Fen Edebiyat Fakültesi / Faculty of Letters and Science

Permanent URI for this collectionhttps://hdl.handle.net/11727/1396

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A model for assessing organizational learning in software development organizations
(Human-Centered Software Engineering / Lecture Notes in Computer Science. 7623, 251-258, 2012) Chouseinoglou, Oumout; Bilgen, Semih
In order to keep up with the continuously increasing competition and to obtain competitive advantage, software developer organizations (SDO) need to possess the characteristics of Learning Software Organizations (LSO). Maturity is directly related to both learning and knowledge management (KM). However, the major software process improvement (SPI) approaches do not explicitly address how learning capabilities of a SDO can be assessed or what knowledge needs to be managed and how, when, where, or by and for whom. This paper introduces a model for evaluating the organizational learning characteristics of a SDO. We report the results of applying the model in a university course on software development.
A Partial Epithelial-Mesenchymal Transition Signature For Highly Aggressive Colorectal Cancer Cells That Survive Under Nutrient Restriction
(JOURNAL OF PATHOLOGY, 2024-01-24) Pastorino, Gil A.; Sheraj, Ilir; Oral, Goksu; Gulec Taskiran, Aliye Ezgi; Palmisano, Ralph; Schneider-Stock, Regine
Partial epithelial-mesenchymal transition (p-EMT) has recently been identified as a hybrid state consisting of cells with both epithelial and mesenchymal characteristics and is associated with the migration, metastasis, and chemoresistance of cancer cells. Here, we describe the induction of p-EMT in starved colorectal cancer (CRC) cells and identify a p-EMT gene signature that can predict prognosis. Functional characterisation of starvation-induced p-EMT in HCT116, DLD1, and HT29 cells showed changes in proliferation, morphology, and drug sensitivity, supported by in vivo studies using the chorioallantoic membrane model. An EMT-specific quantitative polymerase chain reaction (qPCR) array was used to screen for deregulated genes, leading to the establishment of an in silico gene signature that was correlated with poor disease-free survival in CRC patients along with the CRC consensus molecular subtype CMS4. Among the significantly deregulated p-EMT genes, a triple-gene signature consisting of SERPINE1, SOX10, and epidermal growth factor receptor (EGFR) was identified. Starvation-induced p-EMT was characterised by increased migratory potential and chemoresistance, as well as E-cadherin processing and internalisation. Both gene signature and E-cadherin alterations could be reversed by the proteasomal inhibitor MG132. Spatially resolving EGFR expression with high-resolution immunofluorescence imaging identified a proliferation stop in starved CRC cells caused by EGFR internalisation. In conclusion, we have gained insight into a previously undiscovered EMT mechanism that may become relevant when tumour cells are under nutrient stress, as seen in early stages of metastasis. Targeting this process of tumour cell dissemination might help to prevent EMT and overcome drug resistance. (c) 2024 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
Abnormal subcortical activity in congenital mirror movement disorder with RAD51 mutation
(2018) Demirayak, Pinar; Onat, Onur Emre; Gevrekci, Aslıhan Ors; Gulsuner, Suleyman; Uysal, Hilmi; Bilgen, Rengin; Doerschner, Katja; Ozcelik, Tayfun; Boyaci, Hueseyin; 30406765
PURPOSE Congenital mirror movement disorder (CMMD) is characterized by unintended, nonsuppressible, homologous mirroring activity contralateral to the movement on the intended side of the body. healthy controls, unilateral movements are accompanied with predominantly contralateral cortical activity, whereas in CMMD, in line with the abnormal behavior, bilateral cortical activity is observed for unilateral motor tasks. However, task-related activities in subcortical structures, which are known to play critical roles in motor actions, have not been investigated in CMMD previously. METHODS We investigated the functional activation patterns of the motor components in CMMD patients. By using linkage analysis and exome sequencing, common mutations were revealed in seven affected individuals from the same family. Next, using functional magnetic resonance imaging (fMRl) we investigated cortical and subcortical activity during manual motor actions in two right-handed affected brothers and sex, age, education, and socioeconomically matched healthy individuals. RESULTS Genetic analyses revealed heterozygous RAD51 c.401C>T mutation which cosegregated with the phenotype in two affected members of the family. Consistent with previous literature, our fMRI results on these two affected individuals showed that mirror movements were closely related to abnormal cortical activity in M1 and SMA during unimanual movements. Furthermore, we have found previously unknown abnormal task-related activity in subcortical structures. Specifically, we have found increased and bilateral activity during unimanual movements in thalamus, striatum, and globus pallidus in CMMD patients. CONCLUSION These findings reveal further neural correlates of CMMD, and may guide our understanding of the critical roles of subcortical structures for unimanual movements in healthy individuals.
An Abstract Mind is a Principled One: Abstract Mindset Increases Consistency in Responses to Political Attitude Scales
(2018) Alper, Sinan; 0000-0002-9051-0690; ABG-6854-2020
Past literature suggested that not everyone is politically sophisticated. In the current research, it is proposed that an experimental manipulation of abstract mindset would decrease variation in responses to political attitude scales and render individuals more internally consistent in their political attitudes. Three hypotheses are proposed: (1) Abstract mindset would lower within-subject standard deviations (SDs) and increase Cronbach's alphas in responses to political attitude scales; (2) decrease in SDs could not be attributed to a response bias; and (3) abstract mindset would lower SDs even after controlling for differences in mean scores on those scales. In seven experiments, five different paradigms were used to manipulate abstractness and four different political scales were used as dependent measures on samples from two distinct cultures (US and Turkey). Analyses of individual studies and an aggregate analysis of combined data supported all hypotheses and showed that abstract mindset decreases SDs and increases Cronbach's alpha scores in self-reported political attitudes. Results suggest that abstract mindset enhances apparent political sophistication by highlighting core political beliefs behind different attitudinal statements. Implications for construal level theory and political sophistication research are discussed.
Adultization and Blurring the Boundaries of Childhood in the Late Modern Era
(2020) Orman, Turkan Firinci; 0000-0001-9137-0899; JBI-6684-2023
Although the modern Western concept of childhood is rapidly disappearing in the age of late modernity, this study asserts that childhood (as it is lived) has not disappeared but has been transformed. An integrated approach to childhood is employed in order to go beyond binary oppositions such as the Global North versus the Global South and/or childhood versus childhoods. It is argued that children while constructing their childhoods are confronted with processes of individualisation and globalisation through which new forms of adultization have emerged as concepts of 'child consumerism' and 'child citizenship'. Beyond the opposing views involving the disappearance of childhood or its liberation, this study concludes that the concept of adultization can be used to problematise and analyse childhood in its current state.
Advancements in QTL Mapping and GWAS Application in Plant Improvement
(TURKISH JOURNAL OF BOTANY, 2024) Altaf, Muhammad Tanveer; Tatar, Muhammed; Ali, Amjad; Liaqat, Waqas; Mortazvi, Parnaz; Kayihan, Ceyhun; Olmez, Fatih; Nadeem, Muhammad Azhar; Javed, Jazib; Gou, Jin-Ying; Wang, Meng-Lu; Umar, Ummad Ud Din; Dasgan, Hayriye Yildiz; Kurt, Cemal; Yildiz, Mehtap; Mansoor, Sheikh; Dababat, Abdelfattah A.; Celiktas, Nafiz; Baloch, Faheem Shehzad
In modern plant breeding, molecular markers have become indispensable tools, allowing the precise identification of genetic loci linked to key agronomic traits. These markers provide critical insight into the genetic architecture of crops, accelerating the selection of desirable traits for sustainable agriculture. This review focuses on the advancements in quantitative trait locus (QTL) mapping and genome-wide association studies (GWASs), highlighting their effective roles in identifying complex traits such as stress tolerance, yield, disease resistance, and nutrient efficiency. QTL mapping identifies the significant genetic regions linked to desired traits, while GWASs enhance precision using larger populations. The integration of high-throughput phenotyping has further improved the efficiency and accuracyof QTL research and GWASs, enabling precise trait analysis across diverse conditions. Additionally, next-generation sequencing, clustered regularly interspaced short palindromic repeats (CRISPR) technology, and transcriptomics have transformed these methods, offering profound insights into gene function and regulation. Single-cell RNA sequencing further enhances our understanding of plant responses at the cellular level, especially under environmental stress. Despite this progress, however, challenges persist in optimizing methods, refining training populations, and integrating these tools into breeding programs. Future studies must aim to enhance genetic prediction models, incorporate advanced molecular technologies, and refine functional markers to tackle the challenges of sustainable agriculture.
Aiding and Abetting Survival: Americanizing Robinson Crusoe through Adaptation
(2022) Tutan, Defne Ersin
Daniel Defoe's Robinson Crusoe (1719) has been insistently adapted to both the big screen and TV throughout the 20th century and well into the 21st, the earliest version dating back to 1902 and the most recent to 2016. Although a full list of all versions would be elusive and also redundant, almost 50 adaptations are readily available for viewing and/or for analysis. Moving away from the`fidelity' criticism in the earlier vein of adaptation studies and proceeding from the argument that all adaptations are essentially rewritings, alternative ways in which the source text may be reconstructed in an ultimately intertextual framework, this paper scrutinizes American screen adaptations of Robinson Crusoe, namely Robinson Crusoe on Mars (Dir. Byron Haskin, 1964), Lt. Robinson Crusoe, U.S.N. (Dir. Byron Paul, 1966), and Cast Away (Dir. Robert Zemeckis, 2000). Far from shedding new light on an almost-exhausted source text, these rewritings reflect more about their own discourses, relating to the historical and social contexts of their own making. In so doing, they `Americanize' Robinson Crusoe. As such, three centuries after its publication, Robinson Crusoe is still being repeatedly reinvented and reconstructed in film, and this analysis investigates the dialogical relations among these adaptations while, at the same time, emphasizing how every new adapted version of a work of literature aids and abets the survival of its source text.
All the Dark Triad and some of the Big Five traits are visible in the face
(2021) Alper, Sinan; Bayrak, Fatih; Yilmaz, Onurcan; 0000-0001-6350-6234
Some of the recent studies suggested that people can make accurate inferences about the level of the Big Five and the Dark Triad personality traits in strangers by only looking at their faces. However, later findings provided only partial support and the evidence is mixed regarding which traits can be accurately inferred from faces. In the current research, to provide further evidence on whether the Big Five and the Dark Triad traits are visible in the face, we report three studies, two of which were preregistered, conducted on both WEIRD (the US American) and non-WEIRD (Turkish) samples (N = 880). The participants in both the US American and Turkish samples were successful in predicting all Dark Triad personality traits by looking at a stranger's face. However, there were mixed results regarding the Big Five traits. An aggregate analysis of the combined dataset demonstrated that extraversion (only female), agreeableness, and conscientiousness were accurately inferred by the participants in addition to the Dark Triad traits. Overall, the results suggest that inferring personality from faces without any concrete source of information might be an evolutionarily adaptive trait.
Anatolian Cranes -Biology, Culture, Conservation
(2020) Serdaroglu, Ozge Aksoy
Anti-Phytopathogenic Activity of Wild Medicinal Plants Extracts
(2017) Kocabas, Aytac; Iseri, Ozlem Darcansoy; Unlu, Ummuhan; Sahin, Feride Iffet; 0000-0001-7622-1932; 0000-0001-7308-9673; F-5933-2013; AAC-7232-2020
Approximation by Truncated Lupas Operators of Max-Product Kind
(2021) Mediha, Orkcu; Dalmanoglu, Ozge; Hatipoglu, Fatma Busra
The goals of the present paper are to introduce truncated Lupas type operators of max-product kind and give an estimation for the degree of approximation with respect to first modulus of continuity function. We prove that this estimate can not be improved; on the other hand, for some subclasses of functions, better degree of approximation is obtained. We also showed the piecewise convexity of the constructed operators on the interval [0, 1].
Are uninvolved fathers really incompetent and unsatisfied? Testing the mediator role of father involvement from fathers' perspectives
(2019) Pekel-Uludagli, Nilay; AAW-8660-2020
The aim of this study was to examine the relationship between fathers' involvement and maternal gatekeeping, gate-opening, and traditional paternal gender roles, as well as to evaluate fathers' involvement as a mediating role in the relationship between maternal gate-opening, gatekeeping, traditional paternal gender roles, paternal competence, and marital satisfaction. Turkish fathers (N = 239) with a child aged 2-6 years were included in the study. They assessed maternal gatekeeping and gate-opening, their traditional gender roles, parenting competence, and marital satisfaction. Results indicated that fathers' involvement is positively related to maternal gate-opening and negatively associated with traditional paternal gender roles; in addition, fathers' involvement has a mediatory role between maternal gate-opening, traditional paternal gender roles and paternal competence and marital satisfaction. The results suggest that fathers who are involved in their children's lives are more competent and have higher marital satisfaction.
Assessing The Use Of Multiple-Choice Translation Items In English Proficiency Tests: The Case Of The National English Proficiency Test In Turkey
(2022) Dincer, Betul Hazal; Antonova-Unlu, Elena; Kumcu, Alper
The use of translation for language teaching and assessment, by and large, has been abandoned with the adoption of audio-lingual and communicative approaches in language teaching. As a result, nowadays translation items are not commonly used for measuring language proficiency in international language proficiency tests (e. g. TOEFL, IELTS). However, there are several countries that still use translation items in their national language proficiency tests (e. g. Turkey, Japan, China, Romania among others). The present study aims to examine whether or not multiple-choice translation items are an appropriate tool for measuring proficiency in English. To this end, the perceived level of difficulty and validity of multiple-choice translation items in the National English Proficiency Test (YDS) in Turkey were examined. The findings revealed that the participants did significantly better on the translation items than on the rest of the test items. They also perceived the translation items as the easiest among all the rest items in YDS. Moreover, while YDS as a whole indicated a strong validity based on correlation with TOEFL PBT Reading Sample Test, the translation items indicated moderate validity. Importantly, there was a significant difference between the two correlations. These findings suggest that multiple-choice translation items are likely to lower the overall validity of YDS tests, inflate the scores of test-takers and, thus, might be considered as problematic for the quality of the tests.
Assessment of the effects of radiofrequency radiation on human colon epithelium cells
(2019) Tomruk, A.; Terzi, Y.K.; Guler, Ozturk G.; 0000-0001-5612-9696; 31023054; B-4372-2018
OBJECTIVES: The aim of the study was to investigate the possible effects of radiofrequency radiation (RFR) at different frequencies for different exposure durations on caspase-dependent apoptosis pathways in human colon adenocarcinoma (HT-29). METHODS: HT-29 cells were exposed to 1800 MHz; 2100 MHz and 2600 MHz RFR for 3 h cont., 6 h int. and 6 h cont.. Cell viability measurements were performed by Trypan Blue exclusion assay and the gene expressions of CASP8, CASP9, CASP3 and CASP12 were analyzed using qRT-PCR. RESULTS: Exposure to 2100 MHz RFR for all 3 durations of exposures was more effective for the ratio of the number of viable HT-29 cells w.r.t 1800 MHz RFR and 2600 MHz RFR exposures. After 2100 MHz RFR exposure, caspase activation increased significantly (for 3h cont. and 6 h int. exposures CASP8 and CASP9 levels; for 6 h cont. exposure CASP3 levels) (p < 0.05). Exposures to both 1800 MHz and 2600 MHz RFR for 3 different exposure durations did not change the activation of caspases we analyzed in this study (p > 0.05). CONCLUSION: Decreases in the cell viability of HT-29 cells for certain frequencies and also durations are consistent with signifi cant increases in caspase activations. The results of caspase activation after 1800 MHz or 2600 MHz RFR exposures can be interpreted as the activation of different types of cell death pathway by caspase signaling cascades (Fig. 15, Ref. 56).
Associations between early maladaptive schema domains of parents and their adult children: The role of defence styles
(2021) Karaarslan, Cemre; Eldogan, Dilay; Yigit, Ibrahim; 0000-0003-3782-0304; 33624909
Although existing research recognized the associations between early maladaptive schemas (EMSs) of parents and their adult children, the mechanisms that underpin these associations were not fully understood. Therefore, the purpose of the current study was to explore the role of defence styles (DSs) on the associations between two EMS domains (Disconnection/Rejection and Impaired Autonomy) of parents and their adult children. Two hundred and fifteen families (i.e., mother, father, and their adult children) participated in the study. Both parents and their adult children were asked to complete Young Schema Questionnaire-Short Form (YSQ-SF) and Defence Style Questionnaire (DSQ) to assess their EMS domains and DSs. According to the results of the current study, there were significant associations between Disconnection/Rejection and Impaired Autonomy EMS domains of parents and their adult children, and these associations were mediated by only immature DS of parents and their adult children in a serial mediation model. These results contributed to our understanding of the associations between EMS domains of parents and their adult children through immature DSs. Moreover, our findings highlighted the importance of synthesizing the concepts of different theories to enhance our understanding of mental representations in families.
The Basis of Proverb Education (Nogai Turkish and Culture Sample)
(2021) Yilmaz, Aysun Ezgi
beta-Adrenoreceptor antagonists reduce cancer cell proliferation, invasion, and migration
(2014) Iseri, Ozlem Darcansoy; Sahin, Feride Iffet; Terzi, Yunus Kasim; Yurtcu, Erkan; Erdem, S. Remzi; Sarialioglu, Faik; 25026350
Context: Propranolol, atenolol, and ICI118,551 are non-selective beta-adrenergic receptor (AR), beta(1)-AR, and beta(2)-AR antagonists, respectively. Objective: We investigated the efficacy of propranolol, atenolol, and ICI118,551 on proliferation, migration, and invasion of non-stimulated breast (MCF7), colon (HT-29), and hepatocellular (HepG2) cancer cells. Materials and methods: beta-AR expression profiling of cells was performed by real time PCR. Cell proliferation was determined by MTT. Boyden chamber and scratch assays were performed to evaluate invasion and migration. Results and discussion: All cell lines expressed beta-ARs. ICI118,551 was the most cytotoxic, whereas atenolol was the least effective beta-AR antagonist for 24, 48, and 72 h. Cell invasion was inhibited by ICI118,551 (45, 46, and 50% for MCF7, HT29, and HepG2, respectively) and propranolol (72, 65, and 90% for MCF7, HT29, and HepG2, respectively). Propranolol, atenolol, and ICI118,551 reduced migration of MCF7, HT-29, and HepG2 cells to varying extents depending on the application concentration and duration. Propranolol and atenolol reduced migration of MCF7 and HT-29 in a concentration-dependent manner, whereas migration of these cells decreased after 48 and 72 h of ICI118,551 applications. Conclusion: Beta(2)-AR antagonist seemed to be the most cytotoxic beta-blocker on non-stimulated cancer cells. Propranolol and ICI118,551 were more effective than atenolol in inhibiting invasion and migration of non-stimulated MCF7 and HT-29 cells; ICI118,551 being the most potent. Concordantly, beta(2)-selective blockage seemed to be more effective for non-stimulated cells. Effect of the selective beta-AR antagonists showed variation depending on the concentration, incubation time, and histological origin of cells.
Biotization of In Vitro Plants with Endophytic Beneficial Bacterium (PGP_invit) to Understand Plant-bacteria Interaction
(2019) Turkolmez, Nil; Albayrak, Merve; Batool, Maria; Kayihan, Doga Selin; Ekinci, Hamit; Akkaya, Ozlem; Seker, Mine Gul; Kayihan, Ceyhun; Aydinoglu, Fatma; Ciftci, Yelda Ozden
Building Resilience and Interconnectedness among Humans and Nonhuman Entities: Aminatta Forna's Happiness
(2021) Sarikaya Sen, Merve; 0000-0003-2091-2536
Using the theoretical tools provided by the conceptualisations of resilience and interconnectedness, this article carries out a comprehensive analysis of Aminatta Forna's Happiness (2008). The starting hypothesis explored in this article is that Happiness represents the transformational process of suffering and/or psychological wounds through the reparative agency of interconnectedness among humans as well as between humans and animals. Accordingly, this article will first demonstrate how the novel represents the possibility of healing one's psychological wounds through the stories of Attila and Jean, the two protagonists falling in love after a chance encounter. It will then explore how the novel presents the necessity of establishing relationality between the self and the other in coping with adversities. Finally, it will elaborate on the indispensable coexistence between humans and animals in the novel, which provides the characters with the possibility for achieving the ecological self. In doing so, this article will demonstrate that Happiness succeeds in representing the need for an interdependent world and the impossibility of a sovereign self in order to achieve happiness in the contemporary age.
BULGARIAN PLAYGROUNDS IN TRANSITION: DO CHILDREN'S AND PARENTS' PERCEPTIONS DIFFER?
(2017) Orman, Turkan Firinci; 0000-0001-9137-0899
Focusing on ideological dualism reflected in children's playgrounds in Bulgaria, this paper examines cross-generational differences in parents' and children's perceptions of playgrounds and their equipment designed during the Cold War and post-Cold War periods, respectively. This political conception of playgrounds evokes and aligns with Winner's (1980) theory and work, "Do artifacts have politics?" Both qualitative and quantitative methods were used within a mosaic approach that incorporated a range of techniques for eliciting young children's views about extant playground models. The findings of this descriptive analysis provide evidence that both children and their parents endorsed post-Cold War playground designs in Bulgaria because of their better functionality. However, their perceptions differed on functional playground dimensions such as joy, safety, nature, socialization, and design. Significantly, Cold War playground designs were praised for their notable affordance of children's socialization.