Tıp Fakültesi / Faculty of Medicine

Permanent URI for this collectionhttps://hdl.handle.net/11727/1403

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2014 - 20162

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Author: search.filters.author.Ikizceli, IbrahimSubject: search.filters.subject.emergency

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    Comparison of Ischemia Modified Albumin Levels with Total Oxidant, Total Antioxidant Status, Oxidative Stress Index in Carbon Monoxide Poisoning
    (2014) Durukan, Polat; Koyuncu, Murat; Salt, Omer; Kavalci, Cemil; Ozkan, Seda; Muhtaroglu, Sebahattin; Kavalci, Gulsum; Ozdemir, Caglar; Duzgun, Ali; Ikizceli, Ibrahim; https://orcid.org/0000-0003-2529-2946; AGG-1308-2022
    Aim: The most common cause of death in CO poisoning is ventricular arrhythmias due to tissue hypoxia. In this study we aimed to investigate the relationship between severity of poisoning and Total Oxidant Status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI) and also change in the levels of ischemia modified albumin (IMA) and neutrophil gelatinase-associated lipocalin (NGAL) over time in the patients with CO poisoning. Material and methods: This study was performed at Erciyes University Faculty of Medicine, Department of Emergency Medicine. Fifty patients between the ages of 18-65 who were diagnosed CO poisoning in the emergency department were included in the study. As a control group 30 adult individuals with no history of any disease were included in the study. Ischemia modified album, NGAL, OSI, TOS and TAS levels were studied. Mann-Whitney U test was using to compare of control and patient group. The Wilcoxon test was used to compare the change in TAS, TOS, OSI, IMA, NGAL, COHb and lactate. p<0.05 was considered as statistically significant. Results: When the 0th hour levels of Lactate, TOS, OSI, and IMA and TAS of the patient group were compared to the control group, there was a significant difference between these groups (p <0.05). There was no significant difference in terms of the NGAL level (p> 0.05). When 0th, 3rd, 6th, 12 and 24th hrs TAS, TOS, OSI, IMA, NGAL and lactate levels compared with each other, there was no difference between them (p>0.05). Conclusion: The levels of IMA, TOS, TAS and OSI were detected high in CO poisoning, but it is not meaningful in evaluating the effectiveness of treatment.
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    A Comparison of Human Prothrombin Complex and Fresh Frozen Plasma for Reversal of Warfarin Anticoagulant Effect in The Emergency Department
    (2016) Altinbilek, Ertugrul; Ozturk, Derya; Ikizceli, Ibrahim; Kavalci, Cemil; https://orcid.org/0000-0003-2529-2946; AGG-1308-2022
    Introduction: Warfarin, the most commonly used oral anticoagulant worldwide. Bleeding represents the most significant complication of warfarin therapy. The aim of the present study was to compare the efficacies of Human Prothrombin Complex (PCC) and Fresh Frozen Plasma (FFP) for reversal of warfarin-induced anticoagulant effect in the emergency department. Materials and methods: This observational, retrospective study was retrospectively conducted at Sisli Hamidiye Etfal Training and Research Hospital. The study included 32 patients aged over 18 years who presented to the emergency department with warfarin-induced INR elevation and major bleeding. The patients were divided into PCC (Group 1) and FFP (Group 2) groups. The two groups were compared with each other with respect to age, gender distribution, duration of emergency department stay, warfarin dosing schedule (mg/day), bleeding site, amount of PCC (number*10 ml/IU) or FFP (number*200 ml) used for treatment, pre-treatment INR, aPTT levels, and INR, PT, and aPTT levels 15 minutes after FFP and 240 minutes after PCC administration. Results: The two groups were not significantly different with respect to age and gender distribution (p > 0.05). PCC group had an average duration of emergency department stay of 4.8 hours whereas FFP group had an average duration of emergency department stay of 12.25 hours (p<0.05). The number and cost of PCC was significantly greater than FFP (p<0.05). However, the volume of drug was significantly lower in the PCC group (p<0.05) Conclusion: PCC has a limited role in clinical practice due to its cost and limited availability. However, with the possible exceptions of blood transmissible diseases, volume loading, and loss of time, administration of a combination of FFP and vitamin K is not a medically inappropriate practice.