Tıp Fakültesi / Faculty of Medicine
Permanent URI for this collectionhttps://hdl.handle.net/11727/1403
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Item Can Strain Elastography Combined with Ultrasound Breast Imaging Reporting and Data System Be A More Effective Method in The Differentiation of Benign and Malignant Breast Lesions?(2017) Arslan, Serdar; Uslu, Nihal; Ozturk, Funda Ulu; Akcay, Eda Yilmaz; Tezcaner, Tugan; Agildere, Ahmet Muhtesem; https://orcid.org/0000-0001-7984-4326; https://orcid.org/0000-0002-6733-8669; https://orcid.org/0000-0001-6831-9585; https://orcid.org/0000-0002-3641-8674; https://orcid.org/0000-0003-4223-7017; 28154989; AAH-9796-2019; ABC-5258-2020; AAK-1960-2021; AAD-9865-2021; AAB-5802-2020To investigate whether a novel method that combines breast imaging reporting and data system (BI-RADS) with strain elastography contributes to diagnostic performance in differentiation of malignant and benign breast lesions. In 81 patients, 81 breast lesions were prospectively investigated. Breast lesions were separately evaluated with ultrasonography and strain elastography. While evaluations with ultrasonography were based on 2003 BI-RADS-US, strain elastography evaluations were based on a 5-point scale and strain ratio. Diagnostic performances of ultrasonography, strain elastography, and the combined method were compared. Among 81 lesions, 43 (53.1%) were benign and 38 (46.9%) were malignant. When a cutoff point of category 3 was used, sensitivity, specificity, positive and negative predictive values, and accuracy for BI-RADS were 100, 11.6, 50, 100, and 53%, respectively. When BI-RADS and strain ratio were combined, sensitivity, specificity, positive and negative predictive values, and accuracy were 89.5, 93, 91.9, 90.9, and 91.3%, respectively. When BI-RADS and elastography scores were combined, sensitivity, specificity, positive and negative predictive values, and accuracy were 86.8, 97.7, 97.1, 89.4, and 92.5%, respectively. The combination of strain elastography and BI-RADS was found to have better diagnostic performances to diagnose breast lesions than BI-RADS alone.Item Utility of Diffusion Weighted Magnetic Resonance Imaging with Multiple B Values in Evaluation of Pancreatic Malignant and Benign Lesions and Pancreatitis(2018) Karadeli, Elif; Erbay, Gurcan; Parlakgumus, Alper; Koc, Zafer; https://orcid.org/0000-0002-0352-8818; https://orcid.org/0000-0002-1706-8680; https://orcid.org/0000-0003-0987-1980; 29394967; AAK-5399-2021; AAK-5370-2021; S-8384-2016Objective: To determine the feasibility of diffusion-weighted imaging in evaluation of pancreatic lesions and in differentiation of benign from malignant lesions. Study Design: Descriptive study. Place and Duration of Study: Baskent University Adana Teaching and Research Center, Adana, Turkey, between September 2013 and May 2015. Methodology: Forty-three lesions [pancreas adenocarcinoma (n = 25)], pancreatitis (n = 10), benign lesion (n = 8)] were utilized with diffusion-weighted magnetic resonance imaging with multiple b-values. Different ADC maps of diffusion weighted images by using b-values were acquired. Results: The median ADC at all b values for malignant lesions was significantly different from that for benign lesions (p < 0.001). When ADCs at all b values were compared between benign lesions/normal parenchyma and malignant lesions/normal parenchyma, there was a significant statistical difference in all b values between benign and malignant lesions except at b 50 and b 200 (p<0.05). The lesion/normal parenchyma ADC ratio for b 600 value (AUC=0.804) was more effective than the lesion ADC for b 600 value (AUC=0.766) in differentiation of benign and malignant lesions. The specificity and sensitivity of the lesion/normal parenchyma ADC ratio were higher than those of ADC values of lesions. When the ADC was compared between benign lesions and pancreatitis, a significant difference was found at all b values (p<0.001). There was not a statistically significant difference between the ADC for pancreatitis and that for malignant lesions at any b value combinations (p>0.05). Conclusion: Diffusion-weighted magnetic resonance images can be helpful in differentiation of pancreatic carcinoma and benign lesions. Lesion ADC / normal parenchyma ADC ratios are more important than lesion ADC values in assessment of pancreatic lesions.Item Benign ve malign nodüler tiroid hastalıklarında metabolik sendrom ve bileşenlerinin değerlendirilmesi(Başkent Üniversitesi Tıp Fakültesi, 2011) Sevinç, Can; Nar, AslıMetabolik Sendrom (MetS) insülin direncinin belirgin rol oynadığı ve metabolik anormalliklerin kümelendiği bir tablodur. Önceki çalışmalarda insülin direnci (İD) olan hastalarda tiroid hacmi ve nodül prevelansının artmış olduğu gösterilmiştir. Biz bu çalışmada benign ve malign nodüler tiroid hastalığı olanlarda metabolik sendrom ve bileşenlerini değerlendirmeyi amaçladık. Dörtyüzotuz ötiroid benign nodüler ve 370 ötiroid malign nodüler tiroid hastalığı olan toplam 800 hasta metabolik sendrom ve bileşenleri yönünden incelendi. MetS parametrelerinin yanı sıra insülin düzeyleri ve homeostasis model assessment- IR (HOMA-IR) ile hesaplanan İD seviyeleri değerlendirildi. Çalışmaya alınan 800 hastanın %59,8’inde metabolik sendrom saptandı. Benign ve malign nodüler tiroid hastalığı olan gruplar arasında metabolik sendrom sıklığı açısından anlamlı fark saptanmadı (benign nodüler grupta % 61,4, malign nodüler grupta % 57,8, p>0,05). Metabolik sendrom bileşenleri incelendiğinde en çok yüksek bel çevresi değeri (%65), ikinci sıklıkta düşük HDL kolesterol düzeyi (%64,8) ve en az da yüksek kan şekeri değeri (%30,8) olduğu saptandı. Benign ve malign nodüler tiroid hastaları ayrı ayrı incelendiklerinde ise benign grubun MetS bileşen dağılımı genel ortalama ile benzer sıklıkta olup, malign grubun MetS bileşen dağılımında en sık düşük HDL kolesterol düzeyi (%71,9), en az ise kan basıncı yüksekliği (%26,2) olduğu bulundu. Benign ve malign nodüler tiroid hastaları arasında insülin düzeyleri ve insülin direnci açısından anlamlı fark saptanmadı. Popülasyon verileri gözönüne alındığında, sonuçlar nodüler tiroid patolojisi olan hastaların, nodüler tiroid hastalığı olmayanlara göre anlamlı olarak artmış metabolik sendrom prevalansına sahip olduklarını göstermektedir. Bizim verilerimiz nodül formasyonu için insülin direncinin bağımsız bir risk faktörü olduğunu ancak benign ve malign noduler gruplar arasında MetS bileşen dağılımı açısından fark olmadığını göstermektedir.