Tıp Fakültesi / Faculty of Medicine

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    Urachal Adenocarcinoma: A Case Report with 4-Year Follow-up
    (2023) Kayra, Mehmet Vehbi; Kahraman, Oguzhan; Egilmez, Mehmet Tulga; Hasbay, Bermal; 0000-0003-3691-8617; 0000-0002-7349-9952; AAC-8630-2022; AAK-8372-2021
    The urachus is an embryological remnant that lies between the bladder and umbilicus as a fibrous band that attaches the cloaca to the allantois in the intrauterine period. Urachal adenocarcinoma is a rare tumor and more aggressive in behavior than primary bladder tumors. In this case report, we present a 37 years old female patient with urachal adenocarcinoma in whom transurethral resection of the bladder revealed a signet ring adenocarcinoma of the bladder with invasion of the muscularis propria. The patient had left manubrium sterni and bone marrow infiltration. Partial cystectomy and sternal resection were performed, followed by radiotherapy and chemotherapy. There was no recurrence or new metastasis at the 4-year follow-up. In conclusion, a combination of surgery, chemotherapy, and radiotherapy is a suitable approach for the treatment of oligo-metastatic urachal carcinoma.
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    Prostate Biopsy in the Elderly: Histologic Findings and Treatment Necessity
    (2014) Akman, Ramazan Yavuz; Koseoglu, Hikmet; Oguzulgen, Ahmet Ibrahim; Sen, Erhan; Yaycioglu, Ozgur; 25374232
    The aim of this study is to determine results of high prostate specific antigen (PSA) or abnormal digital rectal examination driven prostate biopsies performed in our Department in men aged 75 or more and to show the characteristics of pathology results. The hospital records of the patients who had high PSA or abnormal digital rectal examination driven prostate biopsy in two common university based research hospitals have been reviewed retrospectively. Patients aged 75 years or older at the date of biopsy whose records provided pathology results and full medical history were evaluated for the study. A total of 103 patients were evaluated with a mean age of 79.4 +/- 3.4 years. More than half of the patients (55.1%) were in their seventh decade and the rest were in the eighth decade. Median PSA value was 15.0 (range 2.1-4500) ng/ml. In most of the biopsies (67%), PSA levels were lower than 20 ng/ml. In almost half of the patients (48%), digital rectal examination was abnormal. In 68.9% of the patients, there were at least one or more associated co-morbid diseases. Gleason scores were 7 or higher in 73%, and 8 or higher in 37% of the patients with prostate cancer. Four of the 70 (6%) patients had bone metastases. Castrations were applied to most of the patients with prostate adenocarcinoma (% 79). High percentage of high grade (Gleason 7 or more) prostate adenocarcinoma in the elderly refutes the perception of prostate cancer in this age group as clinically insignificant. Therefore, it is to be kept in mind that prostate cancer in the elderly an be clinically significant and prostate biopsies are to be performed when necessary.