausal women, it is rarely diagnosed during the postpartum period as pregnancy-lactation associated osteoporosis (PAO). The aim of the study reported here was to investigate low bone mineral density and its associated risk factors in postpartum women. Materials and methods: The sample consisted of 93 females aged 18-40 years and in the first month of the postpartum period. All the women had low back pain. The bone mineral density (BMD) Z-score values of the lumbar vertebrae, femur (neck and total) were examined using dual energy x-ray absorbtiometry four weeks after birth. Patients body mass index (BMI), 25-hydroxyvitaminD (25-OHD) levels and complete blood counts were recorded. Participants were divided into two groups to their Z scores: the normal group (n = 71) and the low BMD group (n = 22). Results: The 25-OHD levels were significantly lower (p = .02) in the low BMD group [4.45 (4.0-12.4)] than in the control group [22 (12-48)], however, NLR and PLR values were similar between groups. BMI positively correlated with BMD scores for the lumbar, femoral neck and femoral overall (p = .011, p = .026 and p = .026, respectively). Conclusion: Vitamin D deficiency and BMI may play a critical role in PAO. Low back pain during postpartum period should be carefully evaluated. Adequate calcium and vitamin D supplementation may prevent possible bone loss. (C) 2019 Taiwan Association of Obstetrics & Gynecology. Publishing services by Elsevier B.V.Item Are Bone Turnover Markers Related with Fracture Risk in Initial Diagnose Postmenopausal Osteoporosis? A Cross-Sectional Clinical Study(2015) Yalbuzdag, Seniz Akcay; Sarifakioglu, Banu; Sengul, Ilker; Cetin, NuriObjective: In this study, we investigated the relationships between 10 year fracture risk calculated with FRAX assessment tool and bone turnover markers (BTM) in women with diagnosed as postmenopausal osteoporosis for the first time. Materials and Methods: After exclusion of the causes of secondary osteoporosis 61 postmenopausal women diagnosed with osteoporosis for the first time were enrolled. Height and weight measurements, comorbid diseases, menopause age, and laboratory investigations were recorded. Lumbar and femur neck and femur total T scores were measured by dual-energy x-ray absorptiometry (DXA). As BTM, serum osteocalcin (OC) and urine deoxypridinoline levels were measured. 10-year fracture risk of hip and major osteoporotic fracture was calculated with FRAX assessment tool. Results: The mean age of patients was 61 +/- 39 years. Median value of menopause year was 15.13 years (min: 2, max: 40). The median 10-year hip fracture and major osteoporotic fracture risks were calculated as 1.10% (min: 0, max: 23), 6.9% (min: 3, max: 34) respectively. There was no significant relationship between BTM and fracture risk. Positive significant correlation was found between menopause year and hip fracture risk, and between menopause year and major osteoporotic fracture risks (p=0.031, 0.276; p=0.025, r=0.287). Negative significant correlation was detected between body mass index and hip fracture risk (p=0.002, r=-0.392). Conclusion: In our study, we couldn't find relationship between BTM and fracture risks assessed by using FRAX tool in patients with initially diagnosed of postmenopausal osteoporosis. Further studies are needed to investigate the relationship between BTM and fracture risk in different patient groups.Item Vertebroplasty in Vertebral Compression Fractures: Single Institute Experience with 49 Cases(2017) Altınel, Faruk; Soylev, Gozde Ozcan; Tuncali, Bahattin; Altinors, Mehmet Nur; 0000-0002-7898-2943; 0000-0001-8742-5543; 0000-0002-8326-3900; AAJ-7840-2021; AAJ-4917-2021; AAJ-5382-2021Objective: Percutaneous vertebroplasty (PVP) is the preferred treatment option for vertebral compression fractures (VCF). In this study, the efficacy and complications of PVP were investigated among 49 patients with VCF. Methods: Forty-nine patients with VCF due to osteoporosis, trauma, osteolytic bone tumors, metastases or leukemia who were admitted to our hospital between 2012 and 2015 and treated with PVP were included in the study. In patients' preoperative and postoperative evaluation, a visual analogue scale (VAS) was used to assess back and leg pain, preoperative routine lumbar vertebral radiography was used for fracture morphology, lumbar magnetic resonance imaging was performed, and the segmental kyphotic angle, vertebral corpus compression rate, polymethylmethacrylate (PMMA) cement volume, and diffusion of PMMA were recorded. Results: Preoperative and postoperative VAS scores were 8.6 +/- 0.9 vs. 1.13 +/- 1.1 (p < 0.01). The approximate compression rate was 24.72 +/- 13.99 %, the ratio of approximate restoration height was 3.47 +/- 5.36, and the mean kyphosis angle was 7.35 +/- 6.81 degrees. The mean pre- and postoperative values of vertebral height were 1.83 +/- 0.39 cm vs1.88 +/- 0.36 cm (P <.01). Conclusion: In this study, preoperative pain in patients with VCF prominently diminished in the postoperative early and late phase. After PVP, vertebral height showed a subtle increase.Item The effect of alendronate sodium on trabecular bone structure in an osteoporotic rat model(2017) Ozsahin, Esin Tokmak; Cam, Burcu; Dere, Fahri; Kurkcu, Mehmet; Evruke, Cuneyt; Soames, Roger; Oguz, Ozkan; 31453446Objectives: This study aims to investigate the effect of alendronate sodium on trabecular bone structure in an osteoporotic rat model. Materials and methods: Between May 2006 and July 2006, 60 female Wistar Albino rats aged three months were randomly allocated to three groups: sham operated receiving no treatment (Shm); ovariectomized-alendronate receiving 1 mg/kg/day alendronate sodium (Ovx-A), and ovariectomized-vehicle receiving 1 mL/kg/day physiological saline (Ovx-PS). Both Ovx groups received treatment through gastric gavage for 56 days. Results: Densitometric measurements showed that bone mineral density decreased in the Ovx-PS and increased in Ovx-A groups (p<0.05). Biomechanical measurements showed a decrease in the breaking force in the Ovx-PS group and an increase in the Ovx-A group (p<0.05). Histomorphometric measurements showed that the Shm group had normal trabecular structure, while the Ovx-PS group had a less well-formed trabecular structure with a loss in the trabecular number and thickness and a corresponding increase in the trabecular spacing (p<0.05). In the Ovx-A group, there was an improvement in the trabecular structure with an increase in the trabecular number and thickness and a loss in the trabecular space (p<0.05). Conclusion: Our study results suggest that alendronate sodium is a valuable treatment agent for osteoporosis in postmenopausal women.