Tıp Fakültesi / Faculty of Medicine
Permanent URI for this collectionhttps://hdl.handle.net/11727/1403
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Item Biochemical, Radiologic, Ultrastructural, and Genetic Evaluation of Iron Overload in Acute Leukemia and Iron-chelation Therapy(2014) Olcay, Lale; Hazirolan, Tuncay; Yildirmak, Yildiz; Erdemli, Esra; Terzi, Yunus Kasim; Arda, Kemal; Ozturkmen, Seda; Akyay, Arzu; Kaymak-Cihan, Meric; Bicakci, Zafer; Bal, Ceylan; https://orcid.org/0000-0001-5612-9696; https://orcid.org/0000-0002-4480-7784; 23887025; B-4372-2018; ABI-7551-2020Iron overload in hereditary hemochromatosis and hematologic malignancy has unfavorable effects on morbidity. Herein, 53 children (age 108.4 +/- 58.3 mo, 25 girls and 28 boys) with acute myeloblastic and lymphoblastic leukemia, who received 4 different chemotherapy protocols, were evaluated for iron overload throughout chemotherapy. Iron overload arose: (1) before chemotherapy, which was dependent on neither chemotherapy nor packed red blood cell transfusions and (2) after chemotherapy, which was dependent on the duration and nature of chemotherapy and partially on transfusion of packed red blood cells. Iron overload was documented in 75% of patients with a ferritin level >1000 ng/mL, by liver and heart magnetic resonance imaging, and they were administered iron-chelation therapy with success. Three of 10 radiologically iron-overloaded patients were heterozygous for H63D mutation. Aminolevulinic acid and porphobilinogen levels were normal. Light microscopic examination of the bone marrow revealed increased iron granules in erythroblasts, platelets, and megakaryocytes, iron-laden macrophages, free iron in the matrix, dyshematopoiesis, and apoptotic cells. Electron microscopic examination revealed iron-laden secondary lysosomes and autolysosomes in normoblasts and iron-laden primary granules in promyelocytes, irrelevant to the ferritin level, implying autophagia due to chemotherapy as a source of the excess iron. We think that iron overload, which is an important complication of acute leukemia, should be evaluated separately from transfusion overload, and the management principles specific to leukemia should be implemented.Item Primary Ovarian Malignant Melanoma Arising in Teratomatous Component of Mixed- Germ Cell Tumor in a Child: Case report(2014) Ozyoruk, Derya; Demir, Haci Ahmet; Emir, Suna; Haberal, Asuman Nihan; Bugdayci, Meral; Otgun, Ibrahim; https://orcid.org/0000-0001-9852-9911; 24499012; AAK-4587-2021Primary ovarian malignant melanoma arising in teratomatous component of germ cell tumors is seen extremely rare with most reports being only of single cases and small series in reproductive aged woman and mostly from cystic teratoma, whereas information on pediatric presentation is sparse. This case is reported for being extremely rare tumor.Item Management of Early Hepatic Arterial Thrombosis After Liver Transplantation(2014) Moray, G.; Kirnap, M.; Soy, E. Ayvazoglu; Yildirim, S.; Sezgin, A.; Boyvat, F.; Haberal, M.; https://orcid.org/0000-0003-2498-7287; https://orcid.org/0000-0002-0993-9917; https://orcid.org/0000-0002-5735-4315; https://orcid.org/0000-0002-3462-7632; AAE-1041-2021; AAH-9198-2019; AAC-5566-2019; AAF-4610-2019; F-4230-2011; AAJ-8097-2021Item Posterior Reversible Encephalopathy Syndrome After Solid Organ Transplantation(2016) Ulas, Aydin; Ozdemirkan, Aycan; Can, Ufuk; Zeyneloglu, Pinar; Pirat, Arash; https://orcid.org/0000-0001-8689-417X; AAH-7003-2019; AAJ-2999-2021Item Changes in Body Composition and Growth Pattern After Adenotonsillectomy in Prepubertal Children(2016) 26810289Objective: Adenotonsillar hypertrophy and chronic tonsillitis are associated with growth interruption during childhood, while adenotonsillectomy has been associated with growth improvement and increased body mass index (BMI). However, no reported study has investigated the effect of adenotonsillectomy on the proportion of body muscle and fat mass. The aim of this prospective study was to evaluate the effect of adenoidectomy and adenotonsillectomy on body muscle and fat composition in prepubertal children. Methods: Thirty prepubertal children (22 boys, 8 girls; 3-9 years of age) were followed up for 6 months after adenoidectomy or adenotonsillectomy. Twenty-eight age-matched healthy children (12 boys, 16 girls) were followed for the same period, as controls. Data on dietary habits and physical activity were obtained from parent-completed questionnaires at baseline and 6 months. Height and weight z-scores, the amount and percentage of body fat and muscle mass, BMI z-scores, relative BMI and basal metabolic rate were evaluated before and 6 months after surgery with bioelectrical impedance analysis. Results: After 6 months, body muscle mass and basal metabolic rate scores were significantly higher than at baseline in both groups (P < 0.05). The rate of increase was not different between the groups. In the study group, the relative BMI scores improved significantly (P < 0.05). Increases in body fat mass, body fat percentage, height z-scores, weight z-scores and BMI z-scores were not significantly different between the groups at 6 months (P > 0.05). The number of overweight and obese children did not change significantly in either group (P < 0.05). Conclusions: Adenotonsillectomy led to improvement in relative BMI and promoted healthy weight gain without increased body fat percentage in prepubertal children. (C) 2015 Elsevier Ireland Ltd. All rights reserved.Item Polyphasic Temporal Behavior of Finger-Tapping Performance: A Measure of Motor Skills and Fatigue(2016) Aydin, Leyla; Kiziltan, Erhan; Gundogan, Nimet Unay; https://orcid.org/0000-0001-6029-3835; https://orcid.org/0000-0001-7784-9641; 25988674; ABC-5392-2020; AAD-6090-2021; AAK-4338-2021Successive voluntary motor movement involves a number of physiological mechanisms and may reflect motor skill development and neuromuscular fatigue. In this study, the temporal behavior of finger tapping was investigated in relation to motor skills and fatigue by using a long-term computer-based test. The finger-tapping performances of 29 healthy male volunteers were analyzed using linear and nonlinear regression models established for inter-tapping interval. The results suggest that finger-tapping performance exhibits a polyphasic nature, and has several characteristic time points, which may be directly related to muscle dynamics and energy consumption. In conclusion, we believe that future studies evaluating the polyphasic nature of the maximal voluntary movement will lead to the definition of objective scales that can be used in the follow up of some neuromuscular diseases, as well as, the determination of motor skills, individual ability, and peripheral fatigue through the use of a low cost, easy-to-use computer-based finger-tapping test.Item Association of Interleukin-10 Gene Promoter Polymorphisms with Obstructive Sleep Apnea(2016) Ozdas, Sibel; Ozdas, Talih; Acar, Mustafa; Erbek, Selim S.; Koseoglu, Sabri; Gokturk, Gokhan; Izbirak, Afife; https://orcid.org/0000-0003-4825-3499; 26139223; B-7604-2019Interleukin-10 (IL) is an anti-inflammatory cytokine that regulates normal sleep patterns, and recent studies have reported that it is a potential useful biomarker to identify presence and severity of sleep apnea syndrome (OSAS). Promoter polymorphisms of IL-10 gene have been associated with altered expression levels, which contributes to OSAS. The aim of this study was to determine the prevalence of -1082 G/A, -819 C/T, and -592 C/A promoter polymorphisms of IL-10 gene in individuals with OSAS and controls. An open-label study was performed in the Otorhinolaryngology and Sleep Disorders Outpatient Clinics. One hundred four cases with OSAS were included as the study group, and 78 individuals without OSAS were included as the controls. DNAs were extracted from peripheral blood leukocytes, and the sites that encompassed those polymorphisms were identified by DNA sequencing analyses. Data were analyzed with SNPStats and multifactor dimensionality reduction (MDR) software. The prevalence of OSAS was higher in males in the study group when compared to controls (P = 0.0003). The IL-10-1082 G/A, -819 C/T, and -592 C/A SNPs, and their minor alleles were associated with a significantly increased risk for OSAS compared to the controls (P E, 0.05 for all). Furthermore, ATA haplotype frequency was significantly higher in the study group compared to the control group, but the GCC haplotype frequency was lower (P = 0.0001 and P = 0.0001). As indicated in MDR analysis, combinations of IL-10 gene were associated with OSAS in single-, double-, and triple-locus analyses. The prevalences of the IL-10 gene promoter polymorphisms were different in OSAS patients and the controls in Turkish population. IL-10 gene polymorphisms may lead to altered inflammatory cascade, which might contribute to OSAS. Further studies on larger cohorts are needed to validate our findings.Item Home Noninvasive Ventilation to Reduce Readmissions for Chronic Obstructive Pulmonary Disease(2017) Hill, Nicholas S.; Ugurlu, Aylin Ozsancak; https://orcid.org/0000-0003-3598-3986; 28528346; AAA-2925-2020Item Successful Cardiovascular Surgery Experience and Enzyme Replacement Therapy in Type 3C Gaucher Disease(2017) Mungan, Neslihan; Bulut, Derya; Salih, Orhan; Gulcan, Oner; Deniz, Ali; Erdem, Sevcan; Kor, Deniz; Yilmaz, Berna; Acar, Sebile; Ozbarlas, Nazan; https://orcid.org/0000-0003-0529-2404; J-8564-2018Item Sliding hiatal hernia mimicking a left atrial mass(2019) Kocabas, Umut; Ozkalayci, Flora; Altun, Armagan; 0000-0002-3233-8263; 0000-0001-6424-9399; 32082840; ABB-5844-2020; AAG-5856-2020