Tıp Fakültesi / Faculty of Medicine
Permanent URI for this collectionhttps://hdl.handle.net/11727/1403
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Item Serum YKL-40 (Chitinase 3-Like Protein 1) Levels in Migraine Patients During An Attack(2023) Horasanli, Bahriye; Sak, Zeynep Caliskan; Ozsahin, Aysun; Karabulut, Keziban UcarObjectives: The aim of this study was to investigate YKL-40 in migraine patients during migraine attacks. Methods: In this prospective study, 30 migraine patients with aura (MWA) and 30 migraine patients without aura (MWOA) who presented to the Neurological Outpatient Department of Konya City Hospital during a migraine episode as well as 28 healthy controls were included. According to the manufacturer's recommendations, serum YKL-40 levels were determined using an ELISA kit (FineTest). Statistical analysis of the data was performed with the IBM SPSS version 20.0 program. Results: The mean gender and age were similar between groups (p > 0.05). The serum YKL-40 level was 3575 +/- 604.975 pg/ml in the MWA group, 3339 +/- 492.689 pg/ml in the MWOA group and 3190 +/- 544.018 pg/ml in the control group. YKL-40 levels were significantly higher in MWA than in the control group (p=0.028). YKL-40 levels were similar in the MWA and MWOA groups (p=0.302). No significant difference was found between the group with MWOA and the control group (p=0.915). Conclusion: Although YKL-40 levels are increased in patients with migraine with aura during an attack, comprehensive studies with a larger sample are needed to clarify the relationship between YKL-40 and migraine.Item Transient Homonymous Hemianopia Caused by Cerebral Venous Sinus Thrombosis: Case Report(2014) Coban, Goken; Karalezli, Aylin; Horasanli, Bahriye; Yesilirmak, Nilufer; https://orcid.org/0000-0002-4010-2883; https://orcid.org/0000-0003-3142-1011; https://orcid.org/0000-0002-8632-2873; 25284115; P-7533-2014; AAD-7299-2020Item Effect of Fingolimod (FTY720) on Choroidal Thickness in Patients with Multiple Sclerosis(2017) Kal, Ali; Ulusoy, Mahmut Oguz; Horasanli, Bahriye; Cezairlioglu, Sefik; Kal, Oznur; 0000-0002-7751-4961; 0000-0001-7544-5790; 0000-0003-3142-1011; 28619430; AAJ-7586-2021; AAJ-4936-2021Objective: Using spectral domain optical coherence tomography (SD-OCT), to compare the choroidal thickness in a healthy population (group 1), with newly diagnosed multiple sclerosis (MS) patients (group 2), with MS patients who underwent beta-interferon monotherapy (group 3) and MS patients who underwent fingolimod therapy for 1 year (group 4) Methods: Twenty-five control subjects (25 eyes), 24 newly diagnosed (24 eyes) MS patients, 22 MS patients who underwent fingolimod monotherapy for 1 year (22 eyes), and 24 MS patients who underwent beta-interferon monotherapy for 1 year (24 eyes) were included in this study. The control group consisted of age- and gender matched healthy individuals. The choroidal thickness measurements were performed using a high-speed and high-resolution SD-OCT device. The choroidal thickness measurements were compared using a One Way Anova and Post-Hoc Tukey test. Results: Ninety-five eyes of 95 participants were included in this study. The mean age of the control group was 27.83 +/- 4.60, and it was 26.83 +/- 6.79, 27.87 +/- 6. 46 and 27.58 +/- 6.65 in the newly diagnosed MS group, fingolimod group and beta-interferon group, respectively. In fingolimod group N-1000, N-1500 and T-1500 was significantly lower than control group. (p = 0.026, p = 0.06 p = 0.13) Conclusion: Choroidal thickness values at N-1000, N-1500 and T-1500 levels in fingolimod group were found lower than in control but higher than in newly diagnosed MS group. This result can be explained with the therapeutic effect of the fingolimod on MS.Item Comparative Evaluation of the Electrophysiological, Functional and Ultrastructural Effects of Alpha Lipoic Acid and Cyanocobalamin Administration in A Rat Model of Sciatic Nerve Injury(2017) Horasanli, Bahriye; Hasturk, Askin Esen; Arikan, Murat; Togral, Guray; Helvacioglu, Fatma; Dagdeviren, Atilla; Mut, Senem; Harman, Ferhat; Argun, Guldeniz; https://orcid.org/0000-0003-3142-1011; https://orcid.org/0000-0002-6026-0045; 28968230; AAH-8887-2021; AES-7155-2022BACKGROUND: Vitamin B12 and alpha lipoic acid (ALA) are known to promote functional and morphological recovery after peripheral nerve injury. OBJECTIVE: To compare the regenerative and neuroprotective effects of vitamin B12 and ALA treatment after sciatic nerve injury. METHODS: A total of 40 rats were randomly assigned to control (sciatic nerve exposure without injury or anastomosis), sham (sciatic nerve injury and epineural anastomosis were performed but no treatment was administered), PS (isotonic saline was administered for 12 weeks after surgery), ALA (2 mg/kg ALA was administered for 12 weeks after surgery), and vitamin B12 groups (2 mg/kg cyanocobalamin was administered for 12 weeks after surgery). Functional recovery was determined by footprint analysis, in vivo neurophysiology, and ex vivo histopathological examination. RESULTS: ALA treatment produced significant improvements in sciatic functional index values and non-significant improvements on electroneuromyography compared to vitamin B12 treatment. Upon histopathological examination, the regenerative effects of ALA were relevant to axonal structural recovery whereas vitamin B12 produced greater improvements in edema and myelination. CONCLUSIONS: While both vitamin B12 and ALA produced improvements after sciatic nerve injury, ALA was more functionally effective. The unique ultrastructural effects of vitamin B12 and ALA treatment should be considered in future studies.Item The Relationship Between Vitamin B12 and Vitamin D Levels and Subjective Cognitive Complaints in Patients with First Episode Major Depressive Disorder(2021) Ulusoy, Selen Isik; Horasanli, Bahriye; Kulaksizoglu, Sevsen; 0000-0003-3142-1011Objective: Cognitive dysfunction is an important component of major depressive disorder (MDD). The aim of this study is to investigate the relationship between vitamin B12 and D and subjective cognitive complaints in patients with first-episode MDD. Method: In this cross-sectional study, patients (n=120) diagnosed with first-episode MDD filled out self-report questionnaires that evaluate subjective neurocognitive symptoms (Perceived Deficits Questionnaire-Depression [PDQ-D] and British Columbia Cognitive Complaints Inventory [BC-CCI]). Disease severity was evaluated using the Hamilton Depression Rating Scale (HDRS). Serum 25-OH vitamin D and vitamin B12 levels were measured using a chemiluminescence microparticle immunoassay technology. Results: The PDQ-D and BC-CCI scores were significantly higher in patients with combined vitamin B12 and D deficiency than patients with normal vitamin levels. We found a negative correlation between vitamin B12 level and HDRS, BC-CCI and PDQ-D scores. In addition, there was a positive correlation between HDRS scores and PDQ-D and BC-CCI scores. Linear regression analysis revealed that HDRS score and vitamin B12 level have influence on PDQ-D and BC-CCI scores. Conclusion: In this study, it was found that subjective cognitive impairment was significantly higher in MDD patients with both of vitamin B12 and vitamin D deficiency. Vitamin B12 levels were also associated with depressive symptom severity and subjective cognitive impairment. Depression severity and vitamin B12 level were found to be significant predictors of subjective cognitive impairment. Our findings highlight the importance of depression severity and vitamin B12 and D levels during routine clinical evaluation of MDD.Item Optical coherence tomography angiography findings of multiple sclerosis with or without optic neuritis(2020) Ulusoy, Mahmut Oguz; Horasanli, Bahriye; Isik-Ulusoy, Selen; 32048550Objective: Nowadays, retinal microvascular structures can be investigated using optical coherence tomography angiography (OCTA). We aimed to evaluate the probable vascular changes in the foveal and peripapillary regions of patients with multiple sclerosis (MS). Methods: A total of 20 patients with relapsing remitting multiple sclerosis (RRMS) and 24 healthy controls were recruited in this study. All participants' superficial and deeper retinal and peripapillary layers were evaluated using OCTA after a total ophthalmologic examination. Results: In the superficial plexus, the whole image (49.53 +/- 3.9% and 51.83 +/- 2.1%, p = 0.009), superior hemisphere (49.44 +/- 4.11% and 51.63 +/- 2.3%, p = 0.018), inferior hemisphere (49.75 +/- 3.9% and 52.03 +/- 2.2%, p = 0.012), parafoveal (51.87 +/- 3.9% and 53.08 +/- 3.46%, p = 0.048) and perifoveal (50.41 +/- 3.86% and 52.76 +/- 2.1%, p = 0.007) vascular densities were statistically significant lesser in patients with RRMS than in controls. In the optic disc OCTA parameters, the vessel density of the inferior (50.15 +/- 6.99% and 53.04 +/- 3.63% p = 0.043) and temporal sector (48.09 +/- 5.47% and 50.85 +/- 5.24%, p = 0.045) were statistically significantly lesser in patients with RRMS than in controls. Conclusion: The reductions in vessel density of the retinal or peripapillary area of patients with RRMS shown in this study should be investigated further to determine whether it is a secondary lesion to optic neuritis (ON) or a primary vasculopathic condition of MS.Item Childhood traumas in patients with multiple sclerosis and its relationship with suicide probability(2019) Ulusoy, Selen Isik; Horasanli, BahriyeObjective: It is known that suicide probability is more than the normal population in patients with multiple sclerosis (MS). It has been reported that childhood trauma increases suicide probability in many psychiatric disorders. The aim of this study is to investigate the relationship between childhood traumas and the probability of suicide in patients with MS..Method: The study included 61 patients with MS. The functional status of the patients with MS was evaluated with the Expanded Disability Status Scale (EDSS). Hospital Anxiety Depression Scale (HAD), Childhood Trauma Inventory (CTQ-28) and Suicide Probability Scale (SPS) were applied to all patients. Results: The patients were divided into two groups as 26 patients with childhood trauma (CTQ >= 35) and 35 patients without childhood trauma (CTQ<35). The most common childhood trauma was emotional neglect (n=28; 45,90%) and the patients' mean EDSS score was 2.43 +/- 1.68. The mean of HAD anxiety subscale (HAD-A) scores (p=0,005), HAD depression subscale (HAD-D) scores (p=0,034), SPS despair subscale scores (p=0,031) and SPS total scores (p=0,020) were higher in patients with childhood trauma. All CTQ subscales, except physical neglect, were found positively correlated with the SPS total score. Discussion: Suicide probability was significantly higher in patients with MS with childhood trauma. Patients should be evaluated in terms of childhood traumas in order to take necessary measures for suicide probability and to perform correct interventions in patients with MS.Item The importance of craniovertebral and cervicomedullary angles in cervicogenic headache(2014) Coban, Goken; Coven, Ilker; Cifci, Bilal Egemen; Yildirim, Erkan; Yazici, Ayse Canan; Horasanli, BahriyePURPOSE Many studies have indicated that cervicogenic headache may originate from the cervical structures innervated by the upper cervical spinal nerves. To date, no study has investigated whether narrowing of the craniovertebral angle (CVA) or cervicomedullary angle (CMA) affects the three upper cervical spinal nerves. The aim of this study was to investigate the effect of CVA and/or CMA narrowing on the occurrence of cervicogenic headache. MATERIALS AND METHODS Two hundred and five patients diagnosed with cervicogenic headache were included in the study. The pain scores of patients were determined using a visual analog scale. The nonheadache control group consisted of 40 volunteers. CVA and CMA values were measured on sagittal T2-weighted magnetic resonance imaging (MRI), on two occasions by two radiologists. Angle values and categorized pain scores were compared statistically between the groups. RESULTS Intraobserver and interobserver agreement was over 97% for all measurements. Pain scores increased with decreasing CVA and CMA values. Mean angle values were significantly different among the pain categories (P < 0.001). The pain score was negatively correlated with CMA (Spearman correlation coefficient, r(s), -0.676; P < 0.001) and CVA values (r(s), -0.725; P < 0.001). CONCLUSION CVA or CMA narrowing affects the occurrence of cervicogenic headache. There is an inverse relationship between the angle values and pain scores.Item Therapeutic evaluation of interleukin 1-beta antagonist Anakinra against traumatic brain injury in rats(2015) Hasturk, Askin Esen; Yilmaz, Erdal Resit; Turkoglu, Erhan; Kertmen, Hayri; Horasanli, Bahriye; Hayirli, Nazli; Erguder, Imge Berrin; Evirgen, Oya; 25779705BACKGROUND: The aim of this study was to evaluate the therapeutic efficiency of Anakinra, an IL-1 beta antagonist with anti-inflammatory effects, in an experimental model of traumatic brain injury (TBI). METHODS: Fifty-four rats underwent TBI after a weighted object was dropped onto a metal disc secured to their skulls. Animals were randomized into 3 main groups: control (n=18), TBI + saline (n=18; six animals per time-point) with samples obtained at the first, sixth and twenty-fourth h postoperatively, and TBI + Anakinra (n=18; six animals per time-point) with brain samples obtained at the first, sixth and twenty-fourth h postoperatively. Brain tissue and blood serum were extracted for the analysis of IL-1 beta, malondialdehyde, glutathione peroxidase, superoxide dismutase, and catalase levels. Tissue sections were evaluated histopathologically under a light microscope. RESULTS: After trauma, tissue and serum IL-1 beta levels were significantly elevated and after Anakinra administration, these levels substantially decreased. Glutathione peroxidase, superoxide dismutase, and catalase activity decreased following TBI and Anakinra administration proved effective in increasing the activity of these antioxidant enzymes. Histopathological analysis confirmed that Anakinra might protect the brain tissue and nerve cells from injury. CONCLUSION: Results demonstrate that Anakinra reduces the development of inflammation and tissue injury events associated with TBI.Item Histomorphometric and Ultrastructural Evaluation of Long-Term Alpha Lipoic Acid and Vitamin B12 Use After Experimental Sciatic Nerve Injury in Rats(2016) Arikan, Murat; Togral, Guray; Hasturk, Askin Esen; Horasanli, Bahriye; Helvacioglu, Fatma; Dagdeviren, Atilla; Tekindal, Mustafa Agah; Parpucu, Murat; 0000-0002-6026-0045; 0000-0002-4060-7048; 0000-0003-0376-5589; 0000-0003-3142-1011; 27476916; AAH-8887-2021; AAE-5065-2019; U-9270-2018; S-4175-2018AIM: To analyze the therapeutic effects of long-term alpha lipoic acid (A-LA) and vitamin B12 use via histomorphometric methods and electron microscopy in the transected sciatic nerves of rats. MATERIAL and METHODS: Forty rats were randomized into five groups (n=8/group). In group I, 1 cm segment of sciatic nerve was resected without any other intervention. In group II (sham), following right sciatic nerve transection, primary epineurial anastomosis was performed by placing the edges of the nerve end-to-end. In group III (saline), after right sciatic nerve transection, the ends of the nerves were brought together and closed after application of intraperitoneal physiologic saline. In group IV, 2 mg/kg of alpha lipoic acid and in group V, 2 mg/kg of vitamin B12 was administered intraperitoneally before surgical intervention. RESULTS: Histomorphometric and electron microscopic analyses revealed that vitamin 312 did not prevent structural changes, abnormal myelination and g-ratio deviations regarding the functional aspects of the sciatic nerve. Alpha lipoic acid was more effective in restructuring the histomorphometric and structural aspects of the nerve with more myelinated fibers with optimal values (0.55-0.68) than vitamin B12 groups, in which the number of myelinated nerve fibers significantly decreased at optimal intervals (0.55-0.68). CONCLUSION: A-LA administration following peripheral nerve transection injury is more effective in promoting nerve healing regarding the structural aspects of the sciatic nerve compared to vitamin B12 and also myelination of nerve fibers by increasing g-values.