Tıp Fakültesi / Faculty of Medicine
Permanent URI for this collectionhttps://hdl.handle.net/11727/1403
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Item Effect of Topical Platelet-Rich Plasma on Burn Healing After Partial-Thickness Burn Injury(2016) Ozcelik, Umit; Ekici, Yahya; Bircan, Huseyin Yuce; Aydogan, Cem; Turkoglu, Suna; Ozen, Ozlem; Moray, Gokhan; Haberal, Mehmet; 27262706Background: To investigate the effects of platelet-rich plasma on tissue maturation and burn healing in an experimental partial-thickness burn injury model. Material/Methods: Thirty Wistar albino rats were divided into 3 groups of 10 rats each. Group 1 (platelet-rich plasma group) was exposed to burn injury and topical platelet-rich plasma was applied. Group 2 (control group) was exposed to burn injury only. Group 3 (blood donor group) was used as blood donors for platelet-rich plasma. The rats were killed on the seventh day after burn injury. Tissue hydroxyproline levels were measured and histopathologic changes were examined. Results: Hydroxyproline levels were significantly higher in the platelet-rich plasma group than in the control group (P=.03). Histopathologically, there was significantly less inflammatory cell infiltration (P=.005) and there were no statistically significant differences between groups in fibroblast development, collagen production, vessel proliferations, or epithelization. Conclusions: Platelet-rich plasma seems to partially improve burn healing in this experimental burn injury model. As an initial conclusion, it appears that platelet-rich plasma can be used in humans, although further studies should be performed with this type of treatment.Item Epidemiological and cost analysis of burn injuries admitted to the emergency department of a tertiary burn center(2016) Eser, Tolga; Kavalci, Cemil; Aydogan, Cem; Kayipmaz, Afsin Emre; 0000-0003-1547-1297; 27610329; AAJ-5296-2021; AAC-2597-2020Background: Burn injury is an emergency medical condition that rapidly develops as a result of tissue exposure to electrical, chemical or thermal energy. Therefore, its treatment usually begins at the emergency department. In this study we aimed to perform an epidemiological analysis of burn injuries presenting to the emergency department of a tertiary burn center, and factors affecting the cost of their medical care. Methods: Patients who presented to Baskent University Ankara Hospital Adult Emergency Department with burn injuries between January 2012 and December 2014 were studied for age, sex, time of admission, type of burn injury, clinical prognosis, mortality rate, percent burn area, and total cost of care. A total of 264 patients were enrolled. Chi square test was used for the comparison of categorical variables. Non-parametric tests were used for the comparison of continuous variables. Results: This study included 179 (67.8 %) women and 85 (32.2 %) men. The most common types of burn injuries were hot water burns and scalding. Eleven point seven percent of the patients sustained burn injuries in occupational accidents. 95.1 % of the patients were discharged from the emergency and 4.5 % of them were hospitalized. Only 1 (0.4 %) patient died. There was no significant difference between patient outcomes (discharge vs. hospital admission) with respect to the cost of care (p = 0.846) No significant difference was found between the cost of care of surgical and non-surgical management of burn injuries (p = 0.206). No significant difference was found between the costs of care of different types of burn injuries (p = 0.053). There was a significant difference between burn degrees with respect to the cost of care (p = 0.038). A significant difference was found between the costs of care of patients with a percent burn area of less than 10 % and those with a percent burn area of more than 10 % (p < 0.001), indicating that as percent burn area increased, a proportional increase occurred in the cost of care. Conclusions: Burn degree and percent burn area were the main determinants of the cost of care of burn injuries. In conclusion, burn injuries are preventable by taking occupational measures and raising public awareness about domestic accidents.Item Reliability and Validity of the Turkish Version of Patient and Observer Scar Assessment Scale in Patients with Burnso(2017) Aydogan, Cem; Kabuk, Ayse; Kazan, Ebru Erek; 0000-0003-1547-1297; AAJ-5296-2021Objective: To evaluation reliability and validity of the Turkish version of Patient and Observer Scar Assessment Scale (POSAS) in patients with burns. Methods: This is a methodologically study. Data were collected using POSAS, survey form and plexiglas. Patient Scar Assessment Scale (PSAS) was completed by patients (n=53) and Observer Scar Assessment Scale (OSAS) was completed by two observers separately. The test-retest was measured applying the scales in 25 patients after two weeks. Data were analyzed by Kruskal-Wallis and Mann-Whitney U test. Content validity was determined using Kaiser-Meyer-Olkin, Barlett's test and structure validity was performed by explanatory factor analysis (EFA) and confirmatory factor analysis (CFA); reliability was evaluated using internal consistency, Cronbach's alpha and intraclass correlation coefficient (ICC). Results: Factor weights were in appropriate range according to EFA, 6 items single factor structure of the original scale was valid and had high consistency index according to CFA, ICC between the 7th item and the total points was proportional, inner consistency was highly reliable (PSAS alpha=0.992, OSAS alpha=0.993), consistency between the observers was high (alpha=0.952, r=0.909). It was determined OSAS scores increased as the burn degree increased (p<0.05). Conclusion: POSAS was determined to be a valid and reliable scale in patients with burns in the Turkish society.Item Yanık sonrası akut dönemde gelişen kemik kaybı(Osteoporoz Dünyasından ,13 ,2 ,33-36, 2007) Leblebici, Berrin; Adam, Mehmet; Tarım, Akın M.; Akman, Nafız M.; Haberal, Mehmet A.Bu çalışmanın amacı yanık sonrası akut dönemde kemik kaybının olup olmadığı ve çeşitli parametrelerin kemik kaybı üzerine etkisini araştırmaktır. Hastalar ve Yöntem: Bu çalışma, yanık yüzey alanı %20 ve üzerinde olan 20-50 yaşındaki 19 hasta üzerinde gerçekleştirildi. Hastalar yanık nedeni, yeri, yüzdesi, derecesi, ambulasyon durumu ve fonksiyonel açıdan değerlendirildi. Birinci ayın sonunda total L1-L4 vertebra, distal sol önkol ve total sol femur kemik mineral yoğunluğu ölçüldü. Z skorunun -1'in altında olması kemik kaybı olarak değerlendirildi. Bulgular: Ondördü erkek beşi kadın olan 19 hastanın yaş ortalaması 33.09±11.61 idi. Hastalarımızın %68.4 ünde distal sol ön kol, %21.1 inde total sol femur, %36.8 inde total L1-L4 vertebra z skoru <-1 olarak bulundu. Yanık total vücut yüzey alanı yüzdesi, Fonksiyonel Ambulasyon Skalası ve Fonksiyonel Bağımsızlık Ölçütü ile distal sol ön kol, total sol femur ve total L1-4 vertebra Z skorları arasında istatistiksel açıdan anlamlı bir ilişki yoktu. Sonuç: Yanık hastalarında ilk bir ayda görülen kemik mineral yoğunluğundaki azalma kemik kaybının erken dönemde başladığını göstermekte olup akut dönemdeki kaybın yanık yüzdesi ve fonksiyonel durum ile ilişkili olmadığı bulunmuştur. The purpose of this study was to determine whether a bone loss occurs during acute period following burn injury or not, and to investigate the effects of various parameters on it. Materials and Methods: This study was conducted on 19 patients, ages between 20 and 50, who had a burn injury with more than %20 of Total Body Surface Area (TBSA). We recorded the patients' burn cause, localization, percantage, ambulation and functional status. At the end of the first month, we measured bone mıneral densıty of total L1-L4 vertebrae, left distal forearm, left total femur, in all patients. A Z score less than -1 was accepted to be the indicator of bone loss. Results: The mean age of the patients (14 male and 5 female) was 33.09±11.61. We found a Z score less then -1 in 68.4% of left distal forearm, 21.1% of left total femur and 36.8% of total L1-L4 vertabrae measurements. There were no significant correlations between TBSA, Functional Ambulatıon Scale and Functional Independence Measure, and Z scores. Conclusion: There is a reduction in Bone Mineral Density in patıents wıth moderate/severe burn ınjuries in the acute period which is not correlated wıth neither TBSA nor functional status.