Sağlık Bilimleri Enstitüsü / Health Science Institute
Permanent URI for this collectionhttps://hdl.handle.net/11727/1393
Browse
14 results
Search Results
Item The Effects of Instrument-Assisted Soft Tissue Mobilization and Kinesio Taping on Pain, Functional Disability and Depression in Patients with Chronic Low Back Pain: A Randomized Trial(2022) Cakmak, Ozge; Atici, Emine; Gulsen, MustafaPurpose: Low back pain is a common condition that can become chronic, which reduces the life quality of the patient by causing functional disability and depression. This study aimed to investigate the effects of instrument-assisted soft tissue mobilization (IASTM) and kinesio taping (KT) along with conservative treatment in patients with chronic nonspecific low back pain (CNLBP). Methods: A total of 30 patients with chronic low back pain aged between 30-50 years included in the study were randomized to IASTM (n=15) and KT (n=15) groups. Both the groups underwent conservative treatment that comprised of a hot pack, ultrasound, transcutaneous electrical nerve stimulation (TENS) and home exercises. In this study, assessments were made using the Visual Analogue Scale (VAS), Roland Morris Disability Questionnaire (RMDQ), and Beck Depression Inventory (BDI). The measurements were carried out at the beginning and end of the treatment. Results: As a result of the study, IASTM method improved in parameters such as pain (p<0.05), functionality (p=0.001) and depression (p<0.05). As a result of the study, the KT group improved in parameters such as pain, functionality and depression compared to pre-treatment (p<0.05). However, the two treatments were not superior to each other in pain (p=0.241), functionality (p=0.687) and depression (p=0.699) parameters. Conclusion: It has been observed that both treatments have positive effects on many parameters such as pain, disability, depression and mental state in patients with CNLBP. This study demonstrates that IASTM and KT treatments can be used to support therapeutic effects in patients with CNLBP.Item The correlation between serum vitamin d and oocyte quality, potential of fertilization and embryo development in the assisted reproductive technology (art) cases(Başkent Üniversitesi Sağlık Bilimleri Enstitüsü, 2022) Ben Zair, Asma Bashir; Dolu, NazanThere is increasing interest in vitamin D research as a result of the increased incidence of vitamin D insufficiency. Vitamin D deficiency has been associated with a number of acute and chronic disorders. There is increasing evidence that 25-hydroxy[25(OH)] vitamin D has important effects on a variety of systems, including the human reproductive system. Vitamin D can help regulate the menstrual cycle, endometrial proliferation, follicular development, relief of early dysmenorrhea, and decrease vaginal fibroid. Studies show that women with high levels of vitamin D in their blood are more likely to conceive. The aim of this study is to show whether there is a relationship between 25 (OH) vitamin D blood levels and oocyte quality, in vitro division success and embryo quality in IVF patients. Individuals who underwent IVF treatment at a health center in Misurata, Libya between January 2018 and December 2020 were retrospectively analyzed. Luteinizing Hormone (LH) levels of the patients were recorded before and after the treatment. All patients in the study were administered vitamin D at a dose of 1,500 to 2,000 IU (3 sprays per day) for two months after treatment was started. A statistically significant difference was found in LH levels before and after treatment. However, no significant difference was observed between vitamin D supplementation and oocyte quality, in vitro division success and embryo quality. In this study, it was shown that vitamin D supplementation did not affect women in infertile marriages. Additional studies are needed to see in more detail whether vitamin D supplementation will help in vitro fertilization success.D vitamini yetersizliği insidansının artmasının bir sonucu olarak D vitamini araştırmalarına daha fazla ilgi duyulmaktadır. D vitamini yetersizliği, bir dizi akut ve kronik bozuklukla ilişkilendirilmiştir. 25-hidroksi [25(OH)] D vitamininin insan üreme sistemi de dahil olmak üzere çeşitli sistemlere önemli etkileri olduğuna dair kanıtlar artmaktadır. D vitamini, adet döngüsün düzenlenmesi, endometriyal proliferasyon, foliküler gelişim, erken dismenorenin rahatlaması ve vajinal fibroidin azalmasına yardımcı olabilir. Çalışmalar, kanında D vitamini düzeyi yüksek olan kadınların gebe kalma olasılığının daha yüksek olduğunu göstermektedir. Bu çalışmanın amacı, tüp bebek hastalarında 25 (OH) D vitamini kan seviyeleri ile oosit kalitesi, in vitro bölünme başarısı ve embriyo kalitesi arasında bir ilişki olup olmadığını göstermektir. Ocak 2018 ile Aralık 2020 tarihleri arasında Libya, Misurata'daki bir sağlık merkezinde tüp bebek tedavisi gören bireyler geriye dönük olarak incelendi. Hastaların tedavi öncesi ve sonrası Luteinizan Hormon (LH) seviyeleri kaydedildi. Çalışmaya katılan tüm hastalara tedaviye başlandıktan sonra, iki ay boyunca günde 1.500 ile 2.000 IU (günde 3 sprey) dozunda D vitamini uygulandı. Tedaviden önce ve sonra LH seviyelerinde istatistiksel olarak anlamlı farklılık bulundu. Ancak D vitamini takviyesi ile oosit kalitesi, in vitro bölünme başarısı ve embriyo kalitesi arasında anlamlı farklılık gözlenmedi. Bu çalışmada, D vitamini takviyesinin kısır evliliklerdeki kadınlar üzerindeki etkisinin olmadığı gösterilmiştir. D vitamini takviyesinin invitro fertilizasyon başarısına yardımcı olup olmayacağını daha ayrıntılı görmek için ek çalışmalara ihtiyaç bulunmaktadır.Item The effects of vitamin d and zinc on anxiety and exploratory behaviors in rats.(Başkent Üniversitesi Sağlık Bilimleri Enstitüsü, 2022) Baroud, Amna Abdulsalam; Dolu, NazanD vitamini lipofilik bir vitamindir Koronavirüs pandemisi sırasında birçok kişi virüse karşı bağışıklıklarını güçlendirmek için D Vitamini (D vit) ve çinko takviyeleri almaya başlamıştır. Ancak, D vit ve çinkonun anksiyete ve keşif davranışları üzerine etkilerini araştıran bir çalışmaya rastlanmamıştır. Bu çalışmada, sıçanlarda değişik dozlardaki D vit ve çinko takviyesinin, anksiyete ve keşif davranışı üzerindeki etkisinin açık alan testi ve yükseltilmiş artı labirent ile araştırılması amaçlamaktadır. Bu çalışmada 48 genç (8 haftalık) erkek Wistar sıçan eşit olarak dört gruba ayrıldı. 8 hafta boyunca günde bir kez olmak üzere Grup 1’e (sham grubu) normal su, Grup II'ye 400 IU/gün D vit, Grup III'e 1000IU/gün D vit gavajla verildi. Grup IV’e altı gün boyunca serum fizyolojik (ip) içinde çözülmüş olarak 30 mg/kg ZnSO4 verildi. 8 hafta sonra, D vit gruplarına altı gün boyunca ZnSO4 (30 mg/kg, serum fizyolojik içinde çözülmüş, ip) ve D vit (400 IU/gün ve 1000 IU/gün, ağızdan) birlikte verildi. Bu sürenin sonunda, sıçanlara açık alan testi (AAT) ve yükseltilmiş artı labirent testi (YAL) uygulandı. Açık alan testinde Grup 2 (p<0.013) ve Grup 3’ün (p<0.003) merkezi alana giriş sayısı (MAG) ve Grup 2 (p<0,039) ve Grup 3’ün (p<0,003) merkez alanda geçirilen süreleri (MAGS) Grup 1'den düşüktü. Grup 2 (p<0,000), Grup 3 (p<0,000) ve Grup 4’de (p<0,000) gerinme sayıları (GS) ve Grup 2 (p<0,000), Grup 3 (p<0,000) ve Grup 4 (p<0,004)’ün dışkılama sayıları (DS) Grup 1’den anlamlı olarak düşüktü. YAL'de Grup 2’nin kapalı alanda geçirilen süresi (KAGS) tüm gruplar arasında en yüksekti. KAGS değeri Grup 2'de Grup 1'e (p<0.01) ve Grup 4'e (p<0.01) göre istatistiksel olarak daha yüksek, açık alanda geçirilen süre (AAGS) değeri Grup 2'de Grup 1'e göre istatistiksel olarak daha düşüktü (p<0.04). Grup 1’in açık kola giriş sayısı (AKG), en yüksek bulundu. Grup 2 (p<0.01) ve Grup 3’ün (p<0.03) AKG değerleri Grup 1'den istatistiksel olarak daha düşüktü. AAT ve YAL sonuçlarımıza göre farklı dozlardaki D vit ile birlikte çinko verilen ratlarda anksiyojenik etkiler görüldü; ancak çinko tek başına uygulandığında anksiyeteyi etkilemedi.Farklı çinko dozlarının kaygı üzerindeki etkisini araştırmak için daha fazla çalışmaya ihtiyacımız bulunmaktadır. Vitamin D is a lipophilic vitamin. During the coronavirus pandemic, many people started taking Vitamin D (vit D) and zinc supplements to increase their immunity against the virus. However, there is no study investigating the effects of vitamin D and zinc on anxiety and exploratory behaviors. In this study, it is aimed to investigate the effect of different doses of vitamin D and zinc supplementation on anxiety and exploratory behavior in rats by open field test and elevated plus maze. In this study, 48 young (8 weeks old) male Wistar rats were equally divided into four groups. Normal water was given to Group 1 (sham group), 400 IU/day D vit to Group II, 1000 IU/day D vit to Group III, once a day for 8 weeks by gavage. 30 mg/kg ZnSO4 dissolved in physiological saline (ip) was administered to group IV for six days. After 8 weeks, vit D groups were given concomitant ZnSO4 (30 mg/kg, dissolved in saline, ip) and vit D (400 IU/day and 1000 IU/day, orally) for six days. At the end of this period, the rats underwent open field test (OFT) and elevated plus maze test (EPM). In the open field test, the number of entrances to the central area (NEC) of Group 2 (p<0.013) and Group 3 (p<0.003) and the time spent in the central area (STC) of Group 2 (p<0.039) and Group 3 (p<0.003) was lower than Group 1. The number of rearing (NR) values for Group 2 (p<0.000), Group 3 (p<0.000) and the number of defecation (ND) values of Group 2 (p<0.000), Group 3 (p<0.000) and Group 4 (p<0.004) were significantly lower than Group1. At EPM, Group 2 had the highest spent time in the closed area (STCA) value among all the groups. STCA value was statistically higher at Group 2 than Group 1 (p<0.01) and Group 4 (p<0.01), while spent time in the open area (STOA) value was statistically lower at Group 2 than Group 1 (p<0.04). Group 1 had the highest enter the open arm (EOA). EOA values for Group 2 (p<0.01) and Group 3 (p<0.03) were statistically lower than Group 1. According to our OFT and EPM results, anxiogenic effects were observed in rats given different doses of vitamin D and zinc; however, zinc did not affect anxiety when administered alone. We need more studies to investigate the effect of different doses of zinc on anxiety.Item Evaluation of electrodermal activity in diabetic rats treated with vildagliptin and metformin(Başkent Üniversitesi Sağlık Bİlimleri Enstitüsü, 2022) Muftah Shawesh, Muftah Mohamed; Yiğit, Ayşe ArzuElectrodermal activity (EDA) is the measurement of the electrical conductivity of skin, which indicates the activation of sympathetically innervated eccrine sweat glands. Thus, sympathetic system activity that innervates eccrine sweat glands. In our study, it was aimed to evaluate electrodermal activity and thus changes in sympathetic activity in diabetic rats treated with vildagliptin, metformin and metformin+vildagliptin combination. 50 male rats were used in this study. Rats were divided into control (n=10) and experimental groups (n=40). Forty animals in experimental group were injected with 45 mg/kg streptozotocin as a single dose intraperitoneally. After 3 days, animals whose blood glucose level exceeded 250 mg/dl were considered as diabetic. Rats were divided into 4 groups as diabetes, vildagliptin, metformin and metformin+vildagliptin. Vildagliptin (50 mg/kg), metformin (500 mg/kg) and 500 mg/kg metformin+50 mg/kg vildagliptin were administered by gavage for 15 days. After that blood glucose were be measured again end of the 15 days and seeing that diabetes continues, tonic activity was recorded before sound stimulus, and phasic skin conductivity level (SCR) was recorded in response to the auditory stimulus by using Biopac MP35 device. Differences between groups were determined by one-way Anova test. Tukey test was used to determine the significance between the groups. P<0.05 was considered significant. Both tonic SCL and phasic SCR were higher (p<0.001) in diabetic groups than the control group. These findings might explain the increase in the sympathetic activity in diabetic groups. In additiona, the blood glucose levels of the metformin and vildagliptin groups were lower than the diabetic group. Intrestingly, the metformin+vildagliptin group had a lower tonic SCL than the other experimental groups, whereas the metformin group had a less phasic SCR than the diabetes group (p <0.0001). Peak number of vildagliptin and metformin+vildagliptin groups decreased in tonic recording compared to diabetic group (p<0.0001, p<0.01 respectively). Our study, the fact that diabetic drugs caused a decrease in SCL indicates that these drugs may reduce eccrine sweat gland and sympathetic activity affecting these sweat glands. Further studies are needed on whether a decrease in sympathetic activity will have a positive effect on diabetes. Elektrodermal aktivite (EDA), sempatik sinir sistemi ile innerve olan ekrin ter bezlerinin aktivitesini yansıtan derinin elektriksel iletkenliğinin ölçümüdür. Çalışmamızda, metformin, vildagliptin ve metformin+vildagliptin kombinasyonu uygulanan diyabetik sıçanlarda elektrodermal aktivitenin, dolayısıyla sempatik aktivitedeki değişikliklerin değerlendirilmesi amaçlandı. Çalışmada 50 adet erkek Wistar sıçan kullanıldı. Sıçanlar 10’u kontrol, 40’ı deney grubu olacak şekilde ayrıldı. Deney grubundaki 40 hayvanda 45 mg/kg ip streptozotosin (STZ) uygulamasından sonra kan glikoz düzeyi 250 mg/dl’ yi geçen hayvanlar diyabetli olarak kabul edildi. Sıçanlara 15 gün boyunca gavaj ile çeşme suyu, 500 mg/kg metformin, 50 mg/kg vildagliptin, ve 500 mg/kg metformin+50 mg/kg vildagliptin verilerek diyabetik kontrol (n=10) ve deney grupları (3 grup, n=10) oluşturuldu. 15 gün sonunda kan glikozluri tekrar ölçüldükten ve diyabetin devam ettiği görüldükten sonra Biopac MP35 cihazı kullanılarak, ses uyarısı verilmeden önce dinlenim durumundaki tonik, işitsel uyarıdan sonra gelişen cevap fazik deri iletkenlik seviyesi (DİS) olarak kaydedildi. Gruplar arasındaki farklılıklar one-way Anova testi ve Posthoc Tukey testi ile belirlendi. P<0.05 anlamlı olarak kabul edildi. Hem tonik hem de fazik DİS diyabetli gruplarda arttı (p<0.001) ki bu diyabetli gruplarda sempatik aktivitenin arttığını gösterebilir. Metformin ve vildagliptin verilen gruplarda kan şekeri diyabetli gruba göre daha düşüktü. Tonik DİS, metformin+vildagliptin grubunda diğer deney gruplarına göre, fazik DİS ise metformin grubunda diyabetik gruba göre azaldı (p<0.0001). Vildagliptin ile metformin+vildagliptin gruplarının pik sayısı da tonik kayıtta diyabetik gruba göre azaldı (sırasıyla p<0.0001 ve p<0.05). Çalışmamızda, metforminin, ve metformin vildagliptin kombinasyonlarının fazik DİS de azalma oluşturması, bu ilaçların ekrin ter bezi ve bu ter bezlerine etkiyen sempatik aktiviteyi azalttığını gösterebilir. Sempatik aktivitede azalmanın diyabette olumlu etki oluşturup oluşturmayacağı ile ilgili daha ileri çalışmalara ihtiyaç bulunmaktadırItem Effectiveness Of Negative-Pressure Wound Therapy Compared To Wet-Dry Dressing In Pressure Injuries(2022) Sahin, Ezgi; Rizalar, Selda; Ozker, Emre; 35022147This study aims to compare the effects of Negative-Pressure Wound Therapy (NPWT) and wet-to-dry dressing on Stages 3 and 4 pressure injuries (PI), This study is a randomized controlled trial. A total of 30 patients with Stages 3 and 4 pressure injuries were included in the study. The patients were divided into two groups: NPWT group and the wet-to-dry dressing group. All patients received 3 rounds of treatment. Data were collected with a Patient Identification Form, Pressure Ulcer Scale for Healing (PUSH) Tool and the findings of the Three-Dimensional Wound Measurement (3DWM) device. We found that granulation tissue formation was more significant in the experimental group (p < .05), and that there was more significant wound shrinkage (p < .05) with a more significant decrease in the PUSH Tool scores (p < .05). The wounds were assessed with the tool and the 3DWM system. Device measurements were found to be correlated with PUSH Tool findings (p < .05). There was a significant correlation between device-measured granulation findings and PUSH Tool score results of the experimental group's third measurements (p < .05). We conclude that NPWT is an effective treatment method for pressure injuries, and 3DWM device is a useable wound assessment tool.Item Validity and Reliability Testing Study of the Turkish Version of the Misophonia Scale(2022) Sakarya, Merve Deniz; Cakmak, EdaMisophonia is a disorder where individuals experience decreased tolerance to certain sounds that trigger intense emotional or physiological responses in them. People with misophonia can feel disgust, anger, anxiety, and they may experience anger outbursts when exposed to certain sounds that are insignificant to other people, such as chewing, lip-smacking, and breathing. There is no consensus on the prevalence, assessment, and management of misophonia. A major barrier to the research on misophonia is the lack of robust psychometric assessment tools. This study aims to meet the need for a measurement tool for clinical and population-based evaluations intended for misophonia by adapting the Misophonia Questionnaire (Wu et al., 2014) to Turkish. The research was carried out on 638 undergraduate students at Baskent University, from 18 to 26 years of age. Exploratory factor analysis was conducted on 420 participants (73% female, 27% male) and confirmatory factor analysis was conducted on 218 participants (62% female, 38% male). The statistical reliability was evaluated using the internal consistency coefficient, split half, and test-retest methods. In the Misophonia Questionnaire, misophonia was explained by the following three subscale factors: misophonia symptoms, misophonia emotions and behaviors-avoidance and internalization, and misophonia emotions and behaviors-aggression and externalization. These were used in the exploratory factor analysis. The confirmatory factor analysis found that the fit indexes were within acceptable limits. With the discriminant validity, the participants with clinical misophonia were observed to have a higher mean in all factors than those without. The internal consistency coefficient of the scale was calculated at .89, and for the three subscale factors mentioned earlier were .79, .85, and .83, respectively. The calculated test-retest reliability coefficient was .78, which applied to 75 participants. The split-half reliability coefficient was .83 (for each subscale factor, was .86, .87, and .81, respectively). With this study, the Misophonia Questionnaire, which can be used to evaluate misophonia in the general population, was adapted into Turkish. From the psychometric analysis, data supporting the validity and reliability of the Misophonia Scale were obtained.Item Compliance with Long-Term Use of Orthoses Following Spinal Cord Injury(2022) Yemisci, Oya U.; Ozen, Selin; Cosar, Sacide N. Saracgil; Afsar, Sevgi, I; 35532629Background: Prescription of orthoses and assistive devices that facilitate physical function is a major component of the rehabilitation process in spinal cord injury (SCI). Objective: To evaluate the long-term use of orthoses prescribed during inpatient rehabilitation in people with SCI and investigate the factors related to discarding the device. Materials and Methods: Medical records of 202 SCI patients who were included in an inpatient rehabilitation program of a tertiary research hospital were reviewed retrospectively. Patients' demographic data, neurological level of spinal cord injury functional state and use of assistive devices for ambulation (orthoses, walkers, etc.) at discharge were recorded. At follow-up, study participants were contacted by telephone and queried regarding the frequency and duration of use of orthoses; if the individual had discontinued using the orthoses, the reasons for discarding the device were sought. Results: The majority of the study participants (62.7%) had been prescribed a knee-ankle-foot orthosis during their inpatient stay. At follow-up, the regular use of orthoses was ongoing in 67.6% of the participants, and nonuse was determined in 32.4%. The most common cited reasons for discarding the device were difficulty in donning and doffing, functional improvement, and mechanical problems of the orthoses. Conclusions: A significant number of patients had discarded their orthoses at the long-term follow-up and the main reasons for discarding the devices were orthotic factors. Timely reevaluation of the patient and orthosis modification according to patients' needs is necessary to achieve long-term compliance.Item Musculoskeletal Manifestations And Postcovid Syndrome In Hospitalized Patients Infected With Covid-19(2022) Kuculmez, O.; Genctoy, G.Item Effects of Non-Pharmaceutical Interventions Against COVID-19: A Cross-Country Analysis(2021) Gokmen, Yunus; Baskici, Cigdem; Ercil, Yavuz; 0000-0003-0712-1481; 33819370Prolonging non-pharmaceutical interventions (NPIs) used in the control of pandemics can cause a devastating effect on the overall economic and social welfare levels. Therefore, policymakers are facing a difficult duty in terms of implementing economically and socially sustainable and acceptable measures. The aim of this study is to investigate the effectiveness of NPIs implemented to control the COVID-19 pandemic. To this end, eight NPI measures were analysed, and their effects on the number of cases were investigated for France, Spain, China, and South Korea. In the study, the treatment effect of these mechanisms on the daily increase rate of the total number of cases during a certain period was analysed by using logarithmic linear regression with a dummy variables model. The findings indicate that the measures are effective against the spread of the pandemic at different levels. The findings also suggest that the most effective measure in decreasing the number of cases is workplace closure. An analysis comparing the effectiveness of countrywide measures and regional measures shows that school closing is the most effective measure to decrease the number of cases when implemented countrywide as opposed to regional implementation.Item Disease Characteristics of Psoriatic Arthritis Patients May Differ According to Age at Psoriasis Onset: Cross-Sectional Data from the Psoriatic Arthritis-International Database(2021) Bilgin, E.; Aydin, S. Z.; Tinazzi, I.; Bayindir, O.; Kimyon, G.; Ozisler, C.; Dogru, A.; Dalkilic, E.; Aksu, K.; Cetin, G. Yildirim; Yilmaz, S.; Solmaz, D.; Omma, A.; Can, M.; Kucuksahin, O.; Yavuz, S.; Ersozlu, E.D.; Kilic, L.; Tarhan, E.F.; Tufan, M.A.; Akyol, L.; Cinar, M.; Erden, A.; Gonullu, E.; Yildiz, F.; Bakirci, S.; Erbasan, F.; Esmen, S.Ergulu; Kucuk, A.; Tufan, A.; Balkarali, A.; Mercan, R.; Erten, S.; Akar, S.; Kasifoglu, T.; Duruoz, T.; Yazisiz, V.; Kalyoncu, U.; 32662407Objective To explore the impact of early versus late-onset psoriasis (PsO) on the disease characteristics of psoriatic arthritis (PsA) in a large-multicentre cohort. Methods The data from a multicentre psoriatic arthritis database was analysed. Patients were grouped according to age at psoriasis onset (early onset; 40 years of age, late-onset; 40 years of age) and disease characteristics of the groups were compared by adjusting for BMI and PsA duration, where necessary. Results At the time of analyses, 1634 patients were recruited [62.8% females; early onset 1108 (67.8%); late-onset, 526 (32.2%)]. The late-onset group was more over-weight [66.8% vs. 86.8%, p<0.001; adjusted for age -aOR 1.55 (1.11-2.20; 95% CI)]. The early onset group had more scalp psoriasis at onset (56.7% vs. 43.0%, p<0.001), whereas extremity lesions were more common in the late-onset group (63.8% vs. 74.2%, p<0.001). Axial disease in males and psoriatic disease family history in females were significantly higher in the early onset group [38.0% vs. 25.4%; p=0.005; adjusted for PsA duration -aOR 1.76 (1.19-2.62; 95% CI) / 39.5% vs. 30.1%; p=0.003; OR 1.51 (1.15-1.99; 95% CI), respectively]. Psoriatic disease activity parameters, patient-physician reported outcomes and HAQ-DI scores were similar in both groups. Conclusion Clinical features of PsA may be affected by the age at onset of PsO. Different genetic backgrounds in early and late-onset PsO may be driving the differences in psoriasis and PsA phenotypes.