Tıp Fakültesi / Faculty of Medicine
Permanent URI for this collectionhttps://hdl.handle.net/11727/1403
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Item Gender and Exposure to Childhood Violence are Important Determinants of Domestic Violence Among Academics(2023) Kurt, Gonca; Akin, Ayse; 38034745Domestic violence is a common and significant social problem that threatens public health, violates human rights, and poses significant obstacles to national development. This study aimed to evaluate both male and female academics' knowledge and views on domestic violence, and determine its incidence and risk factors among academics. Participants comprised 304 academics working at universities, who were selected by cluster sampling from seven regions of Turkey. Data were analyzed using thematic coding, descriptive statistics, and multivariate logistic regression. Of the 304 participants, 56.9 % were female academics. The incidence of domestic violence among the academics was 21.4 %, with 25.4 % of female and 16.0 % of male academics reporting having experienced it. Academics who were victims of domestic violence were mostly exposed to it from their spouses. Academics also reported experiencing emotional violence. Female academics were 2.3 times more likely to experience domestic violence than men. Academics who were exposed to violence in childhood experienced 14.1 times more domestic violence than those who were not. Although it seems that a high status in society as an academic reduces the rates of exposure to domestic violence, gender, and witnessing or experiencing violence in early childhood are the most important risk factors for this population. The lack of a solution for domestic violence can be attributed to non-deterrent punishments.Item The Ways to How Patients with Chronic Hepatitis C Find Out Their Disease and Risk Factors(2019) Turan Ozden, HaleIntroduction: Transmission routes and seroprevalence of hepatitis C virus (HCV) may vary between countries and geographic regions. In this study, we planned to investigate patients with chronic hepatitis C admitted to our hospital in order to identify associated risk factors of HCV transmission in our region. Materials and Methods: Eighty-two patients who were admitted to the Infectious Diseases and Clinical Microbiology Outpatient Clink of our hospital between January 2011-December 2014 and who were diagnosed with chronic hepatitis C and/or liver cirrhosis were included into the study. Results: Forty-six (56.1%) of the patients were female and 36 (43.9%) were male patients. Mean age was 60.8 +/- 10.0 (26-81) year. Most common risk factors were surgical intervention (58.5%) and dental treatment (31.7%). Vast majority of the patients found out about their illnesses during routine examinations (81.7%). Conclusion: Early detection of the HCV infection is important in the follow-up and treatment of the disease. This study also emphasized the importance of routine screening in the detection of anti-HCV positivity.Item Correlation of Clinical Risk Factors with Diffusion-Weighted Magnetic Resonance Images in Prostate Cancer Patients Treated with Definitive Radiotherapy(2015) Erbay, Gurcan; Onal, Cem; Guler, Ozan C.; Karadeli, Elif; Koc, ZaferThis study is aimed to correlate apparent diffusion coefficient (ADC) values and clinical T-stage, serum PSA, pathology Gleason scores. We also further analyzed whether ADC values could be used to appropriately define the risk groups. 135 biopsy-proven, radiotherapy-(RT)-treated, prostate cancer patients who underwent pre-RT DW-MRI and standard T2W pelvic MRI were included. ADC and normalized ADC (nADC) values were calculated from DW-MRI delivered a median 8.1 weeks after prostate biopsy. ADC values were correlated with clinical risk factor values by using Pearson correlation test. ADCs in low-, intermediate-, and high-risk patients were 0.873 +/- 0.122X10(-3) mm(2)/s, 0.763 +/- 0.124X10(-3) mm(2)/s, and 0.701 +/- 0.132X10(-3) mm(2)/s (p = 0.001), respectively. Patients with preRT PSA <10 ng/mL had significantly higher ADCs than patients with preRT PSA 10-20 ng/mL (p = 0.02) or >20 ng/mL (p < 0.001). Mean ADC for patients with Gleason score <7 was significantly higher than patients scoring 7 (p = 0.001) or >7 (p < 0.001). Clinical stageItem Risk Factors for Urothelial Cancers(2016) Kuzgunbay, Baris; Gul, Umit; 0000-0003-3249-0895; AAK-8394-2021Urothelial cancers affect renal pelvis and ureters in the upper urinary tract, however they affect bladder and urethra in the lower urinary tract. The rate of the urothelial carcinoma makes up 3% pf cancers in the world. Although urothelial cancer locations and frequencies show difference, their etiology are similar. Environmental factors are responsible for most urothelial cancer cases. Major risk factors are smoking and chemical carcinogens. Other important factors include radiotherapy, alcohol, coffee consumption, artificial sweeteners, arsenic exposure, schistomiasis, cronical cystitis, urolithiasis, analgesics, cyclophosphamide and genetic predisposition. Identification of these factors and avoiding them are important for the prevention of the disease. The evaluation and follow up of the whole urothelium is critical since the urothelial cancers are a kind of panurethelial diseases.Item Maternal and perinatal characteristics of small-for-gestational-age newborns: Ten-year experience of a single center(2017) Gulumser, Cagri; Uysal, Nihal Sahin; Yanik, Filiz Bilgin; 0000-0001-5385-5502; 28490415; AAA-9475-2020Objective: To analyze the maternal and perinatal characteristics of small-for-gestational-age (SGA) newborns compared with appropriate-for-gestational- age (AGA) newborns in singleton pregnancies managed at our hospital between January 2006 and December 2015. Material and Methods: The study (n=456) and control (n=4925) groups included pregnancies resulting in SGA and AGA newborns, respectively. Additionally, two SGA subgroups were defined according to abnormal (n=34) and normal (n=57) Doppler findings. Maternal demographic features; intracytoplasmic sperm injection (ICSI) pregnancies; gestational age at delivery; birth weight; major congenital anomalies, karyotype abnormalities, and genetic syndromes; maternal and obstetric problems such as hypertensive disorders, diabetes, oligohydramnios, preterm birth; admission to the neonatal intensive care unit (NICU), and perinatal mortality were recorded, and the two groups were compared with respect to these parameters. Results: Mean maternal age, parity, gestational age at delivery, and birthweight were significantly lower; the frequencies of ICSI pregnancies, hypertensive disorders, oligohydramnios, preterm delivery, major congenital anomalies, karyotype abnormalities and genetic syndromes, admission to the NICU and perinatal mortality were significantly higher in the study group (p<0.05). None of the study parameters were significantly different between the two SGA subgroups (p>0.05). Conclusion: The association of SGA with ICSI pregnancies, hypertensive disorders, oligohydramnios, preterm delivery, congenital/chromosomal anomalies, NICU admission and perinatal mortality may be important in perinatal care. Clinical suspicion of SGA necessitates appropriate monitorization and management. Although obstetric outcomes were not significantly different between the two SGA subgroups with abnormal and normal Doppler findings in this study, this finding must be evaluated with caution due to the small sizes.Item Early Life Markers to Predict the Risk for Frequent Wheezing in Infants; Going on a Mysterious Road with an Old Friend, "The Eosinophil"(2018) Turhan, Ali Haydar; Arikoglu, Tugba; Tezol, Ozlem; Aslan, Gonul; Kuyucu, SemanurObjective: In most cases of asthma, wheezing symptoms start in early childhood. Although there are studies evaluating the factors that play a role in the development of childhood asthma, the predictive markers for frequent wheezing in early childhood are still unclear. The aim of our study was to investigate the relation between the wheezing episodes and the familial, prenatal, and postnatal risk factors, and the sensitivity of serum eosinophilic cationic protein (ECP) and eosinophil levels for predicting frequent wheezing. Materials and Methods: Fifty-seven children with acute wheezing and fifty healthy children aged between 1-36 months were included in the study. The children who had >= 3 episodes of wheezing in the next year after presentation were classified as the frequent wheezing group and those with fewer episodes were classified as the infrequent wheezing group. Administration of a comprehensive questionnaire about risk factors for wheezing; blood sampling for serum total IgE, ECP, eosinophil count, food and inhaled specific IgE levels and RSV/adenovirus serology; and skin prick tests were performed. Oral provocation tests were applied in cases of suspected food allergy. Results: Male gender (p=0.024), low socioeconomic level (p=0.046), initiation of milk formula (p=0.009) and eggs (p=0.018) before the fourth month, the presence of mold / umidity at home (p=0.023), eczema (p<0.001), and atopy (p=0.017) rates were significantly higher in the frequent wheezing group. The children with serum ECP levels >= 7.9 mu g/L at enrollment had higher risk of frequent wheezing than those with serum ECP 7.9 mu g/L (p=0.008). The sensitivity of ECP >= 7.9 mu g/L for frequent wheezing was 75.9% and the specificity was 68.7%. Similarly, serum total IgE (>= 154 IU/ml) and total eosinophil count (>= 390 /mm3) were found to be significantly higher in infants in the frequent wheezing group than the other groups (p=0.049, p=0.019). The multivariate analysis showed that the risk of frequent wheezing was 6.6 fold higher in children with a serum ECP level >= 7.9 mu g /L and 5.3 fold higher in the presence of RSV / adenovirus infection (p=0.026, p=0.038, respectively). Conclusion: In conclusion, our study suggested that the increase in serum ECP levels and the presence of RSV / denovirus infection significantly increased the risk of frequent wheezing in children with acute wheezing attacks.