Tıp Fakültesi / Faculty of Medicine

Permanent URI for this collectionhttps://hdl.handle.net/11727/1403

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Subject: search.filters.subject.Antioxidants

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    The Protective Effect of Lycopene on Kidney Against Experimentally Induced Unilateral Ureteral Obstruction
    (2016) Atilgan, Hasan Ikbal; Aydin, Arif; Sadic, Murat; Korkmaz, Meliha; Karakan, Tolga; Ogus, Elmas; Borcek, Pelin; Koca, Gokhan
    Introduction: To investigate the possible protective effect of lycopene on kidney after unilateral ureteral obstruction. Materials and methods: Twenty-one Wistar albino rats were divided into three groups in experimental study. In lycopene group, lycopene was administered two days before left ureteral ligation and was continued for 15 days. In control group, left ureteral ligation was applied with no medication. In sham group, midline incision was made to abdomen and then closed. Histopathological, biochemical and scintigraphic evaluations were made. Results: Microscopic score was 50.56 +/- 34.32 in lycopene, 97.22 +/- 39.14 in control and 28.33 +/- 12.58 in sham group. Microscopic score was lower in lycopene group than control group (p= 0.033). In biochemical analysis, mean value of myeloperoxidase (MPO), malondialdehyde (MDA) and nitrite levels were 0.05 +/- 0.03, 4.64 +/- 1.49 and 0.06 +/- 0.01 respectively in lycopene group, 0.10 +/- 0.03, 8.37 +/- 3.31 and 0.14 +/- 0.09 in control group and 0.04 +/- 0.01, 18.76 +/- 9.30 and 0.05 +/- 0.01 in sham group. MPO, MDA and nitrite levels were lower in lycopene group than in control group (p= 0.033, p= 0.007 and p < 0.001, respectively). Postoperative mean Technetium-99m dimercaptosuccinic acid (Tc-99m DMSA) uptake values of left kidneys were 6.26 +/- 5.17 in lycopene, 2.09 +/- 1.03 in control and 49.17 +/- 1.37 in sham group. There was no statistically significant difference between lycopene and control groups in respect of postoperative DMSA uptake values (p= 0.063). Conclusion: Lycopene is effective for the protection of kidney after ureteral obstruction as shown by microscopic parameters and decreased reactive oxygen species.
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    Antioxidant treatment of increased sperm DNA fragmentation: Complex combinations are not more successful
    (2020) Ozer, Cevahir; 0000-0002-7850-6912; 33348968; AAM-2222-2020
    Objective: Oral antioxidant supplementation is part of the treatment of infertility associated with oxidative stress-related sperm damage. It is possible to assume that the combined use of antioxidants will be better than single agent use. The purpose of this study was to compare the effectiveness of different antioxidant combinations in infertile men with increased sperm DNA fragmentation. Materials and methods: We retrospectively reviewed the records of 637 patients who underwent antioxidant support therapy for increased sperm DNA damage between 2014 and 2019. Patients with DNA damage of 30% or more were included study. Result: A total of 163 patients with follow-up data and who fulfilled the study criteria were included in the study. There were four different treatment groups. No statistically significant differences were found between the groups. After 3 months of antioxidant treatment, there was a statistically significant decrease in sperm DNA damage in all treatment groups. However, there was no statistically significant difference between the treatment groups. Conclusions: The complexity of the antioxidant combination may not contribute to the success of the treatment or may cause possible side effects, increase the cost of treatment and decrease patient compliance.