Tıp Fakültesi / Faculty of Medicine

Permanent URI for this collectionhttps://hdl.handle.net/11727/1403

Browse

Filters

2019 - 201912020 - 20231

Settings

search.filters.applied.f.rights: search.filters.rights.info:eu-repo/semantics/openAccessSubject: search.filters.subject.YKL-40

Search Results

Now showing 1 - 2 of 2
  • No Thumbnail Available
    Item
    Serum YKL-40 (Chitinase 3-Like Protein 1) Levels in Migraine Patients During An Attack
    (2023) Horasanli, Bahriye; Sak, Zeynep Caliskan; Ozsahin, Aysun; Karabulut, Keziban Ucar
    Objectives: The aim of this study was to investigate YKL-40 in migraine patients during migraine attacks. Methods: In this prospective study, 30 migraine patients with aura (MWA) and 30 migraine patients without aura (MWOA) who presented to the Neurological Outpatient Department of Konya City Hospital during a migraine episode as well as 28 healthy controls were included. According to the manufacturer's recommendations, serum YKL-40 levels were determined using an ELISA kit (FineTest). Statistical analysis of the data was performed with the IBM SPSS version 20.0 program. Results: The mean gender and age were similar between groups (p > 0.05). The serum YKL-40 level was 3575 +/- 604.975 pg/ml in the MWA group, 3339 +/- 492.689 pg/ml in the MWOA group and 3190 +/- 544.018 pg/ml in the control group. YKL-40 levels were significantly higher in MWA than in the control group (p=0.028). YKL-40 levels were similar in the MWA and MWOA groups (p=0.302). No significant difference was found between the group with MWOA and the control group (p=0.915). Conclusion: Although YKL-40 levels are increased in patients with migraine with aura during an attack, comprehensive studies with a larger sample are needed to clarify the relationship between YKL-40 and migraine.
  • No Thumbnail Available
    Item
    Relationship between plasma YKL-40 levels and endothelial dysfunction in chronic kidney disease
    (2019) Keskin, Gul Sema; Helvaci, Ozant; Yayla, Cagri; Pasaoglu, Ozge T.; Keskin, Caglar; Arinsoy, Turgay; Deric, Ulver B.; 30763987
    Background/aim: We aimed to evaluate the relationship between YKL-40 and endothelial dysfunction in chronic kidney disease. Materials and methods: Twenty-nine hemodialysis patients, 101 patients with nondialytic (stage 2, 3, 4, and 5 ND) chronic kidney disease (CKD), and 38 healthy individuals as a control group were included. YKL-40 levels were measured by ELISA. Endothelial dysfunction was indirectly measured by flow-mediated dilatation percentage (FMD) in the brachial artery. Results: YKL-40 levels were higher in CKD patients than controls and highest in HD patients (P = 0.001). FMD values were lower in nondialytic CKD patients and lowest in HD patients (P = 0.001). YKL-40 negatively correlated with eGFR and FMD values (r = -0.674 and r = -0.471, respectively). Conclusion: This study shows that YKL-40 increases with CKD stage and is negatively correlated with FMD measurements.