Tıp Fakültesi / Faculty of Medicine

Permanent URI for this collectionhttps://hdl.handle.net/11727/1403

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Author: search.filters.author.Kiziltan, ErhanHas files: Yes

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    Detection of Visual-Auditory Reaction Rates in Individuals with Type 2 Diabetes Mellitus
    (2023) Bilaloglu, Melisa; Ergun, Ahmet; Altay, Feride P.; Iyidir, Ozlem T.; Kiziltan, Erhan; 0000-0002-9994-9405; 0000-0001-6029-3835; 0000-0001-5305-6807; AAL-7975-2021; AAD-6090-2021; K-7904-2019
    AIM:The primary purpose of our study was to understand the damage in the peripheral nerves of patients with diabetes and to determine the change in patients' reaction rates and perceptions by the age groups, duration of diabetes, fasting plasma glucose and HbA1c values, and compare these with those of the healthy individuals. METHODS: This study was carried out at the Baskent University Hospital Endocrinology and Metabolic Diseases Outpatient Clinic. A total of 64 patients diagnosed with type 2 diabetes and 64 healthy controls were included in the study. Finger tapping, visual, and auditory reaction time tests were performed on the subjects, respectively. The subjects' fasting plasma glucose and HbA1c levels, and the duration of their diabetes were recorded. Analyses were per -formed using the SPSS version 25. Differences were considered statistically significant when the p-value is <0.05. RESULTS: It was observed that the participants in the control group between the ages of 18-34 showed a faster reaction in all tests (p=0.01), but the difference in reaction rates in both groups decreased as the age increased. There were positive cor-relations between the duration of type 2 diabetes and the visual and auditory examination results (r= 0.69, p<0.05, r=0.52, p<0.05, respectively). There was also a positive correlation between the HbA1c (%) and the visual (r=0.97, p<0.05) examina-tion results. CONCLUSIONS: As the patients' HbA1c levels and the time spent with type 2 diabetes increased, their reaction rate and per-ception skills decreased. Especially in the early stages of the disease, cognitive decline was observed to be rapid. It is thought that diabetic control is significant.
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    Polyphasic Temporal Behavior of Finger-Tapping Performance: A Measure of Motor Skills and Fatigue
    (2016) Aydin, Leyla; Kiziltan, Erhan; Gundogan, Nimet Unay; https://orcid.org/0000-0001-6029-3835; https://orcid.org/0000-0001-7784-9641; 25988674; ABC-5392-2020; AAD-6090-2021; AAK-4338-2021
    Successive voluntary motor movement involves a number of physiological mechanisms and may reflect motor skill development and neuromuscular fatigue. In this study, the temporal behavior of finger tapping was investigated in relation to motor skills and fatigue by using a long-term computer-based test. The finger-tapping performances of 29 healthy male volunteers were analyzed using linear and nonlinear regression models established for inter-tapping interval. The results suggest that finger-tapping performance exhibits a polyphasic nature, and has several characteristic time points, which may be directly related to muscle dynamics and energy consumption. In conclusion, we believe that future studies evaluating the polyphasic nature of the maximal voluntary movement will lead to the definition of objective scales that can be used in the follow up of some neuromuscular diseases, as well as, the determination of motor skills, individual ability, and peripheral fatigue through the use of a low cost, easy-to-use computer-based finger-tapping test.
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    Distribution of Dynamic Forces on Patient Specific Vascular Model:Application of computational Hemodynamics
    (2015) Kiziltan, Erhan
    Objective: Recent advances in computerized image processing made the early diagnosis and elective invasive treatment of vascular pathologies possible. However, studies state that the complication rates of elective procedures are higher thatn that the of untreated cases. And, making the decision between protection from life threatening complications and unnecessary interventions is a controversial issue. Therefore, recent studies put emphasis on multidisciplinary motivation,; consequently "computational fluid dynamics" took place in medical simulations. With the aim of setting up hemodynamic forces were discussed in vascular models. Methods: Three dimensional distribution of hmodynamic forces in aneurisam and stenotic models were computed by uisng two different patient specific simulations which were constructed on two different vessel models of "parametric" and "realistic" approaches. Results: The results were consistent with almost all common practical knowledge. Continuity and Bernoulli's laws imply that a fluid moving through a wide vessel must move more quickly when the vessel narrows and the pressure decreases gradually. The relation between vessel geometry and velocity vectors in maintained laminor flow conditions was demonstrated. The impacts of radial forces and vessel wall structure on spatial distribution of the displacement in vessel geometry were also shown. Additionally spatial distribution of the axial force of "wall shear stress" which was recently suggested to be a hightly reliable measure was evaluated. Conclusion: Patient specific simulations that are belived to be the core of the future project of "clinical diagnostic expert systems" will be an important tool; in prescribing patient specific treatment and in the assessment of complications risks.
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    The Impacts of Central Fatigue on the Polyphasic Nature of Tapping Performance
    (2018) Kiziltan, Erhan; Aydin, Leyla; Ogus, Ersin; Azizagaoglu, Bahadir; Buyukkaraman, Arda; Doga, Selen; Ertuk, Gizem; Kus, Cansel; 0000-0002-9877-421X; 0000-0001-6029-3835; AAJ-1058-2021; ABC-5392-2020; AAD-6090-2021
    Objective: As a non-specific symptom muscle fatigue mostly accompanies neuromuscular diseases and also occurs frequently in healthy individuals. Fatigue phenomenon is considered to be multidimensional symptom. There have been still discussions on the origin whether it depends primarily on the intrinsic properties of muscle itself (peripheral mechanisms) or the nervous system that controls muscle (central mechanisms). This study aimed to investigate the effects of central fatigue on the performance of maximal voluntary repetitive movement and discusses the specificity of finger tapping task test as a simple diagnostic tool for fatigue. Methods: For this purpose, 27 healthy, male, right-handed volunteer performed the 20-s of finger tapping task test for four times. The one was for control and the other three were performed right after induction of three different central fatigue models. Temporal behavior of tapping performances were evaluated based on inter-tap intervals and the statistical comparison were made by regression analysis. Results: The results showed that the partial evaluation of the task in time domain instead of complete test period yielded with statistically significant differences between control and fatigue models (p<0.001) and even in between the fatigue models. Conclusion: Approximately the first 5-s of a finger tapping task consists of both motor learning processes and dynamics of energy consumption from anaerobic sources. However, it reflects dominantly the central components of fatigue. We may conclude that the temporal behavior of tapping performance following the induction of specific fatigue model may help making further discrimination for the origin of fatigue.