Tıp Fakültesi / Faculty of Medicine

Permanent URI for this collectionhttps://hdl.handle.net/11727/1403

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Subject: search.filters.subject.Adverse events

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    Acidosis and Hyperkalemia Caused By Losartan and Enalapril in Pediatric Kidney Transplant Recipients
    (2014) Sakalli, Hale; Baskin, Esra; Bayrakci, Umut Selda; Moray, Gokhan; Haberal, Mehmet; https://orcid.org/0000-0003-4361-8508; https://orcid.org/0000-0003-2498-7287; https://orcid.org/0000-0002-3462-7632; 24447308; B-5785-2018; AAE-1041-2021; AAJ-8097-2021
    Objectives: To evaluate the efficacy and safety of losartan and enalapril in pediatric kidney transplant recipients. Materials and Methods: A retrospective review was performed in 31 pediatric kidney transplant recipients who were treated with losartan (50 mg/d, oral) for 1 to 6 months because of mild hypertension and persistent proteinuria. All patients were treated concurrently with enalapril (5 or 10 mg daily, oral), and 12 patients (39%) also were treated with amlodipine (5 or 10 mg daily, oral). Demographic and clinical characteristics of the patients were reviewed. Results: Losartan use was associated with a significant decrease in mean systolic (before losartan was started, 123 +/- 14 mm Hg; before losartan was stopped, 111 +/- 10 mm Hg; P <= .001) and diastolic blood pressure (before losartan was started, 78 +/- 11 mm Hg; before losartan was stopped, 69 +/- 10 mm Hg; P <= .001) and urinary protein excretion (before losartan was started, 51 +/- 45 mg/m(2)/h; before losartan was stopped, 28 +/- 34 mg/m(2)/h; P <= .001). However, losartan therapy was associated with a significant mean increase in serum potassium level (before losartan was started, 4.0 +/- 0.4 mmol/L; before losartan was stopped, 5.7 +/- 0.5 mmol/L; P <= .001) and decrease in pH (before losartan was started, 7.35 +/- 0.0; before losartan was stopped, 7.23 +/- 0.0; P <= .001). Losartan was stopped because of hyperkalemia and acidosis earlier in patients who were on tacrolimus than cyclosporine immunosuppression (tacrolimus, 3 +/- 1 mo; cyclosporine, 4.7 +/- 0.8 mo; P <= .001). Conclusions: Losartan and enalapril may be beneficial in pediatric kidney transplant recipients by decreasing blood pressure and proteinuria, with maintenance of stable graft function, but may be associated with serious adverse events including hyperkalemia and life-threatening acidosis.
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    Side effects and antibody response of an inactive severe acute respiratory syndrome coronavirus 2 vaccine among health care workers
    (2021) Gumus, Hatice Hale; Odemis, İlker; Aliska, Hikmet Eda; Karsli, Asli; Kara, Sibel; Ozkale, Murat; Gul, Eylem; 0000-0001-9071-9606; 0000-0001-9060-3195; 0000-0003-2638-0163; 34909957; AAJ-2108-2021; AAE-2282-2021
    OBJECTIVE: This study aims to investigate the antibody response and the side effects of the two-dose inactive SARS-CoV-2 vaccine (CoronaVac, Sinovac, China) among a health care worker population in Turkey. METHODS: This study was a prospective, cross-sectional, single-center study conducted between December 16, 2020, and March 15, 2021. We evaluated the side effects from a questionnaire, and anti-spike immunoglobulin G response to the vaccine (0- and 28-day schedule) using an enzyme-linked immunosorbent assay. RESULTS: A total of 94 of 184 health care workers completed this study. The percentages of participants who were seronegative at baseline and achieved to the seropositivity were 21.3 and 97.9%, respectively, on day 21 after vaccinations. The seropositivity was predominantly detected in 31-45 years of the age group (55.4%, p=0.636), normal body mass index (47.8%, p=0.999), nonsmokers (64.1%, p=0.999), those without any comorbidities (73.9%, p=0.463), and those without any side effects (70.2%, p=0.256). The frequencies of overall side effects within seven days after the first and second doses of CoronaVac were 37.2 and 28.7%, respectively. The most common side effects was localized pain at the injection site (15.7 and 11.6%, respectively). CONCLUSIONS: We found that vaccination by two-dose CoronaVac could elicit a specific humoral response, and it was well tolerated in health care workers. The high seropositivity developed after the second dose attracted attention. Our study will be useful in terms of showing short-term immunity and side effects.