Tıp Fakültesi / Faculty of Medicine
Permanent URI for this collectionhttps://hdl.handle.net/11727/1403
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Item Effects of Pesticides on Testes at Ultrastructural and Hormonal Levels(2023) Unlukal, Nejat; Karabay, Gulten; Dagdeviren, Attila; Bayraktar, Nilufer; Guvercin, Ayse Canan Yazici; Tekindal, Mustafa Agah; 0000-0002-8107-4882Aim: Endocrine disruptors damage the functions of hormones in the body by imitating or blocking them. They and their metabolites change hormone levels and functions in the body. Pesticides constitute a significant group of endocrine disruptors. It is known that Profenofos, and 4-chloro-2-methylphenoxyacetic acid (MCPA) have negative effects on male genital system. However, studies about the effect on ultrastructural size are limited. Therefore, it is intended to compare the effect of MCPA and Profenofos on the ultrastructural level of the testes. Material and Methods: There were three groups in the study (control, Profenofos, MCPA), each of which included ten fourteen-week-old male rats. Electron microscopy and biochemical investigation were performed on the excluded tissues of the testes. Results: In histopathologic investigations, spermatogenesis was healthy in the control group. Structural degenerations were observed on spermatogenic cells and Sertoli cells in the profenofos group. The gaps among spermatogenetic cells, cellular degeneration (i.e. structural damage) in the MCPA group was more obvious than in the Profenofos group. Considering the biochemical results, a significant decrease in testosterone level was observed in the animals receiving both profonefos and MCPA. Discussion: Profenofos and MCPA prevent the healthy continuation of spermatogenesis and therefore may cause infertility.Item Noninvasive Evaluation of Swallowing Sound is an Effective Way of Diagnosing Feeding Maturation in Newborn Infants(2014) Ince, Deniz Anuk; Ecevit, Ayse; Acar, Banu Oskay; Saracoglu, Ahmet; Kurt, Abdullah; Tekindal, Mustafa Agah; Tarcan, Aylin; https://orcid.org/0000-0002-4369-2110; https://orcid.org/0000-0002-2232-8117; https://orcid.org/0000-0002-4430-444X; https://orcid.org/0000-0002-4060-7048; 24814215; I-6746-2016; AAJ-4616-2021; HIU-0129-2022; U-9270-2018Aim: Despite extensive research, there is still controversy regarding the time at which sucking and swallowing functions mature in preterm infants. This study aimed to evaluate maturation using the noninvasive method of swallowing sound. Methods: We compared 52 preterm infants of between 27 and 36 weeks' gestational age with a control group of 42 healthy full-term infants. Feeding performance was based on swallowing data collected during two-minute audio recordings. The following variables were generated for each evaluation: total number of swallows, total number of rhythmic swallows, total number of resting intervals, average time between resting intervals, average time between swallows, average time between rhythmic swallows, maximum number of rhythmic swallows and volume of milk ingested. The dependency of the variables on postmenstrual age was also investigated. Results: The volume of milk ingested by the preterm infants and the maximum number of rhythmic swallows were positively correlated with postmenstrual age (PMA). The preterm infants reached the 10th percentile of the control infants at 34-35 weeks' PMA and were not significantly different from the control infants at 38-40 weeks' PMA. Conclusion: Swallowing sound can be used to assess feeding maturation in preterm infants during neonatal intensive care unit follow-up.Item Radial Artery, Saphenous Vein versus Left Internal Thoracic Artery in Recurrent Ischemic Symptoms after Coronary Artery Bypass Graft Surgery(2014) Gunday, Murat; Coskun, Isa; Ciftci, Ozgur; Ozulku, Mehmet; Tekindal, Mustafa Agah; Guven, Aytekin; Aslamaci, Sait; https://orcid.org/0000-0002-6463-6070; https://orcid.org/0000-0002-4060-7048; 25065278; A-7318-2017; U-9270-2018; AAJ-8546-2021Background: The long-term results of coronary artery bypass surgery depend mostly on the type of the grafts. For a long time, it has been accepted that arterial grafts are superior to venous grafts. In this study, we evaluated the angiographic patency rates of arterial and venous grafts. Methods: The study took place between 2003 and 2013 in the Departments of Cardiovascular Surgery in Baskent University. The study included 52 patients with recurrent ischemic symptoms (of total 2183 coronary artery bypass surgery patients) following coronary artery bypass surgery. The patients were evaluated by control angiography during over mid- and long-term postoperative period (mean, 75.25 +/- 35.15 months). Based on the angiographic findings, the grafts were divided into 3 groups: severe stenosis, moderate stenosis, and patent. Results: The preoperative demographics (age, gender, hypertension or diabetes mellitus) were similar in the three groups. The mean numbers of distal anastomoses were 3.27 +/- 0.89 (range 2-5), the degree of native coronary artery stenosis for radial artery anastomosis was 79.65 +/- 17.72, and the mean numbers of radial artery and saphenous vein grafts were 1.19 +/- 0.44 and 1.10 +/- 0.89, respectively. The patency rate was 80.77%for radial arteries, 63.2% for saphenous veins, and 82.4% for left internal thoracic arteries in the three groups. Conclusion: The internal thoracic artery graft was confirmed to be the best option for aorta-coronary bypass surgery, as it has the highest patency rate compared to the other grafts. Radial artery and saphenous vein patency rate were also seen to be similar in the long-term.Item Acupressure at BL60 and K3 Points Before Heel Lancing in Preterm Infants(2015) Abbasoglu, Aslihan; Cabioglu, Mehmet Tugrul; Tugcu, Ali Ulas; Ince, Deniz Anuk; Tekindal, Mustafa Agah; Ecevit, Ayse; Tarcan, Aylin; 0000-0002-2232-8117; 0000-0002-4060-7048; 0000-0002-4369-2110; 26242287; ABI-2113-2020; AAJ-4616-2021; U-9270-2018; I-6746-2016Context: Acupressure is an ancient Chinese healing art. In this pain-relieving method, the fingers are used to press key acupuncture points on the skin surface that stimulates the body's regulatory processes. Objective: The aim of this study was to investigate the effect of acupressure at Kun Lun (UB60) and Taixi (K3) points for pain management in preterrn infants prior to heel lancing for blood collection. Design: This was a prospective, randomized controlled study. Setting: The study setting was the neonatal intensive care unit at Baskent University Hospital in Turkey. Patients: A total of 32 preterm infants between 28 and 36 weeks' gestational age were randomly assigned to one of two groups: an acupressure group (n = 16) or a control group (n = 16). Intervention: In the acupressure group, immediately before the heel prick, acupressure was applied for three minutes at UB60 and K3 points. Main Outcome Measures: A behavioral pain score was determined using the Premature Infant Pain Profile (PIPP) scale. Results: There were no significant differences between the groups with respect to gestational age, birth weight, sex, mode of delivery, age at time of procedure, weight at time of procedure, or PIPP score. Mean duration of procedure and mean duration of crying were both shorter in the acupressure group (both P = .001). Conclusions: Applying acupressure at the BL60 and K3 points before heel lancing was associated with shorter procedural time and shorter duration of crying in preterm infants.Item Goniometer Measurements of Oral Labial Angle and Evaluation of Oral Motor Reflexes in Preterm Infants: Comparison to Findings in Term Infants(2015) Ince, Deniz Anuk; Tugcu, Ali Ulas; Ecevit, Ayse; Ciyiltepe, Muzeyyen; Kurt, Abdullah; Abbasoglu, Aslihan; Tekindal, Mustafa Agah; Tarcan, Aylin; 0000-0002-4430-444X; 0000-0002-2232-8117; 0000-0002-4369-2110; 0000-0003-4161-8117; 0000-0002-4060-7048; 25792430; HIU-0129-2022; AAJ-4616-2021; I-6746-2016; Q-1547-2019; U-9270-2018; ABI-2113-2020To date, no study has evaluated changes in oral labial angle as preterm infants mature. The main purpose of this study was to document goniometer measurements of the labial angle of the mouth in preterm infants, to assess changes with development, to compare to findings in healthy term infants, and also evaluate oral motor reflexes in these groups. Seventy-eight preterm infants and 45 healthy term infants were recruited for the prospective study. Labial angle was assessed via goniometer, and oral motor reflexes and the volume of milk ingested were evaluated. There was significant difference between term and preterm infants' labial angles (P < .01). The distribution of preterm infants' angles were similar to term infants' by 36 to 40 weeks' postmenstrual age. Goniometer measurements of the oral labial angle may reveal oral motor performance in preterm infants and may be relevant for feeding skills assessment in this group of infants.Item The Influence of Igm-Enriched Immunoglobulin Therapy on Neonatal Mortality and Hematological Variables in Newborn Infants with Blood Culture-Proven Sepsis(2014) Abbasoglu, Aslihan; Ecevit, Ayse; Tugcu, Ali Ulas; Yapakci, Ece; Tekindal, Mustafa Agah; Tarcan, Aylin; Ecevit, Zafer; https://orcid.org/0000-0002-4060-7048; 25341598; ABI-2113-2020; U-9270-2018The aim of this study was to determine the effects of adjuvant immunoglobulin M (IgM)-enriched intravenous immunoglobulin (IVIG) therapy on mortality rate, hematological variables and length of hospital stay in newborn infants with blood culture-proven sepsis. Demographic and clinical features and outcome measures of 63 newborn infants with blood culture-proven sepsis were documented retrospectively from the medical records. The patients were divided into two groups according to their treatment history. The patients in Group 1 received antibiotic therapy only and the patients in Group 2 received both antibiotic and adjuvant IgM-enriched IVIG. The study revealed that mortality rates were 28.1% and 12.9% in Group 1 and Group 2, respectively. The mortality rate was lower in Group 2, but the difference between the two groups was not statistically significant (p=0.21). Coagulase-negative Staphylococcus was the most common type of bacteria isolated from the blood culture in both groups. When changing laboratory results were compared between the two groups, hemoglobin, leukocyte count and C-reactive protein levels were different during the first three days of antibiotic treatment. Our study revealed that if diagnosed at an early stage and treated aggressively with appropriate and effective antibiotics, adjuvant IgM-enriched IVIG treatment has no additional benefits in neonatal sepsis.Item AMH Levels at Central Precocious Puberty and Premature Thelarche: Is It A Parameter?(2015) Sahin, Nursel Muratoglu; Kinik, Sibel Tulgar; Tekindal, Mustafa Agah; Bayraktar, Nilufer; 0000-0002-7886-3688; 0000-0002-4060-7048; 0000-0002-8215-0146; 26226120; Y-8758-2018; U-9270-2018; AAA-1266-2019Background: The possible difference of antimllrin hormone (AMH) levels at central precocious puberty (CPP) and premature thelarche (PT) has not been properly evaluated. Objective/hypothesis: By evaluating AMH levels in girls with diagnosed CPP and PT, we aim to show the change of AMH levels at the pubertal onset. Subjects: Sixty-five girls who have breast development before the age of 8 years and 25 healthy girls were enrolled in the study. Methods: The subjects were divided into two groups as CPP and PT, according to results of GnRH test. AMH levels were determined in the two groups. Results: The mean AMH levels of the CPP group were significantly lower than those in the PT group (13.57 +/- 9.85 pmol/L and 58.42 +/- 12.78 pmol/L, respectively, p=0.022). Conclusion: These results suggest that the AMH levels decrease in the duration of the hypothalamus-pituitaryovarian axis activation. We thought that AMH might/may be a marker for distinguishing between CPP and PT.Item Laser Acupuncture Before Heel Lancing for Pain Management in Healthy Term Newborns: A Randomised Controlled Trial(2015) Abbasoglu, Aslihan; Cabioglu, Mehmet Tugrul; Tugcu, Ali Ulas; Yapakci, Ece; Tekindal, Mustafa Agah; Tarcan, Aylin; 0000-0002-4060-7048; 26438556; AIC-4823-2022; ABI-2113-2020; U-9270-2018Background Healthy term newborns commonly undergo painful procedures during routine follow-up visits. Non-pharmacological strategies have currently become more important than pharmacological analgesic agents in neonatal pain management. Acupuncture is a new non-pharmacological method for preventing pain in newborns. Objective We aimed to investigate the effect of laser acupuncture (LA) at the Yintang point before heel lancing as a non-pharmacological intervention for procedural pain management in infants. MethodsForty-two term newborns, who were undergoing heel lancing between postnatal days 3 to 8 as part of routine neonatal screening, were randomly assigned to the LA group or the oral sucrose group. In the LA group, 2 min before the heel lancing, 0.3 J of energy was applied to the Yintang point using a Laser PREMIO-30 unit for 30 s. In the sucrose group, each infant received 0.5 mL of 24% sucrose orally via syringe 2 min before the heel lancing. Each baby's behaviour was scored using the Neonatal Infant Pain Scale (NIPS), assessed blinded to group. Results There were no significant differences between the LA and oral sucrose groups with respect to means for gestational week of age at birth, birth weight, actual weight, or Apgar score. Mean procedure time was significantly shorter in the LA group; however, mean crying time was longer and NIPS score was lower compared to the oral sucrose group. Conclusions Our results indicate that 0.3 J of LA at the Yintang point before heel lancing is less effective than oral sucrose for reducing the discomfort of this procedure.Item The Influence of Igm-Enriched İmmunoglobulin Therapy on Neonatal Mortality and Hematological Variables in Newborn İnfants with Blood Culture-Proven Sepsis Reply(2014) Abbasoglu, Aslihan; Tekindal, Mustafa Agah; https://orcid.org/0000-0002-4060-7048; 26022601; ABI-2113-2020; U-9270-2018Item Relationships among Retropalatal Airway, Pharyngeal Length, and Craniofacial Structures Determined By Magnetic Resonance Imaging in Patients with Obstructive Sleep Apnea(2019) Avci, Suat; Lakadamyali, Hatice; Lakadamyali, Huseyin; Aydin, Erdinc; Tekindal, Mustafa Agah; https://orcid.org/0000-0003-2155-8014; https://orcid.org/0000-0001-6864-7378; https://orcid.org/0000-0002-4060-7048; 29728955; O-3636-2018; AAJ-2379-2021; U-9270-2018BackgroundThe integration of anatomical and nonanatomical parameters will improve our ability to predict the outcomes of OSA treatment. Currently, no standardized, quantitative classification of upper airway anatomical traits is available. The retropalatal (RP) airway is the most important area to consider when planning anatomical treatment. However, current evaluation methods feature qualitative conventional endoscopy. Here, we describe a quantitative magnetic resonance imaging (MRI) method used to classify RP airway patterns.MethodsWe recruited 117 males; 20 simple snorers and 97 patients with OSA. Lateral/anteroposterior ratios were calculated in three parallel planes and RP patterns were classified accordingly. Lateral wall soft tissue structures, skeletal dimensions representing those planes, pharyngeal lengths, and skeletal and vertical axis ratios were also measured.ResultsBoth the cross-sectional area at the hard palate level and the RP lateral dimension were associated with OSA. OSA patients had longer pharynges than controls. The oblique pattern was associated with narrow lateral dimensions. The vertical pattern was associated with a narrow nasopharynx but a longer pharynx. The airway ratio at the hard palate level and the skeletal ratios of all three planes were negatively correlated with the vertical axis ratio and together explained 40.8% of the variance in the vertical axis ratio.ConclusionsThe data suggest that anatomical imbalances between the craniofacial skeletal and soft tissue structures affect pharyngeal airway morphology in all three dimensions. The dimensions of the nasopharynx, the cross-sectional area at the hard palate level, and pharyngeal length were associated not only with the RP patterns but also with OSA severity. This study affords insights into upper airway anatomy and RP patterns and may help diagnose OSA patients and aid in the selection of an appropriate therapy.
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