Tıp Fakültesi / Faculty of Medicine

Permanent URI for this collectionhttps://hdl.handle.net/11727/1403

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    FDG PET/CT Imaging in Prostate Adenocarcinoma Presenting as Isolated Brain Metastases of Unknown Origin
    (2015) Erhamamci, S.; Reyhan, M.; Alkan, O.; 0000-0001-8550-3368; 0000-0001-7526-3460; 25052407; AAJ-5242-2021; AAM-4169-2021
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    In Vitro Effects on Biofilm Viability and Antibacterial and Antiadherent Activities of Silymarin
    (2015) Evren, Ebru; Yurtcu, Erkan; 0000-0003-4930-8164; 25937395; AAA-2998-2021; JWP-3001-2024
    Limited treatment options in infectious diseases caused by resistant microorganisms created the need to search new approaches. Several herbal extracts are studied for their enormous therapeutic potential. Silymarin extract, from Silybum marianum (milk thistle), is an old and a new remedy for this goal. The purpose of this study is to evaluate the antibacterial and antiadherent effects of silymarin besides biofilm viability activity on standard bacterial strains. Minimal inhibitory concentration (MIC), minimal bactericidal concentration (MBC), antiadherent/antibiofilm activity, and effects on biofilm viability of silymarin were evaluated against standard bacterial strains. MIC values were observed between 60 and > 241 mu g/mL (0.25-> 1 mmol/L). Gram-positive bacteria were inhibited at concentrations between 60 and 120 mu g/mL. Gram-negative bacteria were not inhibited by the silymarin concentrations included in this study. MBC values for Gram-positive bacteria were greater than 241 mu g/mL. Adherence/biofilm formations were decreased to 15 mu g/mL silymarin concentration when compared with silymarin-untreated group. Silymarin reduced the biofilm viabilities to 13 and 46 % at 1 and 0.5 mmol/L concentrations, respectively. We demonstrated that silymarin shows antibacterial and antiadherent/antibiofilm activity against certain standard bacterial strains which may be beneficial when used as a dietary supplement or a drug.
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    Responding to Veiga Et Al. 'Long Term Radiological Features of Radiation-Induced Lung Damage'
    (2018) Oymak, Ezgi; Yildirim, Berna Akkus; Guler, Ozan Cem; Onal, Cem; 0000-0001-6661-4185; 0000-0001-6908-3412; 0000-0002-2742-9021; 30021696; AGG-9214-2022; V-5717-2017; AAC-5654-2020; D-5195-2014
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    The effect of helicobacter pylori eradication on atrophic gastritis and intestinal metaplasia : a retrospective single center research
    (2020) Suna, N.; Etik, D.; Ocal, S.; Gunduz, C.; Acikgoz, A.; Bildik, I; Gursoy, A.; Kasgoz, I; Tuleylioglu, H.; Boyacioglu, A.; 0000-0003-3719-9482; 0000-0002-4724-0728; 0000-0001-6234-7788; 33094583; ABH-4817-2020; AAJ-4707-2021; AAI-8822-2021
    Background and study aims : Gastric cancer (GC) is one of the major causes of cancer-related deaths worldwide. Helicobacter pylori (Hp) plays an important role in gastric carcinogenesis by inducing precancerous changes such as atrophic gastritis (AG) and intestinal metaplasia (IM). In our study, we aim to compare the grade of AG and IM before and after Hp eradication in patients who underwent esophagogastroduodenoscopy (EGD) in our center. Patients and methods : The data of 40.060 patients who underwent EGD for various reasons in our Endoscopy Unit between June 2011 and November 2017 were retrospectively evaluated. The grade of AG and IM before and after Hp eradication of patients meeting the study criteria were compared with each other. In addition, these findings were compared using OLGA and OLGIM staging systems. Results : A total of 175 patients, 89 (50.9%) women and 86 (49.1%) men, were included in the study. The mean age was 55 +/- 12 years. The mean time between two EGD examinations was 38 +/- 14 months. Significant improvement was observed in the grade of AG on corpus and antrum after Hp eradication (P=0.000, P=0.008). In the corpus and antrum, the grade of IM was regressed but this was not significant (P=0.80 and P=0.370 respectively). There was a decrease in OLGA stages after Hp eradication (P=0.000). There was also a reduction in the OLGIM stages, but this was not significant(P=0.341). Conclusion: Our study demonstrates that Hp eradication may reduce the risk of developing GC by providing an improvement in AG and IM which are precancerous changes in GC.