Tıp Fakültesi / Faculty of Medicine
Permanent URI for this collectionhttps://hdl.handle.net/11727/1403
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Item Angiogenesis Inhibition Impairs Testicular Morphology in Experimental Left Varicocele Rat Model(2014) Gokhan-Kose, M.; Erdem, S. R.; Peskircioglu, C. L.; Caylak, B.; https://orcid.org/0000-0002-2491-0178; https://orcid.org/0000-0002-7537-2170; 24702910; AHI-3170-2022; AAJ-2370-2021Introduction: It has been reported that varicocele might promote angiogenesis. However, it is not clearly identified how angiogenesis affect testicular morphology or spermatogenic activity. The objective of the study is to investigate the effect of spironolactone, as an angiogenesis inhibitor, on the ipsilateral testis morphology in left varicocele-induced rats. Materials and methods: Twenty four adult (12-14 mo), male Wistar albino rats were randomly assigned to four groups (n=6, for each): 1. Control group, 2. Sham-operated group, 3. Experimental left varicocele group and, 4. Spironolactone (20 mg/kg/day)-treated experimental left varicocele group. Histopathological findings in rat testis were investigated. Results: Microvessel density increased in varicocele group and spironolactone inhibited angiogenesis neither by antimineralocorticoid, nor by antiandrogenic effect. However, spermatogenesis impaired in spironolactone treated varicocele group. Conclusion: Angiogenesis seems to be a protective process in varicocele. Spironolactone treatment, probably by inhibiting angiogenesis, impairs testicular morphology. (C) 2013 AEU. Published by Elsevier Espana, S.L. All rights reserved.Item Cardioprotective Effect of Postconditioning Against Ischemia-Reperfusion Injury Is Lost in Heart Of 8-Week Diabetic Rat(2016) Altunkaynak-Camca, Hande Ozge; Ozcelikay, Arif T.; 26492068; CAG-1071-2022Although ischemic preconditioning (IPC) and ischemic postconditioning (IPost) result in protection against ischemia-reperfusion (I/R) injury in healthy hearts, pathological conditions such as diabetes can modify the protective effects of IPC and IPost. There are a few studies concerning the effect of IPost only in diabetic hearts which have similar or decreased tolerance to I/R injury. In the present study we investigated the effects of IPost in diabetic hearts which had increased tolerance to I/R injury. Isolated hearts from control and diabetic rats were subjected to global ischemia (40 min) followed by reperfusion (40 min). IPost was induced by six cycles (10 s) of reperfusion and ischemia after the global ischemia. After I/R, cardiac recovery in diabetic hearts was better than that in control hearts. IPost did not produce any further protection in the diabetic hearts whereas it resulted in a significant recovery in the control hearts. Similarly, the decreased troponin I (TnI) levels of diabetic hearts did not change after IPost. However, IPost significantly lowered the increase in TnI levels of control hearts. In conclusion, these results show that IPost can not produce a further protection in the hearts of 8 -week diabetic rats which have increased tolerance to I/R injury.Item The Effect of Intraperitoneal N-Acetylcysteine on Postoperative Adhesions in Rat Models(2017) Asian, Gizem Inal; Otgun, Ibrahim; Acer, Tugba; Tepeoglu, Merih; Hicsonmez, Akgun; https://orcid.org/0000-0002-9894-8005; 28874629; AAK-5222-2021ATM: In this study, we researched the effect of local administration of N-acetylcysteine (NAC) on postoperative intra-abdominal adhesion formation in the rat models. METHODS: 20 female Wistar Albino rats which were 5-7 months old are used for the study. The rats were divided into two equal groups. Group one was administered saline solution (n=10) while group two was administered NAC (n=10) after caecal abrasion. They were dissected on postoperative tenth day and were examined macroscopically and microscopically for the adhesion formation. Intraperitoneal adhesion formation was scored blinded with Evans model. The most adherent bowel section was excised for histopathologic examination. Mann Whitney U test were used for statistical analysis. RESULTS: In Group one, all rats have had adhesions. None of the rats in Group two had either severe inflammatory cell reaction or dense interstitial fibrosis. Macroscopic adhesion formation and microscopic inflammatory cell reaction and interstitial fibrosis formation after surgery were less at the group two (NAC applied) (p<0.05, p<0.05, p<0.05). CONCLUSION: We believe that the intraperitoneal single dose usage of NAC may be promising for decreasing the postoperative intraabdominal adhesions.Item The Effect of High Dose Vitamin D on the Sympathetic Skin Response in Rats(2022) Masud, Haifa; Dolu, NazanItem The Effects of High Dose Vitamin D and Zinc on Anxiety and Exploratory Activity in Rats(2022) Baroud, Amna Abdulsalam; Dolu, Nazan