Tıp Fakültesi / Faculty of Medicine
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Item Comment on Toxicities in long-term survivors of head and neck cancer-A multi-national cross-sectional analysis(Başkent Üniversitesi Tıp Fakültesi, 2025) Somay, Efsun; Bascil, Sibel; Topkan, Erkan; Selek, Ugur; 41396789Item Mitigating infusion-related reactions (IRRs) with cetirizine and montelukast in patients (pts) receiving REGN7075, an EGFRxCD28 bispecific antibody (bsAb)(Başkent Üniversitesi Tıp Fakültesi, 2025) Segal, N. H.; Girda, E.; Keenan, B. P.; Hecht, J. R.; Le, X.; Johnson, M. L.; Jimenez, J. Torres; Gomez-Roca, C. A.; Ghiringhelli, F.; Ates, O.; Garcia, V. Moreno; Laux, D.; Berz, D.; Chen, R.; Wang, J.; Han, H.; Mathias, M. D.; Seebach, F. A.; Kinnaman, M. D.; Sohal, D.Item Identifying future risk factors of uncontrolled asthma control: the TAAR study perspective(Başkent Üniversitesi Tıp Fakültesi, 2025) Erdogan, Tuba; 41305966Objective: Risk factors associated with asthma symptom control is crucial for disease management. This study aimed to determine the risk factors of patients with uncontrolled asthma and to examine the relationship with their geographical patterns. Methods: This cross-sectional study was conducted at 36 centers across Turkey. Future risk factors (FRFs) such as exposure to triggers/allergens and inadequate or poor inhalation technique, etc., were identified based on the Global Initiative for Asthma (GINA) guidelines. The associations between FRFs and demographic and clinical characteristics, geographical regions, and levels of asthma control were analyzed. Results: The study included 2,053 adult asthma patients. At least one FRF was identified in 1576(76.8%) patients. The most common FRFs were exposure to allergens/triggers (n: 664; 32.3%), impaired asthma symptom control (n: 540; 26.3%), and eosinophilia (n: 526; 25.6%). Regarding regional differences, the most prevalent FRFs in the Marmara region were exposure to allergens/triggers and frequent use of short-acting beta-2 agonists (>3 boxes/year). In contrast, eosinophilia was more common in the Southeastern region, while inadequate or poor inhalation technique, noncompliance with treatment, and psychosocial or socioeconomic problems were more frequently observed in the Eastern Anatolia region. Asthma control was achieved in 79.5% of patients without any FRFs; however, this rate decreased significantly to 25% among patients with more than four FRFs. Conclusions: This study demonstrates that FRFs in asthma vary according to demographic and disease characteristics, as well as geographical distribution. An increased number of FRFs was associated with asthma control. However, an individualized approach remains essential for achieving optimal asthma management.Item Impact of adjuvant radiotherapy and mitotane on survival in localized adrenocortical carcinoma: A retrospective cohort study(Başkent Üniversitesi Tıp Fakültesi, 2025) Elmali, Aysenur; Guler, Ozan Cem; Ozyigit, Gokhan; Hurmuz, Pervin; Onal, Cem; 41399138Objectives: Adrenocortical carcinoma (ACC) is a rare, aggressive tumor with high recurrence rates after surgery. Although radiotherapy (RT) has historically been underutilized in ACC, modern RT techniques have renewed interest in its potential role for improving local control (LC). This study evaluated long-term outcomes and prognostic factors in high-risk localized ACC treated with adjuvant RT and mitotane. Methods: In this multicenter retrospective study, 23 patients with localized, high-risk ACC who underwent complete surgical resection followed by adjuvant RT between 2003 and 2023 were analyzed. All received mitotane, and 21.6% also received platinum-based chemotherapy. RT was delivered using image-guided IMRT or VMAT to a median dose of 50.4 Gy, targeting the tumor bed with or without regional lymphatics. Survival was estimated using the Kaplan-Meier method, and prognostic factors were assessed with Cox regression analyses. Results : At a median follow-up of 84.7 months, the 5-year LC, overall survival (OS), and disease-free survival (DFS) rates were 85.5%, 58.6%, and 45.6%. Locoregional recurrence occurred in two patients (8.6%), with isolated local failure in one (4.3%). Distant metastasis (DM) developed in 47.8% and was the predominant failure pattern. On univariable analysis, age > 55 years predicted worse OS and DFS, while female sex independently predicted inferior DFS. Treatment was well tolerated, with no grade >= 3 RT-related toxicities. Conclusions: Adjuvant RT achieves excellent LC with minimal toxicity in high-risk localized ACC. These exploratory findings, limited by small cohort size, retrospective design, and absence of a comparator group, warrant confirmation in larger prospective multicenter studies.Item Siroz hastalarında mide prekanseröz lezyonların değerlendirilmesi(Başkent Üniversitesi Tıp Fakültesi, 2024) Aizirek, Abdikaiyrova; Haldun, SelçukAmaç: Son epidemiyolojik araştırmalar, karaciğer sirozu olan bireylerin mide kanserine yakalanma olasılığının daha yüksek olduğunu göstermiştir. Sirotik hastalarda yapılan çalışmalarda genel popülasyon ile karşılaştırıldığında mide kanseri prevalansı 2,6 kat daha sık görülmüştür. Ancak sirozda mide kanseri prevalansının yüksek olmasının ardındaki faktörler belirsizliğini korumaktadır. Bu çalışmada, sirozun mide kanseri gelişimi için bir risk faktörü olabileceği ve sirozun intestinal metaplazi (İM) ile ilişkisi yönünden değerlendirilmesi amaçlanmıştır. Gereç ve yöntem: Çalışmamızda Başkent Üniversitesi Tıp Fakültesi Gastroenteroloji Bilim Dalı Endoskopi Ünitesinde 01.01.2011-01/12/2023 tarihleri arasında farklı endikasyonlarla özofagogastroduodenoskopi (ÖGD) yapılmış 115 erişkin siroz tanılı hasta restrospektif olarak incelendi. Ayrıca 01/10/2022-31/10/2023 tarihleri arasında dispeptik şikayetlerle başvuran 510 erişkin hasta kontrol grubu olarak alındı. Çalışmamıza dahil edilen toplam 625 erişkin hastada demografik veriler, komorbiditeler, endoskopik ve histopatolojik özellikler gruplar arasında analiz edildi. İM sıklığı ve niteliği her iki grupta karşılaştırıldı. Bulgular: Bu çalışma kapsamında ÖGD yapılan sirotik 685 hasta ve dispeptik kontrol grubundan oluşan 1817 hasta olmak üzere toplam 2502 hasta incelendi. Dışlama kriterlerine göre toplam 1877 hasta çalışma dışı bırakıldı. Çalışma kriterlerine uygun sirotik 115 (ortalama yaş 54,6±13,4 yıl) hasta ve kontrol grubunda dispeptik yakınması olan 510 (ortalama yaş 55,8±14,6 yıl) hasta çalışmaya dâhil tutuldu. Siroz hastalarının %53’ü (n=61) kadın, %46,9’u (n=54) erkek, kontrol grubunun %62,3’ü (n=318) kadın, %37,6’sı (n=192) erkekti. Çalışmamızda İM siroz hastalarının %28,7’inde, kontrol grubunun %21,2’inde mevcuttu. Fokal İM oranları sirotik grupta %11,4 ve kontrol grubunda %13,5 tespit edildi. Yaygın İM oranı sirotik grupta %16,6 ve kontrol grubunda %7,47 idi ve sirotik grupta yaygın İM oranı istatistiksel olarak anlamlı derecede yüksek saptandı (p=0,002). Atrofi sıklığına bakıldığında sirotik grupta %51,3 hastada, kontrol grubunda %31,7 hastada bulunmuştur(p<0,001). Atrofi oranı siroz hastalarında yaygın İM de olduğu gibi kontrol grubuna göre anlamlı derecede yüksekti. Çalışmamızda Helicobacter pylori (H. pylori) pozitifliği sirotik grupta 20 (%17,3 ) hastada ve kontrol grubunda 136 (%26,7) hastada mevcuttu (p=0,038) ve kontrol grubunda siroz grubuyla karşılaştırıldığında anlamlı derecede yüksekti. H.pylori enfeksiyonu olan siroz hastalarının 11’inde (%55) ve kontrol grubunun 31’inde (%22,7) İM mevcuttu (p<0,002). H.pylori enfeksiyonu olan siroz hastalarının 12’sinde (%60) ve kontrol grubunun 48’inde (%35,2) atrofi görüldü (p=0,034). Sonuç: Çalışmamızda literatürde ilk defa, sirozda İM’nin midede topografik yaygınlığı değerlendirilmiş ve kontrol grubuyla karşılaştırıldığında siroz hastalarında yaygın İM görülme olasılığının arttığını ve bu durumun mide kanseri gelişimi riskini artırabileceğini ortaya koyuyor. Bu çalışma, sirozun gastrik mukozal lezyonları ile mide kanseri arasındaki bağlantıyı anlamak açısından önemli bilgiler sunmaktadır. Aim: Recent epidemiological studies have shown that individuals with liver cirrhosis are more likely to develop gastric cancer. In studies conducted in cirrhotic patients, the prevalence of gastric cancer was found to be 2.6 times higher compared to the general population. The factors behind the high prevalence of gastric cancer in cirrhosis remain unclear. This study aimed to evaluate whether cirrhosis may be a risk factor for the development of gastric cancer and the relationship between cirrhosis and intestinal metaplasia (IM). Material and method: In our study, 115 adult patients with cirrhosis who underwent esophagogastroduodenoscopy (EGD) for different indications at the Endoscopy Unit of the Gastroenterology Department of Başkent University Faculty of Medicine between 01.01.2011 and 01/12/2023 were retrospectively examined. In addition, 510 adult patients who applied with dyspeptic complaints between 01/10/2022-31/10/2023 were included as the control group. Demographic data, comorbidities, endoscopic and histopathological features were analyzed between the groups in a total of 625 adult patients included in our study. The frequency and nature of IM were compared in both groups. Results: In this study, a total of 2502 patients were examined, including 685 cirrhotic patients who underwent EGD and 1817 patients in the dyspeptic control group. A total of 1877 patients were excluded from the study according to the exclusion criteria. 115 cirrhotic patients (mean age 54.6±13.4 years) who met the study criteria and 510 patients with dyspeptic complaints in the control group (mean age 55.8±14.6 years) were included in the study. Of the cirrhotic patients, 53% (n=61) were female, 46.9% (n=54) were male, and of the control group, 62.3% (n=318) were female and 37.6% (n=192) were male. In our study, IM was present in 28.7% of the cirrhotic patients and 21.2% of the control group. Focal IM rates were found to be 11.4% in the cirrhotic group and 13.5% in the control group. The rate of extensive IM was 16.6% in the cirrhotic group and 7.47% in the control group, and the rate of extensive IM was found to be statistically significantly higher in the cirrhotic group (p=0.002). When the frequency of atrophy was examined, it was found in 51.3% of the cirrhotic group and 31.7% in the control group (p<0.001). The rate of atrophy was significantly higher in cirrhotic patients compared to the control group, as in extensive IM. In our study, Helicobacter pylori (H. pylori) positivity was present in 20 (17.3%) patients in the cirrhotic group and 136 (26.7%) patients in the control group (p=0.038) and was significantly higher in the control group compared to the cirrhosis group. IM was present in 11 (55%) of the cirrhotic patients with H. pylori infection and in 31 (22.7%) of the control group (p=0.002). Atrophy was observed in 12 (60%) of the cirrhotic patients with H. pylori infection and in 48 (35.2%) of the control group (p=0.034). Conclusion: In our study, for the first time in the literature, the topographic prevalence of IM in the stomach in cirrhosis was evaluated and it reveals that the probability of extensive IM is increased in cirrhotic patients compared to the control group and this situation may increase the risk of developing gastric cancer. This study provides important information in terms of understanding the connection between gastric mucosal lesions of cirrhosis and gastric cancer.Item Characteristics and Outcomes of Myelodysplastic Syndrome Patients Treated With Darbepoetin Alfa for Anemia in Turkey: A Multicenter Retrospective Study(CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2023) Acar, Ibrahim Halil; Atalay, Figen; Demirsoy, Esra Terzi; Can, Ferda; Guven, Zeynep Tugba; Cetiner, Mustafa; Tombak, Anil; Comert, Melda; Guvenc, BirolItem The Influence of Different Sugammadex Doses on Neural Tube Development in Early-Stage Chick Embryos(2023) Ayhan, Asude; Efe, Ekin; Fidan, Pinar A.; Efe, Oguzhan E.; Ates, Eylem Gul; Sahinturk, Fikret; Ayhan, Selim; 0000-0002-6166-2601; 0000-0001-6955-9839; 0000-0002-3243-7843; 0000-0003-3047-0305; 0000-0002-0471-3177; 37565787; HGE-9282-2022; AAJ-2057-2021; AAJ-4728-2021; W-7908-2019; ABG-5365-2020; AAI-7972-2021Background: Sugammadex is a modified gamma-cyclodextrin that has been developed with the goal of reversing the steroidal neuromuscular blocking agents. The aim of the present study is to investigate the effects of different sugammadex doses on embryologic and neural tube development in an early-stage chick embryo model. Methods: A total of 100 specific pathogen-free, fertilized domestic chicken eggs were randomly divided into five groups (n = 20, each), and placed in an automatic cycle incubator. The eggs in the "control (C)" group were incubated without administration of any drug till the end of the experiment. Subblastodermic administration of 0.9% NaCl as vehicle control (VC) and different doses of sugammadex solutions prepared with the latter [2 mg/mL (LD), 4 mg/mL (MD), 16 mg/mL (HD)] were performed at 30 hr of incubation. All embryos were removed from the eggs at 72 hr when they were expected to reach Hamburger-Hamilton (HH) stages 19-20, then they were fixed, and evaluated histo-morphologically. Results: Embryonic development was not observed in 11 eggs (1 in C, 1 in VC; 3 in LD, 3 in MD, and 3 in HD). All the developed embryos were compatible with the HH stages 19-20. A neural tube closure defect was detected in one embryo in the HD group. No statistically significant difference was found between the groups in terms of embryonic and neural tube developments. Conclusions: No significant association was found between the drug and adverse outcomes; however, a trend with dosing was seen. Further studies are required before conclude on safety and extrapolate these results to human beings.Item The Effect of Acupressure Applied to Different Fistula Area on Fistule Needle Entry Pain(2023) Turgay, Gulay; Cevik, Banu; Inanoglu, Isilay; Kaya, Semiha; AAN-3284-2021Item The Effect of Glomerular C3 Deposition on Renal Outcome in Patients with Membranous Nephropathy: Data of the Tsn-Gold Study(2023) Gursu, Meltem; Ceheci, Egemen; Turkmen, Aydin; Dervisoglu, Erkan; Sezen, Mehnet; Turgutalp, Kenan; Sahin, Gulizar Manga; Trablus, Sinan; Kutlay, Sim; Uzun, Sami; Ustundag, Sedat; Dursun, Belda; Ayli, Deniz; Tatar, Erhan; Oztop, Kenan Evren; Basturk, Taner; Cevher, Simal Koksal; Yilmaz, Zulfikar; Tunca, Onur; Sevinc, Mustafa; Yadigar, Serap; Duranay, Murat; Arikan, Izzet Hakki; Elciuglu, Omer Celal; Karakan, Sebnem; Turkmen, Kultigin; Torun, Dilek; Gungor, Ozkan; Artan, Ayse Serra; Ozturk, Savas; Unsal, Abdulkadir; Seyahi, Nurhan; AAD-9111-2021Item Characteristics and Survival Data of Patients with Primary Focal Segmental Segmental Glomerulosclerosis: Tsn-Goldmulti-Center Study(2023) Dheir, Hamad; Cebeci, Egemen; Karadag, Serhat; Yildiz, Abdulmecit; Guller, Nurana; Altiparmak, Mehmet Riza; Eren, Necmi; Yilmaz, Zulfikar; Basturk, Taner; Sipahi, Savas; Sahin, Gulizar; Bakar, Betul; Okyay, Gulay Ulusal; Suleyman, Gultekin; Piskinpasa, Serhan Vahit; Dursun, Belda; Balal, Mustafa; Turgutalp, Kenan; Guzel, Fatma Betul; Kutlay, Sim; Tatar, Erhan; Elcioglu, Omer Celal; Karakan, Sebnem; Kayalar, Arzu Ozdemir; FarukAkcay, Omer; Yildirim, Tolga; Sahin, Idris; Sahin, Garip; Ogutmen, Melike Betul; Tokgoz, Bulent; Tunca, Onur; Gul, Cuma Bulent; Kurultak, Ilhan; Torun, Dilek; Ayar, Yavuz; Uzun, Sami; Yavuz, Mahmut; Oto, Ozgur Akin; Dincer, Mevlut Tamer; Ergul, Metin; Ozturk, Savas; Turkmen, Aydin; AAD-9111-2021