Tıp Fakültesi / Faculty of Medicine

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2016 - 20186

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Author: search.filters.author.Ogus, ErsinHas files: No

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    Comparing the Short-term Effect of Drinking Caffeinated Coffee on Hand Skill Rate Performance Ability Due to its Hotness, Smelling and Caffeine Ingredient
    (2016) Gundogan, Nimet Unay; Ilhan, A. Sebnem; Ogus, Ersin; Olsen, Anil Cenk; Gurcan, Buse; Ozer, Dogancan; Koru, Mine; Durak, Nazenin; Ugur, Duygu; 0000-0002-9877-421X; 0000-0001-7784-9641; AAJ-1058-2021; AAK-4338-2021
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    The Role of Finger Tapping Task in the Assessment of Central Fatigue
    (2016) Aydin, Leyla; Kiziltan, Erhan; Ogus, Ersin; Azizagaoglu, Bahadir; Buyukkaraman, Arda; Dogan, Selen; Erturk, Gizem; Kus, Cansel; 0000-0002-9877-421X; 0000-0001-6029-3835; ABC-5392-2020; AAJ-1058-2021; AAD-6090-2021
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    Effect of Melatonin on Cytokine Levels in A Hyperthermia-Induced Febrile Seizure Model
    (2017) Aydin, Leyla; Yurtcu, Erkan; Korkmaz, Yesim; Sezer, Taner; Ogus, Ersin; 0000-0003-4930-8164; 0000-0002-2278-1827; 0000-0002-9877-421X; 29208169; ABC-5392-2020; AAA-2998-2021; AAJ-5931-2021; AAJ-1058-2021
    Higher serum cytokine levels have been reported in children admitted with febrile seizures and in some experimental models. However, other studies have shown that cytokine levels are influenced by melatonin. In this study, we investigated serum cytokine levels in a hyperthermia-induced febrile rat seizure model and the effect of melatonin. A total of 28 male Sprague-Dawley rats were divided into four groups: the control (C) group, healthy melatonin (MT) group, and hyperthermia-induced febrile seizure groups with (HIFS-MT) and without (HIFS) administration of melatonin. Melatonin (80 mg/kg) was given intraperitoneally 15 min before the seizure. HIFS was induced by placing the rats in 45 degrees C water. The rats were sacrificed under anesthesia after the seizure. Blood samples were drawn by transcardiac puncture to measure serum cytokine and melatonin levels. Serum interleukin (IL)-1 beta, IL-6, IL-10, and tumor necrosis factor (TNF)-alpha levels were lower in the HIFS group than those in the C group (p = 0.005, p = 0.200, p = 0.011, and p = 0.016, respectively). All serum cytokine levels of rats in the MT and HIFS-MT groups were similar to those in the C group. This experimental rat model demonstrated that serum cytokine levels decrease with HIFS and that administering melatonin maintains serum cytokine levels. These results suggest that cytokines may play role in the anticonvulsive activity of melatonin in rats with febrile seizures.
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    Relationship Between Academic Successes of Physiology and Pathology Courses
    (2017) Aydin, Leyla; Ogus, Ersin; 0000-0002-9877-421X; ABC-5392-2020; AAJ-1058-2021
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    Is Central Origin of Muscle Fatigue Distinguished Solely in Finger Tapping Performance?
    (2017) Aydin, Leyla; Buyukkaraman, Arda; Kiziltan, Erhan; Dogan, Selen; Ogus, Ersin; Erturk, Gizem; Azizagaoglu, Bahadir; Kus, Cansel; 0000-0001-6029-3835; 0000-0002-9877-421X; ABC-5392-2020; AAD-6090-2021; AAJ-1058-2021
    As a non-specific symptom muscle fatigue mostly accompanies neuromuscular diseases and also occurs frequently in healthy individuals. Fatigue phenomenon is considered to be multidimensional symptom. There have been still discussions on the origin whether it depends primarily on the intrinsic properties of muscle itself (peripheral) or the nervous system that controls muscle (central). This study aimed to investigate the effects of central fatigue on finger tapping performance and discusses the specificity of finger tapping task test as a simple diagnostic tool for fatigue. For this purpose, 27 healthy, male, right-handed volunteer performed four 20-s of finger tapping task tests. The one was for control and the other three were followed by three different central fatigue models. Temporal behavior of tapping performances were evaluated based on inter-tap intervals and the statistical comparison were made by regression analysis. The results showed that the partial evaluation of the task instead of complete test period yielded with statistically significant differences between control and fatigue models (p<0.001) and even in between fatigue models. Approximately the first 5-s of a finger tapping task consists of motor learning processes and dynamics of energy consumption from anaerobic sources therefore, reflects the central components of fatigue, dominantly. We may conclude that the temporal behavior of tapping performance following the induction of specific fatigue model may help making further discrimination for the origin of fatigue.
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    The Protective Effect of Metformin Against the Noise-Induced Hearing Loss
    (2018) Kesici, Gulin Gokcen; Ocal, Fatma Ceyda Akin; Gurgen, Seren Gulsen; Erdem, Saban Remzi; Ogus, Ersin; Erbek, Hatice Seyra; Ozluoglu, Levent Naci; 0000-0003-0409-6225; 0000-0002-7537-2170; 0000-0002-9877-421X; 0000-0002-2150-0237; 30306316; AAT-2326-2021; AAJ-2370-2021; AAJ-1058-2021; AAI-8020-2021
    ObjectiveTo test the protective effect of metformin against noise-induced hearing loss.Methods24 rats were included in the study. The first group was exposed to noise only, the second group took metformin, the third group was exposed to noise and took metformin, and the fourth group was neither exposed to noise nor took metformin as control group. After measurement of baseline DPOAE and ABR of rats, the metformin group and the metformin+noise group received 300mg/kg/day metformin via gavage for 10days. On the 11th day, group 1 and group 3 were exposured to white noise at 105dB SPL for 15h. After noise exposure, DPOAE and ABR measurements of all rats were repeated on days 1st, 7th, and 21st. At the end of the study, all animals were sacrificed and cochlear tissues were separated for immunohistochemical assessments.ResultsABR threshold values and DPAOE measurements of groups 1 and 3 were deteriorated on the 1st day after noise, while deterioration in group 1 continued on 7th and 21st days, but normalized on 7th day in group 3. After immune staining, a significant immunoreaction was observed in the noise group, while the reaction in the noise+metformin group was close to the control group.ConclusionMetformin has a protective effect on noise-induced hearing loss in rats. As a conclusion, it is determined that metformin protects from permanent threshold shift in rats. It can be considered a good alternative for protecting noise-induced hearing loss.