Fen Edebiyat Fakültesi / Faculty of Letters and Science

Permanent URI for this collectionhttps://hdl.handle.net/11727/1396

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English language teaching
(Başkent Üniversitesi Fen Edebiyat Fakültesi, 1997) Koç, Sabri
Üniversiteler için Türk dili ders kitabı
(2008) Guzel, Abdurrahman; Demir, Nurettin; Celik, Yakup; Demir, Ahmet; Atabey, Ibrahim; Aslan Demir, Sema; Kuzu, Tulay; Ay, Arif
A model for assessing organizational learning in software development organizations
(Human-Centered Software Engineering / Lecture Notes in Computer Science. 7623, 251-258, 2012) Chouseinoglou, Oumout; Bilgen, Semih
In order to keep up with the continuously increasing competition and to obtain competitive advantage, software developer organizations (SDO) need to possess the characteristics of Learning Software Organizations (LSO). Maturity is directly related to both learning and knowledge management (KM). However, the major software process improvement (SPI) approaches do not explicitly address how learning capabilities of a SDO can be assessed or what knowledge needs to be managed and how, when, where, or by and for whom. This paper introduces a model for evaluating the organizational learning characteristics of a SDO. We report the results of applying the model in a university course on software development.
Early Maladaptive Schema Domains and Social Phobia Symptoms: Is There a Mediator Role of Emotion Regulation Difficulties?
(2014) Eldogan, Dilay; Bariskin, Elif
The purpose of the study was to investigate the mediator role of emotion regulation difficulties on the relationship between early maladaptive schema domains and symptoms of social phobia. The sample included 240 university students. Liebowitz Social Anxiety Scale (LSAS), Beck Depression Inventory (BDI), Young Schema Questionaire-Short Form 3 (YSQ) and Difficulties in Emotion Regulation Scale (DERS) were administered. Analysis revealed that there is a mediator role of emotion regulation difficulties in the relation between Disengagement, Impaired Autonomy and Impaired Limits schema domains and the symptoms of social phobia. Strenghts, limitations and implications of the current study are discussed in the light of relevant research.
The Turkish Adaptation of the Friendship Qualities Scale: A Validity and Reliability Study
(2014) Atika, Zeynep Erkan; Cok, Figen; Coban, Aysel Esen; Dogan, Turkan; Karaman, Neslihan Guney; ITT-6781-2023; AAW-7154-2021
In this study, the authors have aimed to adapt the Friendship Qualities Scale (FQS) in order to determine friendship relation levels among adolescents. A total of 603 high school students from Ankara Turkey, were selected using convenient sampling to participate in this study. During the course of this study, the FQS was first translated into Turkish and then its psychometric properties were examined. The construct validity of the FQS was tested using a confirmatory factor analysis (CFA). Before performing the CFA, the assumption of missing values, outliers, normality, and collineriaty were checked. According to the results, the 22-item FQS consisting of 5 dimensions had acceptable goodness of fit indexes (S-Bx(2)/df = 669.12/199, p = .00, RMSEA = .063, CFI = .97, GFI = .88, NNFI = .96). The Cronbach alpha coefficients of the subscales ranged between .66 and .86. The internal consistency for the entire scale was alpha = .85. In conclusion, an instrument consisting of 22 items and 5 subscales was prepared for future researchers.
Validation and Correlates of The Vicarious Embarrassment Scale
(2014) Uysal, Ahmet; Akbas, Gulcin; Helvaci, Elif; Metin, Irem; HGT-9462-2022
Vicarious embarrassment can be defined as embarrassment resulting from witnessing embarrassing behaviors of strangers. We developed a scale to measure individual differences in the tendency to experience vicarious embarrassment, and examined its association with related constructs. In Study 1, we found that vicarious embarrassment is associated positively with susceptibility to embarrassment, empathy, perspective-taking, and fear of negative evaluation, while it is associated negatively with self-esteem. In Study 2, we found that vicarious embarrassment is uniquely associated with embarrassment in response to a poor performance of a stranger on a TV show, independent of susceptibility to embarrassment, empathy, perspective-taking, and fear of negative evaluation. Although the limited literature on this topic focused on the role of empathy in this type of embarrassment, these findings suggest that there is more to vicarious embarrassment than empathy or perspective-taking. (C) 2013 Elsevier Ltd. All rights reserved.
On The Q - Seidel Matrix
(2014) Firengiz, M. Cetin; Tuglu, Naim; https://orcid.org/0000-0002-9588-0295; HNQ-9215-2023
Clarke and et. al recently introduced the q-Seidel matrix, and obtained some properties. In this article, we define a different form of q-Seidel matrix by a(n)(k) (x, q) = xq(n+2k-3)a(n)(k-1) (x, q)+an(k-1)(x, q)+a(n+1)(k-1) with k >= 1, n >= 0 for an initial sequence a(n)(0) (x, q) = a(n) (x, q). By using our definition, we obtain several properties of the q-analogues of generalized Fibonacci and Lucas polynomials.
beta-Adrenoreceptor antagonists reduce cancer cell proliferation, invasion, and migration
(2014) Iseri, Ozlem Darcansoy; Sahin, Feride Iffet; Terzi, Yunus Kasim; Yurtcu, Erkan; Erdem, S. Remzi; Sarialioglu, Faik; 25026350
Context: Propranolol, atenolol, and ICI118,551 are non-selective beta-adrenergic receptor (AR), beta(1)-AR, and beta(2)-AR antagonists, respectively. Objective: We investigated the efficacy of propranolol, atenolol, and ICI118,551 on proliferation, migration, and invasion of non-stimulated breast (MCF7), colon (HT-29), and hepatocellular (HepG2) cancer cells. Materials and methods: beta-AR expression profiling of cells was performed by real time PCR. Cell proliferation was determined by MTT. Boyden chamber and scratch assays were performed to evaluate invasion and migration. Results and discussion: All cell lines expressed beta-ARs. ICI118,551 was the most cytotoxic, whereas atenolol was the least effective beta-AR antagonist for 24, 48, and 72 h. Cell invasion was inhibited by ICI118,551 (45, 46, and 50% for MCF7, HT29, and HepG2, respectively) and propranolol (72, 65, and 90% for MCF7, HT29, and HepG2, respectively). Propranolol, atenolol, and ICI118,551 reduced migration of MCF7, HT-29, and HepG2 cells to varying extents depending on the application concentration and duration. Propranolol and atenolol reduced migration of MCF7 and HT-29 in a concentration-dependent manner, whereas migration of these cells decreased after 48 and 72 h of ICI118,551 applications. Conclusion: Beta(2)-AR antagonist seemed to be the most cytotoxic beta-blocker on non-stimulated cancer cells. Propranolol and ICI118,551 were more effective than atenolol in inhibiting invasion and migration of non-stimulated MCF7 and HT-29 cells; ICI118,551 being the most potent. Concordantly, beta(2)-selective blockage seemed to be more effective for non-stimulated cells. Effect of the selective beta-AR antagonists showed variation depending on the concentration, incubation time, and histological origin of cells.
Longer Language Map of the Discoveries in Turku
(2014) Eker, Suer; AAN-8254-2021
Epigallocatechin 3-gallate applications on HT-29 and MCF-7 cell lines and evaluation of tumor suppressor gene methylation
(2015) Terzi, Yunus Kasim; Kaya, Ozge Ozer; Iseri, Ozlem Darcansoy; Celik, Zerrin; Sahin, Feride Iffet
Epigallocatechin 3-gallate (EGCG) is an antitumor molecule and shows this activity by binding to the active center of a methyltransferase enzyme (DNMT1). The methylation of DNA sequences of tumor suppressor and DNA repair genes is observed in different stages of carcinogenesis. In this study, we analyzed the effect of EGCG on the methylation status of 25 tumor suppressor genes in cancer cell lines HT-29 and MCF-7. HT-29 and MCF-7 cells were incubated with 10 mu M, 20 mu M, and 50 mu M and 1 mu M, 5 mu M, and 10 mu M EGCG for 48 h, respectively. We found promoter hypermethylation of (1) CDH13, GATA5, and RAR beta genes in MCF-7 cell line and (2) RAR beta, ESR1, PAX6, WT1, CADM1, CHFR, CDH13, and GATA5 genes in HT-29 cell line. However, (3) after EGCG application, no changes in methylation status were detected in our samples. Our results suggest that methylation status of tumor suppressor genes did not change with different EGCG doses.
High salt induced oxidative damage and antioxidant response in tomato grafted on tobacco
(2015) Iseri, Ozlem Darcansoy; Korpe, Didem Aksoy; Sahin, Feride Iffet; Haberal, Mehmet
One of the major limitations on agricultural development in many countries is the high salinity of the groundwater used in irrigation. Grafted plants may exhibit phenotypic variations from scion and rootstock plants in terms of abiotic stress tolerance, and be a method for improvement of tolerance in agricultural practices. The aim of the present study was to investigate response of Solanum lycopersicum L. ('Elazig') grafted on Nicotiana tabacum L. ('Samsun') and Nicotiana rustica L. ('Hasankeyf'), namely "Tomacco" plant (patent nr TR-2008-05391-B), to 10-d high NaCl irrigation. Physical development, chlorophyll a and b, total chlorophyll, total carotenoid, and anthocyanin levels were evaluated. Proline, lipid peroxidation, and electrolyte leakage levels were assayed in roots and leaves together with ascorbate peroxidase (APX) and catalase (CAT) activities. Considering alterations in chlorophyll contents, proline, malondialdehyde (MDA), and conductivity levels, and antioxidant enzyme activity levels scion and self-grafted plants seem to be more affected by salt treatments than tobacco and rootstock grafted plants. Tobacco roots seem to have better adaptive responses against salt stress in comparison to tomato as supported by changes in proline, APX, and CAT levels. Self-grafting experiments further supported grafting tomato onto tobacco rootstocks enhanced salt tolerance and adaptive response of scions and these changes seem to be dependent on rootstock rather than graft-induced changes. In conclusion, we demonstrated that previously defined graft unions of tomato on tobacco, which have increased fruit yield, had also enhanced tolerance to high salt stress and a promising technique for the cultivation of more salt tolerant varieties.
Mesenchymal Stem Cells Administered Intraperitoneally Have A Potent Effects on the Experimental Allergic Airway Disease
(2015) Isik, S.; Adan Gokbulut, A.; Karaman, M.; Kiray, M.; Bagriyanik, H. A.; Caglayan Sozmen, S.; Kozanoglu, I; Karaman, O.; Baran, Y.; Uzuner, N.; 0000-0002-5268-1210; 0000-0003-4064-7637; AAE-1241-2021; H-7577-2013
Three Assessment Scales on Awareness: Psychological Mindedness, Integrative Self Knowledge and Toronto Trait Mindfulness Scales
(2015) Sahin, Nesrin Hisli; Yeniceri, Zuhal; 0000-0001-9228-9961; F-8366-2010
Awareness is a phenomenon which is increasingly attracting attention. However as a complex concept, it incorporates different dimensions. In spite of this increasing attention, there are very few instruments in the Turkish Language to be used in research aiming to conceptualize the construct. The purpose of the current study is to adapt three scales used in the related literature into Turkish, in order to study awareness with its several conceptual dimensions (psychological awareness, self awareness, and mindfulness). With this purpose in mind, the Psychological Mindedness Scale, the Integrative Self Awareness Scale, and Toronto Mindfulness Scale were translated into Turkish; and their psychometric properties, reliabilities and validities (construct validity and concurrent validity) were investigated. The results are interpreted in light of the related literature. The study revealed that these three scales can reliably and validly be used in studies on awareness.
Fractalkine receptor polymorphism may not be associated with the development and clinical course of ulcerative colitis
(2015) Gokcan, Hale; Yurtcu, Erkan; Selcuk, Haldun; Sahin, Feride I.; 26042517
Fractalkine (CX3C), a chemokine expressed by epithelial cells within normal and inflamed colorectal mucosa, induces leukocyte adhesion and migration via fractalkine receptor. The aim of this study was to investigate two single nucleotide polymorphisms of the fractalkine receptor gene as a risk factor both for the development and clinical findings of ulcerative colitis. In this study, si patients with ulcerative colitis (UC) and 8o controls were recruited. Genotypes of fractalkine receptorc.743G>A (V249I) and c.839C>T (T280M) polymorphisms were identified by restriction fragment length polymorphism analyses after polymerase chain reaction.Genotype distribution and allele frequencies of V249I and T280M were not statistically significantly different between UC and control groups (p>0.05). No statistically significant relationship was found between fractalkine receptor polymorphisms and clinical findings of UC. We observed no significant difference in fractalldne receptor polymorphism between patients and control group and no genotype-phenotype relation. Therefore, we concluded that fractalkine receptor polymorphisms may not contribute to the molecular pathogenesis of UC.
Edith Wharton in Washington, 2-4 June 2016
(2016) Kiran-Raw, Meltem
The Roles of SPBC409.08 and SPAC9.02c Hypothetical Genes in Cell Cycle and Stress Response, in Schizosaccharomyces Pombe
(2016) Gungor, I.; Gevrekci, A. Ors; 27188733
Polyamine molecules are known to have important roles in the cell cycle control and fighting against stress in the cell. The mechanism and modification of polyamines are regulated by the cooperation of many proteins such as polyamine transporter proteins and polyamine acetyl-transferases. In this study, our aim is to characterize two hypothetical Schizosaccharomyces pombe genes, SPBC409.08 and SPAC9.02c, which show sequence similarity to spermine family transporters and polyamine N-acetyltransferases, respectively. To this end, we generated deletion mutants of SPBC409.08 and SPAC9.02c genes using Bahler method and checked the cell cycle progression and stress responses of these mutants. Our results showed that SPBC409.08 Delta cells showed some defects in the cell size, while SPAC9.02c Delta cells showed some sensitivity to UV irradiation. These data support their potential roles in the cell cycle and stress response. To our knowledge our results are the first experimental characterization of these genes.
The Re-Materialization of Yasar Kemal's Teneke at The Crossroads of Genres
(2017) Dundar, Leyla Burcu
Yasar Kemal (1923-2015) is a leading author of Turkish literature with worldwide acclaim, whose oeuvre is regarded as the incarnation of Anatolian culture. Teneke, one of his early works, was written in 1954 and published in installments in a newspaper the very same year. Although the text appeared as a book as early as 1955, it is apparent that an indecision regarding its genre was present. Teneke, translated into English as The Drumming-Out, was addressed as a "short novel or a long novelette" on the book cover of the second edition dating from 1959. Besides, it was included in the collected short stories of the author published in 1967; however, it was excluded from the 4th edition in 1972. Therefore, this year onwards, it came into being as a separate book. But more was yet to come: In 1965, Yasar Kemal adapted the text into a play, which was staged both in Turkey and abroad. Yet this version of the text was not published for years to come. 1978 onwards, The Drumming-Out was published as a book with novel and play versions together; and since then, this format has been preserved. Its publishing history proves that, Yasar Kemal was continuously occupied with issues regarding the intersection of literary genres. The text's being fictionalized as a novel, short story, and play gradually; and it's finally being materialized as a novel and play simultaneously invites a comparative analysis. In this paper, different versions of the text are analyzed so as to discuss the author's perceptions and assumptions on genres and their reading public. For this purpose, the dissociation of contents and employment of diverse techniques specific to certain genres are investigated. As a result, the boundaries between genres and corresponding production/consumption strategies are scrutinized by examining the materialization of the same text in different forms.
Ottoman Turkish in the high school curriculum: current language planning discussions in Turkey
(2017) Yazan, Bedrettin; Uzum, Melike; 0000-0002-1888-1120; 0000-0002-2338-8066; ABC-2329-2020
This paper explores the recent policy decision about the teaching of Ottoman Turkish at high schools in Turkey and unpacks its historical, political, and social undercurrents. It theoretically rests upon Spolsky's [2004. Language policy. Cambridge: Cambridge University Press, 2009. Language management. Cambridge: Cambridge University Press] and Shohamy's (2006. Language policy: Hidden agendas and new approaches. London: Routledge] work on language policy and management at the state level, and Liddicoat and Baldauf's [2008. Language planning in local contexts: Agents, contexts and interactions. In A. J. Liddicoat & R. B. Baldauf (Eds.), Language planning and policy: Language planning in local contexts (pp. 3-17). Clevedon: Multilingual Matters] and Chua and Baldauf's [2011. Micro language planning. In E. Hinkel (Ed.), Handbook of research in second language teaching and learning (Vol. 2, pp. 936-951). New York, NY: Routledge] explorations of micro language planning and agency. After providing background on the orthographic revolution in 1928 and the subsequent lexical purification in Turkey, this paper analyzes the policy decision about the incorporation of Ottoman Turkish into the high school curriculum. The analysis leads to three main observations. First, this policy decision emerged as part of the national identity reconstruction efforts stage-managed by the ruling political party aligned with neo-Ottomanist ideals. Second, the government has ideologically constructed the teaching of Ottoman Turkish at high school as essential to rebuild the connection with Ottoman-Islamic heritage lost purportedly after the Turkish Language Reform. Third, save for the attempts to address the issues about linguistic expertise and fairness in selecting teachers, this policy mostly neglected the micro-level agentive responses. This paper closes with conclusions that connect the analysis of the Ottoman Turkish case in Turkey to broader language planning research.
The role of predicted spermidine family transporters in stress response and cell cycle in Schizosaccharomyces pombe
(2017) Gevrekci, Aslihan Ors
Fission yeast Schizosaccharomyces pombe has a variety of stress-signaling proteins that protect cells against environmental or intracellular stress. These proteins help the cells to respond to stress conditions and regulate intracellular functions such as cell division or gene expression. Polyamines (spermidine, spermine, and putrescine) are known to be important in the regulation of stress response and cell division. In this study, we tried to experimentally characterize novel S. pombe genes that are involved in the polyamine pathway and understand their potential roles. Sequence analysis revealed four genes that code for (predicted) spermidine family transporters in S. pombe. In an attempt to characterize these (predicted) spermidine family transmembrane transporters and their possible roles, deletion mutants of these candidate genes were created. These mutants were exposed to different stress conditions, such as DNA-damaging agents and osmotic stress, to understand their significance in the stress response. Next, the mutants were analyzed in terms of cell size, growth rate, and spore formation to understand their contribution to cell cycle control. The results revealed that individual deletion of two of these genes, SPBC36.01c and SPBC36.02c, resulted in sensitivity to DNA-damaging agents, indicating their role in DNA damage response.
Fission Yeast srm1 is Involved in Stress Response and Cell Cycle
(2017) Gevrekci, Aslihan Ors; 28345120
Polyamines are well-conserved, multifunctional polycations that contribute to a number of processes in the cells such as cell cycle, apoptosis, stress response, and gene expression. Therefore, polyamine levels should be kept under strict regulation by specific polyamine transporters and polyamine synthases. In this study, the aim is to experimentally characterize a predicted spermidine synthase gene srm1, which was identified upon sequence similarity, in fission yeast Schizosaccharomyces pombe. In an attempt to understand the role of this gene in cell cycle and stress response, deletion mutant of srm1 was generated and analyzed in terms of cell cycle regulation and environmental stress response. The results showed that srm1 Delta cells had elongated cell size and were sensitive to osmotic stress, while they showed no sensitivity to DNA-damaging agents. To the best of our knowledge, this is the first experimental characterization of srm1 gene and its role in cell cycle progression and stress response.