Fakülteler / Faculties
Permanent URI for this communityhttps://hdl.handle.net/11727/1395
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Item Investigation of Antibacterial Prescribing Situations in Dentistry Faculties and Other Dental Health Institutions(2017) Kirmizi, N. Ipek; Aydin, Mehtap; Koyuncuoglu, Cenker Z.; Aksoy, Mesil; Kadi, Esma; Alkan, Ali; Akici, Ahmet; https://orcid.org/0000-0003-4044-9366; HLX-0937-2023Objective: The relationship between the institutions where dentists work and their prescribing performance is not known. This study aimed to investigate antibacterial prescribing practices of dentists working in different healthcare institutions. Material and Method: Dentists' antibacterial-containing prescriptions were analyzed by using Prescription Information System (PIS) of Turkish Medicines and Medical Devices Agency. Distribution of antibacterial-containing prescriptions that were prescribed by dentists in universities and other healthcare institutions, starting from January 2013 for a total of 32 months was examined in terms of diagnosis and time periods. Results: It was found that very few number of antibacterials (n=9,952) were prescribed in dentistry faculties (DF) while most of them (n=13,069,333) were prescribed in other dental health institutions (DHI). In both DF and DHI, the most common prescribed antibacterial group was "beta lactam antibacterials-penicillins" (93.7% and 71.3%, respectively) and as an antibacterial agent it was "amoxicillin + enzyme inhibitors" (69.7% and 57.9%, respectively). These were followed by amoxicillin (21.9%) and clindamycin (1.5%) in DF; spiramycin (10.4%) and amoxicillin (9.2%) in DHI. The most frequently prescribed diagnoses were "embedded teeth" and "periapical abscesses-without sinus" in DF and DHI, respectively. Conclusion: This study was the first to reveal similar and different aspects of antibacterial prescribing behaviors between the DF and DHI dentists in Turkey. Although preference of the most common drug was similar, detailed examinations showed variations in antibacterial prescribing behaviors of dentists practicing in universities and other institutions.Item Coating of silver nanoparticles on polyurethane film surface by green chemistry approach and investigation of antibacterial activity against S. epidermidis(2022) Kara, Filiz; Aksoy, Eda Ayse; Aksoy, Serpil; Hasirci, Nesrin; 0000-0002-5017-0783; AAC-5455-2020Silver nanoparticles with potential antibacterial properties are included in biomaterials for the production of medical devices, which are used for diagnoses or treatment purposes. The aim of the current study was coating the polyurethane (PU) films with silver nanoparticles (AgNPs) due to their antibacterial efficacy. PU films were first modified by chitosan (CH), treated with AgNO3 to let CH chelate with silver ions, and then treated with vitamin-C (vit C) or glucose (Glu) to reduce the adsorbed ions to atomic silver to form AgNPs. The surfaces of the films were examined by ATR-FTIR, XPS, XRD, and SEM. Chemical bond formation between CH and Ag ions and AgNPs were determined by ATR-FTIR. Meanwhile, XPS and SEM analyses proved the presence of reduced metallic silver and nanoparticles on the film surfaces, respectively. According to the SEM analyses, a homogeneous distribution of AgNPs, with sizes 99-214 nm and 37-54 nm, on the film surfaces were obtained depending on Glu or vit C reduction, respectively. The films presented excellent antibacterial performance against Gram positive Staphylococcus epidermidis (S. epidermidis). These results suggested that the mentioned green technology can be easily applied to obtain AgNP coated polymeric surfaces with very high antibacterial efficacy. Although there are some studies dealing with AgNP formation on PU sponges or fibers, to the best of our knowledge, this is the first study showing AgNP formation on the CH conjugated PU films.Item Antibacterial, Antifungal and Antibiofilm Activity of Methylglyoxal: A Phytochemical from Manuka Honey Metilglioksalin Antibakteriyel, Antifungal ve Antibiyofilm Aktivitesi: Manuka Balindan Bir Fitokimyasal(2021) Uskudar-Guclu, Aylin; Simsek, Derya; Ata-Vural, Ilgin; Unlu, Sezin; Basustaoglu, Ahmet; 0000-0002-1872-028X; AAU-6196-2020Introduction: Honey has been known for its ability to promote wound healing for a long time. It is utilized for several skin and soft tissue infections caused by a wide range of microorganisms due to its antimicrobial property. Methylglyoxal (MGO), the unique antibacterial compound contained by Manuka honey, is believed as the reason for the antimicrobial activity of Manuka honey. This study aims to identify the antibacterial, antifungal and anti-adherent activity of MGO in changing concentrations and determine the viable number of bacteria and fungi in biofilm after the treatment of MGO. Materials and Methods: Antibacterial and antifungal activity of MGO was determined by broth microdilution method for identifying minimum inhibitory and bactericidal and fungicidal concentrations (MIC, MBC and MFC, respectively). Percentage of biofilm formation inhibition and the number of viable microorganisms in biofilm after the MGO treatment was determined by the colony-forming unit method. Results: Minimum inhibitory concentration values for the bacterial strains ranged from 0.0078 to 0.125010 (v/v), while MBC ranged from 0.0312 to 2010 (v/v). Among fungi, MIC and MFC values were higher than those for tested bacterial strains; MIC values ranged from 0.0156 to 1010 (v/v), while MFC values ranged from 0.0625 to 2010 (v/v). Methylglyoxal was able to prevent biofilm formation in the all tested biofilm forming isolates. Number of viable bacteria, even in the sub-inhibitory doses of MGO, reduced remarkably. Conclusion: Unique compound of Manuka honey, MGO, exerts significant antimicrobial and antibiofilm activity against clinically important strains of both bacteria and fungi which may be utilized for the search of promising alternatives for antibiotics and may lead to combat antibiotic resistance.