Tıp Fakültesi / Faculty of Medicine

Permanent URI for this collectionhttps://hdl.handle.net/11727/1403

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    Effect of gabapentin on primary surgical treatment of experimental sciatic nerve injury in rats
    (2018) Kardes, Ozgur; Civi, Soner; Bulduk, Erkut Baha; Selcuk, Fazilet Kaya; Suner, Halil İbrahim; Durdag, Emre; Tufan, Kadir; 30394505
    BACKGROUND: The aim of our study is to minimize the morbidity related to nerve injury by determining the protective effects of gabapentin in experimental sciatic nerve injury and end-to-end anastomosis model in rats and to guide clinical studies on this subject. METHOD: In our study, 40 adult male Sprague-Dawley rats were randomly divided into the following five groups: I: Only surgical intervention was applied; II: The sciatic nerve was cut properly and was repaired by end-to-end anastomosis. No additional procedure was performed; III: A single dose of gabapentin at 30 mg/kg was given after anastomosis; IV: 30 mg/kg gabapentin was given for 3 days after anastomosis; and V: 30 mg/kg gabapentin was given for 7 days after anastomosis. The experiment was terminated with high-dose thiopental (50 mg/kg) 60 days after the surgical intervention. The right sciatic nerve was taken from all animals. The obtained sections were examined immunohistopathologically. RESULT: Immunohistochemical properties and Schwann cell proliferation were found to be statistically significantly lower in the control group than in the other groups. Schwann cell proliferation was higher in Group 3 than in Group 5. Immunohistochemical changes were significantly lower in Group 4 than in Group 3. Axonal degeneration was also higher in Group 4 than in Group 3. CONCLUSION: Gabapentin promotes neurological recovery histopathologically in peripheral nerve injury due to its neuroprotective properties. Our study results show that gabapentin can be used as an adjunctive therapy to primary surgical treatment after peripheral nerve injury.
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    Pulmoner arteryel venting ile aort kökü venting yöntemlerinin karşılaştırılması ve iki yöntemin koroner arter bypass cerrahisi sonrası solunum fonksiyonları üzerine etkileri
    (Türk Göğüs Kalp Damar Cerrahisi Dergisi ,16 ,4 ,211-215, 2008) Haberal, İsmail; Akyıldız, Mahmut; Aksoy, Tamer; Ertürk, Esra; Zorman, Yılmaz; Kaplan, Mehmet; Zengin, Mustafa
    Koroner arter bypass ameliyatında kullanılan pulmoner arteryel venting ya da çıkan aort kökü venting yöntemlerinin ameliyat sonrası solunum fonksiyonları üzerindeki etkileri karşılaştırıldı. Çalışma planı: Koroner arter bypass ameliyatı yapılan 301 hasta kullanılan venting yöntemine göre iki grupta incelendi. Aort kökü ventingi (grup I) 151 hastada (109 erkek, 42 kadın; ort. yaş 61±9), pulmoner arteryel ventingi (grup II) 150 hastada (79 erkek, 71 kadın; ort. yaş 61±10) kullanıldı. İki grubun amaliyat öncesi, amaliyattaki ve ameliyat sonrası verileri karşılaştırıldı. Bulgular: Ortalama anastomoz sayısı grup I'de 2.8±0.8, grup II'de 2.4±0.8 (p=0.001), kros klemp süresi grup I'de 42.7±17.4 dk, grup II'de 54.1±23.8 dk (p=0.001) bulundu. Kardiyopulmoner bypass zamanı iki grupta benzer idi (sırasıyla 86.4±56.1 dk ve 77.4±28.6 dk). Ameliyat sonrası ortalama PO2 grup I'de 92.8±4.8 mmHg, grup II'de 106.9±22 mmHg (p=0.001) bulunurken, SO2 değerleri sırasıyla 97.3±23.4% ve 96±8% idi (p=0.001). İki grup, göğüs tüpü drenaji ve kan transfüzyonu miktarları, entübasyon süresi, yoğun bakım ünitesinde ve hastanede kalış süreleri açısından anlamlı farklılık göstermedi. Nazotrakeal aspirasyon grup I'de 20 hastada (%80) gerekirken, grup II'de beş hastada (%20) gerekti (p=0.002). Bronkodilatör ihtiyacı (p=0.01) ve atriyal fibrilasyon gelişimi (p=0.02) grup II'de anlamlı derecede daha azdı. Yeniden entübasyon yedi hastada gerekti; bu hastaların hepsi grup I'de idi (p=0.001). Sonuç: Pulmoner arteryel venting ile akciğerlerin ve sol kalp boşluklarının dekompresyonu etkin bir şekilde sağlanabilir. Aortik venting yöntemiyle karşılaştırıldığında, hastaların ameliyat sonrası solunum fonksiyonları daha iyi olmaktadır. We compared the effects of pulmonary artery and ascending aorta root venting on postoperative pulmonary functions following coronary artery bypass graft (CABG) surgery. Methods: A total of 301 patients undergoing CABG were divided into two groups according to the method of venting. Aortic root venting (group I) was performed in 151 patients (109 males, 42 females; mean age 61±9 years), and pulmonary arterial venting (group II) was performed in 150 patients (79 males, 71 females; mean age 61±10 years). Preopererative, intraoperative, and postoperative findings were compared. Results: The mean number of anastomoses was 2.8±0.8 in group I, and 2.4±0.8 in group II (p=0.001). The mean duration of cross clamping was 42.7±17.4 min in group I, and 54.1±23.8 min in group II (p=0.001). The two groups did not differ with respect to the mean duration of cardiopulmonary bypass (86.4±56.1 min vs 77.4±28.6 min). The mean postoperative PO2 was 92.8±4.8 mmHg in group I, and 106.9±22 mmHg in group II (p=0.001). The corresponding figures for SO2 were 97.3±23.4% and 96±8%, respectively (p=0.001). The amount of chest tube drainage and blood transfusion, intubation time, intensive care unit stay, and hospital stay were similar in the two groups. Nasotracheal aspiration was required in 20 patients (80%) in group I, and in five patients (20%) in group II (p=0.002). The need for bronchodilator treatment and the development of atrial fibrillation were significantly less in group II (p=0.01 and p=0.02, respectively). All the patients that needed reintubation (n=7) were in group I (p=0.001). Conclusion: Pulmonary arterial venting enables effective decompression of the lungs and left ventricle and is associated with better postoperative pulmonary functions compared to aortic venting