Tıp Fakültesi / Faculty of Medicine
Permanent URI for this collectionhttps://hdl.handle.net/11727/1403
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Item Are Diabetic Patients Aware of The Danger in Turkey?(2016) Ulusoy, Mahmut Oguz; Kivanc, Sertac Argun; Atakan, Mehmet; Uzun, Ozgur; Ozturk-Sahin, Bilge; Olcaysu, Osman Okan; Karatepe, Arzu Seyhan; Zorlu-Ozturk, Sibel; Turker, IbrahimPurpose: The aim of this study is to assess the awareness of the diabetic retinopathy and the level of the diabetic retinopathy in the diabetic patients, which consulted to the state hospitals in Turkey. Methods: A total of 1071 patients, admitted to 8 different state hospitals' ophthalmology clinics around the country, were included to this cross sectional multicentred study. All diabetic patients were asked to respond specifically prepared questionnaire including diabetic retinopathy and diabetes mellitus and underwent fundus examination to assess the diabetic retinopathy level. Results: The mean age of the study population was 57.5 years and the 57.4 % of the patients were women. 34.7% of the patients' were responded "NO" to the question of "Are you aware of the eye complications of diabetes mellitus?". The study also showed that 200 of 699 patients (28.6%) who aware of the diabetic retinopathy, despite having this information do not have regular eye examination for the diabetic retinopathy. It was seen that even 40.62% (26/64) of the college graduates don't go regular checks. The majority of the aware patients (40.5 %) pointed out that they took information from internal medicine or endocrinologists and the 28.1% of the patients were informed from elsewhere (family, neighbor, TV, etc.). Conclusion: One third of the subjects monitored were not aware of diabetic retinopathy. It is noteworthy to emphasize the importance of the routine eye examination for preventing vision loss, regardless of the educational level. The warning of the physicians through written and visual media is thought to be effective in preventing irreversible condition of this disease.Item Evaluation of Electrodermal Activity and Anxiety Behaviors in Diabetic Rats Given Vildagliptin and Metformin(2022) Shawesh, Muftah; Alshareef, Mohammed; Boyuk, Gulbahar; Yigit, Ayse Arzu; Dolu, NazanItem Determination of Audio-Visual Reaction Times in Individuals with Type 2 Diabetes Mellitus(2022) Bilaloglu, Melisa; Altay, Feride Pinar; Gul, Eylem; Ergun, Ahmet; Kiziltan, ErhanItem The Screening of Comorbid Depressive Disorders and Associated Risk Factors in Adult Patients with Type 2 Diabetes(2020) Demirci, Ibrahim; Haymana, Cem; Sonmez, Alper; Bolu, Abdullah; Kirnap, Nazli; Demir, Orhan; Meric, Coskun; Oysul, Guven; Aydogdu, Aydogan; Ersoz Gulcelik, Nese; Azal, OmerObjective: Elevated depressive symptoms and disorders affect one in five patients with diabetes. Current guidelines recommend screening depression in the diabetic population. Turkey has the highest (13.7%) prevalence of diabetes in Europe. However, there are limited data about the prevalence of depressive disorders among diabetic patients in Turkey. We aim to investigate the prevalence of a comorbid depressive disorder in Type 2 diabetic patients who were referred to the Endocrinology outpatient unit of a tertiary hospital. Material and Methods: All the Type 2 diabetic patients admitted to our endocrinology department were consecutively included in the study. Their sociodemographics, concomitant diseases and medications, macro and microvascular complications, lifestyle and personal habits, and treatment regimens were obtained by a specifically designed questionnaire. Laboratory data were obtained from the hospital records. The Patient Health Questionnaire-9 (PHQ-9), a depression screening tool, was used as a screening method for depression. Patients with a score of 10 or above determined high risk for depressive disorder according to PHQ-9. The scores were re-evaluated by a psychiatrist to minimize the false negative and positive results. Result: A total of 460 patients with Type 2 diabetic were enrolled in this crosssectional study. 18.9% (n=87) of the participants were found to have depressive disorders according to the psychiatric evaluation done after the PHQ-9 questionnaire. Patients with depressive disorders were predominantly female (69.0% vs. 55.5%; p=0.022), younger (57.2 +/- 10.5 vs. 60.0 +/- 9.5; p=0.014), had higher HbAlc (8.51 +/- 2.51 vs. 7.98 +/- 2.05; p=0.042), total cholesterol (205.6 +/- 44.2 vs. 194.2 +/- 46.0; p=0.045), LDL-cholesterol (123.1 +/- 37.8 vs. 113.1 +/- 35.4; p=0.026) and non-HDL-cholesterol (158.5 +/- 41.61 vs. 146.6 +/- 42.7; p=0.024). These patients had frequent neuropathy (37.3% vs. 19.0%, p=0.001), they were less likely to perform exerdse (31.8% vs. 53.1%; p<0.001) while smoke in excess (31.4% vs. 14.3%; p<0.001). The analysis showed that female gender (OR=4.4; 95% CI=1.6-12.8; p=0.005) and smoking (OR=7.6; 95% CI=2.8-20.5, p<0.001) are independent determinants of a depressive disorder. Conclusion: Approximately one-fifth of diabetic patients had a depressive disorder, and their metabolic parameters were worse than those without a depressive disorder. Therefore, to assess a diabetic patient from all aspects, screening for depressive disorder should be made an indispensable part of the evaluation process.Item An international survey on hypoglycemia among insulin-treated type I and type II diabetes patients: Turkey cohort of the non-interventional IO HAT study(2018) Tutuncu, Neslihan Basci; Emral, Rifat; Tetiker, Tamer; Sahin, Ibrahim; Sari, Ramazan; Kaya, Ahmet; Yetkin, Ilhan; Cil, Sefika Uslu; 0000-0002-1816-3903; 29433560; ABG-5027-2020Background: Limited real-world data are currently available on hypoglycemia in diabetes patients. The International Operations Hypoglycemia Assessment Tool (IO HAT) study was designed to estimate hypoglycemia in insulin-treated type I (T1DM) and type II (T2DM) diabetes mellitus patients from 9 countries. The data from Turkey cohort are presented here. Methods: A non-interventional study to determine the hypoglycemia incidence, retrospectively and prospectively, in Turkish T1DM and T2DM patients using a 2-part self-assessment questionnaire. Results: Overall, 2348 patients were enrolled in the Turkey cohort (T1DM = 306 patients, T2DM = 2042 patients). In T1DM patients, 96.8% patients reported hypoglycemic events (Incidence rate [IR]: 68.6 events per patient-year [ppy]), prospectively, while 74.0% patients reported hypoglycemic events (IR: 51.7 events ppy), retrospectively. In T2DM patients, 95.9% patients (IR: 28.3 events ppy) reported hypoglycemic events, prospectively, while 53.6% patients (IR: 23.0 events ppy) reported hypoglycemic events, retrospectively. Nearly all patients reported hypoglycemia during the prospective period. Conclusions: This is a first patient-reported dataset on hypoglycemia in Turkish, insulin-treated diabetes patients. A high incidence of patient-reported hypoglycemia confirms that hypoglycemia remains under-estimated. Hypoglycemia increased healthcare utilization impacting patients' quality of life. Hypoglycemia remains a common side effect with insulin-treatment and strategies to optimize therapy and reduce hypoglycemia occurrence in diabetes patients are required.