Sağlık Bilimleri Enstitüsü / Health Science Institute
Permanent URI for this collectionhttps://hdl.handle.net/11727/1393
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Item Developing an Educational Material Based on The Needs and Health Literacy of Patients Receiving Radiotherapy and Their Relatives(2014) Ozdogan, P. Seref; Kav, S.; https://orcid.org/0000-0003-0361-7498; V-9745-2019Item Investigating The Effects of Poverty on Health and Quality of Life in Poor People Aged 65 and Over in Etimesgut District, Ankara(2014) Yilmaz, Fikriye; Celik, Cansu; Numanoglu Tekin, Rukiye; https://orcid.org/0000-0002-4884-3803; AAZ-4775-2020Introduction: The purpose of this research was to examine the effects of poverty on health and quality of life of poor people aged 65 and over in Etimesgut District, Ankara. Materials and Method: A questionnaire was administered to 116 people over the age of 65 who were deemed a priority group for assistance by the Etimesgut Social Assistance and Solidarity Foundation in Ankara. The questionnaire comprised questions related to socio-demographic characteristics, health status and health care utilization of elderly people, along with the World Health Organization Quality of Life Instrument-Older Adults Module. Research data were evaluated using the Chi-Square Test, Independent Samples T Test, One-Way Analysis of Variance, Mann-Whitney U Test and Kruskal-Wallis Test. Results: The average monthly income of the elderly participants was 168.94 +/- 54.67 Turkish liras and they lived completely under the poverty line determined for Turkey. However, it was found that women, illiterate participants and those receiving the old age pension were poorer, and of those whose income was below average, more delayed/did not seek help when they were ill. Statistical analysis revealed that total quality of life scores of participants aged 65-74 and literate participants were higher; the "social participation" scores of participants whose income was below average and those received an old-age pension were lower. Conclusion: Poverty has negative effects on the health status, health care utilization and quality of life of elderly people.Item The Effects of Instrument-Assisted Soft Tissue Mobilization and Kinesio Taping on Pain, Functional Disability and Depression in Patients with Chronic Low Back Pain: A Randomized Trial(2022) Cakmak, Ozge; Atici, Emine; Gulsen, MustafaPurpose: Low back pain is a common condition that can become chronic, which reduces the life quality of the patient by causing functional disability and depression. This study aimed to investigate the effects of instrument-assisted soft tissue mobilization (IASTM) and kinesio taping (KT) along with conservative treatment in patients with chronic nonspecific low back pain (CNLBP). Methods: A total of 30 patients with chronic low back pain aged between 30-50 years included in the study were randomized to IASTM (n=15) and KT (n=15) groups. Both the groups underwent conservative treatment that comprised of a hot pack, ultrasound, transcutaneous electrical nerve stimulation (TENS) and home exercises. In this study, assessments were made using the Visual Analogue Scale (VAS), Roland Morris Disability Questionnaire (RMDQ), and Beck Depression Inventory (BDI). The measurements were carried out at the beginning and end of the treatment. Results: As a result of the study, IASTM method improved in parameters such as pain (p<0.05), functionality (p=0.001) and depression (p<0.05). As a result of the study, the KT group improved in parameters such as pain, functionality and depression compared to pre-treatment (p<0.05). However, the two treatments were not superior to each other in pain (p=0.241), functionality (p=0.687) and depression (p=0.699) parameters. Conclusion: It has been observed that both treatments have positive effects on many parameters such as pain, disability, depression and mental state in patients with CNLBP. This study demonstrates that IASTM and KT treatments can be used to support therapeutic effects in patients with CNLBP.Item Relationship Between Exercise Perception With Physical Activity Level, Body Awareness, and Illness Cognition in Renal Transplant Patients: A Pilot Study(2019) Tigli, Ayca; Soy, Ebru Hatice Ayvazoglu; Aytar, Aydan; Moray, Gokhan; Haberal, Mehmet; https://orcid.org/0000-0002-0993-9917; https://orcid.org/0000-0003-2498-7287; https://orcid.org/0000-0002-3462-7632; 30777573; AAC-5566-2019; HIR-3735-2022; AAE-1041-2021; AAJ-8097-2021Objectives: Transplantation offers better quality of life and long-term survival benefits. Further knowledge is needed regarding exercise in daily life of transplant recipients. Here, we investigated the relationship between exercise perception and physical activity level, body awareness, and illness cognition in renal transplant patients. Materials and Methods: Our study included 53 renal transplant recipients (Standardized Mini-Mental Test score = 26.35 +/- 1.36; age = 41.11 +/- 13.52 year, body mass index = 25.96 +/- 5.26 kg/m(2), elapsed time after transplant = 3.68 +/- 1.53 year). Perceived benefits and barriers to exercise, physical activity level, body awareness, and illness cognition were assessed with the Exercise Benefits/Barriers Scale, International Physical Activity Questionnaire, Body Awareness Questionnaire, and Patient Illness Perception Questionnaire, respectively. Correlations were established with Spearman test for nonparametric data, with regression analysis used to find determinants of physical activity levels. Results: We observed correlations between physical activity level and perceived benefits and barriers to exercise. There was a positive relationship between body awareness and perceived benefits and barriers to exercise and also illness cognition, with significant correlation between perceived benefits and barriers to exercise and illness cognition (P < .05). Perceived benefits and barriers to exercise (P = .006, R = 0.373, R2 = 0.139, beta = 0.373, t = 2.867, F = 8.22) were determining factors for physical activity level. Conclusions: Psychologic and physical factors, including negative emotions and body dissatisfaction, are risk factors for poor quality of life. Although it is important to increase quality of life, tools to enhance body awareness and to develop strategies to alter motor behaviors in daily living activities are needed. Treatment and assessment strategies on body awareness and illness perception should be considered, with emphasis on the importance of physical activity posttransplant.Item The correlation between serum vitamin d and oocyte quality, potential of fertilization and embryo development in the assisted reproductive technology (art) cases(Başkent Üniversitesi Sağlık Bilimleri Enstitüsü, 2022) Ben Zair, Asma Bashir; Dolu, NazanThere is increasing interest in vitamin D research as a result of the increased incidence of vitamin D insufficiency. Vitamin D deficiency has been associated with a number of acute and chronic disorders. There is increasing evidence that 25-hydroxy[25(OH)] vitamin D has important effects on a variety of systems, including the human reproductive system. Vitamin D can help regulate the menstrual cycle, endometrial proliferation, follicular development, relief of early dysmenorrhea, and decrease vaginal fibroid. Studies show that women with high levels of vitamin D in their blood are more likely to conceive. The aim of this study is to show whether there is a relationship between 25 (OH) vitamin D blood levels and oocyte quality, in vitro division success and embryo quality in IVF patients. Individuals who underwent IVF treatment at a health center in Misurata, Libya between January 2018 and December 2020 were retrospectively analyzed. Luteinizing Hormone (LH) levels of the patients were recorded before and after the treatment. All patients in the study were administered vitamin D at a dose of 1,500 to 2,000 IU (3 sprays per day) for two months after treatment was started. A statistically significant difference was found in LH levels before and after treatment. However, no significant difference was observed between vitamin D supplementation and oocyte quality, in vitro division success and embryo quality. In this study, it was shown that vitamin D supplementation did not affect women in infertile marriages. Additional studies are needed to see in more detail whether vitamin D supplementation will help in vitro fertilization success.D vitamini yetersizliği insidansının artmasının bir sonucu olarak D vitamini araştırmalarına daha fazla ilgi duyulmaktadır. D vitamini yetersizliği, bir dizi akut ve kronik bozuklukla ilişkilendirilmiştir. 25-hidroksi [25(OH)] D vitamininin insan üreme sistemi de dahil olmak üzere çeşitli sistemlere önemli etkileri olduğuna dair kanıtlar artmaktadır. D vitamini, adet döngüsün düzenlenmesi, endometriyal proliferasyon, foliküler gelişim, erken dismenorenin rahatlaması ve vajinal fibroidin azalmasına yardımcı olabilir. Çalışmalar, kanında D vitamini düzeyi yüksek olan kadınların gebe kalma olasılığının daha yüksek olduğunu göstermektedir. Bu çalışmanın amacı, tüp bebek hastalarında 25 (OH) D vitamini kan seviyeleri ile oosit kalitesi, in vitro bölünme başarısı ve embriyo kalitesi arasında bir ilişki olup olmadığını göstermektir. Ocak 2018 ile Aralık 2020 tarihleri arasında Libya, Misurata'daki bir sağlık merkezinde tüp bebek tedavisi gören bireyler geriye dönük olarak incelendi. Hastaların tedavi öncesi ve sonrası Luteinizan Hormon (LH) seviyeleri kaydedildi. Çalışmaya katılan tüm hastalara tedaviye başlandıktan sonra, iki ay boyunca günde 1.500 ile 2.000 IU (günde 3 sprey) dozunda D vitamini uygulandı. Tedaviden önce ve sonra LH seviyelerinde istatistiksel olarak anlamlı farklılık bulundu. Ancak D vitamini takviyesi ile oosit kalitesi, in vitro bölünme başarısı ve embriyo kalitesi arasında anlamlı farklılık gözlenmedi. Bu çalışmada, D vitamini takviyesinin kısır evliliklerdeki kadınlar üzerindeki etkisinin olmadığı gösterilmiştir. D vitamini takviyesinin invitro fertilizasyon başarısına yardımcı olup olmayacağını daha ayrıntılı görmek için ek çalışmalara ihtiyaç bulunmaktadır.Item The effects of vitamin d and zinc on anxiety and exploratory behaviors in rats.(Başkent Üniversitesi Sağlık Bilimleri Enstitüsü, 2022) Baroud, Amna Abdulsalam; Dolu, NazanD vitamini lipofilik bir vitamindir Koronavirüs pandemisi sırasında birçok kişi virüse karşı bağışıklıklarını güçlendirmek için D Vitamini (D vit) ve çinko takviyeleri almaya başlamıştır. Ancak, D vit ve çinkonun anksiyete ve keşif davranışları üzerine etkilerini araştıran bir çalışmaya rastlanmamıştır. Bu çalışmada, sıçanlarda değişik dozlardaki D vit ve çinko takviyesinin, anksiyete ve keşif davranışı üzerindeki etkisinin açık alan testi ve yükseltilmiş artı labirent ile araştırılması amaçlamaktadır. Bu çalışmada 48 genç (8 haftalık) erkek Wistar sıçan eşit olarak dört gruba ayrıldı. 8 hafta boyunca günde bir kez olmak üzere Grup 1’e (sham grubu) normal su, Grup II'ye 400 IU/gün D vit, Grup III'e 1000IU/gün D vit gavajla verildi. Grup IV’e altı gün boyunca serum fizyolojik (ip) içinde çözülmüş olarak 30 mg/kg ZnSO4 verildi. 8 hafta sonra, D vit gruplarına altı gün boyunca ZnSO4 (30 mg/kg, serum fizyolojik içinde çözülmüş, ip) ve D vit (400 IU/gün ve 1000 IU/gün, ağızdan) birlikte verildi. Bu sürenin sonunda, sıçanlara açık alan testi (AAT) ve yükseltilmiş artı labirent testi (YAL) uygulandı. Açık alan testinde Grup 2 (p<0.013) ve Grup 3’ün (p<0.003) merkezi alana giriş sayısı (MAG) ve Grup 2 (p<0,039) ve Grup 3’ün (p<0,003) merkez alanda geçirilen süreleri (MAGS) Grup 1'den düşüktü. Grup 2 (p<0,000), Grup 3 (p<0,000) ve Grup 4’de (p<0,000) gerinme sayıları (GS) ve Grup 2 (p<0,000), Grup 3 (p<0,000) ve Grup 4 (p<0,004)’ün dışkılama sayıları (DS) Grup 1’den anlamlı olarak düşüktü. YAL'de Grup 2’nin kapalı alanda geçirilen süresi (KAGS) tüm gruplar arasında en yüksekti. KAGS değeri Grup 2'de Grup 1'e (p<0.01) ve Grup 4'e (p<0.01) göre istatistiksel olarak daha yüksek, açık alanda geçirilen süre (AAGS) değeri Grup 2'de Grup 1'e göre istatistiksel olarak daha düşüktü (p<0.04). Grup 1’in açık kola giriş sayısı (AKG), en yüksek bulundu. Grup 2 (p<0.01) ve Grup 3’ün (p<0.03) AKG değerleri Grup 1'den istatistiksel olarak daha düşüktü. AAT ve YAL sonuçlarımıza göre farklı dozlardaki D vit ile birlikte çinko verilen ratlarda anksiyojenik etkiler görüldü; ancak çinko tek başına uygulandığında anksiyeteyi etkilemedi.Farklı çinko dozlarının kaygı üzerindeki etkisini araştırmak için daha fazla çalışmaya ihtiyacımız bulunmaktadır. Vitamin D is a lipophilic vitamin. During the coronavirus pandemic, many people started taking Vitamin D (vit D) and zinc supplements to increase their immunity against the virus. However, there is no study investigating the effects of vitamin D and zinc on anxiety and exploratory behaviors. In this study, it is aimed to investigate the effect of different doses of vitamin D and zinc supplementation on anxiety and exploratory behavior in rats by open field test and elevated plus maze. In this study, 48 young (8 weeks old) male Wistar rats were equally divided into four groups. Normal water was given to Group 1 (sham group), 400 IU/day D vit to Group II, 1000 IU/day D vit to Group III, once a day for 8 weeks by gavage. 30 mg/kg ZnSO4 dissolved in physiological saline (ip) was administered to group IV for six days. After 8 weeks, vit D groups were given concomitant ZnSO4 (30 mg/kg, dissolved in saline, ip) and vit D (400 IU/day and 1000 IU/day, orally) for six days. At the end of this period, the rats underwent open field test (OFT) and elevated plus maze test (EPM). In the open field test, the number of entrances to the central area (NEC) of Group 2 (p<0.013) and Group 3 (p<0.003) and the time spent in the central area (STC) of Group 2 (p<0.039) and Group 3 (p<0.003) was lower than Group 1. The number of rearing (NR) values for Group 2 (p<0.000), Group 3 (p<0.000) and the number of defecation (ND) values of Group 2 (p<0.000), Group 3 (p<0.000) and Group 4 (p<0.004) were significantly lower than Group1. At EPM, Group 2 had the highest spent time in the closed area (STCA) value among all the groups. STCA value was statistically higher at Group 2 than Group 1 (p<0.01) and Group 4 (p<0.01), while spent time in the open area (STOA) value was statistically lower at Group 2 than Group 1 (p<0.04). Group 1 had the highest enter the open arm (EOA). EOA values for Group 2 (p<0.01) and Group 3 (p<0.03) were statistically lower than Group 1. According to our OFT and EPM results, anxiogenic effects were observed in rats given different doses of vitamin D and zinc; however, zinc did not affect anxiety when administered alone. We need more studies to investigate the effect of different doses of zinc on anxiety.Item Exposure of Pregnant Women to Violence by Partners and Affecting Factors in Turkey(2016) Alan, Hacer; Koc, Gulten; Taskin, Lale; Eroglu, Kafiye; Terzioglu, FusunThis study aims to determine the exposure of women to violence by their partners during pregnancy and the factors affecting this condition. The current study conducted as descriptive included a total of 442 pregnant women who were married and at the last trimester of their pregnancy. The data were collected using a semi-structure questionnaire and face to face interview with the pregnant women and were evaluated using descriptive statistics, chi-square test, and logistic regression analysis. Of the pregnant women, 39.8 % experienced at least one type of violence, and the most common type of violence experienced was verbal violence (31.4 %). Among the participants, 18.2 % exposed to violence expressed that their partners perpetrated violence because of jealousy, and 30.1 % reported that they just cried when exposed to violence. According to the results of the logistic regression analysis, insufficient prenatal care increases all types of violence in pregnancy. Working with pregnant women and their partners together under the scope of prenatal care services, and especially planning the attempts to prevent violence by discussing the causes of violence with couples, will facilitate more successful violence prevention programs.Item Evaluation of electrodermal activity in diabetic rats treated with vildagliptin and metformin(Başkent Üniversitesi Sağlık Bİlimleri Enstitüsü, 2022) Muftah Shawesh, Muftah Mohamed; Yiğit, Ayşe ArzuElectrodermal activity (EDA) is the measurement of the electrical conductivity of skin, which indicates the activation of sympathetically innervated eccrine sweat glands. Thus, sympathetic system activity that innervates eccrine sweat glands. In our study, it was aimed to evaluate electrodermal activity and thus changes in sympathetic activity in diabetic rats treated with vildagliptin, metformin and metformin+vildagliptin combination. 50 male rats were used in this study. Rats were divided into control (n=10) and experimental groups (n=40). Forty animals in experimental group were injected with 45 mg/kg streptozotocin as a single dose intraperitoneally. After 3 days, animals whose blood glucose level exceeded 250 mg/dl were considered as diabetic. Rats were divided into 4 groups as diabetes, vildagliptin, metformin and metformin+vildagliptin. Vildagliptin (50 mg/kg), metformin (500 mg/kg) and 500 mg/kg metformin+50 mg/kg vildagliptin were administered by gavage for 15 days. After that blood glucose were be measured again end of the 15 days and seeing that diabetes continues, tonic activity was recorded before sound stimulus, and phasic skin conductivity level (SCR) was recorded in response to the auditory stimulus by using Biopac MP35 device. Differences between groups were determined by one-way Anova test. Tukey test was used to determine the significance between the groups. P<0.05 was considered significant. Both tonic SCL and phasic SCR were higher (p<0.001) in diabetic groups than the control group. These findings might explain the increase in the sympathetic activity in diabetic groups. In additiona, the blood glucose levels of the metformin and vildagliptin groups were lower than the diabetic group. Intrestingly, the metformin+vildagliptin group had a lower tonic SCL than the other experimental groups, whereas the metformin group had a less phasic SCR than the diabetes group (p <0.0001). Peak number of vildagliptin and metformin+vildagliptin groups decreased in tonic recording compared to diabetic group (p<0.0001, p<0.01 respectively). Our study, the fact that diabetic drugs caused a decrease in SCL indicates that these drugs may reduce eccrine sweat gland and sympathetic activity affecting these sweat glands. Further studies are needed on whether a decrease in sympathetic activity will have a positive effect on diabetes. Elektrodermal aktivite (EDA), sempatik sinir sistemi ile innerve olan ekrin ter bezlerinin aktivitesini yansıtan derinin elektriksel iletkenliğinin ölçümüdür. Çalışmamızda, metformin, vildagliptin ve metformin+vildagliptin kombinasyonu uygulanan diyabetik sıçanlarda elektrodermal aktivitenin, dolayısıyla sempatik aktivitedeki değişikliklerin değerlendirilmesi amaçlandı. Çalışmada 50 adet erkek Wistar sıçan kullanıldı. Sıçanlar 10’u kontrol, 40’ı deney grubu olacak şekilde ayrıldı. Deney grubundaki 40 hayvanda 45 mg/kg ip streptozotosin (STZ) uygulamasından sonra kan glikoz düzeyi 250 mg/dl’ yi geçen hayvanlar diyabetli olarak kabul edildi. Sıçanlara 15 gün boyunca gavaj ile çeşme suyu, 500 mg/kg metformin, 50 mg/kg vildagliptin, ve 500 mg/kg metformin+50 mg/kg vildagliptin verilerek diyabetik kontrol (n=10) ve deney grupları (3 grup, n=10) oluşturuldu. 15 gün sonunda kan glikozluri tekrar ölçüldükten ve diyabetin devam ettiği görüldükten sonra Biopac MP35 cihazı kullanılarak, ses uyarısı verilmeden önce dinlenim durumundaki tonik, işitsel uyarıdan sonra gelişen cevap fazik deri iletkenlik seviyesi (DİS) olarak kaydedildi. Gruplar arasındaki farklılıklar one-way Anova testi ve Posthoc Tukey testi ile belirlendi. P<0.05 anlamlı olarak kabul edildi. Hem tonik hem de fazik DİS diyabetli gruplarda arttı (p<0.001) ki bu diyabetli gruplarda sempatik aktivitenin arttığını gösterebilir. Metformin ve vildagliptin verilen gruplarda kan şekeri diyabetli gruba göre daha düşüktü. Tonik DİS, metformin+vildagliptin grubunda diğer deney gruplarına göre, fazik DİS ise metformin grubunda diyabetik gruba göre azaldı (p<0.0001). Vildagliptin ile metformin+vildagliptin gruplarının pik sayısı da tonik kayıtta diyabetik gruba göre azaldı (sırasıyla p<0.0001 ve p<0.05). Çalışmamızda, metforminin, ve metformin vildagliptin kombinasyonlarının fazik DİS de azalma oluşturması, bu ilaçların ekrin ter bezi ve bu ter bezlerine etkiyen sempatik aktiviteyi azalttığını gösterebilir. Sempatik aktivitede azalmanın diyabette olumlu etki oluşturup oluşturmayacağı ile ilgili daha ileri çalışmalara ihtiyaç bulunmaktadırItem Scenarios to Manage The Hepatitis C Disease Burden and Associated Economic Impact of Treatment in Turkey(2017) Ormeci, Necati; Malhan, Simten; Balik, Ismail; Ergor, Gul; Razavi, Homie; Robbins, Sarah; 29027109Hepatitis C virus (HCV) infection is a significant health problem. The aim of this study is to evaluate the cost-effectiveness of HCV treatment and estimate its economic burden in Turkey. An Excel-based disease progression model was used to estimate the HCV-infected population for 2015-2030. Direct costs in US dollars (USD) including diagnostic, laboratory, and healthcare costs were provided by experts in the country. Indirect costs were estimated as lost productivity using the World Health Organization (WHO) disability-adjusted life years (DALYs) metric from the Global Burden of Disease study. Three scenarios were developed to estimate the cost-effectiveness of HCV treatment through 2030: Base 2016, Increase Treatment and SVR (where SVR is sustained virological response), and WHO Targets. Additionally, the WHO Targets scenario was assessed at three different treatment price points: 10,900 USD, 16,730 USD (base cost), and 27,285 USD. Cumulative total direct and indirect costs (2015-2030) for the WHO Targets scenario were estimated to be 10.8 billion USD, or a 1.5 % increase compared with Base 2016. However, by the following decade, due to a marked decline in DALYs, cumulative direct and indirect costs were estimated to be 45 % less when compared with Base 2016. At a threshold of 9125 USD, all scenarios were cost-effective. By implementing the WHO Targets scenario, Turkey would be able to lower HCV prevalence by 80 % and reduce the total number of liver-related deaths by > 65 % by 2030. Treating HCV infection in the country is cost-effective if healthcare and indirect costs are taken into consideration.Item The Effects of Clinical Pilates Exercises on Patients with Shoulder Pain: A Randomised Clinical Trial(2017) Atilgan, Esra; Aytar, Aydan; Caglar, Aslican; Tigli, Ayca Aytar; Arin, Gamze; Yapali, Gokmen; Kisacik, Pinar; Berberoglu, Utku; Sener, Hulya Ozlem; Unal, Edibe; 29037638; HIR-3735-2022Aim: The purpose of this study was to determine the effect of Clinical Pilates exercises on patients with shoulder pain. Material and methods: Thirty-three patients, experiencing shoulder pain continuously for at least four weeks were selected as study subjects. The patients were randomly divided into two groups, namely Clinical Pilates exercise (n = 17) group and conventional exercise (n = 16) group. The patients were treated for five days a week, the total treatment being carried out for 10 days. The assessment of pain and disability amongst the patients were done at the baseline and at the end of the treatment sessions, using Visual Analogue Scale (VAS) and Shoulder Pain and Disability Index (SPADI). Results: The clinical Pilates exercise group showed a significant improvement in all scores used for assessment (p < 0.05), while the conventional exercise group demonstrated a significant improvement only in the SPADI total score (p < 0.05). A comparison of scores for the VAS, SPADI-Pain and SPADI-Total between the two groups, revealed a significant improvement in the Clinical Pilates exercise group (p < 0.05). Conclusion: It was demonstrated by the study that Clinical Pilates exercise is an efficient technique for patients experiencing shoulder pain, as it helps reduce pain and disability among them. (c) 2017 Elsevier Ltd. All rights reserved.