Tıp Fakültesi / Faculty of Medicine
Permanent URI for this collectionhttps://hdl.handle.net/11727/1403
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Item Influence of Exercise on Leptin, Adiponectin and Quality of Life in Type 2 Diabetics(2015) Dede, Nesrin Dogan; Ipekci, Suleyman Hilmi; Kebapcilar, Levent; Arslan, Mihriban; Kurban, Sevil; Yildiz, Mustafa; Gonen, Mustafa SaitPurpose: This study aimed to investigate the influence of aerobic exercise on the quality of life and leptin and adiponectin levels in patients with type 2 diabetes mellitus. Material and Method: Patients were randomized into two groups: aerobic exercise-training and control group. Parameters were assessed at baseline and end of the twelve-week follow-up for 60 type 2 diabetic patients who completed the program. The 36-item Short Form Health Survey was administered to the patients. Results: The exercise-training group results showed a decrease in adiponectin and leptin levels, a reduction of waist circumference and percentage of body fat (p=0.007, 0.023, 0.012 and 0.048, respectively). The leptin levels in the aerobic exercise group were positively correlated with body mass index (r=0.303, p=0.021) and percentage of body fat (r=0.371, p=0.005); they were negatively correlated with physical problems (r=-0.482; p=0.009) and pain (r=-0.540; p=0.003). Exercise led to statistically significant improvements in the SF-36 physical functioning and mental health subscales (p=0.020 and 0.023, respectively). Discussion: The association of better HbA1c, waist circumference, and percentage of body fat with improved mental and physical scores may be related to a decrease in leptin levels, despite a significant reduction in serum adiponectin levels.Item Serum adiponektin ve leptin seviyeleri ile diz osteoartritinin klinik ve radyolojik şiddeti arasındaki ilişki(Başkent Üniversitesi Tıp Fakültesi, 2016) Güngör Oygür, Ayşegül; Nur, Sacide NurEn yaygın erişkin eklem hastalığı olan osteoartritin sistemik bir bozukluk olduğunu gösteren ve metabolik sendroma benzer etkileşimlere sahip olduğunu öne süren kanıtlar gün geçtikçe artmaktadır. Adipokinlerin çeşitli inflamatuvar belirteçlerin salınımında etkili olarak osteoartrit patofizyolojisinde rol oynadıkları düşünülmekte ve hastalık progresyonu için biyokimyasal belirleyici olarak kullanılması konusunda çalışmalar devam etmektedir. Bu amaçla çalışmamızda serum adiponektin ve leptin seviyeleri ile diz OA' nin klinik ve radyolojik şiddeti arasındaki ilişki araştırılmıştır. ACR diz OA tanı kriterlerine göre primer diz OA tanısı konmuş, 40 yaş ve üzerinde toplam 76 hasta aydınlatılmış onamları alındıktan sonra çalışmaya dahil edilmiştir. Hastaların demografik verileri, vücut kitle indeksleri (VKİ), serum adiponektin ve leptin seviyeleri tespit edilmiştir. OA radyolojik şiddeti Kellgren-Lawrence evrelemesiyle; klinik şiddeti ise visüel analog skala (VAS), Western Ontario and McMaster Universities Arthritis Index (WOMAC) ve Short Form- 36 (SF-36) soru skalalarıyla değerlendirilmiştir. Serum leptin ve adiponektin düzeyleriyle diz OA‟nın radyolojik ve klinik şiddeti arasında aşikar bir ilişki gösterilememiştir. Ancak literatürle uyumlu olacak şekilde serum leptin seviyeleri VKİ ile adiponektin seviyeleri ise yaş ile korele bulunmuştur. Elde edilen veriler ve yapılmış diğer çalışmalar ışığında adiponektin ve leptin serum düzeylerinin OA' in klinik izlem ve prognoz tayininde etkili belirteçler olamayacağı ön görülebilir, fakat bu yaygın hastalıkta etkin ve kolay kullanılabilecek laboratuar belirteçlerin gerekliliği bir kez daha vurgulanmıştır. With each passing day evidence indicating osteoarthritis, the most prevalent type of adult arthritis, as a systemic affliction and having metabolic syndrome-like effects is increasing. Adipokines are thought to play a role in the pathophysiology of osteoarthritis (OA) by mediating the secretion of variable inflammatory molecules and research about their use as biochemical markers for monitoring the disease is ongoing. In the light of this information, we have investigated the relationship between serum adiponectin and leptin levels and the clinical and radiological severity of knee OA in our study. A total of 76 patients, fulfilling the diagnostic criteria of the ACR knee OA, with at least 40 years of age were enrolled into our study after giving informed consents. Demographic datas, body mass indexes (BMI), serum adiponectin and leptin levels were obtained for each patient. Radiological severity of the OA was assesed by Kellgren-Lawrence staging system; and clinical severity was assesed by visual analog scale (VAS), Western Ontaria and McMaster Universities Arthritis Index (WOMAC) and Short Form-36 (SF-36) scores. We found no significant corelation between serum leptin and adipokine levels between clinical and radiological severity of knee OA. But corelations were found between serum leptin level and BMI, and between serum adiponectin level and age as shown in other studies. With our study data and datas from other variable studies it could be concluded that serum adiponectin and leptin levels would not be effective markers for monitoring and predicting the outcomes of OA; and it was once again stressed that we need more effective and easy-to-use laboratory markers for this common disease.