Başkent Üniversitesi Yayınları
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Item Long-Term Outcome of Reusing a Kidney Allograft Retrieved From a Living Recipient and Retransplanted Into a Second Recipient(Başkent Üniversitesi, 2013-04) Bellière, Julie; Rostaing, Lionel; Kamar, Nassim; Guilbeau-Frugier, Céline; Sallusto, FedericoThis case report shows that the 5-year outcome of a reused kidney from live-kidney allograft recipients because of intractable recurrence of thrombotic microangiopathy was excellent.Item Response to "A Novel Technique To Reduce Surgical Tissue Trauma" by Claas Brockschmidt and Associates(Başkent Üniversitesi, 2013-02) Brockschmidt, Claas; Wittau, Mathias; Henne-Bruns, DorisItem "A Novel Technique To Reduce Surgical Tissue Trauma" by Claas Brockschmidt and Associates(Başkent Üniversitesi, 2013-02) Zomorrodi, AfsharItem Soft Tissue Sarcomas in Disused Arteriovenous Fistulae(Başkent Üniversitesi, 2013-02) Herbert, Paul E.; Crane, Jeremy S.Item Experimental and Clinical Transplantation: A Commitment To Integrity, Accountability, and Ethics in Publication(Başkent Üniversitesi, 2013-02) Haberal, Mehmet; Shaheen, Faissal A. M.; Rizvi, S. Adibul Hasan; Ghods, Ahad J.; Masri, MarwanFor the past few years, the social, economic, and political issues surrounding the field of organ transplantation have entered into many ethical discussions. Transplant tourism, and organ trade in particular, have finally received the attention they deserve and many commendable developments have ensued. The “Declaration of Istanbul on Organ Trafficking and Transplant Tourism,” the result of a collective effort by hundreds of transplant professionals the world over, is one such example and is now considered the universal charter for ethical conduct in the field of transplantation. The Middle East Society for Organ Transplantation and its official journal Experimental and Clinical Transplantation were among its first endorsers, and it is our policy to ensure that all authors of articles published in our Journal adhere fully to the rules and regulations stated in The Declaration of Istanbul and by the Committee on Publication Ethics. We believe that the medical community must ensure that a foundation of ethical conduct and scientific integrity is maintained throughout the field, and we must strive toward this goal in all our clinical and scholarly efforts.Item Fibromuscular Dysplasia of the Renal Artery in a Kidney Donor May Cause Long-term Complications(Başkent Üniversitesi, 2012-12) Sharma, RajeevItem Two-hour Postdose Level of Cyclosporine Monitoring of Solid Organ Transplant Patients(Başkent Üniversitesi, 2012-08) Einollahi, BehzadItem Three Aspects Are Critical for Carrying Out Intraportal Islet Transplants Successfully in a Diabetes Mouse Model(Başkent Üniversitesi, 2012-06) Wang, Yanyun; Zhang, Lin; Wang, TaoItem Future Immunosuppression in Organ Transplantation: Treating the Innate Immune System of the Deceased Donor—Start Tomorrow(Başkent Üniversitesi, 2012-06) Land, Walter G.This article, based in part on an invited talk at the Annual International Conference of Saudi Society of Nephrology & Transplantation in 2012, reviews current notions of the emerging field of innate alloimmunity by highlighting novel thoughts regarding future immunosuppressive therapy in organ transplantation. In light of new insights into the mechanisms of innate immunity on one hand and the essential role of regulatory T cells in controlling alloimmune responses on the other hand, potential clinical tools to generate tolerogenic dendritic cells are explored. These cells have been shown to promote induction of regulatory T cells that possess the potential to prevent acute and chronic allograft rejection. Experimental findings from both research areas are discussed in support of the notion that presentation of alloantigens under subimmunogenic noninflammatory conditions, achieved by vigorous inhibition of oxidative injury-induced allograft inflammation (known to occur in both the deceased donor and the recipient during allograft reperfusion), may lead to the induction of tolerogenic dendritic cells-mediated regulatory T cells, thereby offering a realistic opportunity to induce allotolerance in transplant recipients. However, before planning clinical trials in recipients, the start of such a novel therapeutic strategy to prevent allograft rejection could consist of designing and performing a quadruple drug treatment of deceased (brain-dead) donors aimed at generating donor-derived tolerogenic dendritic cells. The combination use of (1) an antioxidant, (2) a complement-inhibiting agent, (3) an IL-1β inhibitor, and (4) a polyclonal antilymphocytic preparation is recommended as the preferred choice of such a donor treatment. If proven successful in organ donors, similar therapeutic modalities should subsequently be considered to apply to the recipient during allograft reperfusion under strict study conditions.Item The Global Role of Kidney Transplantation(Başkent Üniversitesi, 2012-04) Garcia, Guillermo Garcia; Chapman, Jeremy; Harden, PaulWorld Kidney Day on March 8th 2012 provides a chance to reflect on the success of kidney transplantation as a therapy for end stage kidney disease that surpasses dialysis treatments both for the quality and quantity of life that it provides and for its cost effectiveness. Anything that is both cheaper and better, but is not actually the dominant therapy, must have other drawbacks that prevent replacement of all dialysis treatment by transplantation. The barriers to universal transplantation as the therapy for end stage kidney disease include the economic limitations which, in some countries place transplantation, appropriately, at a lower priority than public health fundamentals such as clean water, sanitation and vaccination. Even in high income countries the technical challenges of surgery and the consequences of immunosuppression restrict the number of suitable recipients, but the major finite restrictions on kidney transplantation rates are the shortage of donated organs and the limited medical, surgical and nursing workforces with the required expertise. These problems have solutions which involve the full range of societal, professional, governmental and political environments. World Kidney Day is a call to deliver transplantation therapy to the one million people a year who have a right to benefit.