Tıp Fakültesi / Faculty of Medicine

Permanent URI for this collectionhttps://hdl.handle.net/11727/1403

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Author: search.filters.author.Kocer, Nazim Emrah

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    Temporal Muscle Capillary Hemangioma: Case Report
    (2014) Cologlu, Harun; Ozkan, Burak; Uysal, Ahmet Cagri; Kocer, Nazim Emrah; Borman, Huseyin; https://orcid.org/0000-0003-3093-8369; https://orcid.org/0000-0001-6236-0050; https://orcid.org/0000-0002-5943-9283; AAO-4286-2020; AAI-5063-2020; AAJ-2949-2021; AAM-5436-2021
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    Kikuchi-Fujimoto Disease as A Rare Cause of Benign Lymphadenopathy and 18F-FDG PET/CT Findings
    (2014) Erhamamci, Seval; Reyhan, Mehmet; Kocer, Nazim Emrah; https://orcid.org/0000-0001-8550-3368; https://orcid.org/0000-0002-5943-9283; 24563878; AAJ-5242-2021; AAM-5436-2021
    Kikuchi-Fujimoto disease (KFD) is an uncommon benign and self-limited disease, characterized by cervical lymphadenopathy. This disease is generally diagnosed on the basis of an excisional biopsy of affected lymph nodes. However, clinical presentation and histopathological findings of KFD could lead to a wrong initial diagnosis, of tuberculosis, systemic lupus erythymatosus or malignant lymphoma. Laboratory tests are not specific. Imaging modalitites give confusing results. Affected lymph nodes of patients; with KFD can exibit F-18-FDG uptake on PET/CT imaging similar to malignant lymphoma. Therefore, the differential diagnosis of KFD should be considered in patients with cervical and/or generalized lymphadenopathy. Accurate diagnosis of KFD by histology is essential in avoiding unnecessary emotional and mental distress associated with the diagnosis of lymphoma.
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    Cervical Burst Fracture Caused by Brown Tumor
    (2015) Aydemir, Fatih; Kardes, Ozgur; Cekinmez, Melih; Tufan, Kadir; Kocer, Nazim Emrah; 0000-0002-5943-9283; 0000-0003-1509-4575; 0000-0003-2854-941X; 0000-0002-3400-9025; 25751484; AAM-5436-2021; AAK-1686-2021; P-5895-2018; A-3652-2017
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    Is Availability of Anti-EGFR Therapy for The Colorectal Adenocarcinomas Showing Fascin Expression Limited?
    (2014) Kocer, Nazim Emrah; Kayaselcuk, Fazilet; https://orcid.org/0000-0002-5943-9283; https://orcid.org/0000-0002-1180-3840; 23588415; AAM-5436-2021; AAE-2550-2021
    Colorectal adenocarcinoma (CRC) is a major cause of death. Fascin expression in CRCs was proved to be related with higher metastatic rates and poor prognosis, while metastatic patients with only wild type K-RAS gene are the candidates of recent molecularly targeted anti-epidermal growth factor receptor (EGFR) therapies. This study is designed to investigate the correlation between the fascin expression status and the K-RAS mutational status of CRCs in order to assess the availability rate of anti-EGFR therapies for patients with fascin-expressing CRCs. Immunohistochemical expression of fascin and mutational status of K-RAS were investigated in the archival materials of randomly selected 50 metastatic colorectal carcinoma patients. Strength of fascin expression and tumor percentage stained with fascin were scored semi quantitatively. c.34 > C (p.G12R), c.35 g > C (p.G12C), c.34G > A (p.G12S), c.35G > A (p.G12D), c.35G > T (p.G12V), c.35G > C (p.G12A), and c.38G > A (p.G13.D) mutations in K-RAS gene were studied by using RT-PCR. In immunohistochemical evaluation, 32 of the 50 cases stained positive with fascin, while 21 were positive for K-RAS mutations in codon 12 (10 patients) or in codon 13 (3 patients). The correlation between the positivity of fascin and the presence of K-RAS mutations, the strength of fascin staining and the presence of K-RAS mutations, and the tumor cell percentage stained with fascin and the presence of K-RAS mutations were found statistically significant. The results of this study suggest that patients with fascin-expressing CRCs have a greater tendency to carry an activating K-RAS mutation which will prevent them from taking targeted anti-EGFR therapies. Larger series are needed to confirm these results.
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    Spontaneous Giant Splenic Hydatid Cyst Rupture Causing Fatal Anaphylactic Shock: A Case Report and Brief Literature Review
    (2014) Belli, Sedat; Akbulut, Sami; Erbay, Gurcan; Kocer, Nazim Emrah; https://orcid.org/0000-0002-1706-8680; https://orcid.org/0000-0002-5943-9283; 24918138; AAK-5370-2021; AAM-5436-2021
    Hydatid disease is a parasitic infection characterized by cyst formation in any organ, although the liver and lungs are most commonly involved. Hydatid disease of the spleen is uncommon, representing <8% of all human hydatid diseases. Splenic hydatid cysts usually coexist with liver hydatid cysts (secondary form), although the spleen is the primary location (primary form) in some cases. The clinical signs and symptoms of splenic hydatid cysts depend on their size, relationship with adjacent organs, and complications. One of the complications of splenic hydatid cysts is cyst rupture either after trauma or spontaneously as a result of increased intracystic pressure. These cysts may rupture into a hollow organ, through the diaphragm into the pleural cavity, or directly into the peritoneal cavity. A splenic hydatid cyst that ruptures into the peritoneal cavity may cause complications, including signs of peritoneal irritation, urticaria, anaphylaxis, and death, as in our case. Therefore, a hydatid cyst rupture requires both emergency surgery and careful postoperative care. In this study, we present a case of a giant splenic hydatid cyst that ruptured into the peritoneal cavity without any trauma. A review of cases reported in the English literature about splenic hydatid cyst perforation is also discussed.
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    Simultaneous Occurrence of Medullary and Differentiated Thyroid Carcinomas. Report of 4 Cases and Brief Review of The Literature
    (2014) Erhamamci, Seval; Reyhan, Mehmet; Kocer, Nazim Emrah; Nursal, Gul Nihal; Torun, Nese; Yapar, Ali Fuat; https://orcid.org/0000-0001-8550-3368; https://orcid.org/0000-0002-5943-9283; https://orcid.org/0000-0002-5302-4386; https://orcid.org/0000-0002-5597-676X; https://orcid.org/0000-0003-1715-4180; 24997082; AAJ-5242-2021; AAM-5436-2021; R-3735-2016; AAE-2718-2021; AAI-8973-2021
    Simultaneous occurence of medullary thyroid carcinoma (MTC) and papillary thyroid carcinoma (PTC) in a single patient is an unusual event. The incidence, cell origin, histopathology features and prognosis of these two carcinomas are considered completely different. The aim of this retrospective study was to describe clinical, pathologic characteristics and the prevalence of diagnosing such patients in our clinic. Between October 2003 and December 2013, 1.420 consecutive patients diagnosed by histology as having differentiated thyroid carcinoma (DTC) and treated with radioactive iodide (RAI) were retrospectively investigated. Of these, 4 patients were diagnosed by histology as having simultaneous MTC and PTC. The clinical and pathology characteristics of these patients are described. The prevalence of simultaneous MTC and PTC of these 4 patients in our clinic was 0.28% of all patients with DTC.The age of the 4 patients ranged from 44 to 63 years and were three females and one male.These patients are currently alive without disease from either of the two types of cancer. In two of these patients, MTC was located in the left and PTC in the right thyroid lobe. One patient had MTC in the right lobe and PTC in both lobes. The remaining patient had both cancers in the left lobe as a mixed tumor. We are able to present the pathology of only 2 of these 4 patients. In these 2 patients MTC was located in the left and PTC in the right thyroid lobe, one of them was female and the other was male, aged 44 and 49, respectively. In conclusion, our results suggested that simultaneous occurrence of MTC and PTC had a prevalence in our clinic of 0.28% among 1420 consecutive patients with DTC or 0.14%, if only the 2 patients in whom we are able to present their pathology slides are considered. Our cases suggest that these two tumors are usually independent and coincidental events in patients.
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    Localized Secondary Amyloidosis of the Prostate
    (2014) Bal, Nebil; Kocer, Nazim Emrah; https://orcid.org/0000-0002-5943-9283; AAM-5436-2021
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    An Unusual Site, Breast Involvement in An Adolescent Girl with Burkitt's Lymphoma
    (2015) Yazici, Nalan; Sarialioglu, Faik; Nursal, Gul Nihal; Pourbagher, Aysin; Demir, Senay; Kocer, Nazim Emrah; 0000-0002-8257-810X; 0000-0002-5302-4386; 0000-0002-4209-9075; 0000-0002-5943-9283; AAL-7766-2021; R-3735-2016; AAM-5138-2021; AAK-9310-2021; AAM-5436-2021
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    Clinicohistopathological Features and Treatment Outcomes in Testicular Lymphomas: A Single Center Experience
    (2018) Sedef, Ali Murat; Kocer, Nazim Emrah; Besen, Ali Ayberk; Mertsoylu, Huseyin; Sezer, Ahmet; Sumbul, Ahmet Taner; Kose, Fatih; Ozyilkan, Ozgur; https://orcid.org/0000-0002-5943-9283; https://orcid.org/0000-0001-8825-4918; AAM-5436-2021; AAD-2817-2021
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    The Effects of Infusion of Perineural Pregabalin in the Experimentally Created Sciatic Nerve Anastomosis in Rats
    (2018) Civi, Soner; Bulduk, Erkut Baha; Kocer, Nazim Emrah; Kardes, Ozgur; Suner, Halil Ibrahim; Durdag, Emre; Tufan, Kadir; 0000-0002-5943-9283; 0000-0003-2854-941X; 0000-0002-5957-8611; 0000-0001-6939-5491; 0000-0003-1509-4575; 30569903; AAM-5436-2021; P-5895-2018; AAJ-5381-2021; AAK-1734-2021; AAK-1686-2021
    INTRODUCTION AND OBJECT: The aim of our study was to assess the effect of perineural pregabalin administration on the success of coaptation in experimental rat sciatic nerve anastomosis by measuring the expression of anti-inflammatory cytokine TGF-beta. It is thus to provide alternative solutions to this problem which we often see in clinical practice and whose results are not satisfactory. METHODS: In our study, 40 adult, male, Sprague-Dawley rats; 5 groups were randomly assigned Group 1: This group's sciatic nerves were dissected and the surgical site was sutured. Group 2: Rats whose sciatic nerves are sectioned transversely through the fill-thickness and end-to-end anastomosis is performed and no additional procedure is performed. Group 3: Intraperitoneal administration of 30 mg / kg pregabalin for 7 days with anastomosis. Group 4: 30 mg/kg pregabalin given orally for 7 days with anastomosis. Group 5: Given 10 microliters / h pregabalin subcutaneous perineural infusion for 7 days with anastomosis. After 60 days of surgery, the experiment was terminated with high dose thiopental (50 mg/kg). The right sciatic nerves of all animals were taken and sections obtained were examined immunohistopathologically. RESULTS: Inflammation was significantly less in the 5th group than in the other groups. TGF-beta expression in Groups 3, 4, and 5 is significantly higher than Groups 1 and 2, which also supports this situation. Although the expression in group 5 was not statistically significant, the number of TGF-beta expression was higher than Groups 3 and 4. In terms of immunohistochemical properties; 1 to 3, 1 to 4, 1 to 5, 2 to 5 groups were statistically significant (p<0,05). CONCLUSIONS: In conclusion, perinural infusion of pregabalin into the anastomotic region has not been previously tried in the literature and it has been found that immunohistochemistry provides positive contributions to healing of anastomosis. More research is needed to demonstrate that this effect is superior to other methods of administration of the drug.