Tıp Fakültesi / Faculty of Medicine

Permanent URI for this collectionhttps://hdl.handle.net/11727/1403

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    The Influence of On-pump Versus Off-pump Surgery on Short- and Medium-term Postoperative Coronary Flow Reserve After Coronary Artery Bypass Grafting
    (2016) Ozulku, Mehmet; Caliskan, Mustafa; Saba, Tonguc; Aksu, Feyza; Ciftci, Ozgur; Gullu, Hakan; Guven, Aytekin; Kostek, Osman; Caklili, Ozge Telci; Aslamaci, Sait; 0000-0001-7566-5427; 0000-0002-9635-6313; 0000-0002-1901-5603; 27269474; AAT-7733-2020; AAG-8233-2020; AAA-3604-2019; AAJ-8546-2021
    Background Although several clinical trials have compared surgical outcomes between off-pump and on-pump coronary artery bypass grafting (CABG), whether there is a difference in the early- and medium-term postoperative coronary microvascular functions is not fully understood. We compared short- and medium-term coronary microvascular function after off-pump and on-pump CABG. Methods A prospective study of patients undergoing off-pump and on-pump CABG. Eighty-two patients scheduled for CABG were recruited: 38 underwent off-pump surgery and 44 on-pump surgery. Each participant's coronary flow reserve (CFR) and diastolic function were measured with transthoracic Doppler echocardiography six and 12 months after surgery. Results Baseline and hyperaemic diastolic peak flow velocity in the left anterior descending artery were similar in both groups, as was CFR (2.22 +/- 0.66) in the off-pump group compared with (2.13 +/- 0.61) in the on-pump group, (P = 0.54). Coronary flow reserve was significantly and inversely correlated with high sensitivity C-reactive protein concentration (r = -0.416; P < 0.001) and positively correlated with mitral E/ A-wave velocity ratio (r = 0.247; P = 0.02). Stepwise linear regression analysis revealed that only high sensitivity C-reactive protein concentration was independently correlated with CFR (beta = -0.272, P = 0.02). Conclusions Heart-lung bypass technique had no medium-term influence on the coronary microcirculation, despite a possible initial unfavourable effect. Serum hs-CRP concentration was an independent predictor of medium-term coronary microvascular dysfunction.
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    The Effect of Epicardial Adipose Tissue Thickness with İrritable Bowel Syndrome
    (2018) Cicek, Yuksel; Durakoglugil, Murtaza Emre; Duman, Hakan; Erdogan, Turan; Rakici, Halil; Balcioglu, Akif Serhat; 30317341
    Objective: To investigate the association of epicardial adipose tissue thickness with irritable bowel syndrome. Methods: This case-control and observational study was conducted in Recep Tayyip Erdogan University between January and December 2014, and comprised patients of irritable bowel syndrome and healthy controls who underwent a complete transthoracic echocardiographic examination as well as measurements of epicardial adipose tissue. They were screened for psychiatric or organic bowel diseases for the sake of precise diagnosis. Epicardial fat thickness was measured perpendicularly in front of the right ventricular free wall at end-diastole.SPSS 15 was used to analyse the data. Results: Of the 75 subjects, 44(59%) were patients and 31(41%) were controls. There was no statistically significant difference between the groups except epicardial adipose tissue thickness, which was significantly elevated in patients (p<0.001). C-reactive protein was significantly higher in patients (p=0.002). Epicardial adipose tissue (p<0.001) and haematocrit (p<0.05) were independent predictors of irritable bowel syndrome. Conclusion: Increased epicardial adipose tissue thickness, and accompanying low-grade inflammation appeared to be involved in irritable bowel syndrome pathogenesis.