Tıp Fakültesi / Faculty of Medicine

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    Analysis of the patients admitted to emergency department due to urogenital trauma and investigation of factors that affect mortality
    (2017) Kavalci, Cemil; Sozen, Semih; Celik, Simsek; Akpinar, Cafer; Guven, Fatma Mutlu Kukul; Yel, Cihat; Sait, Omer
    Objective: To determine the general characteristics of urogenital trauma, and the factors that impact on mortality. Methods: Patients who were over 18 years of age admitted to the emergency service with urogenital injury between 1 January 2010 and 31 December 2014 were evaluated retrospectively. Age, gender, type of trauma, injured urogenital organs, vital parameters, additional organ injuries and mortality rate were investigated. Categorical variables were compared by using Chi-square test and comparing to groups data were performed with the Mann-Whitney and Kruskal-Wallis tests. P < 0.05 was considered statistically significant. Results: The median age of 174 patients was 35 years (interquartile range: 22), and 150 patients (86.2%) were males. It was determined that the incidence of urogenital trauma increased in August and September. The kidney was the most frequently injured organ (41.4%) and the most common cause of injury was traffic accidents (49.4%). Mean arterial pressure and revised trauma score were the lowest while pulse rate was the highest in renal trauma patients (P < 0.05). Mean arterial pressure, revised trauma score and respiratory rate were low in mortal group while pulse rate and Glasgow coma scale scores were significantly higher (P < 0.05). Conclusions: It is determined that the most common injured organs in trauma patients are kidneys and bladder and also no single factor is effective on mortality.
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    Scintigraphic, histopathologic, and biochemical evaluation of lycopene effects on renal ischemia reperfusion injury in rats
    (2017) Börcek, Pelin; Sadic, Murat; Atilgan, Hasan Ikbal; Aydin, Arif; Koca, Gokhan; Korkmaz, Meliha; Karakan, Tolga; Surer, Hatice
    Introduction/Objective Medical protection of kidneys against ischemia reperfusion injury is very important. Many agents have been used for the protection of ischemia reperfusion renal tissue injury. We aimed to evaluate the radioprotective effect of lycopene on kidneys in ischemia reperfusion injury with histopathological, biochemical, and scintigraphic parameters. Methods Twenty-one Wistar male albino rats were divided into the following three groups: lycopene, control, and sham group. In the lycopene group, lycopene was started three days before right renal ischemia reperfusion injury and continued for 15 days. In the control group, right renal ischemia reperfusion injury was applied with no medication. In the sham group, neither right renal ischemia reperfusion injury nor medication were applied. On the 15th day, all rats were sacrificed after Tc-99m-dimercaptosuccinic acid (DMSA) scintigraphies were taken. Histopathological, biochemical, and scintigraphic evaluations were made. Results The histopathological score was lower in the lycopene group. In biochemical analysis, myeloper-oxidase levels were lower in the lycopene group than in the control group, but not statistically significant. Malondialdehyde and nitrite levels were lower in the lycopene group than in the control group. The postoperative mean Tc-99m-DMSA uptake values were 44.82 +/- 1.84 in the lycopene group, 38.92 +/- 1.17 in the control group, and 50.21 +/- 1.35 in the sham group. DMSA uptake values were higher in the lycopene group than in the control group. Conclusion Lycopene seems to be an effective agent for protection of kidneys in ischemia reperfusion injury as demonstrated by the histopathological, biochemical, and scintigraphic parameters.
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    An Extremely Rare Kidney Tumor: Primary Intraparenchymal Squamous Cell Carcinoma
    (2017) Ipekci, Tumay; Yuksel, Mustafa; Yildiz, Ali; Inal, Gulsah; Ipekci, Oncel; 0000-0002-2755-0526; AAB-2986-2020
    Primary squamous cell carcinoma of the renal parenchyma is a rare entity and only 4 cases have been reported in the literature. A 73-year-old female patient presented to our clinic with the complaint of right flank pain. On radiologic evaluation, a 6x5x4 cm hypodense mass showing heterogeneous contrast enhancement was observed in the upper pole of the right kidney. An uneventful laparoscopic radical nephrectomy was performed. Final pathologic diagnosis was squamous cell carcinoma. No pathological involvement was observed on postoperative positron emission tomography/ computed tomography. Our patient is still alive and she has not received any adjuvant treatment.