Tıp Fakültesi / Faculty of Medicine
Permanent URI for this collectionhttps://hdl.handle.net/11727/1403
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Item Prognosis of Stage III NSCLC Patients Presenting with Isolated Brain Failure after Definitive Concurrent Chemoradiotherapy(2015) Topkan, Erkan; Yildirim, Berna Akkus; Guler, Ozanc; Ozdemir, Yurday; 0000-0001-8120-7123; 0000-0002-2218-2074; 0000-0001-6661-4185; AAG-2213-2021; AAG-5629-2021; V-5717-2017Item Elective Nodal Irradiation Does Not Alter Isolated Nodal Failure and Survival Outcomes in Stage III NSCLC Patients Undergoing Chemoradiotherapy(2015) Topkan, Erkan; Yildirim, Berna Akkus; Guler, Ozanc; Ozdemir, Yurday; 0000-0002-2218-2074; 0000-0001-8120-7123; 0000-0001-6661-4185; AAG-5629-2021; AAG-2213-2021; V-5717-2017Item Survival Analysis of 51 Leptomeningeal Metastatic Non Small Cell Lung Cancer Patients Treated with Whole Brain Radiotherapy(2015) Topkan, Erkan; Yildirim, Berna Akkus; Guler, Ozan C.; Ozdemir, Yurday; 0000-0001-6908-3412; 0000-0001-8120-7123; 0000-0001-6661-4185; 0000-0002-2218-2074; AAC-5654-2020; AAG-2213-2021; V-5717-2017; AAG-5629-2021Item Weight Loss before Radical Chemoradiotherapy Is Associated with Poorer Survival Outcomes in Overweight Locally Advanced NSCLC Patients(2015) Topkan, Erkan; Yildirim, Berna Akkus; Ozdemir, Yurday; Guler, Ozan C.; Ozyilkan, Ozgur; 0000-0001-6661-4185; 0000-0002-2218-2074; 0000-0001-8825-4918; 0000-0001-8120-7123; 0000-0001-6908-3412; V-5717-2017; AAG-5629-2021; AAD-2817-2021; AAG-2213-2021; AAC-5654-2020Item Effective Resolution of Lung Cancer Related Tracheal and/or Bronchial Obstruction with External Beam Radiotherapy(2015) Topkan, Erkan; Yildirim, Berna Akkus; Ozdemir, Yurday; Guler, Ozan C.; Kose, Fatih; 0000-0001-6908-3412; 0000-0001-8120-7123; 0000-0002-2218-2074; 0000-0001-6661-4185; AAC-5654-2020; AAG-2213-2021; AAG-5629-2021; V-5717-2017Item Factors Associated with Brain Metastasis Development in Radically Treated Stage IIIB Non-Small Cell Lung Cancer Patients(2015) Topkan, Erkan; Yildirim, Berna Akkus; Guler, Ozan C.; Ozdemir, Yurday; 0000-0001-6908-3412; 0000-0001-6661-4185; 0000-0001-8120-7123; 0000-0002-2218-2074; AAC-5654-2020; V-5717-2017; AAG-2213-2021; AAG-5629-2021Item Prognostic Role of fox-p3 Positive T-Regulatory Cells in Curatively Resected NSCLC Other than Stage IA(2015) Kose, Fatih; Besen, Ayberk; Findikcioglu, Alper; Canbolat, Tuba; Ozdemir, Yurday; Sedef, Ali M.; Mertsoylu, Huseyin; Sumbul, Ahmet T.; Ozyilkan, Ozgur; Abali, Huseyin; 0000-0002-2218-2074; 0000-0002-1932-9784; 0000-0001-5596-0920; 0000-0002-7862-0192; 0000-0001-8825-4918; 0000-0002-5573-906X; AAG-5629-2021; M-9530-2014; D-7660-2016; AAD-6910-2021; AFT-2303-2022; AAD-2817-2021; D-4793-2014Item Second Primary Malignancies in Laryngeal Carcinoma Patients Treated with Definitive Radiotherapy(2019) Ozdemir, Yurday; Topkan, Erkan; https://orcid.org/0000-0002-2218-2074; https://orcid.org/0000-0001-8120-7123; 30950440; AAG-5629-2021; AAG-2213-2021INTRODUCTION: Second primary malignancy (SPM) is associated with decreased overall survival (OS) in laryngeal carcinomas (LC). METHODS: One hundred eighty three LC patients were analyzed retrospectively. The primary and secondary endpoints were the incidence of SPM and the OS difference between patients with and without SPM. RESULTS: SPM developed in 22 (12.0%) patients at median 52 months (range, 4-131 months), with a yearly 2.8% incidence, of which 19 (10.4%) and 3 (1.6%) were metachronous and synchronous, respectively. Lung was the commonest SPM (72.7%). Of 47 deaths, 12 (25.5%) were SPM related. Comparatively SPM patients had significantly shorter median OS (68.0 months vs. median not reached; P = 0.005), with lower 5-year (67.0% vs. 78.9%) and 8-year (32.6 vs. 69.8%) survival rates. CONCLUSION: The present findings suggested the SPM as a competing risk factor for death in index LC patients with its annual incidence rate of 2.8% and for accounting one of every four deaths in this patients group. Emergence of lung carcinoma as the most frequent type of SPM and the ability to treat >50% of them with an estimated long-term outcomes emphasizes the importance of early diagnosis and curative treatment of SPMs.Item The İmpact of Androgen Deprivation Therapy on Setup Errors During External Beam Radiation Therapy for Prostate Cancer(2017) Onal, Cem; Dolek, Yemliha; Ozdemir, Yurday; 0000-0002-2742-9021; 0000-0002-2218-2074; 28409246; HOC-5611-2023; AAG-5629-2021Purpose To determine whether setup errors during external beam radiation therapy (RT) for prostate cancer are influenced by the combination of androgen deprivation treatment (ADT) and RT. Materials and methods Data from 175 patients treated for prostate cancer were retrospectively analyzed. Treatment was as follows: concurrent ADT plus RT, 33 patients (19%); neoadjuvant and concurrent ADT plus RT, 91 patients (52%); RT only, 51 patients (29%). Required couch shifts without rotations were recorded for each megavoltage (MV) cone beam computed tomography (CBCT) scan, and corresponding alignment shifts were recorded as left-right (x), superior-inferior (y), and anterior-posterior (z). The nonparametric Mann-Whitney test was used to compare shifts by group. Pearson's correlation coefficient was used to measure the correlation of couch shifts between groups. Mean prostate shifts and standard deviations (SD) were calculated and pooled to obtain mean or group systematic error (M), SD of systematic error (Sigma), and SD of random error (sigma). Results No significant differences were observed in prostate shifts in any direction between the groups. Shifts on CBCT were all less than setup margins. A significant positive correlation was observed between prostate volume and the z-direction prostate shift (r = 0.19, p = 0.04), regardless of ADT group, but not between volume and x- or y-direction shifts (r = 0.04, p = 0.7; r = 0.03, p = 0.7). Random and systematic errors for all patient cohorts and ADT groups were similar. Conclusion Hormone therapy given concurrently with RT was not found to significantly impact setup errors. Prostate volume was significantly correlated with shifts in the anterior-posterior direction only.Item Whole Brain Radiotherapy In Management of Non-Small-Cell Lung Carcinoma Associated Leptomeningeal Carcinomatosis: Evaluation of Prognostic Factors(2016) Ozdemir, Yurday; Yildirim, Berna Akkus; Topkan, Erkan; 0000-0001-8120-7123; 0000-0001-6661-4185; 0000-0002-2218-2074; 27306442; AAG-2213-2021; V-5717-2017; AAG-5629-2021To assess the efficacy of whole-brain radiotherapy (WBRT) and prognostic factors in leptomeningeal carcinomatosis (LMC) of non-small-cell lung cancer (NSCLC) patients. WBRT records of 51 LMC patients confined to brain were reviewed. Eligible patients had squamous-cell carcinoma (SCC) or adenocarcinoma, and Eastern Cooperative Oncology Group Performance Status (ECOG PS) 0-3. The WBRT was either 20 or 30 Gray. The primary and secondary objectives were to determine overall survival (OS) and prognostic factors for improved treatment response, respectively. Median age was 53 years (range 39-68), 58.8 % had SCC, 74.5 % had ECOG PS 1-2, and 70.6 % had LMC accompanied by parenchymal brain metastases (BM). The median follow-up was 4.1 months (range 0.7-14.4); all patients died due to disease progression. Median OS was 3.9 months (95 % CI 3.3-4.5) with 6 and 12 month estimates of 19.6 and 5.9 %, respectively. Evaluation of prognostic factors revealed that patients with ECOG 1, longer time to LMC (TT-LMC) from NSCLC diagnosis (> 11.3 months), and absence of parenchymal BM had significantly superior OS than those patients with ECOG 2 (p = 0.01) or 3 (p < 0.001), TT-LMC < 11.3 months (p = 0.001), and parenchymal BM (p = 0.012). Median OS of 3.9 months after WBRT appeared to confirm the poor prognosis of LMC. WBRT might be most effective for patients with favorable PS, longer TT-LMC, and no accompanying BM. Therefore, we identified ECOG PS 1, TT-LMC > 11.3 months, and no BM as independent prognosticators for better response to WBRT in NSCLC patients with LMC.