Tıp Fakültesi / Faculty of Medicine

Permanent URI for this collectionhttps://hdl.handle.net/11727/1403

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    Aneurysmal Bone Cyst in a Renal Transplant Patient
    (2022) Sahinturk, Fikret; Sonmez, Erkin; Altinors, Nur; Terzi, Aysen; Haberal, Mehmet; 0000-0002-3462-7632; 0000-0002-0471-3177; 31324137; AAJ-8097-2021; AAI-7972-2021
    Aneurysmal bone cysts constitute 1% to 2% of all primary bone tumors. They are rapidly growing benign bone tumors. Nearly 80% of aneurysmal bone cysts occur in the first 20 years of life, and most are primary tumors. Aneurysmal bone cysts are mostly benign, locally aggressive, and highly vascularized tumors. Generally, the period required for postoperative recovery and new bone formation is long. The relapse rate can be up to 50%. Although computed tomography and magnetic resonance imaging scans are the preferred diagnostic methods, biopsy is the most necessary prerequisite to confirm diagnosis, as aspects of these cysts can show similarity to many other bone lesions. Correct histopathologic diagnosis is important since malignancies may be seen in transplant recipients.
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    Evaluation of Acute Rejection by Measuring Strain and Strain Rate in Children With Heart Transplant: A Preliminary Report
    (2017) Gursu, Hazim Alper; Varan, Birgul; Sade, Elif; Erdogan, Ilkay; Sezgin, Atilla; Aslamaci, Sait; 0000-0002-0707-2678; 0000-0002-6719-8563; 0000-0001-6887-3033; 27310367; AHI-4502-2022; ABB-1767-2021; ABB-2220-2021
    Objectives: Asymptomatic rejection after heart transplant is difficult to detect by noninvasive methods. The present study investigated the efficacy of echocardiographic strain and the strain rate imaging method in detecting rejection after pediatric heart transplant. Materials and Methods: Fourteen pediatric patients with heart transplant were examined both with endomyocardial biopsy and strain imaging. Patients were divided into 2 groups: group 1 included patients with rejection, and group 2 included patients without rejection. Patients underwent endomyocardial biopsy at regular intervals. Regional systolic function was evaluated by longitudinal myocardial peak systolic values of strain and of strain rate. Differences between the 2 groups were assessed with unpaired t test or Mann-Whitney U test. Results: Acute rejection was detected in 7 patients (4 were female patients). Cardiac diagnosis was restrictive cardiomyopathy in 3 patients, dilated cardiomyopathy in 3 patients, and complex congenital heart disease in 1 patient. After heart transplant, 6 patients had rejection once and 1 patient had rejection twice. Evaluation of biopsy samples revealed grade IB rejection in all patients in group 1. Systolic functions of the 6 patients were determined as normal in standard echocardiographic examination. There were no significant differences in deformation and deformation rates between group 1 and 2 except in midseptal region (P<.05). Conclusions: One of the most significant complications in patients with heart transplant is rejection. Our results suggested that myocardial strain imaging may be valuable in defining low-grade rejection.
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    Microscopic study of human nasal cavity microanatomy using semi-thin resin embedding and methylene blue staining
    (2019) Firat, Aysegul; Onerci-Celebi, Ozlem; Tuncel, Alican; Ergun, Mine; Hayran, Murvet
    The nasal cavity is a part of the respiratory tract which humidifies, filters, and warms the air we breathe, as well as being the organ of olfaction. It is easily accessible in terms of morphological and histopathological evaluation for clinical and research purposes. There have been many studies and textbooks showing the histological evaluation of the nasal cavity's three functional regions: the vestibule, respiratory, and olfactory. The present study aimed to examine the nasal mucosa in a detailed manner in 11 predetermined anatomic areas. Specimens were collected from six fresh-frozen cadavers using a standard punch biopsy procedure. Microscopic evaluation was done on the nasal mucosa, glands, blood vessels, muscles, connective tissue, and neural anatomy. Also, examined and described were the epithelial cell and glandular transitions in the mucosal lining. The microscopic investigation of these features in the nasal cavity provided important information for both clinical and research purposes.