Ceftazidime - Avibactam susceptibility among carbapenem-resistant Enterobacterales in a pilot study in Turkey
dc.contributor.author | Erol, Cigdem | |
dc.contributor.author | Azap, Ozlem | |
dc.contributor.orcID | 0000-0002-2535-2534 | en_US |
dc.contributor.pubmedID | 34324428 | en_US |
dc.contributor.researcherID | AAJ-1219-2021 | en_US |
dc.date.accessioned | 2022-06-24T07:36:24Z | |
dc.date.available | 2022-06-24T07:36:24Z | |
dc.date.issued | 2021 | |
dc.description.abstract | This study aimed to detect carbapenemase genes and to determine the in vitro susceptibility of Ceftazidime-Avibactam (CZA) in Enterobacterales isolates. Carbapenemase genes were detected by polymerase chain reaction. CZA sensitivity of isolates was evaluated with broth microdilution (BMD) and disk diffusion methods. A total of 318 carbapenem-resistant Enterobacterales isolates were included. Most of the isolates (n = 290, 91.2%) were identified as Klebsiella pneumoniae. The most common carbapenemase type was OXA-48 (n = 82, 27.6%). CZA susceptibility was evaluated in 84 isolates with OXA-48 and KPC carbapenemase activity. Both BMD and disk diffusion methods revealed that 95.2% of the isolates were sensitive to CZA; whereas, 4 (4.76%) isolates were resistant to CZA. Among colistin resistant isolates, 96.5% (n = 80) of them were susceptible to CZA. Our study demonstrated high in vitro efficacy of CZA in Enterobacterales isolates producing OXA-48 carbapenemase. High susceptibility rates against colistin resistant isolates which generally are also pan drug resistant, makes CZA a promising therapeutic choice for difficult-to-treat infections. Due to its high correlation with the BMD, disk diffusion method is a suitable and more practical method in detecting CZA in vitro activity. | en_US |
dc.identifier.endpage | 261 | en_US |
dc.identifier.issn | 1217-8950 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.scopus | 2-s2.0-85132665086 | en_US |
dc.identifier.startpage | 256 | en_US |
dc.identifier.uri | http://hdl.handle.net/11727/7143 | |
dc.identifier.volume | 68 | en_US |
dc.identifier.wos | 000727197500005 | en_US |
dc.language.iso | eng | en_US |
dc.relation.isversionof | 10.1556/030.2021.01525 | en_US |
dc.relation.journal | ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | carbapenemase | en_US |
dc.subject | ceftazidime-avibactam | en_US |
dc.subject | colistin | en_US |
dc.subject | Enterobacterales | en_US |
dc.title | Ceftazidime - Avibactam susceptibility among carbapenem-resistant Enterobacterales in a pilot study in Turkey | en_US |
dc.type | article | en_US |
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