Tıp Fakültesi / Faculty of Medicine

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search.filters.applied.f.rights: search.filters.rights.info:eu-repo/semantics/closedAccessSubject: search.filters.subject.patent ductus arteriosus

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    Association of Respiratory Distress Syndrome and Perinatal Hypoxia with Histologic Chorioamnionitis in Preterm Infants
    (2014) Ecevit, Ayse; Anuk-Ince, Deniz; Yapakci, Ece; Kupana-Ayva, Sebnem; Kurt, Abdullah; Yanik, Filiz F.; Tarcan, Aylin; 0000-0002-4369-2110; 0000-0002-4430-444X; 0000-0002-2232-8117; 24827948; I-6746-2016; HIU-0129-2022; AAJ-4616-2021; AIC-4823-2022
    The aim of this study was to evaluate the relationship between neonatal mortality-morbidity and pregnancies with preterm premature rupture of membranes (PPROM), particularly those complicated by histologic chorioamnionitis (HCA), in preterm infants. A retrospective study was conducted on 58 preterm neonates born to 46 pregnant women with PPROM. Maternal characteristics, placental examination, and neonatal morbidity and mortality were analyzed. Of 1,392 deliveries, 46 (3.3%) pregnancies and 58 newborn infants were complicated with PPROM. HCA was present in 21 (1.5%) cases, and 15 of them were <28 weeks of gestational age. In the HCA (+) group, 8/21(38%) neonates had 5-minute Apgar scores of <5, 12/21 (57.1%) infants had patent ductus arteriosus (PDA), and 16/21 (76.1%) infants had respiratory distress syndrome (RDS). The latency period was significantly longer and the rate of chorioamnionitis and percentage of major neonatal morbidity and mortality were significantly higher in preterm infants with gestational age <28 weeks. Respiratory distress syndrome, perinatal hypoxia and PDA were significantly associated with HCA in preterm infants.
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    "Shunt Index'' Can Be Used to Predict Clinically Significant Patent Ductus Arteriosus in Premature Neonates in Early Post-Natal Life
    (2014) Yapakci, Ece; Ecevit, Ayse; Torer, Birgin; Ince, Deniz Anuk; Gokdemir, Mahmut; Gulcan, Hande; Tarcan, Aylin; https://orcid.org/0000-0002-2232-8117; https://orcid.org/0000-0002-4369-2110; https://orcid.org/0000-0002-5676-2747; 23816200; AIC-4823-2022; AAJ-4616-2021; I-6746-2016; N-4174-2014
    Background: This study aimed to examine the differences between arterial and inferior caval vein oxygen saturation, fractional oxygen extraction, and the shunt index, which were calculated in the diagnosis of patent ductus arteriosus. Methods: Twenty-seven preterm infants were included in this study and were divided into two groups according to patent ductus arteriosus. Among them, 11 (41%) infants had haemodynamically significant patent ductus arteriosus and 16 (59%) did not have significant patent ductus arteriosus. Synchronous arterial and venous blood gases were measured during the first post-natal hours after the insertion of umbilical catheters. The differences between arterial and inferior caval vein oxygen saturation, inferior body fractional oxygen extraction, and the shunt index were calculated. Echocardiography was performed before the 72nd hour of life in a selected group of patients who had haemodynamically significant patent ductus arteriosus. Ibuprofen treatment was administered to patients with patent ductus arteriosus. Echocardiography was performed on the 72nd hour of life in preterm infants without any clinical suspicion of patent ductus arteriosus. Results: The early measured differences between arterial and inferior caval vein oxygen saturation and inferior body fractional oxygen extraction were found to be lower and the shunt index was found to be higher in the haemodynamically significant patent ductus arteriosus group than in the group without haemodynamically significant patent ductus arteriosus. Conclusion: We found that the shunt index, calculated in the first hours of life as >= 63%, predicted haemodynamically significant patent ductus arteriosus with a sensitivity of 78% and specificity of 82% in preterm newborns.