Tıp Fakültesi / Faculty of Medicine

Permanent URI for this collectionhttps://hdl.handle.net/11727/1403

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Has files: YesSubject: search.filters.subject.Immunosuppression

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    The Distribution and Antimicrobial Susceptibility Profiles of Etiologic Agents Isolated From Bacteremia Episodes Among Immunocompromised Patients
    (2017) Demirkaya, Melike Hamiyet; Yesilkaya, Aysegul; Akcil-Ok, Mehtap; Kurt-Azap, Ozlem; 0000-0002-3171-8926; AAK-4089-2021
    Objective: Bacteremia is the leading cause of morbidity and mortality among immunocompromised patients. The aim of this study is to evaluate the etiology of bacteremia and the antibiotic susceptibilities of etiologic agents among immunocompromised patients followed up from January 1, 2012 to July 30, 2013. Methods: Immunocompromised patients, both inpatient and outpatient treated in our hospital, were followed prospectively. The definition of "immunocompromised patients" consisted of solid organ (kidney, liver) transplantation recipients and hemato-oncologic malignancy patients with a history of chemotherapy in the previous month before bacteremia. Results: This prospective study comprised of 167 bacteremia episodes of 130 consecutive immunocompromised patients. The most isolated group of bacteria was Gram-negative bacteria. Escherichia coli was the most commonly (30.8%) isolated bacteria and the second was coagulase-negative staphylococci (15.1%). Fifty one percent of the E. coli isolates were extended-spectrum beta-lactamasepositive. Acinetobacter baumannii was the second most common bacteria of Gram-negative agents and the ratio of multiple drug-resistant (MDR) isolates among Acinetobacter isolates was 73%. Conclusions: Gram-negative bacteria are the most common causative agents of bacteremia in immunocompromised patients in our hospital. The rising ratio of MDR A. baumannii is a striking problem which causes difficult-to-treat infections.
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    Majocchi's granuloma: current perspectives
    (2018) Durdu, Murat; Boral, Hazal; Ilkit, Macit; 0000-0003-1247-3932; 29861637; H-9068-2019
    Majocchi's granuloma (MG) is a rare fungal infection of the dermis that is mainly caused by dermatophytes (in >= 95% of cases); the most frequently identified cause is anthropophilic Trichophyton rubrum. In the rest of the cases, the causes are non-dermatophytic fungi such as Aspergillus species. This review aimed to provide information about the current perspectives on MG regarding its clinical characteristics, predisposing factors, laboratory diagnosis, and treatment strategies. Although the lower extremities were reported to be the most common site of infection, facial involvement has been predominant in the past 5 years. Our literature research showed that the most common predisposing factor (55%) is the use of topical steroid creams without potassium hydroxide examination during treatment of erythematous squamous dermatoses. A reliable diagnosis of MG is based on histopathological examination, including fungal culture and molecular analyses. MG should be treated not only with topical agents but also with systemic antifungal agents that are continued until the lesions are completely resolved. In systemic treatment, the most preferred drug is terbinafine, because of its efficacy, side effects, and safety.
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    Renal transplantasyon hastalarında kaposi sarkomu: klinik özellikler ve insan herpes virüsü-8'in varlığı
    (Türkderm ,39 ,4 ,249-253, 2005) Saray, Yasemin; Seçkin, Deniz; Butros, Reha; Haberal, Mehmet
    Renal transplantasyon hastalarında Kaposi sarkomu sıklığı artmıştır. Bu çalışmada, renal transplantasyon hastalarında gelişen Kaposi sarkomunun prevelansı, klinik özellikleri ile insan herpesvirusu-8'in etyolojideki rolü araştırıldı. Kaposi sarkomu tanısı alan renal transplantasyon hastalanın dosyaları incelendi. Altı hastada lezyonlu deride insan herpesvirusu-8 DNA'sı araştırıldı. Kaposi sarkomu prevelansı %1.2 idi. Mukokütanöz tutulum %76.9'unda, viseral tutulum %61.5'inde saptanmıştı. Tedavi ile hastaların %61.5'inde remisyon, %23.1'inde parsiyel remisyon izlenmişti. Viseral tutulum olanların %25'i ölümle sonuçlanmıştı. Altı hastanın tümünde virusa ait DNA saptandı. Renal transplantasyon hastalarında gelişen Kaposi sarkomunda viseral tutulum sıktır ve mortaliteyi arttırır. Etyopatogenezde, immünosüpresyon ile birlikte insan herpesvirusu-8 rol oynamaktadır. Background and Design: The frequency of Kaposi's sarcoma is increased in renal transplantation patients. The prevalence, clinical features and the etiopathological role of human herpesvirus-8 in Kaposi's sarcoma in renal transplantation patients were investigated in this study. Patients and Methods: Files of renal transplantation patients who were diagnosed as Kaposi's sarcoma have been examined. Human herpesvirus-8 DNA was investigated in the lesional skin of 6 patients. Results: The prevalence of Kaposi's sarcoma was 1.2%. Mucocutaneous and visceral involvement was noted in 76.9% and 61.5% of the patients, respectively. In 61.5% of the patients total remission, in 23.1% partial remission was observed. Twent-five percen[ of the patients with visceral involvement were died. Viral DNA was detected in all of the 6 patients. Conclusion: Visceral involvement is common in Kaposi's sarcoma developing in renal transplant recipients and increases the mortality. Immunosuppresion with human herpesvirus-8 play roles in etiopathogenesis