Tıp Fakültesi / Faculty of Medicine

Permanent URI for this collectionhttps://hdl.handle.net/11727/1403

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2015 - 20192

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Author: search.filters.author.Arinsoy, TurgaySubject: search.filters.subject.hemodialysis

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    Echocardiographic Epicardial Adipose Tissue Measurements Provide Information About Cardiovascular Risk in Hemodialysis Patients
    (2015) Ulusal Okyay, Gulay; Okyay, Kaan; Polattas Solak, Evsen; Sahinarslan, Asife; Pasaoglu, Ozge; Ayerden Ebinc, Fatma; Pasaoglu, Hatice; Boztepe Derici, Ulver; Sindel, Sukru; Arinsoy, Turgay; 0000-0001-6134-8826; 25643907; AAK-7355-2020
    Epicardial adipose tissue (EAT) is a cardiovascular risk predictor in general population. However, its value has not been well validated in maintainance hemodialysis (MHD) patients. We aimed to assess associations of EAT with cardiovascular risk predictors in nondiabetic MHD patients. In this cross-sectional study, we measured EAT thickness by transthoracic echocardiography in 50 MHD patients (45.8 +/- 14.6 years of age, 37 male). Antropometric measurements, bioimpedance analysis, left ventricular (LV) mass, carotis intima media thickness, blood tests, homeostasis model assessment for insulin resistance (HOMA-IR) and hemodialysis dose by single-pool urea clearence index (spKt/V) were determined. The mean EAT thickness was 3.28 +/- 1.04mm. There were significant associations of EAT with body mass index (=0.590, P<0.001), waist circumference (=0.572, P<0.001), body fat mass (=0.562, P<0.001), percentage of body fat mass (=0.408, P=0.003), percentage of lean tissue mass (=-0.421, P=0.002), LV mass (=0.426, P=0.002), carotis intima media thickness (=0.289, P=0.042), triglyceride/high-density lipoprotein cholesterol ratio (=0.529, P<0.001), 1/HOMA-IR (=-0.386, P=0.006), and spKt/V (=-0.311, P=0.028). No association was exhibited with visfatin C, high-sensitivity C-reactive protein, interleukin-6, and tumor necrosis factor-alpha (for all, P>0.05). Body mass index, waist circumference, body fat mass, percentage of lean tissue mass, LV mass, triglyceride/high-density lipoprotein cholesterol ratio, HOMA-IR, and spKt/V appeared as independent predictors of EAT. EAT was significantly associated with body fat measures, cardiovascular risk predictors, and dialysis dose in MHD patients.
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    Relationship between plasma YKL-40 levels and endothelial dysfunction in chronic kidney disease
    (2019) Keskin, Gul Sema; Helvaci, Ozant; Yayla, Cagri; Pasaoglu, Ozge T.; Keskin, Caglar; Arinsoy, Turgay; Deric, Ulver B.; 30763987
    Background/aim: We aimed to evaluate the relationship between YKL-40 and endothelial dysfunction in chronic kidney disease. Materials and methods: Twenty-nine hemodialysis patients, 101 patients with nondialytic (stage 2, 3, 4, and 5 ND) chronic kidney disease (CKD), and 38 healthy individuals as a control group were included. YKL-40 levels were measured by ELISA. Endothelial dysfunction was indirectly measured by flow-mediated dilatation percentage (FMD) in the brachial artery. Results: YKL-40 levels were higher in CKD patients than controls and highest in HD patients (P = 0.001). FMD values were lower in nondialytic CKD patients and lowest in HD patients (P = 0.001). YKL-40 negatively correlated with eGFR and FMD values (r = -0.674 and r = -0.471, respectively). Conclusion: This study shows that YKL-40 increases with CKD stage and is negatively correlated with FMD measurements.