Tıp Fakültesi / Faculty of Medicine

Permanent URI for this collectionhttps://hdl.handle.net/11727/1403

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search.filters.applied.f.language: search.filters.language.turSubject: search.filters.subject.Hemodialysis

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    The relationship between malnutrition, inflammation and cannulation pain in hemodialysis patients
    (2018) Kal, Ö.
    Malnutrition-inflammation and pain are the most important factors affecting quality of life of end-stage renal failure patients. In this study we looked at the relationship between malnutrition-inflammation and pain perception in hemodialysis (HD) patients. Among patients with chronic renal failure incompliance to treatment, and their diseases is often present. We think that in these patients we can improve treatment performance and quality of life by increasing patient compliance. In 44 hemodialysis patients, we found a positive correlation; between perception of pain and malnutrition-inflammation score (MIS) (p<0.001, r=0.768), C Reactive Protein (CRP) and MIS (p<0.05, r=0.357), CRP and pain (p<0.01, r=0.423), and a negative correlation between pain and albumin (p<0.01, r=-0.47). In conclusion, we have shown that inflammation and malnutrition are related to each other in HD patients in accordance with previous studies. Besides, we have demonstrated that pain perception in these patients is greater than in HD patients without inflammation and malnutrition. We hope that treatment of malnutrition and inflammation will decrease the compliance problems, mortality rates, and increase pain thresholds and quality of life in HD patients. © 2018, Logos Medical Publishing. All rights reserved.
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    Effects of HCV-RNA positivity on serum IL-1 beta levels in chronic hemodialysis patients
    (Gazi Medical Journal ,12 ,4 ,155-158, 2001) Yücel, Ayşegül; Köseoğlu, Hamide; Yücel, Ahmet Eftal; Özdemir, Nurhan; Haberal, Mehmet
    Hepatitis C virüs (HCV) positivity and inflammatory cytokines such as interleukin(IL)-} beta, tumor necrosis factor-alpha and IL-6 secreted by activated macrophages are known to be important morbidity factors in chronic hemodialysis (HD) patients. in this preliminary stııdy, we aimed to compare serum IL-1 beta levels of 20 HCV-RNA-positive and 23 HCV-RNA-negative chronic HD patients. Methods: HCV-RNA-positivity and serum IL-1 beta levels were studied using nested reverse transcriptase-polymerase chain reaction and ELISA methods, respectively. Results: We could detect no statistically signifıcant difference between serum IL-1 beta levels in HCV-RNA-positive and HCV-RNA-negative groups (p>0.05). Conclusion: To our knowledge, this is the fırst study to examine the relationship between serum IL-1 beta level and HCV infection in HD patients. We had expected the level of IL-1 beta to be higher in HCV-RNA-positive group, and believe that the blood-dialyzer interaction strongly activated mononuclear cells, thus generating elevated levels of IL-1 beta in both groups. This could explain why HCV infection apparently did not affect serum IL-1 beta levels.