Tıp Fakültesi / Faculty of Medicine

Permanent URI for this collectionhttps://hdl.handle.net/11727/1403

Browse

Filters

2015 - 201922020 - 20231

Settings

Has files: NoSubject: search.filters.subject.Osteoarthritis

Search Results

Now showing 1 - 3 of 3
  • No Thumbnail Available
    Item
    Assessment of Pain, Joint Range of Motion, and Balance in Patients with Knee Osteoarthritis
    (2023) Dag, Muhlis Yigitcan; Ergun, Ahmet; Incekas, Caner; Afsar, Sevgi Ikbali
  • No Thumbnail Available
    Item
    Intra-Articular Zoledronic Acid in A Rat Osteoarthritis Model: Significant Reduced Synovitis May Indicate Chondroprotective Effect
    (2015) Cinar, B. Murat; Ozkoc, Gurkan; Bolat, Filiz; Karaeminogullari, Oguz; Sezgin, Nurzen; Tandogan, Reha N.; 0000-0002-7906-5039; 24664185; AAL-4474-2021
    The aim of this experimental study was to evaluate the effect of intra-articular application of zoledronic acid (ZA) on joint cartilage and synovial tissue following induction of knee osteoarthritis (OA) in a rat model. An OA model was created by anterior cruciate ligament transection (ACLT) in the right knees of 48 adult Wistar albino rats. The rats were randomized into a study and control groups, each including 24 rats, and 10 mu g of ZA was injected in 0.1 ml of sterile saline to 24 animals in the study group on the first day to operation and was repeated weekly until the rats were killed. The same volume of sterile saline was injected with the same schedule to the control group. Eight rats from both the study and control groups were killed, each time, on the 4th day, the 3rd week, and the 6th week after the operation. The groups were compared based on the histological scores of synovitis and cartilage destruction and the evaluation of serum markers. Histological score indicates progression of synovitis was significantly less in the study group (p = 0.047). There was significant increase in the mean Mankin cartilage damage score in the control group (p = 0.021), while no significant change was found in the study group. When the two groups were compared over time, no statistically significant difference was detected in total histological scores, although there was a 47 % less incidence of cartilage tissue damage in the study group and better cartilage structure and tide mark integrity scores were also detected in the study group (p = 0.017 and p = 0.021, respectively). Intra- articular zoledronic acid may suppress synovial inflammation. Furthermore, Zoledronic Acid does not reduce cartilage degeneration in early osteoarthritis models, but may provide some chondroprotective effect in ACLT- induced knee osteoarthritis model in rats.
  • No Thumbnail Available
    Item
    The Efficacy of Intra-Articular Lidocaine Administration in Chronic Knee Pain Due To Osteoarthritis: A Randomized, Double-Blind, Controlled Study
    (2017) Eker, H. Evren; Cok, Oya Yalcin; Aribogan, Anis; Arslan, Gulnaz; https://orcid.org/0000-0002-7901-0185; https://orcid.org/0000-0003-3004-2626; https://orcid.org/0000-0002-4419-5693; 27485803; AAI-8769-2021; AAI-7998-2021; S-8336-2019
    Background: Intra-articular injections for the treatment of knee pain due to osteoarthritis are performed when conservative therapies have failed. The intra-articular injection of lidocaine may be an effective treatment modality due to its neuronal membrane-stabilizing effect and long-lasting anti-inflammatory action. In this study, we compared the efficacy of intra-articular 0.5% lidocaine versus saline injection on pain, stiffness and physical function in patients with osteoarthritis. Methods: Patients with osteoarthritis were randomly allocated to two groups. Group I (n = 26) received 7 mL 0.5% lidocaine and group II (n = 26) received 7 mL saline into the painful knee for a series of three injections spaced by 1 week intervals under ultrasound guidance. Knee pain was measured with a numeric rating score (NRS) at baseline and 3 months after the 3rd injection. WOMAC scales, including pain (WOMAC-P), stiffness (WOMAC-S) and physical function (WOMAC-F), were assessed and recorded at baseline, 30 minutes after the 1st injection, immediately prior to the 2nd and 3rd injections and 3 months after the 3rd injection. Results: Demographic data were comparable between groups. The NRS after 3 months was significantly lower in group I (P = 0.001). The WOMAC-P, immediately prior to the 3rd injection and 3 months afterwards, was significantly lower in group I (P = 0.006, P = 0.001, respectively). The WOMAC-S was improved prior to the 3rd injection and sustained until 3 months in group I (P = 0.035, P = 0.004, respectively). The WOMAC-F was improved after the 1st injection and sustained until 3 months in group I (P = 0.002, P < 0.0001 and P < 0.0001, respectively). Conclusions: Intra-articular 0.5% lidocaine injection under ultrasound guidance has a potential role in the management of chronic knee pain due to osteoarthritis for a 3-month period. (C) 2016 Societe francaise d'anesthesie et de reanimation (Sfar). Published by Elsevier Masson SAS. All rights reserved.