Tıp Fakültesi / Faculty of Medicine

Permanent URI for this collectionhttps://hdl.handle.net/11727/1403

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    Serum YKL-40 (Chitinase 3-Like Protein 1) Levels in Migraine Patients During An Attack
    (2023) Horasanli, Bahriye; Sak, Zeynep Caliskan; Ozsahin, Aysun; Karabulut, Keziban Ucar
    Objectives: The aim of this study was to investigate YKL-40 in migraine patients during migraine attacks. Methods: In this prospective study, 30 migraine patients with aura (MWA) and 30 migraine patients without aura (MWOA) who presented to the Neurological Outpatient Department of Konya City Hospital during a migraine episode as well as 28 healthy controls were included. According to the manufacturer's recommendations, serum YKL-40 levels were determined using an ELISA kit (FineTest). Statistical analysis of the data was performed with the IBM SPSS version 20.0 program. Results: The mean gender and age were similar between groups (p > 0.05). The serum YKL-40 level was 3575 +/- 604.975 pg/ml in the MWA group, 3339 +/- 492.689 pg/ml in the MWOA group and 3190 +/- 544.018 pg/ml in the control group. YKL-40 levels were significantly higher in MWA than in the control group (p=0.028). YKL-40 levels were similar in the MWA and MWOA groups (p=0.302). No significant difference was found between the group with MWOA and the control group (p=0.915). Conclusion: Although YKL-40 levels are increased in patients with migraine with aura during an attack, comprehensive studies with a larger sample are needed to clarify the relationship between YKL-40 and migraine.
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    Relationship between Helicobacter pylori infection and white matter lesions in patients with migraine
    (2022) Ocal, Serkan; Ocal, Ruhsen; Suna, Nuretdin; 35597897
    Background/aim White matter lesions (WML) are more frequently observed in migraine patients than in the average population. Associations between Helicobacter pylori (H. pylori) infection and different extraintestinal pathologies have been identified. Here, we aimed to investigate the association between H. pylori infection and WML in patients diagnosed with episodic migraine. Materials and methods A retrospective study was conducted with 526 subjects with a diagnosis of episodic migraine. Hyperintensity of WML had been previously evaluated in these patients with brain magnetic resonance imaging (MRI) examinations. Previous endoscopic gastric biopsy histopathological examination of the same patients and reports on H. pylori findings were recorded. The demographic characteristics of the patients, such as age, gender and chronic systemic diseases such as hypertension and diabetes mellitus (DM) were recorded. Statistical evaluation was made. Results Evaluation was made among 526 migraine patients who met the inclusion criteria, comprising 397 (75.5%) females and 129 (24.5%) males with a mean age of 45.57 +/- 13.46 years (range, 18-69 years). WML was detected on brain MRI in 178 (33.8%) patients who were also positive for H. pylori (p < 0.05). Subjects who are H. pylori-positive with migraine, WML were observed at a 2.5-fold higher incidence on brain MRI (odds ratio: 2.562, 95% CI 1.784-3.680). WML was found to be more significant in patients with hypertension and migraine than those without (p < 0.001). Older age was also found to be associated with WML (OR = 1.07, 95% CI: 0.01-0.04, p < 0.001). The age (p < 0.001), H. pylori (p < 0.001), hypertension (p < 0.001), and hypertension + DM (p < 0.05), had significant associations in predicting WML according to the multivariate logistic regression analysis. The presence of hypertension had a higher odds ratio value than the other variables. Conclusion It was concluded that H. pylori infection, as a chronic infection, can be considered a risk factor in developing WML in subjects with migraine.
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    HEADACHE CHARACTERISTICS IN GERIATRIC AGE GROUP ACCORDING TO ICHD-3 BETA VERSION
    (2018) Ciftci, Eda Derle; Toprak, Munire Kilinc; Yildirim, Irem
    Introduction: The aim of this study was to screen patients aged >= 65 years admitted to the Baskent University Hospital Neurology Polyclinic between 2011 and 2013 and classify them according to the International Classification of Headache Disorders, 3rd edition. Materials and Method: In total, 175 patients (126 females and 49 males) were screened. First, they were separated into primary and secondary headache groups, and the subgroup headache types were then defined within these groups according to the International Classification of Headache Disorders, 3rd edition; then, the concurrence of accompanying chronic diseases were examined. Results: In the primary headache group, 21.1% of the patients had migraine, 39.4% had tension-type headache, and 51% had trigeminal neuralgia; in the secondary headache group, 24.2% of the patients had headache attributed to hypertension, 18.2% had headache attributed to temporal arteritis, 18.2% had headache attributed to cervical pathology, and 12.1% had headache attributed to intracranial mass. Conclusion: This study was conducted to detect the most commonly seen headache types in geriatric population, and the results of this study are important in terms of increasing awareness of the evaluation of both primary and secondary headaches in geriatric patients. Because the study was conducted with a less patient population, it is important in terms of more accurately demonstrating the factors constituting the etiology of headache in this patient group.