Tıp Fakültesi / Faculty of Medicine
Permanent URI for this collectionhttps://hdl.handle.net/11727/1403
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Item The Effects of Orlistat on Spatial Memory, Recognition Memory and Hippocampal Tissue in Experimentally Induced Obesity in Rats(2023) Yigit, Ayse Arzu; Kilinc, Sevtap; Olcuoglu, Rukiye; Arnous, Elif Azra; 0000-0002-0429-008X; 0000-0002-4162-1554; JZJ-5475-2024; ISP-2968-2023Item The Effect of Ginkgo Biloba on Anxiety and Oxidative Stress Parameters in Healthy Young Rats(2023) Arnous, Elif Azra; Yigit, Ayse ArzuItem The Impact of Orlistat on Nitrosative Stress and Paraoxonase-1 Enzyme Activity in Serum, Heart, Kidney, and Testicular Tissues of Rats with Experimentally Induced Obesity(2023) Kilinc, Sevtap; Olcuoglu, Rukiye; Yigit, Ayse Arzu; 0000-0002-0429-008X; 0000-0002-4162-1554; JZJ-5475-2024; ISP-2968-2023Item Evaluation of Electrodermal Activity and Anxiety Behaviors in Diabetic Rats Given Vildagliptin and Metformin(2022) Shawesh, Muftah; Alshareef, Mohammed; Boyuk, Gulbahar; Yigit, Ayse Arzu; Dolu, NazanItem A Preliminary Study on the Effect of Age and Gender to the Amplitudes of Cochlear Microphonics Recorded by Click Stimulus in Individuals with Normal Hearing(2022) Guneser, Ozgecan; Alniacik, Asuman; Yigit, Ayse Arzu; Koycu, Alper; Cakmak, Eda; Yanarates, Kursat; https://orcid.org/0000-0003-1290-3509; AAF-3650-2021Item Investigation of the Effects of Metribuzine on Cow Granulosa Cell Steroidogenesis(2022) Yigit, Ayse Arzu; Kahveci, Metehan Eser; Kabakci, RuhiItem Assessment of tebuconazole exposure on bovine testicular cells and epididymal spermatozoa(2021) Kabakci, Ruhi; Kaya, Abdulkadir; Yigit, Ayse Arzu; Varisli, Omer; 0000-0001-5837-6877; 34214047; C-2636-2017This study is the first to investigate the effects of tebuconazole (TEB) on the physiological functions of bovine testicular cells and epididymal spermatozoa. Motility and plasma membrane integrity of spermatozoa exposed to TEB (0.001-100 mM) were evaluated at different incubation times (0-6 h), while TEB-induced spermiotoxicity was assessed after 24 h in cell cultures. Testicular cells, obtained from the parenchyma of bovine testes, were seeded at 1.0 x 10(4) and 1.5 x 10(6) cells/well in 96- and 12-well culture plates and incubated for 48 h in culture media containing TEB (0.001- 100 mM) to evaluate cytotoxicity and hormone release, respectively. TEB did not affect the motility and plasma membrane integrity. However, significant spermiotoxicity occurred at higher TEB (1-100 mM) concentrations (P < 0.05) compared to control and lower doses. Although no dose caused cytotoxicity in testicular cells (P > 0.05), 1 and 100 mM TEB caused a significant increase in testosterone secretion (P < 0.05). As a result, high doses of TEB (1-100 mM) had slightly suppressive effects on spermatozoa; however, these doses had stimulatory effects on testosterone secretion by testicular cells. It appears that the disruption of hormonal homeostasis of testicular cells after TEB exposure may result in metabolic and especially reproductive adverse effects in bulls.