Tıp Fakültesi / Faculty of Medicine

Permanent URI for this collectionhttps://hdl.handle.net/11727/1403

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Author: search.filters.author.Oruz, Oguzhan

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    Refractive Change in Pediatric Patients with Intermittent Exotropia
    (2023) Oruz, Oguzhan; Pelit, Aysel; Akar, Serpil; Ates, Eylem Gul; Oto, Sibel; 0000-0002-4771-4698; 37730159; U-5246-2018
    PURPOSE To determine the relationship between intermittent exotropia (IXT) and refractive change and the effects of the methods applied in IXT follow-up on refractive change.METHOD The medical records of 228 patients with IXT (group 1) and 110 patients without strabismus (group 2) who were followed between 2008 and 2022 were analyzed retrospectively. Group 1 was divided into three subgroups: overminus correction (group 1A), patients who underwent surgery (group 1B), and patients who were observed (group 1C).RESULTS Annual myopic progression was-0.21 +/- 0.32 D (range,-1.26 to +1.92) in group 1 and -0.07 +/- 0.30 D (range,-1.13 to +1.00) in group 2 (P < 0.001). Annual myopic progression was-0.26 +/- 0.29 D (range,-1.26 D to +0.12 D) in group 1A,-0.25 +/- 0.35 D (range, -1.15 D to +0.25 D) in group 1B, and-0.19 +/- 0.33 D (range,-1.12 D to +1.92 D) in group 1C. There was no difference in annual myopic progression between the subgroups (P = 0.670). The annual change in myopic refraction between each of the group 1 subgroups and group 2 was statistically significantly different (P < 0.001, P = 0.023, P < 0.001, resp.).CONCLUSIONS Myopia progression was significantly greater in children with IXT than in the normal population. Myopia progression did not vary with exotropia treatment.
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    Histopathological effects of topical coenzyme q 10+Vit E TPGS in experimental ischemic optic neuropathy
    (2022) Oruz, Oguzhan; Yar, Kemal; Saker, Dilek; Acikalin, Arbil; Daglioglu, Yusuf Kenan; Polat, Sait; 0000-0002-4771-4698; 34978274
    We aimed to create a mechanical optic nerve damage model in rats and to investigate the neuroprotective effects of topical Coenzyme Q10 + Vitamin E TPGS (CoQ10+Vit E) molecule on retinal ganglion cells. In our study, 30 eyes of 20 male Wistar rats were used. Three groups, each consisting of 10 eyes, were formed as control, experimental, and treatment groups. The control group was used to test the formation of optic nerve damage. Topical CoQ10 + Vit E TPGS solution was applied to the rats in the treatment group, one drop twice a day for 3 weeks. On the other hand, physiological drops were applied to the experimental group 2 times a day for 3 weeks. After 3 weeks, the optic nerves of the rats were dissected and examined histopathologically. In electron microscopic examination of the treatment group, it was noted that the myelin sheath in the majority of myelinated nerve fibers and the normal structures of mitochondria, neurotubules, and neurofilaments in the axoplasm were preserved. It was observed that the oligodendrocytes surrounded the myelinated axons. In the experimental group, significant degenerative changes were observed in myelinated nerve fibers in many areas. The number of myelinated axons was significantly increased in the treatment group compared to the experimental group (p = .0028). In the light of the data obtained, the neuroprotective effect of the topically used CoQ10 + Vit E TPGS molecule was found to be histopathologically effective in our experimental study.