Fen Edebiyat Fakültesi / Faculty of Letters and Science

Permanent URI for this collectionhttps://hdl.handle.net/11727/1396

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search.filters.applied.f.language: search.filters.language.en_USSubject: search.filters.subject.Neuroinflammation

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    Omega Fatty Acid Ratios and Neurodegeneration in A Healthy Environment
    (PROSTAGLANDINS & OTHER LIPID MEDIATORS, 2024) Yelken, H. Dere; Elci, M. P.; Turker, P. F.; Demirkaya, S
    Neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, Multiple Sclerosis pose substantial public health challenges. While genetics play a primary role, recent research emphasizes the impact of environmental factors, particularly diet and lifestyle. This study investigates the initiating effects of Omega (omega)3 and Omega (omega)- 6 fatty acids on neuroinflammation, potentially contributing to these diseases. Using BV-2 microglial cells, we explored the influence of different fatty acid compositions and ratios on cell viability, cytokine production, morphological changes, and lipid peroxidation. Notably, a 2/1 omega-6:omega-3 ratio led to decreased cell viability. Fatty acid compositions influenced cytokine secretion, with reduced TNF-alpha suggesting anti-inflammatory effects. IL-17 increased, while IL-4 and IL-10 decreased in the 15/1 omega-6:omega-3 ratio, indicating complex cytokine interactions. This study found that polyunsaturated fatty acids interventions induced microglial activation, altering cell morphology even without immunostimulants. These findings demonstrate the intricate nature of fatty acid interactions with microglial cells and their potential implications for neuroinflammation. Further research is needed to clarify mechanisms and their relevance to neurodegenerative diseases, informing possible therapeutic strategies.
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    Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Inflammatory Markers in Schizophrenia: A Comparative Analysis of Drug-Naive Schizophrenia Patients, Remitted Patients, and Healthy Controls
    (JOURNAL OF PSYCHIATRIC RESEARCH, 2024) Ciftci, Hatice; Asut, Gonca; Kaya, Hasan; Cakmak, Isik Batuhan; Yilmaz, Meltem Aydiner; Copur, Ahmet; Calci, Esin; Oguz, Esra Firat; Turhan, Turan; Goka, Erol
    This study aims to examine the plasma concentrations of NGAL and other inflammatory parameters, including TNF-alpha, IL-1 beta, and IFN-gamma, in schizophrenia patients and healthy volunteers. It also investigates potential associations between these biomarkers and symptom severity in schizophrenia and the utility of NGAL as a potential diagnostic and monitoring biomarker for schizophrenia. The study included 49 drug-naive schizophrenia patients (DNS), 59 patients with schizophrenia in remission (REM) on antipsychotic treatment, and 58 healthy volunteers (HC). The Positive and Negative Symptoms Evaluation Scale (PANSS) was utilized to assess the severity of symptoms in schizophrenia patients. Plasma levels of TNF-alpha, IL-1 beta, IFN-gamma, and NGAL were measured for all participants. NGAL levels were significantly lower in the DNS group than in HC. Significantly lower TNF-alpha levels were observed in both the DNS and REM groups compared to the HC group. Notably, a statistically significant positive correlation was detected between TNF-alpha and NGAL levels. The findings of this study are noteworthy, as they demonstrate that drug-naive individuals with schizophrenia exhibit significantly diminished levels of NGAL and TNF-alpha compared to healthy controls. These identified biomarkers hold promise for providing valuable insights into the complex and evolving pathophysiology of schizophrenia.