Tıp Fakültesi / Faculty of Medicine

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Author: search.filters.author.Haberal, MehmetSubject: search.filters.subject.Mortality

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    Acute Renal Injury in Liver Transplant Patients and Its Effect on Patient Survival
    (2014) Kirnap, Mahir; Colak, Turan; Baskin, Esra; Akdur, Aydincan; Moray, Gokhan; Arslan, Gulnaz; Haberal, Mehmet; https://orcid.org/0000-0002-8372-7840; https://orcid.org/0000-0003-4361-8508; https://orcid.org/0000-0002-8726-3369; https://orcid.org/0000-0003-2498-7287; https://orcid.org/0000-0002-3462-7632; 24635816; AAH-9198-2019; AAJ-8554-2021; B-5785-2018; AAA-3068-2021; AAE-1041-2021; AAJ-8097-2021
    Objectives: Acute renal injury is a common complication in liver transplant patients. Acute kidney injury is due to nephrotoxic drugs used after liver transplant, infections, and hemorrhage. Though it is generally reversible, it has effects on grafts and patients survival. In this retrospective observational study carried out at a single center, the effects of acute renal disease on liver recipient's survival were investigated. Materials and Methods: Liver transplant recipients of live-donor and deceased-donor transplants between January 2002 and May 2013 were included in this study; there were 310 liver transplant patients (mean age, 28 y; age range, 6 mo-62 y; 165 males, 145 females). The acute kidney disease diagnosis and staging was based on the nephrology department evaluation and daily serum creatinine levels. Patients with acute kidney injury before undergoing liver transplant and those undergoing a transplant for the second time were excluded. Kidney functions were evaluated by the nephrology department 1 week, 3 months, and 1 year after the liver transplant. Results: Acute kidney disease rates in these patients were 5%, 8%, and 12%. Four patients developed chronic kidney failure during follow-up. The mortality rate was higher (18%) in acute renal failure patients compared with those that did not have acute renal failure. The mortality rate was 11% in patients without acute renal failure. Conclusions: Acute renal injury is common after liver transplant and has an effect on mortality.
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    Clinical Characteristics of Acinetobacter baumannii Infection in Solid-Organ Transplant Recipients
    (2018) Serifoglu, Irem; Dedekarginoglu, Balam Er; Bozbas, Serife Savas; Akcay, Sule; Haberal, Mehmet; 0000-0002-7230-202X; 0000-0002-8360-6459; 0000-0002-7230-202X; 0000-0002-3462-7632; 29528021; AAS-6628-2021; AAI-8064-2021; AAB-5175-2021; AAJ-8097-2021
    Objectives: Acinetobacter baumannii, depending on the immune status of the host, may result in one of the most serious hospital infections. Infections involving A. baumannii infection have been recently rising. However, little is known about the clinical features of A. baumannii infection in solid-organ transplant recipients. We aimed to share our clinical experiences with A. baumannii infection in our transplant recipients. Materials and Methods: Between 2011 and 2017, 41 solid-organ transplant patients developed A. baumannii infection at Baskent University Hospital. Medical records were reviewed, and patient demographics, microbiology results, and overall outcome data were noted. Results: Of 41 solid-organ transplant patients with A. baumannii infection, 29 were male and 12 were female patients with mean age of 47.15 +/- 13.24 years. Our infection rate with A. baumannii infection was 6.1%. The most common sites of infection were deep tracheal aspirate (48.8%)and bloodstream (36.6%). Onset of infection 1 year post-transplant was identified in 58.5% of recipients. Risk factors included presence of invasive procedures (56.1%) and administration of high-dose corticosteroids for rejection 1 year before infection (68.3%). Thirty-day mortality rate was 41.5% (17/41 patients)and was not associated with the infection site, microbiological cure, clinical cure, and drug resistance in our study group. Conclusions: Acinetobacter baumannii is an important cause of hospital-acquired infection and mortality worldwide. A major problem with A. baumannii infection is delayed initiation of appropriate antibiotic treatment and the rising numbers of extensively drugresistant organisms. Predicting the potential risk factors, especially in the already at-risk solid-organ transplant population, has an important role in patient outcomes.
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    Safra kesesi ameliyatı sonrası cerrahi müdahale gerektiren ciddi komplikasyonlar ve yaklaşımlar
    (Ulusal Cerrahi Dergisi ,25 (2) ,62-67, 2009) Törer, Nurkan; Nursal, Tarık Zafer; Çalışkan, Kenan; Ezer, Ali; Çolakoğlu, Tamer; Karakayalı, Hamdi; Haberal, Mehmet
    Kolosistektomi sonrası görülen ciddi komplikasyonlarla ilgili kliniğimizin deneyimlerini paylaşmak ve önemli gördüğümüz noktaları belirtmek. Gereç-Yöntem: Mayıs 1999 - Kasım 2007 tarihleri arasında kolesistektomi sonrası ciddi sorun gelişen ve hastanemizde ameliyat edilen hastaların dosyaları incelendi. Kolesistektominin tipi, başvuru süresi, başvuru anındaki bulguları, yaralanma tipi, başvurudan ameliyata kadar geçen süre, ameliyat sonrası sonuçları kaydedildi. Bulgular: Yirmi iki hastanın yaş ortancası 50 (27 - 73), kadın/erkek oranı 1,2 idi. Dokuz hastada laparoskopik kolesistektomi (LK), sekiz hastada açık kolesistektomi (AK), üç hastada laparoskopik başlanıp AK, iki hastada kolesistektomi sonrası benign biliyer darlık nedeniyle bilioenterostomi yapılmıştı. Amsterdam sınıflamasına göre hastaların yedisi Tip-B, onbiri Tip-C, üçü Tip-D yaralanma, biri damar yaralanmasıydı Tip-B yaralanma, LK veya laparoskopik başlanıp açığa geçilen olgularda gözlenirken, AK yapılanlarda hiç görülmedi. AK yapılanlardaki hakim yaralanma ise Tip-C idi (n=6/8) (p=0,029). Mortalite bir, ciddi komplikasyon yedi, uzun dönemde sorun iki hastada gözlendi. Komplikasyon gelişme oranları; Tip-D yaralanmalarda 3 hastadan ikisinde (p=0,167), erken dönemde başvuran (10 günden önce) hastalarda (5/9 - 2/13 p=0,046), erken müdahale yapılan (10 günden önce) hastalarda daha yüksekti (6/13 - 1/9 p=0,069). Uzun dönemde sorun yaşama oranı erken müdahale yapılan hastalarda (2/12 - 0/9 p=0,178) daha fazlaydı. Sonuç: AK ile safra yolu darlıkları, LK ile safra kaçaklarının daha sık meydana geldiği görüldü. We aim to share our experience on major complications of cholecystectomy. Methods: Records of patients operated for major cholecystectomy complications between May 1999 - November 2007 were analyzed. Type of cholecystectomy, clinical complaint, type of injury, period from first operation to referral and referral to corrective surgery, postoperative complications and long-term outcome were recorded. Results: Median age of 22 patients was 50 (27 - 73), female/male ratio was 1.2. Type of cholecystectomy was laparoscopic cholecystectomy (LC) (n=9), open cholecystectomy (OC) (n=8), bilioenterostomy (due to post-cholecystectomy benign biliary stricture) (n=2), conversion to open cholecystectomy (COC) (n=3). Detected type of injury was; Type-B (n=7), Type-C (n=11), Type-D (n=3) and unclassified (n=1) according to Amsterdam classification. All of the Type-B injuries were observed in four LC and three COC patients and none of the OC patients. However, in the OC group, most frequent type of injury was Type-C (n=6/8) (p=0.029). One patient died, 7 patients had complication, and two patients had recurrent biliary problems. Complication rate was more frequent for; Type-D injury (2/3 p=0.167), patients with early (<10 days) presentation (5/9 - 2/13) (p=0.046) and patients with early (<10 days) surgical intervention (6/13 - 1/9) (p=0.069). Experiencing recurrent problem rate was more frequent for the patients with early surgical intervention (2/12 - 0/9) (p=0.178). Conclusion: Most frequent complication of OC was biliary strictures and that of LC was bile leakage.