Tıp Fakültesi / Faculty of Medicine

Permanent URI for this collectionhttps://hdl.handle.net/11727/1403

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2018 - 20192

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Author: search.filters.author.Yilmaz, Tugba Hansearch.filters.applied.f.language: search.filters.language.eng

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    Changes in Serum Lipid Levels After Laparoscopic Sleeve Gastrectomy in Morbidly Obese Dyslipidemic and Normalipidemic Patients
    (2018) Erol, Varlik; Yilmaz, Tugba Han; Tuncali, Bahattin; Arslan, Baha; Gulay, Huseyin; https://orcid.org/0000-0002-9590-0276; https://orcid.org/0000-0002-7898-2943; https://orcid.org/0000-0003-4461-4904; https://orcid.org/0000-0002-0442-6178; 29251221; AAJ-6354-2021; AAJ-7840-2021; AAD-6127-2021; AAJ-6407-2021
    Background: This study investigated the effect of laparoscopic sleeve gastrectomy (LSG) performed for morbid obesity on serum lipid levels of dyslipidemic and normolipidemic patients. Methods: 141 patients who underwent LSG between September 2014 and January 2016 were included in the study. Results: The patients' mean body mass index was 46.27 +/- 6.79 kg/m(2) preoperatively, 31.60 +/- 5.37 kg/m(2) in the 6th month postoperatively and 27.80 +/- 4.25 kg/m(2) in the 12th month (p < .001). Preoperatively and 12 months after the operation, mean total cholesterol (TC) levels and mean LDL cholesterol, mean HDL cholesterol, and mean triglyceride (TG) levels were statistically significantly decreased (p < .01). Comparing TC levels in the 12th month with preoperative levels, dyslipidemic patients showed a statistically more significant decrease than normolipidemic patients. LDL cholesterol levels were significantly decreased in both the groups. HDL cholesterol levels increased significantly in both groups while mean TG levels decreased significantly in patients with high preoperative TG levels, but not in patients with normal preoperative TG levels. Conclusions: Although this technique exerts its effect primarily by reducing gastric volume, besides its metabolic and hormonal effects, it also improves serum lipid levels (decreasing TC, LDL cholesterol and TG levels, and increasing HDL cholesterol levels). It therefore contributes to decreasing cardiovascular diseases.
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    Diagnostic Accuracy of Axillary Ultrasound in Early-Stage Breast Cancer
    (2019) Yilmaz, Tugba Han; Yerli, Hasan; Arslan, Baha; Erol, Varlik; Gulay, Huseyin
    Sentinel lymph node biopsy is the standard application for evaluating the axilla in patients with breast cancer. The Z0011 trial conducted by The American College of Surgeons Oncology Group (ACOSOG) revealed that axillary dissection may be redundant in selected patients with positive sentinel node. This raises questions regarding the application of this result to ultrasound-positive patients. This research therefore aimed to evaluate how accurate an ultrasound scan is for axillary node status in early-stage breast carcinoma. The study included 156 newly diagnosed clinical T1-T2, N0 breast cancer patients attending our breast clinic between January 2010 and February 2016. Sentinel lymph node biopsy and axillary lymph node clearance in the presence of sentinel lymph node metastasis was performed on all the breast cancer patients. Axillary ultrasound reports were reviewed retrospectively and the results compared with surgical pathology results. The sensitivity and specificity of axillary ultrasound for detecting axillary lymph node disease was 69.2% and 98%, respectively, with a negative predictive value of 86.4% and positive predictive value of 94.7%. Given the high sensitivity and specificity, and high positive predictive value and negative predictive value demonstrated in the present study, axillary ultrasound represents a potential alternative to sentinel lymph node biopsy for staging of the axilla in early breast cancer. Subsequent trials (SOUND) comparing axillary ultrasound alone with sentinel lymph node biopsy in early breast cancer patients will provide additional information about the subject.