Sağlık Bilimleri Enstitüsü / Health Science Institute

Permanent URI for this collectionhttps://hdl.handle.net/11727/1393

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Celebrating the 25th anniversary of the International Conference on Population and Development: A perspective from Turkey
(2019) Akin, Ayse; Ali, Moazzam; 31709532
Compliance with Long-Term Use of Orthoses Following Spinal Cord Injury
(2022) Yemisci, Oya U.; Ozen, Selin; Cosar, Sacide N. Saracgil; Afsar, Sevgi, I; 35532629
Background: Prescription of orthoses and assistive devices that facilitate physical function is a major component of the rehabilitation process in spinal cord injury (SCI). Objective: To evaluate the long-term use of orthoses prescribed during inpatient rehabilitation in people with SCI and investigate the factors related to discarding the device. Materials and Methods: Medical records of 202 SCI patients who were included in an inpatient rehabilitation program of a tertiary research hospital were reviewed retrospectively. Patients' demographic data, neurological level of spinal cord injury functional state and use of assistive devices for ambulation (orthoses, walkers, etc.) at discharge were recorded. At follow-up, study participants were contacted by telephone and queried regarding the frequency and duration of use of orthoses; if the individual had discontinued using the orthoses, the reasons for discarding the device were sought. Results: The majority of the study participants (62.7%) had been prescribed a knee-ankle-foot orthosis during their inpatient stay. At follow-up, the regular use of orthoses was ongoing in 67.6% of the participants, and nonuse was determined in 32.4%. The most common cited reasons for discarding the device were difficulty in donning and doffing, functional improvement, and mechanical problems of the orthoses. Conclusions: A significant number of patients had discarded their orthoses at the long-term follow-up and the main reasons for discarding the devices were orthotic factors. Timely reevaluation of the patient and orthosis modification according to patients' needs is necessary to achieve long-term compliance.
The correlation between serum vitamin d and oocyte quality, potential of fertilization and embryo development in the assisted reproductive technology (art) cases
(Başkent Üniversitesi Sağlık Bilimleri Enstitüsü, 2022) Ben Zair, Asma Bashir; Dolu, Nazan
There is increasing interest in vitamin D research as a result of the increased incidence of vitamin D insufficiency. Vitamin D deficiency has been associated with a number of acute and chronic disorders. There is increasing evidence that 25-hydroxy[25(OH)] vitamin D has important effects on a variety of systems, including the human reproductive system. Vitamin D can help regulate the menstrual cycle, endometrial proliferation, follicular development, relief of early dysmenorrhea, and decrease vaginal fibroid. Studies show that women with high levels of vitamin D in their blood are more likely to conceive. The aim of this study is to show whether there is a relationship between 25 (OH) vitamin D blood levels and oocyte quality, in vitro division success and embryo quality in IVF patients. Individuals who underwent IVF treatment at a health center in Misurata, Libya between January 2018 and December 2020 were retrospectively analyzed. Luteinizing Hormone (LH) levels of the patients were recorded before and after the treatment. All patients in the study were administered vitamin D at a dose of 1,500 to 2,000 IU (3 sprays per day) for two months after treatment was started. A statistically significant difference was found in LH levels before and after treatment. However, no significant difference was observed between vitamin D supplementation and oocyte quality, in vitro division success and embryo quality. In this study, it was shown that vitamin D supplementation did not affect women in infertile marriages. Additional studies are needed to see in more detail whether vitamin D supplementation will help in vitro fertilization success.D vitamini yetersizliği insidansının artmasının bir sonucu olarak D vitamini araştırmalarına daha fazla ilgi duyulmaktadır. D vitamini yetersizliği, bir dizi akut ve kronik bozuklukla ilişkilendirilmiştir. 25-hidroksi [25(OH)] D vitamininin insan üreme sistemi de dahil olmak üzere çeşitli sistemlere önemli etkileri olduğuna dair kanıtlar artmaktadır. D vitamini, adet döngüsün düzenlenmesi, endometriyal proliferasyon, foliküler gelişim, erken dismenorenin rahatlaması ve vajinal fibroidin azalmasına yardımcı olabilir. Çalışmalar, kanında D vitamini düzeyi yüksek olan kadınların gebe kalma olasılığının daha yüksek olduğunu göstermektedir. Bu çalışmanın amacı, tüp bebek hastalarında 25 (OH) D vitamini kan seviyeleri ile oosit kalitesi, in vitro bölünme başarısı ve embriyo kalitesi arasında bir ilişki olup olmadığını göstermektir. Ocak 2018 ile Aralık 2020 tarihleri arasında Libya, Misurata'daki bir sağlık merkezinde tüp bebek tedavisi gören bireyler geriye dönük olarak incelendi. Hastaların tedavi öncesi ve sonrası Luteinizan Hormon (LH) seviyeleri kaydedildi. Çalışmaya katılan tüm hastalara tedaviye başlandıktan sonra, iki ay boyunca günde 1.500 ile 2.000 IU (günde 3 sprey) dozunda D vitamini uygulandı. Tedaviden önce ve sonra LH seviyelerinde istatistiksel olarak anlamlı farklılık bulundu. Ancak D vitamini takviyesi ile oosit kalitesi, in vitro bölünme başarısı ve embriyo kalitesi arasında anlamlı farklılık gözlenmedi. Bu çalışmada, D vitamini takviyesinin kısır evliliklerdeki kadınlar üzerindeki etkisinin olmadığı gösterilmiştir. D vitamini takviyesinin invitro fertilizasyon başarısına yardımcı olup olmayacağını daha ayrıntılı görmek için ek çalışmalara ihtiyaç bulunmaktadır.
Developing an Educational Material Based on The Needs and Health Literacy of Patients Receiving Radiotherapy and Their Relatives
(2014) Ozdogan, P. Seref; Kav, S.; https://orcid.org/0000-0003-0361-7498; V-9745-2019
Disease Characteristics of Psoriatic Arthritis Patients May Differ According to Age at Psoriasis Onset: Cross-Sectional Data from the Psoriatic Arthritis-International Database
(2021) Bilgin, E.; Aydin, S. Z.; Tinazzi, I.; Bayindir, O.; Kimyon, G.; Ozisler, C.; Dogru, A.; Dalkilic, E.; Aksu, K.; Cetin, G. Yildirim; Yilmaz, S.; Solmaz, D.; Omma, A.; Can, M.; Kucuksahin, O.; Yavuz, S.; Ersozlu, E.D.; Kilic, L.; Tarhan, E.F.; Tufan, M.A.; Akyol, L.; Cinar, M.; Erden, A.; Gonullu, E.; Yildiz, F.; Bakirci, S.; Erbasan, F.; Esmen, S.Ergulu; Kucuk, A.; Tufan, A.; Balkarali, A.; Mercan, R.; Erten, S.; Akar, S.; Kasifoglu, T.; Duruoz, T.; Yazisiz, V.; Kalyoncu, U.; 32662407
Objective To explore the impact of early versus late-onset psoriasis (PsO) on the disease characteristics of psoriatic arthritis (PsA) in a large-multicentre cohort. Methods The data from a multicentre psoriatic arthritis database was analysed. Patients were grouped according to age at psoriasis onset (early onset; 40 years of age, late-onset; 40 years of age) and disease characteristics of the groups were compared by adjusting for BMI and PsA duration, where necessary. Results At the time of analyses, 1634 patients were recruited [62.8% females; early onset 1108 (67.8%); late-onset, 526 (32.2%)]. The late-onset group was more over-weight [66.8% vs. 86.8%, p<0.001; adjusted for age -aOR 1.55 (1.11-2.20; 95% CI)]. The early onset group had more scalp psoriasis at onset (56.7% vs. 43.0%, p<0.001), whereas extremity lesions were more common in the late-onset group (63.8% vs. 74.2%, p<0.001). Axial disease in males and psoriatic disease family history in females were significantly higher in the early onset group [38.0% vs. 25.4%; p=0.005; adjusted for PsA duration -aOR 1.76 (1.19-2.62; 95% CI) / 39.5% vs. 30.1%; p=0.003; OR 1.51 (1.15-1.99; 95% CI), respectively]. Psoriatic disease activity parameters, patient-physician reported outcomes and HAQ-DI scores were similar in both groups. Conclusion Clinical features of PsA may be affected by the age at onset of PsO. Different genetic backgrounds in early and late-onset PsO may be driving the differences in psoriasis and PsA phenotypes.
The effect of a high dose of vitamin D on spatial learning and memory in rats
(Başkent Üniversitesi Sağlık Bilimleri Enstitüsü, 2021) Elshahoubi, Taha; Dolu, Nazan
“Vitamin D” is a prohormone steroid and has a place with the fat-soluble vitamins. It’s liable for endocrine, paracrine and autocrine functions. Vitamin D is likewise basic for calcium absorption, bone mineralization, calcium and phosphorus homeostasis, nerve conduction, hormonal release, and neuromuscular function, acts as a natural antioxidant. Its impact on learning has not been widely reported. In the literature, there are several of discrepancies among age groups when it comes to this condition. This study aimed to see how vitamin D supplementation affected the cognitive performance of young male rats in the Morris water maze. Serving this purpose, 36 young male Wistar rats aged 8 weeks old age was divided into three groups with the control group (oral gavage normal saline), low dose vitamin D group (400 IU/ day) and high dose vit D group (1000 IU/ day. Rats were tested for their capacity to memorize the location of a platform after 8 weeks of daily supplementation in two phases: acquisition (next 3 days, fixed platform location), and retention (next 3 days, variable platform location) (forth day, removed platform). There were four trials per day (interval between trials 20-25 minutes). In spatial learning and working memory, the time spent finding the platform and duration of time spent in the quarter area of the maze including the platform were compared statistically in a number indicating the percentage of total time. There were no significant inter-group differences (p>0,05). From the first to the third day of training, all groups of animals improved their learning performance while decreasing the time spent searching for the platform (p<0,05). In this study, it was shown that 8 weeks of 400 and 1000 IU/day vit D application did not have any effect on learning to locate, but it did not cause impairment in the learning process either.
The effect of elastic therapeutic taping and rigid taping on pain, functionality, and tissue temperature in lumbar radiculopathy: a randomized controlled study
(2021) Bozkurt, Tugce; Kilic, Rabia Tugba; Yosmaoglu, Hayri Baran; 34635000
Purpose To compare the therapeutic effects of different taping materials and techniques on pain, functionality, and tissue temperature in patients with lumbar radiculopathy. Methods: Patients with lumbar radiculopathy were included in the study (n = 51). Patients were randomly divided into three groups, which were the elastic taping (n = 17), rigid taping (n = 17), and placebo taping groups (n = 17). All patients were enrolled in a physiotherapy and rehabilitation program that included thermotherapy, electrotherapy, and exercise five times a week for 2 weeks. The pain was measured before and after treatment using the Visual Analogue Scale. Functionality and quality of life were measured using the Oswestry Low Back Pain Disability Questionnaire and Roland-Morris Disability Questionnaire. The tissue temperature of the treated area in the lumbar region was measured by digital electronic infra-red thermography. Results: After the treatment, pain, functionality, and quality of life were improved in all groups (p < 0.05). Elastic taping was more effective in decreasing pain and increasing functionality than placebo taping (p < 0.05), but no difference was observed between placebo taping and rigid tapping. Local tissue temperature did not change before and after treatment in the elastic taping group (p > 0.05). Tissue temperature increased in the rigid and placebo taping groups (p < 0.05). Conclusion: Taping therapy in patients with lumbar radiculopathy has a positive effect on pain and functional status. Elastic taping can be recommended for clinical use because its effect is superior in some recovery parameters and its ease of use.
Effect of vildagliptin and metformin on anxiety in streptozotocininduced diabetic rats
(Başkent Üniversitesi Sağlık Bilimleri Enstitüsü, 2022) Alshareef, Mohammed; Yiğit, Ayşe Arzu
Diabetes mellitus is caused by insulin secretion deficiency or a disorder in its action. Vildagliptin and metformin are two of the most recognized drugs that are used in the treatment of type 2 diabetes mellitus. The study aimed to compare the effects of metformin, vildagliptin, and their combined effect in altering behaviours of streptozocin-induced diabetic rats. For this purpose, after 10 of 50 male Wistar rats were separated as the control group (C), diabetes was induced in the others with streptozotocin. After separation of 10 diabetic control group (D), other diabetic animals were divided into 3 and treated with 500 mg/kg metformin (DM), 50 mg/kg vildagliptin (DV) and a combination of both (DMV) for 15 days. The animals were then subjected to open field and elevated plus maze testing. In the open field test, while the number of rearing increased in the group with diabetes (p<0.001), it was significantly decreased in the metformin, vildagliptin and combined treatment group compared to the diabetic control group (p<0.001, p<0.01, and p<0.001, respectively). While the time spent in the center decreased in the D and DM groups compared to the C group (p<0.05), the time spent in the combined treatment group in the center was longer than in all other diabetes groups (p<0.01). The time spent in the periphery was also decreased in the DMV group compared to the other groups with diabetes (p<0.05). The number of urinations increased in the D, DM and DV groups compared to the control group, and decreased in the DMV group compared to the diabetic groups. While the number of defections increased in the D group compared with the C group (p<0.01), it was decreased in the DMV group compared to the D group (p<0.05).In the elevated plus maze test, while the time spent in enclosed arms increased in the group with diabetes compared with the C group (p<0.05), there was no difference in the treatment groups compared to the D group. As a result, our study showed that the effects of vildagliptin and metformin on anxiety in diabetic animals were not evident when they were used alone; also, it showed that combined treatments can be effective in reducing anxiety caused by diabetes. Diabetes mellitus, insülin sekresyon eksikliğinden veya etkisindeki bir bozukluktan kaynaklanan metabolik bir hastalıktır. Metformin ve vildagliptin, tip 2 diabetes mellitus tedavisinde kullanılan en bilinen ilaçlardan ikisidir. Çalışmanın amacı, streptozosin ile diyabet oluşturulmuş sıçanlarda metformin, vildagliptin ve bunların kombine kullanımının anksiyete üzerine etkilerini ortaya koymaktır. Bu amaçla, 50 erkek Wistar sıçanın 10’u kontrol grubu (K) olarak ayrıldıktan sonra diğerlerinde streptozotosin ile diyabet oluşturuldu. Diyabetli hayvanların da 10’u diabetic kontrol grubu (D) olarak ayrıldıktan sonra kalanları 3’e ayrılarak 500 mg/kg metformin (DM), 50 mg/kg vildagliptin (DV) ve her ikisinin kombinasyonu (DMV) ile 15 gün boyunca tedavi edildi. Sonrasında hayvanlar açık alan ve yükseltilmiş artı labirent testine tabi tutuldu. Açık alan testinde, diyabetli grupta artan ayağa kalkma sayısı (p<0.001), metformin, vildagliptin ve kombine tedavi uygulanan grupta diyabetik kotrol grubuna göre anlamlı oranda azaldı (sırasıyla p<0.001, p<0.01 ve p<0.001). Merkezde zaman geçirme süresi D ve DM grubunda K grubuna gore azalırken (p<0.05), kombine tedavi grubunun merkezde geçirdiği süre diğer bütün diyabetli gruplara gore daha çok oldu (p<0.01). Periferde geçirilen süre de DMV grubunda diyabetli diğer gruplara göre azaldı (p<0.05). Diyabet, DM ve DV gruplarında kontrol grubuna göre artan idrar yapma sayısı, DMV grubunda diyabetli gruplara göre azaldı. Defekasyon sayısı ise D grubunda K grubuna göre artarken (p<0.01), DMV grubunda D grubuna gore azalma görüldü (p<0.05).Yükseltilmiş artı labirent testinde de kapalı alanda geçirilen süre diyabetli grupta K grubuna gore artarken (p<0.05), tedavi gruplarında D grubuna gore bir farklılık görülmedi. Sonuç olarak araştırmamız, vildagliptin ve metforminin tek başlarına kullanımlarında diyabetik hayvanlarda oluşan kaygıya karşı etkileri belirgin değilken; kombine kullanıldığı tedavilerin diyabetin oluşturduğu kaygıyı azaltmada etkili olabileceğini gösterdi.
Effectiveness Of Negative-Pressure Wound Therapy Compared To Wet-Dry Dressing In Pressure Injuries
(2022) Sahin, Ezgi; Rizalar, Selda; Ozker, Emre; 35022147
This study aims to compare the effects of Negative-Pressure Wound Therapy (NPWT) and wet-to-dry dressing on Stages 3 and 4 pressure injuries (PI), This study is a randomized controlled trial. A total of 30 patients with Stages 3 and 4 pressure injuries were included in the study. The patients were divided into two groups: NPWT group and the wet-to-dry dressing group. All patients received 3 rounds of treatment. Data were collected with a Patient Identification Form, Pressure Ulcer Scale for Healing (PUSH) Tool and the findings of the Three-Dimensional Wound Measurement (3DWM) device. We found that granulation tissue formation was more significant in the experimental group (p < .05), and that there was more significant wound shrinkage (p < .05) with a more significant decrease in the PUSH Tool scores (p < .05). The wounds were assessed with the tool and the 3DWM system. Device measurements were found to be correlated with PUSH Tool findings (p < .05). There was a significant correlation between device-measured granulation findings and PUSH Tool score results of the experimental group's third measurements (p < .05). We conclude that NPWT is an effective treatment method for pressure injuries, and 3DWM device is a useable wound assessment tool.
The Effects of Clinical Pilates Exercises on Patients with Shoulder Pain: A Randomised Clinical Trial
(2017) Atilgan, Esra; Aytar, Aydan; Caglar, Aslican; Tigli, Ayca Aytar; Arin, Gamze; Yapali, Gokmen; Kisacik, Pinar; Berberoglu, Utku; Sener, Hulya Ozlem; Unal, Edibe; 29037638; HIR-3735-2022
Aim: The purpose of this study was to determine the effect of Clinical Pilates exercises on patients with shoulder pain. Material and methods: Thirty-three patients, experiencing shoulder pain continuously for at least four weeks were selected as study subjects. The patients were randomly divided into two groups, namely Clinical Pilates exercise (n = 17) group and conventional exercise (n = 16) group. The patients were treated for five days a week, the total treatment being carried out for 10 days. The assessment of pain and disability amongst the patients were done at the baseline and at the end of the treatment sessions, using Visual Analogue Scale (VAS) and Shoulder Pain and Disability Index (SPADI). Results: The clinical Pilates exercise group showed a significant improvement in all scores used for assessment (p < 0.05), while the conventional exercise group demonstrated a significant improvement only in the SPADI total score (p < 0.05). A comparison of scores for the VAS, SPADI-Pain and SPADI-Total between the two groups, revealed a significant improvement in the Clinical Pilates exercise group (p < 0.05). Conclusion: It was demonstrated by the study that Clinical Pilates exercise is an efficient technique for patients experiencing shoulder pain, as it helps reduce pain and disability among them. (c) 2017 Elsevier Ltd. All rights reserved.
The effects of enteral supplementation of glutamine and arginine in lipopolysaccharide (LPS) induced sepsis
(2019) Bakir, Binnur Okan; Oztezcan, Serdar; Saka, Mendane; Karalti, Iskender; Ozkan, Ferda; Ok, Mehtap Akcil; AAZ-8170-2020
Sepsis is the leading cause for death in critically ill patients. While the exact mechanisms are not clear, multiple organ dysfunction syndrome induced by sepsis might cause mitochondrial dysfunction. Spesific nutrients may help regulating immunological and inflammatory responses. Glutamine and arginine amino acids have both important roles in growth, tissue repair, cell renewal and collagen synthesis. There are different results of studies with immunmodulatory nutrients in critically ill patients such, they have no effect on mortality or decrease sepsis incidance. The aim of this study is to evaluate the effects of enteral supplementation of glutamine, arginine and glutamine and arginine combination in lipopolysaccharide (LPS) induced sepsis. Twenty eight male Sprague Dawley rats were randomly divided into four groups: Glutamine, Arginine, Glutamine + Arginine and Control. Glutamine group received 500 mg/kg/day glutamine, Arginine group recieved 500 mg/kg/day arginine, Glutamine + Arginine group received 250 mg/kg/day glutamine and 250 mg/kg/day arginine containing suspension. Rats were fed for 10 days and 3 mg/kg LPS was implemented. 24 hours later, all rats were sacrified. C-Reactive Protein (CRP), Interleukin (IL)-1 beta, IL-6, Tumor Necrosis Factor-alpha(TNF-alpha), Aspartat aminotransferase (AST) and Alanine aminotransferase(ALT) levels were studied, livers were examined histopathologically. Serum TNF-alpha levels were significantly lower in Glutamine + Arginine group in comparison with Control group. Liver histopathology analysis showed that apsis, hepatocyte damage, kupffer cell proliferation and portal inflammation were more frequent and severe in control group than all groups. These results revealed that enteral supply of glutamine, arginine and their combination have positive effects on liver damage and inflammation.
The effects of high doses vitamin d on anxiety and exploratory activity behaviours in rats
(Başkent Üniversitesi Sağlık Bilimleri Enstitüsü, 2021) Eddn Asmaeil, Zahour Gamal; Dolu, Nazan
Vitamin D is a fat-soluble vitamin produced in the skin in reaction to exposure to sunshine. It is necessary for a variety of processes, including calcium and phosphate homeostasis, as well as neuromuscular and immunological function. Not many studies have been conducted to examine the relationship between anxiety, exploratory behaviour, and different doses of vitamin D. The current study aimed to evaluate the impact of different doses of vitamin D on anxiety-related behaviours in rats using the elevated plus-maze method and on exploratory behaviour and general activity of rats by using the open field test. In this study, 8 weeks old age 36 young male Wistar rats were used. They were divided into 3 groups as sham group and two different doses of vitamin D groups. They were fed with feed containing 300 IU Vit D ad libitum. Sham group (Group 1) took normal water by gavage (n=12). The vitamin D group (Group 2) took 400IU vitamin D, and the last group (Group 3) took 1000IU vitamin D (n=12). The drugs were given once a day for 8 weeks to the groups by gavage. After 8 weeks, the rats were tested in the elevated plus-maze and open field tests. In the open field, spent time in the central area (STC) values of Group 2 (p<0.02) and Group 3 (p<0.05) were found to be much higher than Group 1. While the STC value of Group 3 was the lowest, the STP value was nearly the same in Group 2 and Group 3. The number of rearing was the highest in Group 2. When the elevated plus-maze test evaluated, there were no statistical differences between groups for the spent time in the closed arm (STCA) and spent time in the open arm (STOA), but in Group 2, STCA value was the lowest and STOA value was the highest from other groups. Entry number of closed arms (ECA) value was statistically higher in Group 2 than Group 3 (p=0.05). Our findings showed that 400IU and 1000IU doses of vitamin D exhibited anxiogenic effects, with no significant difference between the two groups. As a result, an increase in vitamin D supplementation causes an increase in anxiety. D vitamini, güneş ışığına maruz kalmaya tepki olarak deride üretilen yağda çözünen bir vitamindir. Kalsiyum ve fosfat homeostazının yanı sıra nöromüsküler ve immünolojik fonksiyon da dahil olmak üzere çeşitli süreçler için gereklidir. Anksiyete, keşif davranışı ve farklı D vitamini dozları arasındaki ilişkiyi incelemek için çok fazla çalışma yapılmamıştır. Mevcut çalışma, yükseltilmiş artı labirentini kullanarak sıçanlarda farklı D vitamini dozlarının anksiyete ile ilgili davranışlar üzerindeki etkisini değerlendirmeyi amaçlamaktadır. yöntemi ve açık alan testi kullanılarak sıçanların keşif davranışları ve genel aktiviteleri üzerine. Bu çalışmada 8 haftalık 36 adet genç erkek Wistar rat kullanıldı. Sham grubu, D vitamini grubu olarak 3 gruba ayrıldılar. Ad libitum 300 IU Vit D içeren yemle beslendiler. Sham grubu (grup 1) sonda ile normal su aldı (n=12). D vitamini grubu (grup 2) 400 IU D vitamini aldı ve son grup (grup 3) 1000 IU D vitamini (n=12) aldı. İlaçlar gruplara 8 hafta boyunca günde bir kez gavaj yoluyla verildi. 8 hafta sonra, sıçanlar yükseltilmiş artı labirent ve açık alan testlerinde test edildi. Açık alanda Grup 2 (p<0.02) ve Grup 3(p<0.05) orta alanda geçirilen süre (STC) değerleri Grup 1'e göre çok daha yüksek bulundu. En düşük STP değeri Grup 2 ve Grup 3'te hemen hemen aynıydı. Yetiştirme sayısı Grup 2'de en yüksekti. Yükseltilmiş artı labirent testi değerlendirildiğinde. Grup 2'de diğer gruplara göre kapalı kolda geçirilen süre (STCA) değeri en düşük, açık kolda geçirilen süre (STOA) değeri en yüksek bulundu. kapalı kol giriş sayısı (ECA) değeri Grup 2'de G3'e göre istatistiksel olarak daha yüksekti (p=0,05). Bulgularımız, 400 IU ve 100 IU D vitamini dozlarının ikisi arasında anlamlı bir fark olmaksızın anksiyojenik etkiler sergilediğini gösterdi. Sonuç olarak D vitamini takviyesinin artması anksiyetede artışa neden olur.
The Effects of Instrument-Assisted Soft Tissue Mobilization and Kinesio Taping on Pain, Functional Disability and Depression in Patients with Chronic Low Back Pain: A Randomized Trial
(2022) Cakmak, Ozge; Atici, Emine; Gulsen, Mustafa
Purpose: Low back pain is a common condition that can become chronic, which reduces the life quality of the patient by causing functional disability and depression. This study aimed to investigate the effects of instrument-assisted soft tissue mobilization (IASTM) and kinesio taping (KT) along with conservative treatment in patients with chronic nonspecific low back pain (CNLBP). Methods: A total of 30 patients with chronic low back pain aged between 30-50 years included in the study were randomized to IASTM (n=15) and KT (n=15) groups. Both the groups underwent conservative treatment that comprised of a hot pack, ultrasound, transcutaneous electrical nerve stimulation (TENS) and home exercises. In this study, assessments were made using the Visual Analogue Scale (VAS), Roland Morris Disability Questionnaire (RMDQ), and Beck Depression Inventory (BDI). The measurements were carried out at the beginning and end of the treatment. Results: As a result of the study, IASTM method improved in parameters such as pain (p<0.05), functionality (p=0.001) and depression (p<0.05). As a result of the study, the KT group improved in parameters such as pain, functionality and depression compared to pre-treatment (p<0.05). However, the two treatments were not superior to each other in pain (p=0.241), functionality (p=0.687) and depression (p=0.699) parameters. Conclusion: It has been observed that both treatments have positive effects on many parameters such as pain, disability, depression and mental state in patients with CNLBP. This study demonstrates that IASTM and KT treatments can be used to support therapeutic effects in patients with CNLBP.
Effects of Non-Pharmaceutical Interventions Against COVID-19: A Cross-Country Analysis
(2021) Gokmen, Yunus; Baskici, Cigdem; Ercil, Yavuz; 0000-0003-0712-1481; 33819370
Prolonging non-pharmaceutical interventions (NPIs) used in the control of pandemics can cause a devastating effect on the overall economic and social welfare levels. Therefore, policymakers are facing a difficult duty in terms of implementing economically and socially sustainable and acceptable measures. The aim of this study is to investigate the effectiveness of NPIs implemented to control the COVID-19 pandemic. To this end, eight NPI measures were analysed, and their effects on the number of cases were investigated for France, Spain, China, and South Korea. In the study, the treatment effect of these mechanisms on the daily increase rate of the total number of cases during a certain period was analysed by using logarithmic linear regression with a dummy variables model. The findings indicate that the measures are effective against the spread of the pandemic at different levels. The findings also suggest that the most effective measure in decreasing the number of cases is workplace closure. An analysis comparing the effectiveness of countrywide measures and regional measures shows that school closing is the most effective measure to decrease the number of cases when implemented countrywide as opposed to regional implementation.
The effects of vitamin d and zinc on anxiety and exploratory behaviors in rats.
(Başkent Üniversitesi Sağlık Bilimleri Enstitüsü, 2022) Baroud, Amna Abdulsalam; Dolu, Nazan
D vitamini lipofilik bir vitamindir Koronavirüs pandemisi sırasında birçok kişi virüse karşı bağışıklıklarını güçlendirmek için D Vitamini (D vit) ve çinko takviyeleri almaya başlamıştır. Ancak, D vit ve çinkonun anksiyete ve keşif davranışları üzerine etkilerini araştıran bir çalışmaya rastlanmamıştır. Bu çalışmada, sıçanlarda değişik dozlardaki D vit ve çinko takviyesinin, anksiyete ve keşif davranışı üzerindeki etkisinin açık alan testi ve yükseltilmiş artı labirent ile araştırılması amaçlamaktadır. Bu çalışmada 48 genç (8 haftalık) erkek Wistar sıçan eşit olarak dört gruba ayrıldı. 8 hafta boyunca günde bir kez olmak üzere Grup 1’e (sham grubu) normal su, Grup II'ye 400 IU/gün D vit, Grup III'e 1000IU/gün D vit gavajla verildi. Grup IV’e altı gün boyunca serum fizyolojik (ip) içinde çözülmüş olarak 30 mg/kg ZnSO4 verildi. 8 hafta sonra, D vit gruplarına altı gün boyunca ZnSO4 (30 mg/kg, serum fizyolojik içinde çözülmüş, ip) ve D vit (400 IU/gün ve 1000 IU/gün, ağızdan) birlikte verildi. Bu sürenin sonunda, sıçanlara açık alan testi (AAT) ve yükseltilmiş artı labirent testi (YAL) uygulandı. Açık alan testinde Grup 2 (p<0.013) ve Grup 3’ün (p<0.003) merkezi alana giriş sayısı (MAG) ve Grup 2 (p<0,039) ve Grup 3’ün (p<0,003) merkez alanda geçirilen süreleri (MAGS) Grup 1'den düşüktü. Grup 2 (p<0,000), Grup 3 (p<0,000) ve Grup 4’de (p<0,000) gerinme sayıları (GS) ve Grup 2 (p<0,000), Grup 3 (p<0,000) ve Grup 4 (p<0,004)’ün dışkılama sayıları (DS) Grup 1’den anlamlı olarak düşüktü. YAL'de Grup 2’nin kapalı alanda geçirilen süresi (KAGS) tüm gruplar arasında en yüksekti. KAGS değeri Grup 2'de Grup 1'e (p<0.01) ve Grup 4'e (p<0.01) göre istatistiksel olarak daha yüksek, açık alanda geçirilen süre (AAGS) değeri Grup 2'de Grup 1'e göre istatistiksel olarak daha düşüktü (p<0.04). Grup 1’in açık kola giriş sayısı (AKG), en yüksek bulundu. Grup 2 (p<0.01) ve Grup 3’ün (p<0.03) AKG değerleri Grup 1'den istatistiksel olarak daha düşüktü. AAT ve YAL sonuçlarımıza göre farklı dozlardaki D vit ile birlikte çinko verilen ratlarda anksiyojenik etkiler görüldü; ancak çinko tek başına uygulandığında anksiyeteyi etkilemedi.Farklı çinko dozlarının kaygı üzerindeki etkisini araştırmak için daha fazla çalışmaya ihtiyacımız bulunmaktadır. Vitamin D is a lipophilic vitamin. During the coronavirus pandemic, many people started taking Vitamin D (vit D) and zinc supplements to increase their immunity against the virus. However, there is no study investigating the effects of vitamin D and zinc on anxiety and exploratory behaviors. In this study, it is aimed to investigate the effect of different doses of vitamin D and zinc supplementation on anxiety and exploratory behavior in rats by open field test and elevated plus maze. In this study, 48 young (8 weeks old) male Wistar rats were equally divided into four groups. Normal water was given to Group 1 (sham group), 400 IU/day D vit to Group II, 1000 IU/day D vit to Group III, once a day for 8 weeks by gavage. 30 mg/kg ZnSO4 dissolved in physiological saline (ip) was administered to group IV for six days. After 8 weeks, vit D groups were given concomitant ZnSO4 (30 mg/kg, dissolved in saline, ip) and vit D (400 IU/day and 1000 IU/day, orally) for six days. At the end of this period, the rats underwent open field test (OFT) and elevated plus maze test (EPM). In the open field test, the number of entrances to the central area (NEC) of Group 2 (p<0.013) and Group 3 (p<0.003) and the time spent in the central area (STC) of Group 2 (p<0.039) and Group 3 (p<0.003) was lower than Group 1. The number of rearing (NR) values for Group 2 (p<0.000), Group 3 (p<0.000) and the number of defecation (ND) values of Group 2 (p<0.000), Group 3 (p<0.000) and Group 4 (p<0.004) were significantly lower than Group1. At EPM, Group 2 had the highest spent time in the closed area (STCA) value among all the groups. STCA value was statistically higher at Group 2 than Group 1 (p<0.01) and Group 4 (p<0.01), while spent time in the open area (STOA) value was statistically lower at Group 2 than Group 1 (p<0.04). Group 1 had the highest enter the open arm (EOA). EOA values for Group 2 (p<0.01) and Group 3 (p<0.03) were statistically lower than Group 1. According to our OFT and EPM results, anxiogenic effects were observed in rats given different doses of vitamin D and zinc; however, zinc did not affect anxiety when administered alone. We need more studies to investigate the effect of different doses of zinc on anxiety.
Evaluation of electrodermal activity in diabetic rats treated with vildagliptin and metformin
(Başkent Üniversitesi Sağlık Bİlimleri Enstitüsü, 2022) Muftah Shawesh, Muftah Mohamed; Yiğit, Ayşe Arzu
Electrodermal activity (EDA) is the measurement of the electrical conductivity of skin, which indicates the activation of sympathetically innervated eccrine sweat glands. Thus, sympathetic system activity that innervates eccrine sweat glands. In our study, it was aimed to evaluate electrodermal activity and thus changes in sympathetic activity in diabetic rats treated with vildagliptin, metformin and metformin+vildagliptin combination. 50 male rats were used in this study. Rats were divided into control (n=10) and experimental groups (n=40). Forty animals in experimental group were injected with 45 mg/kg streptozotocin as a single dose intraperitoneally. After 3 days, animals whose blood glucose level exceeded 250 mg/dl were considered as diabetic. Rats were divided into 4 groups as diabetes, vildagliptin, metformin and metformin+vildagliptin. Vildagliptin (50 mg/kg), metformin (500 mg/kg) and 500 mg/kg metformin+50 mg/kg vildagliptin were administered by gavage for 15 days. After that blood glucose were be measured again end of the 15 days and seeing that diabetes continues, tonic activity was recorded before sound stimulus, and phasic skin conductivity level (SCR) was recorded in response to the auditory stimulus by using Biopac MP35 device. Differences between groups were determined by one-way Anova test. Tukey test was used to determine the significance between the groups. P<0.05 was considered significant. Both tonic SCL and phasic SCR were higher (p<0.001) in diabetic groups than the control group. These findings might explain the increase in the sympathetic activity in diabetic groups. In additiona, the blood glucose levels of the metformin and vildagliptin groups were lower than the diabetic group. Intrestingly, the metformin+vildagliptin group had a lower tonic SCL than the other experimental groups, whereas the metformin group had a less phasic SCR than the diabetes group (p <0.0001). Peak number of vildagliptin and metformin+vildagliptin groups decreased in tonic recording compared to diabetic group (p<0.0001, p<0.01 respectively). Our study, the fact that diabetic drugs caused a decrease in SCL indicates that these drugs may reduce eccrine sweat gland and sympathetic activity affecting these sweat glands. Further studies are needed on whether a decrease in sympathetic activity will have a positive effect on diabetes. Elektrodermal aktivite (EDA), sempatik sinir sistemi ile innerve olan ekrin ter bezlerinin aktivitesini yansıtan derinin elektriksel iletkenliğinin ölçümüdür. Çalışmamızda, metformin, vildagliptin ve metformin+vildagliptin kombinasyonu uygulanan diyabetik sıçanlarda elektrodermal aktivitenin, dolayısıyla sempatik aktivitedeki değişikliklerin değerlendirilmesi amaçlandı. Çalışmada 50 adet erkek Wistar sıçan kullanıldı. Sıçanlar 10’u kontrol, 40’ı deney grubu olacak şekilde ayrıldı. Deney grubundaki 40 hayvanda 45 mg/kg ip streptozotosin (STZ) uygulamasından sonra kan glikoz düzeyi 250 mg/dl’ yi geçen hayvanlar diyabetli olarak kabul edildi. Sıçanlara 15 gün boyunca gavaj ile çeşme suyu, 500 mg/kg metformin, 50 mg/kg vildagliptin, ve 500 mg/kg metformin+50 mg/kg vildagliptin verilerek diyabetik kontrol (n=10) ve deney grupları (3 grup, n=10) oluşturuldu. 15 gün sonunda kan glikozluri tekrar ölçüldükten ve diyabetin devam ettiği görüldükten sonra Biopac MP35 cihazı kullanılarak, ses uyarısı verilmeden önce dinlenim durumundaki tonik, işitsel uyarıdan sonra gelişen cevap fazik deri iletkenlik seviyesi (DİS) olarak kaydedildi. Gruplar arasındaki farklılıklar one-way Anova testi ve Posthoc Tukey testi ile belirlendi. P<0.05 anlamlı olarak kabul edildi. Hem tonik hem de fazik DİS diyabetli gruplarda arttı (p<0.001) ki bu diyabetli gruplarda sempatik aktivitenin arttığını gösterebilir. Metformin ve vildagliptin verilen gruplarda kan şekeri diyabetli gruba göre daha düşüktü. Tonik DİS, metformin+vildagliptin grubunda diğer deney gruplarına göre, fazik DİS ise metformin grubunda diyabetik gruba göre azaldı (p<0.0001). Vildagliptin ile metformin+vildagliptin gruplarının pik sayısı da tonik kayıtta diyabetik gruba göre azaldı (sırasıyla p<0.0001 ve p<0.05). Çalışmamızda, metforminin, ve metformin vildagliptin kombinasyonlarının fazik DİS de azalma oluşturması, bu ilaçların ekrin ter bezi ve bu ter bezlerine etkiyen sempatik aktiviteyi azalttığını gösterebilir. Sempatik aktivitede azalmanın diyabette olumlu etki oluşturup oluşturmayacağı ile ilgili daha ileri çalışmalara ihtiyaç bulunmaktadır
Exposure of Pregnant Women to Violence by Partners and Affecting Factors in Turkey
(2016) Alan, Hacer; Koc, Gulten; Taskin, Lale; Eroglu, Kafiye; Terzioglu, Fusun
This study aims to determine the exposure of women to violence by their partners during pregnancy and the factors affecting this condition. The current study conducted as descriptive included a total of 442 pregnant women who were married and at the last trimester of their pregnancy. The data were collected using a semi-structure questionnaire and face to face interview with the pregnant women and were evaluated using descriptive statistics, chi-square test, and logistic regression analysis. Of the pregnant women, 39.8 % experienced at least one type of violence, and the most common type of violence experienced was verbal violence (31.4 %). Among the participants, 18.2 % exposed to violence expressed that their partners perpetrated violence because of jealousy, and 30.1 % reported that they just cried when exposed to violence. According to the results of the logistic regression analysis, insufficient prenatal care increases all types of violence in pregnancy. Working with pregnant women and their partners together under the scope of prenatal care services, and especially planning the attempts to prevent violence by discussing the causes of violence with couples, will facilitate more successful violence prevention programs.
Extended use up to 5 years of the etonogestrel-releasing subdermal contraceptive implant: comparison to levonorgestrel-releasing subdermal implant
(2016) Ali, Moazzam; Akin, Ayse; Bahamondes, Luis; Brache, Vivian; Habib, Ndema; Landoulsi, Sihem; Hubacher, David; 0000-0003-2379-3325; 27671673; AAK-1688-2021
Is it possible to extend the use of the 3-year one-rod etonogestrel (ENG)-releasing subdermal contraceptive implant to 5 years? The extended use of the one-rod ENG-releasing subdermal contraceptive implant showed 100% efficacy in years 4 and 5. The initial regulated trials on the ENG-releasing subdermal contraceptive implant conducted in the 1990 s were designed to measure cumulative 3-year efficacy. The ENG-implant has both well established safety and efficacy for up to 3 years. Pharmacokinetic data on ENG show high levels at 3 years and some previous clinical research confirms efficacy beyond the current approved duration of 3 years. Today, many women, because the labeled duration has been reached, have the ENG implant removed at 3 years, increasing costs, inconvenience and risks. For the first 3 years, this study was an open-label, multi-centre randomized trial comparing the 3-year ENG implant to the 5-year levonorgestrel (LNG)-releasing implant. After 3 years, a subset of 390 ENG participants, consented to extended use. We compared efficacy, side effects and removal procedures of both implants. We used Kaplan-Meier (K-M) analysis. We included an observational cohort of copper intrauterine device (IUD) users as non-users of hormonal contraceptive method for comparative purposes. The study took place in family planning clinics in seven countries worldwide. Women were enlisted after an eligibility check and informed consent, and 1328 women were enrolled: 390, 522 and 416 in the ENG-implant, LNG-implant and IUD groups, respectively. Over 200 women used the ENG implant for at least 5 years. No pregnancies occurred during the additional 2 years of follow up in the ENG or LNG implant group. The overall 5-year K-M cumulative pregnancy rates for ENG- and LNG- implants were 0.6 per 100 women-years (W-Y) [95% confidence interval (CI): 0.2-1.8] and 0.8 per 100 W-Y [95% CI: 0.2-2.3], respectively. Complaints of bleeding changes were similar; however, ENG-users were more likely than LNG-users to experience heavy bleeding (p < 0.05). The median duration of the implant removal procedure was 64 seconds shorter for the one-rod ENG-implant (inter-quartile range (IQR) = 30.5, 117.5) compared to the two-rod LNG product (IQR = 77.0, 180.0). The 2-year rate for pregnancy in the IUD group compared with the two implant groups combined was 4.1 per 100 W-Y [95% CI: 2.5-6.5]. Few women were a parts per thousand currency sign19 years old or nulligravida. Although there was no weight limit for enrolment in the study, the number of women a parts per thousand yen70 kg were few. The results from this study corroborate previous evidence showing high contraceptive efficacy through 4 years for the ENG-implant. Data through 5 years are a novel contribution and further proof of the product's capability to provide safe and effective contraception that rivals the current 5-year LNG-subdermal implant. The findings provide valuable information for policy makers, family planning programmers and clinicians that the ENG-releasing subdermal implant is still highly effective up to 5 years after insertion. Compared to previous efforts, our study population was geographically diverse and our study had the highest number of participants completing at least 5 years of use. The trial was registered as ISRCTN33378571. The contraceptive devices and funds for conduct of the study were provided by the United Nations Development Programme/United Nations Population Fund/World Health Organization (WHO)/UNICEF/World Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP), Department of Reproductive Health and Research (RHR), WHO. This report contains the collective views of an international group of experts, and does not necessarily represent the decisions or the stated policy of the WHO. All stated authors have no conflict of interest, except Dr Hubacher who reported grants from United States Agency for International Development, during the conduct of the study; other from Advisory Boards (Teva, Bayer, OCON), outside the submitted work.
HNF1A gene p.I27L is associated with co-existing preeclampsia in gestational diabetes mellitus
(2019) Beysel, Selvihan; Pinarli, Ferda Alparslan; Eyerci, Nilnur; Kizilgul, Muhammed; Hepsem, Sema; Alhan, Ali; Kan, Seyfullah; Caliskan, Mustafa; Bozkurt, Erhan; Cakal, Erman; 31825269
The association of the FTO gene and HNF1 alpha gene on gestational diabetes mellitus (GDM) and preeclampsia remains unclear. This is the first study to examine whether HNF1 alpha gene and FTO gene were associated with having GDM and preeclampsia in Turkish women. Healthy pregnant women (n = 101) and women with GDM (n = 169) were included. GDM was divided into two groups as GDM-only (n = 90) and GDM-preeclampsia (n = 79). Genotyping of HNF1 alpha gene p.I27L, p.A98V, and p.S487N, and FTO gene rs9939609 SNPs were performed using RT-PCR. The frequency of p.S487N, p.A98V, and FTO genotype were similar between the groups (p > .05). p.I27L GG-wild, GT, and TT genotype were 56.5%, 36.6%, and 6.9% in controls; 40.0%, 51.1%, and 8.9% in GDM-only; and 26.6%, 51.9%, and 21.5% in GDM-preeclampsia (p = .034). TT and GT genotype was more frequent in GDM-preeclampsia than in controls (p < .05). GT genotype was increased in GDM-only compared with controls (p < .05). TT genotype was more frequent in GDM-preeclampsia than in GDM-only (p < .05). p.I27L TT genotype was independently associated with increased blood pressure (BP) and urinary protein. p.I27L TT genotype was associated with increased preeclampsia risk in patients with GDM by increasing BP and urinary protein.
HNF1A gene p.I27L is associated with early-onset, maturity-onset diabetes of the young-like diabetes in Turkey
(2019) Beysel, Selvihan; Eyerci, Nilnur; Pinarli, Ferda Alparslan; Kizilgul, Muhammed; Ozcelik, Ozgur; Caliskan, Mustafa; Cakal, Erman; 31109344
BackgroundThe molecular basis of the Turkish population with suspected maturity-onset diabetes of the young (MODY) has not been identified. This is the first study to investigate the association between HNF1A-gene single-nucleotide polymorphisms (SNPs) and having early-onset, MODY-like diabetes mellitus in the Turkish population.MethodsAll diabetic patients (N=565) who presented to our clinic between 2012 and 2015 with a clinical suspicion of MODY were included in the study. Analysis of HNF1A, HNFB, HNF4A, GCK gene mutations was performed using real-time polymerase chain reaction sequencing. After genetic analysis, diabetics (n=46) with HNF1A, HNF1B, HNF4A, GCK gene mutations (diagnosed as MODY) and diabetics (n=30) with HNF1B, HNF4A, GCK gene SNPs were excluded. Patients with early-onset, MODY-like diabetes (n=486) and non-diabetic controls (n=263) were included. Genetic analyses for the HNF1A gene p.S487N (rs2464196), p.A98V (rs1800574) and p.I27L (rs1169288) SNPs were performed using Sanger-based DNA sequencing among the control group.Resultsp.S487N and p.A98V was similar between the diabetics and controls in dominant and recessive models with no association (each, p>0.05). p.I27L GT/TT carriers (GT/TT vs. GG, OR=1.68, 95% CI: [1. 21-2.13]; p=0.035) and p.I27L TT carriers had increased risk of having MODY-like diabetes (GT/GG vs. TT, OR=1.56, 95% CI: [1. 14-2.57]; p=0.048). Family inheritance of diabetes was significantly more common in patients with the p.I27L TT genotype. The p.I27L SNP was modestly associated with having diabetes after adjusting for body mass index and age (=1.45, 95% CI: [1. 2-4.2]; p=0.036).ConclusionsThe HNF1A gene p.I27L SNP was modestly associated with having early-onset, MODY-like diabetes in the Turkish population. HNF1A gene p.I27L SNP might contribute to age at diabetes diagnosis and family inheritance.